CY1114664T1 - Spiropiperidine Compounds as ORL-1 Competitor Receptors - Google Patents
Spiropiperidine Compounds as ORL-1 Competitor ReceptorsInfo
- Publication number
- CY1114664T1 CY1114664T1 CY20131101037T CY131101037T CY1114664T1 CY 1114664 T1 CY1114664 T1 CY 1114664T1 CY 20131101037 T CY20131101037 T CY 20131101037T CY 131101037 T CY131101037 T CY 131101037T CY 1114664 T1 CY1114664 T1 CY 1114664T1
- Authority
- CY
- Cyprus
- Prior art keywords
- orl
- competitor
- receptors
- treatment
- compounds
- Prior art date
Links
- JUXAVSAMVBLDKO-UHFFFAOYSA-N 1-(1-azabicyclo[2.2.2]octan-3-yl)-3-[3-(1h-indol-3-yl)-1-oxo-1-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropan-2-yl]urea Chemical class C1N(CC2)CCC2C1NC(=O)NC(C(=O)N1CCC2(C3=CC=CC=C3CC2)CC1)CC1=CNC2=CC=CC=C12 JUXAVSAMVBLDKO-UHFFFAOYSA-N 0.000 title 1
- 208000008589 Obesity Diseases 0.000 abstract 2
- 206010033307 Overweight Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 235000020824 obesity Nutrition 0.000 abstract 2
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 238000010171 animal model Methods 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 108010020615 nociceptin receptor Proteins 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Ένας ανταγωνιστής υποδοχέα ORL-1 του τύπου Ι, οι χρήσεις του, και μέθοδοι παρασκευής του περιγράφονται. Οι ανταγωνιστές ORL-1 θεωρούνται χρήσιμοι• στη θεραπεία της κατάθλιψης και/ή στη θεραπεία του υπερβολικού βάρους, της παχυσαρκίας, και/ή στη διατήρηση βάρους μετά από θεραπεία για υπερβολικό βάρος ή παχυσαρκία. Ορισμένες ενώσεις έχουν επίσης δείξει μέσω ζωικών μοντέλων ότι οι ενώσεις της παρούσας εφεύρεσης είναι χρήσιμες για τη θεραπεία της ημικρανίας.An ORL-1 receptor antagonist of formula I, its uses, and methods of its preparation are described. ORL-1 antagonists are considered useful in the treatment of depression and / or in the treatment of overweight, obesity, and / or in maintaining weight after treatment for overweight or obesity. Some compounds have also shown through animal models that the compounds of the present invention are useful for the treatment of migraine.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09382246 | 2009-11-16 | ||
| US29862910A | 2010-01-27 | 2010-01-27 | |
| EP10782482.3A EP2501703B1 (en) | 2009-11-16 | 2010-11-10 | Spiropiperidine compounds as orl-1 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1114664T1 true CY1114664T1 (en) | 2016-10-05 |
Family
ID=58448809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20131101037T CY1114664T1 (en) | 2009-11-16 | 2013-11-21 | Spiropiperidine Compounds as ORL-1 Competitor Receptors |
Country Status (1)
| Country | Link |
|---|---|
| CY (1) | CY1114664T1 (en) |
-
2013
- 2013-11-21 CY CY20131101037T patent/CY1114664T1/en unknown
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