TN2012000207A1 - Spiropiperidine compounds as orl-1 receptor antagonists - Google Patents
Spiropiperidine compounds as orl-1 receptor antagonistsInfo
- Publication number
- TN2012000207A1 TN2012000207A1 TNP2012000207A TN2012000207A TN2012000207A1 TN 2012000207 A1 TN2012000207 A1 TN 2012000207A1 TN P2012000207 A TNP2012000207 A TN P2012000207A TN 2012000207 A TN2012000207 A TN 2012000207A TN 2012000207 A1 TN2012000207 A1 TN 2012000207A1
- Authority
- TN
- Tunisia
- Prior art keywords
- orl
- treatment
- receptor antagonists
- compounds
- spiropiperidine compounds
- Prior art date
Links
- 108010020615 nociceptin receptor Proteins 0.000 title abstract 2
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- JUXAVSAMVBLDKO-UHFFFAOYSA-N 1-(1-azabicyclo[2.2.2]octan-3-yl)-3-[3-(1h-indol-3-yl)-1-oxo-1-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropan-2-yl]urea Chemical class C1N(CC2)CCC2C1NC(=O)NC(C(=O)N1CCC2(C3=CC=CC=C3CC2)CC1)CC1=CNC2=CC=CC=C12 JUXAVSAMVBLDKO-UHFFFAOYSA-N 0.000 title 1
- 208000008589 Obesity Diseases 0.000 abstract 2
- 206010033307 Overweight Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 235000020824 obesity Nutrition 0.000 abstract 2
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 238000010171 animal model Methods 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 238000012423 maintenance Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
As ORL-1 receptor antagonist of the formula I, its uses, and methods for its preparation are described. ORL-1 antagonists are deemed to be useful; in the treatment of depression and/or the treatment of overweight, obesity, and/or weight maintenance post treatment for overweight or obesity. Certain compounds have also demonstrated through animal models that the compounds of the present invention are useful for the treatment of migraine.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29862910P | 2010-01-27 | 2010-01-27 | |
| PCT/US2010/056180 WO2011060035A1 (en) | 2009-11-16 | 2010-11-10 | Spiropiperidine compounds as orl-1 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TN2012000207A1 true TN2012000207A1 (en) | 2013-12-12 |
Family
ID=60997181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNP2012000207A TN2012000207A1 (en) | 2010-01-27 | 2012-05-08 | Spiropiperidine compounds as orl-1 receptor antagonists |
Country Status (1)
| Country | Link |
|---|---|
| TN (1) | TN2012000207A1 (en) |
-
2012
- 2012-05-08 TN TNP2012000207A patent/TN2012000207A1/en unknown
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