[go: up one dir, main page]

TN2011000217A1 - Pirfenidone treatment for patients with atypical liver fuction - Google Patents

Pirfenidone treatment for patients with atypical liver fuction

Info

Publication number
TN2011000217A1
TN2011000217A1 TN2011000217A TN2011000217A TN2011000217A1 TN 2011000217 A1 TN2011000217 A1 TN 2011000217A1 TN 2011000217 A TN2011000217 A TN 2011000217A TN 2011000217 A TN2011000217 A TN 2011000217A TN 2011000217 A1 TN2011000217 A1 TN 2011000217A1
Authority
TN
Tunisia
Prior art keywords
pirfenidone
administering
fuction
patients
patient
Prior art date
Application number
TN2011000217A
Other languages
English (en)
Inventor
Javier Szwarcberg
Williamson Ziegler Bradford
Original Assignee
Intermune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41427890&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2011000217(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intermune Inc filed Critical Intermune Inc
Publication of TN2011000217A1 publication Critical patent/TN2011000217A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
TN2011000217A 2008-11-10 2011-05-05 Pirfenidone treatment for patients with atypical liver fuction TN2011000217A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11310708P 2008-11-10 2008-11-10
US22894309P 2009-07-27 2009-07-27
US12/553,292 US7635707B1 (en) 2008-11-10 2009-09-03 Pirfenidone treatment for patients with atypical liver function
PCT/US2009/063702 WO2010054294A1 (fr) 2008-11-10 2009-11-09 Traitement à base de pirfénidone pour des patients présentant une fonction hépatique atypique

Publications (1)

Publication Number Publication Date
TN2011000217A1 true TN2011000217A1 (en) 2012-12-17

Family

ID=41427890

Family Applications (1)

Application Number Title Priority Date Filing Date
TN2011000217A TN2011000217A1 (en) 2008-11-10 2011-05-05 Pirfenidone treatment for patients with atypical liver fuction

Country Status (38)

Country Link
US (9) US7635707B1 (fr)
EP (4) EP2343070B1 (fr)
JP (3) JP2012508253A (fr)
KR (1) KR101699501B1 (fr)
CN (1) CN102209543A (fr)
AP (1) AP2011005740A0 (fr)
AT (1) ATE503480T1 (fr)
AU (3) AU2009313302B2 (fr)
BR (1) BRPI0921022A2 (fr)
CA (2) CA2709997C (fr)
CL (1) CL2011000966A1 (fr)
CO (1) CO6382132A2 (fr)
CU (1) CU20110100A7 (fr)
CY (2) CY1111595T1 (fr)
DE (1) DE602009000986D1 (fr)
DK (2) DK2343070T3 (fr)
EA (1) EA022482B1 (fr)
EC (1) ECSP11011039A (fr)
ES (3) ES2578715T3 (fr)
GE (1) GEP201706719B (fr)
HR (2) HRP20110478T1 (fr)
IL (1) IL212064A (fr)
MA (1) MA32880B1 (fr)
ME (1) ME01189B (fr)
MX (1) MX2011004904A (fr)
MY (1) MY159353A (fr)
NI (1) NI201100091A (fr)
PE (1) PE20110683A1 (fr)
PL (2) PL2343070T3 (fr)
PT (2) PT2343070E (fr)
RS (2) RS53721B1 (fr)
SI (2) SI2191831T1 (fr)
SM (2) SMT201100030B (fr)
SV (1) SV2011003897A (fr)
TN (1) TN2011000217A1 (fr)
TW (2) TW201341361A (fr)
WO (1) WO2010054294A1 (fr)
ZA (1) ZA201102411B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
US7635707B1 (en) 2008-11-10 2009-12-22 Intermune, Inc. Pirfenidone treatment for patients with atypical liver function
CA2747251A1 (fr) * 2009-01-26 2010-07-29 Intermune, Inc. Methodes de traitement d'infarctus du myocarde aigus et troubles associes
US7816383B1 (en) 2009-12-04 2010-10-19 Intermune, Inc. Methods of administering pirfenidone therapy
EP2670242B1 (fr) 2011-01-31 2022-03-16 Avalyn Pharma Inc. Composés analogues de pyridone et de pirfénidone en aérosol, et leurs utilisations
US10105356B2 (en) 2011-01-31 2018-10-23 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
MX2011007675A (es) 2011-07-19 2012-07-11 Cell Therapy And Technology S A De C V Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas.
EP2672539B1 (fr) * 2011-10-13 2016-09-28 Mitsui Chemicals, Inc. Matière piézoélectrique polymère et son procédé de fabrication
HK1201199A1 (en) * 2012-01-18 2015-08-28 霍夫曼-拉罗奇有限公司 Methods of using fgf19 modulators
MX346763B (es) 2012-03-28 2017-03-31 Cell Therapy And Tech S A De C V Composición tópica semisólida conteniendo pirfenidona y dialil óxido de disulfuro modificado (odd-m) para eliminar o prevenir el acné.
MX356551B (es) 2012-08-23 2018-06-04 Grupo Medifarma S A De C V Star Composición antiséptica, antiseborreica y exfoliante para eliminar o prevenir el acné.
CA2819967C (fr) * 2012-08-31 2016-03-22 Intermune, Inc. Utilisation de pirfenidone en simultanee avec du ciprofloxacin
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
US9682071B2 (en) 2013-03-15 2017-06-20 Intermune, Inc. Methods of improving microvascular integrity
US9770443B2 (en) 2014-01-10 2017-09-26 Genoa Pharmaceuticals, Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
US20160331734A1 (en) * 2014-01-24 2016-11-17 Auspex Pharmaceuticals, Inc. Substituted n-aryl pyridinones
KR102397379B1 (ko) * 2014-03-25 2022-05-13 리딩 바이오사이언시즈, 인크. 자가소화의 치료용의 조성물
JP6525437B2 (ja) 2014-04-02 2019-06-05 インターミューン， インコーポレイテッド 抗線維性ピリジノン
EP3253211B1 (fr) 2015-02-05 2025-06-11 Memorial Sloan Kettering Cancer Center Tacrolimus destiné au traitement du lymphoedème
MA41544A (fr) * 2015-02-19 2017-12-26 Novartis Ag Dosages de panobinostat pour le traitement du myélome multiple
WO2017097947A1 (fr) * 2015-12-11 2017-06-15 F. Hoffmann-La Roche Ag Polythérapie associant le vismodégib et la pirfénidone
CA2937365C (fr) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Formulation en granules de 5-methyl-1-phenyl-2-(1h)-pyridone et methode de fabrication associee
WO2018026441A1 (fr) * 2016-08-01 2018-02-08 The Regents Of The University Of California Méthodes de prévention ou de traitement de maladies de type fibrose
MX364040B (es) * 2016-11-11 2019-04-11 Cell Therapy And Tech S A De C V Uso farmacéutico de una composición que contiene pirfenidona de liberación prolongada (pfd-lp) para la reversión y tratamiento de la esteatohepatitis humana (nafld/nash).
US20190388407A1 (en) 2017-02-12 2019-12-26 Aiviva Biopharma, Inc. Multikinase inhibitors of vegf and tfg beta and uses thereof
US11400089B2 (en) * 2017-08-12 2022-08-02 Diane Dan-Shya Tang-Liu Multikinase inhibitors and uses in reproductive and digestive tract fibrosis
MX366086B (es) 2017-08-15 2019-06-27 Cell Therapy And Tech S A De C V Composicion topica semisolida conteniendo un agente antimicrobiano y pirfenidona para el tratamiento de daños cronicos de la piel.
AU2019321429B2 (en) * 2018-08-15 2022-12-08 Aiviva Biopharma, Inc. Multi-kinase inhibitors of VEGF and TGF beta and uses thereof
US12480960B2 (en) 2019-01-11 2025-11-25 University Of Virginia Patent Foundation Compositions and methods for predicting lung function decline in idiopathic pulmonary fibrosis
WO2021057599A1 (fr) * 2019-09-26 2021-04-01 深圳先进技术研究院 Application de pirfénidone dans la préparation d'un médicament pour la prévention et le traitement de la polyarthrite rhumatoïde
US20220396556A1 (en) * 2019-10-18 2022-12-15 The Trustees Of The University Of Pennsylvania Lipid and Lipid Nanoparticle Formulation for Drug Delivery
PH12022551359A1 (en) 2019-12-04 2023-11-20 Idorsia Pharmaceuticals Ltd Combination of an azetidine lpa1 receptor antagonist with pirfenidone and/or nintedanib for use in the treatment of fibrotic diseases
EP4486326A1 (fr) 2022-02-28 2025-01-08 Nuformix Technologies Limited Compositions et méthodes de traitement de la fibrose pulmonaire idiopathique

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1000828A (en) 1907-07-25 1911-08-15 Pierre Lorillard Conveyer.
CA1049411A (fr) 1972-12-18 1979-02-27 Affiliated Medical Research Pyridone n-substituee; methode generale de synthese des pyridones
US4042699A (en) 1972-12-18 1977-08-16 Affiliated Medical Research, Inc. Method for reducing serum glucose levels
US4052509A (en) 1972-12-18 1977-10-04 Affiliated Medical Research, Inc. Method for reducing serum uric acid levels
CA1244894A (fr) 1985-09-27 1988-11-15 William A. Cole Amplificateur de classe b a basse tension utilisant des petits condensateurs de decouplage
JPH02215719A (ja) 1989-02-15 1990-08-28 Yamauchi Akitomo 線維化病変組織の修復並びに線維化病変の阻止剤
US5716632A (en) 1989-11-22 1998-02-10 Margolin; Solomon B. Compositions and methods for reparation and prevention of fibrotic lesions
US5518729A (en) 1989-11-22 1996-05-21 Margolin; Solomon B. Compositions and methods for reparation and prevention of fibrotic lesions
US5310562A (en) 1989-11-22 1994-05-10 Margolin Solomon B Composition and method for reparation and prevention of fibrotic lesions
US6294350B1 (en) 1997-06-05 2001-09-25 Dalhousie University Methods for treating fibroproliferative diseases
US6956044B1 (en) * 2000-02-21 2005-10-18 Margolin Solomon B Compositions and methods for treatment of epilepsy
SE0101762D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab New use
HRP20040877A2 (en) 2002-04-10 2005-02-28 Applied Research Systems Ars Holding N.V. Use of osteoprotegerin for the treatment and/or prevention of fibrotic disease
WO2004019863A2 (fr) 2002-08-28 2004-03-11 Intermune, Inc. Therapie de combinaison pour le traitement de troubles fibrosants
JP4542743B2 (ja) 2002-12-26 2010-09-15 Ｋｄｌ株式会社 ピリドン誘導体の溶液状医薬組成物
WO2005013917A2 (fr) 2003-02-28 2005-02-17 Intermune, Inc. Therapie combinee servant a traiter une infection par un alphavirus et une fibrose hepatique
WO2005011047A2 (fr) 2003-04-09 2005-02-03 Mano Dorsey Judd Technologie d'antenne virtuelle (vat) et applications
WO2004101750A2 (fr) 2003-05-09 2004-11-25 Centocor, Inc. Proteines derivees de l'immunoglobine specifiques de il-23p40, compositions, procedes et utilisations
US20070172446A1 (en) 2003-05-16 2007-07-26 Intermune, Inc. Synthetic chemokine receptor ligands and methods of use thereof
US20070092488A1 (en) 2003-05-16 2007-04-26 Intermune Inc. Methods of treating idiopathic pulmonary fibrosis
WO2005000227A2 (fr) 2003-06-06 2005-01-06 Intermune, Inc. Methodes permettant de traiter des troubles medies par tnf
US20070053877A1 (en) 2003-08-21 2007-03-08 Intermune, Inc. Methods of treating idiopathic pulmonary fibrosis
CN1266144C (zh) 2003-09-01 2006-07-26 上海凯曼生物科技有限公司 黄芩甙和黄芩甙元的用途和剂型
WO2005040758A2 (fr) * 2003-10-24 2005-05-06 Intermune, Inc. Utilisation de pirfenidone dans des posologies therapeutiques
CA2544924A1 (fr) 2003-11-05 2005-05-19 Centocor, Inc. Procedes et compositions pour traiter des pathologies associees a la mcp-1
CA2545813C (fr) 2003-11-14 2011-01-04 Shanghai Genomics, Inc. Derives de pyridone, et utilisation correspondante
WO2005067963A1 (fr) 2003-12-23 2005-07-28 Intermune, Inc. Utilisation d'un interferon modifie par du polyethylene glycol dans des schemas posologiques de dosage therapeutique
WO2005063186A1 (fr) * 2003-12-30 2005-07-14 Council Of Scientific & Industrial Research Composition vegetale pour soins des dents et de la bouche et son procede de preparation
CA2557724A1 (fr) 2004-02-27 2005-10-06 Centocor, Inc. Procedes et compositions pour traiter des pathologies associees a l'il-13
US20070053845A1 (en) 2004-03-02 2007-03-08 Shiladitya Sengupta Nanocell drug delivery system
WO2005110478A2 (fr) 2004-04-13 2005-11-24 Intermune, Inc. Polytherapie destinee a traiter des troubles fibreux
US20060037057A1 (en) 2004-05-24 2006-02-16 Sharp Laboratories Of America, Inc. Method and system of enabling trick play modes using HTTP GET
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
AR051444A1 (es) 2004-09-24 2007-01-17 Centocor Inc Proteinas derivadas de inmunoglobulina especifica de il-23p40, composiciones, epitopos, metodos y usos
US20060246070A1 (en) 2004-09-30 2006-11-02 Heavner George A Methods and compositions for treating renal cell carcinoma related pathologies
US20060105995A1 (en) 2004-10-05 2006-05-18 Schering Aktiengesellschaft TAFI inhibitors and their use to treat pulmonary fibrosis
JP2008518022A (ja) 2004-10-27 2008-05-29 メディミューン，インコーポレーテッド 線維症関連疾患を治療するためのＥｐｈＡ２およびエフリンＡ１モジュレーター
WO2006050058A2 (fr) 2004-10-28 2006-05-11 The General Hospital Corporation Methodes de detection et de therapie de tissus enflammes par immunomodulation
US20070065359A1 (en) 2005-03-14 2007-03-22 Shiladitya Sengupta Nanocells for diagnosis and treatment of diseases and disorders
WO2006105538A2 (fr) 2005-03-31 2006-10-05 Centocor, Inc. Methodes et compositions de traitement de pathologies afferentes a l'il-21
CN1846699A (zh) 2005-04-13 2006-10-18 中南大学湘雅医院 1－(取代苯基)－5－甲基－2－(1h) 吡啶酮(i)化合物用于制备抗除肾间质纤维化外其他器官纤维化或组织纤维化药物的应用
JP2008540345A (ja) 2005-04-29 2008-11-20 セルジーン・コーポレーション １−（５−（１ｈ−１，２，４−トリアゾール−５−イル）（１ｈ−インダゾール−３−イル））−３−（２−ピペリジルエトキシ）ベンゼンの固体形態
HRP20141053T1 (hr) 2005-05-10 2014-12-19 Intermune, Inc. Derivati piridona za moduliranje stresom aktiviranog sustava protein kinaze
US20070009518A1 (en) 2005-05-18 2007-01-11 Biogen Idec Inc. Methods for treating fibrotic conditions
JP2008545396A (ja) 2005-05-18 2008-12-18 インターミューン インコーポレイテッド 非天然ケモカイン受容体リガンドおよびこれらの使用方法
CN101263156A (zh) 2005-07-25 2008-09-10 因特蒙公司 C型肝炎病毒复制的新颖大环抑制剂
WO2007038264A2 (fr) 2005-09-22 2007-04-05 Biogen Idec Ma Inc. Methodes associees a gapr-1
NZ591443A (en) 2005-09-22 2013-04-26 Intermune Inc Granule formation of pirfenidone and pharmaceutically acceptable excipients
ATE551057T1 (de) 2005-10-31 2012-04-15 Intermune Inc Zusammensetzungen von pirfenidon/toll-like rezeptor (tlr)-antagonisten und verfahren zu ihrer verwendung zur stimulierung der produktion des granulozyten-kolonie-stimulierenden faktors (g-csf)
AU2006318428A1 (en) 2005-11-23 2007-05-31 Intermune, Inc. Method of modulating stress-activated protein kinase system
US20070203202A1 (en) 2005-12-02 2007-08-30 Robinson Cynthia Y Methods of reducing adverse events associated with pirfenidone therapy
SG174050A1 (en) 2006-04-13 2011-09-29 Actelion Pharmaceuticals Ltd Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis
US20080003635A1 (en) 2006-06-12 2008-01-03 Intermune, Inc. High Throughput Collagen Synthesis Assay
KR20090024834A (ko) 2006-07-05 2009-03-09 인터뮨, 인크. Ｃ형 간염 바이러스 복제의 신규 억제제
AU2007328206B2 (en) 2006-12-04 2013-08-01 Promedior, Inc. Conjoint therapy for treating fibrotic diseases
SI2124945T1 (sl) * 2006-12-18 2011-08-31 Intermune Inc Postopek dajanja terapije s pirfenidonom pacientu
CA2682666A1 (fr) 2007-03-30 2008-10-09 Centocor Ortho Biotech Inc. Antagonistes de cxcl13 et leur utilisation pour le traitement de maladies inflammatoires
AU2007201663A1 (en) 2007-04-16 2008-10-30 Nautilus Biotech Oral dosage formulations of protease resistant polypeptides
CA2583716A1 (fr) 2007-04-18 2008-10-18 Nautilus Biotech Formes posologiques orales de polypeptides resistant aux proteases
US20080260820A1 (en) 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
US20080287508A1 (en) 2007-05-18 2008-11-20 Intermune, Inc. Altering pharmacokinetics of pirfenidone therapy
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
US7635707B1 (en) 2008-11-10 2009-12-22 Intermune, Inc. Pirfenidone treatment for patients with atypical liver function
US7566729B1 (en) * 2008-11-10 2009-07-28 Intermune, Inc. Modifying pirfenidone treatment for patients with atypical liver function

Also Published As

Publication number Publication date
IL212064A0 (en) 2011-06-30
KR20110094295A (ko) 2011-08-23
RS51787B (sr) 2011-12-31
CL2011000966A1 (es) 2011-08-19
US20170333411A1 (en) 2017-11-23
US20120077850A1 (en) 2012-03-29
PT2191831E (pt) 2011-05-24
AP2011005740A0 (en) 2011-06-30
ECSP11011039A (es) 2011-07-29
KR101699501B1 (ko) 2017-01-24
DK2191831T3 (da) 2011-06-20
TW201020232A (en) 2010-06-01
EP2343070A1 (fr) 2011-07-13
AU2009313302B2 (en) 2011-01-06
ES2578715T3 (es) 2016-07-29
EP2343070B1 (fr) 2014-10-15
JP2015007132A (ja) 2015-01-15
JP2012193193A (ja) 2012-10-11
CO6382132A2 (es) 2012-02-15
ATE503480T1 (de) 2011-04-15
AU2011200385A1 (en) 2011-02-17
AU2011200385B2 (en) 2013-04-18
HRP20110478T1 (hr) 2011-07-31
CU20110100A7 (es) 2012-01-31
US20180200242A1 (en) 2018-07-19
GEP201706719B (en) 2017-08-25
HK1145138A1 (en) 2011-04-08
HK1153668A1 (en) 2012-04-05
BRPI0921022A2 (pt) 2015-12-29
RS53721B1 (sr) 2015-04-30
CA2709997A1 (fr) 2010-05-14
US20140073673A1 (en) 2014-03-13
AU2010212371A1 (en) 2010-09-09
TWI419877B (zh) 2013-12-21
US7635707B1 (en) 2009-12-22
PL2343070T3 (pl) 2015-04-30
US20190060299A1 (en) 2019-02-28
CN102209543A (zh) 2011-10-05
ES2525543T3 (es) 2014-12-26
MY159353A (en) 2016-12-30
US20170100381A1 (en) 2017-04-13
SMT201100030B (it) 2011-09-09
AU2010212371B2 (en) 2010-12-23
EP2191831B1 (fr) 2011-03-30
ES2387421T3 (es) 2012-09-21
AU2009313302A1 (en) 2010-05-14
CY1111595T1 (el) 2015-10-07
CY1115862T1 (el) 2017-01-25
JP2012508253A (ja) 2012-04-05
WO2010054294A1 (fr) 2010-05-14
PL2191831T3 (pl) 2011-09-30
US8609701B2 (en) 2013-12-17
DE602009000986D1 (de) 2011-05-12
CA2709997C (fr) 2012-03-27
SMT201500088B (it) 2015-05-05
CA2765402A1 (fr) 2010-05-14
US8592462B2 (en) 2013-11-26
NI201100091A (es) 2011-11-03
MX2011004904A (es) 2011-06-16
ME01189B (fr) 2011-12-31
TW201341361A (zh) 2013-10-16
SV2011003897A (es) 2011-08-09
EP2505199A1 (fr) 2012-10-03
DK2343070T3 (en) 2015-01-05
HK1176002A1 (en) 2013-07-19
PE20110683A1 (es) 2011-10-20
EP2500019A1 (fr) 2012-09-19
EP2500019B1 (fr) 2016-04-06
ZA201102411B (en) 2014-06-25
EA022482B1 (ru) 2016-01-29
PT2343070E (pt) 2015-01-14
EA201170669A1 (ru) 2011-10-31
EP2191831A1 (fr) 2010-06-02
SI2343070T1 (sl) 2015-01-30
MA32880B1 (fr) 2011-12-01
IL212064A (en) 2016-06-30
US20160250198A1 (en) 2016-09-01
HRP20141224T1 (en) 2015-03-27
SI2191831T1 (sl) 2011-07-29
US20110263656A1 (en) 2011-10-27

Similar Documents

Publication Publication Date Title
TN2011000217A1 (en) Pirfenidone treatment for patients with atypical liver fuction
UA105191C2 (ru) Лечение пирфенидоном пациентов с атипической функцией печени
HK1198869A1 (en) Combination treatments for hepatitis c
EP2216024A3 (fr) Utilisation de ranolazine pour le traitement de maladies cardiovasculaires
EP3241840A3 (fr) Inhibition de la signalisation axl dans une thérapie antimétastasique
EA201401028A1 (ru) Фармацевтическая композиция, содержащая эмпаглифлозин и лекарственное средство от ожирения
FI20135152A7 (fi) Farmaseuttinen yhdistelmäkoostumus ja menetelmiä diabeteksen ja metabolisten sairauksien hoidossa
NZ595046A (en) Compositions and methods for extended therapy with aminopyridines
WO2012063134A3 (fr) Analogues de glycoside cardiaque en combinaison avec l'émodine pour le traitement du cancer
HK1210699A1 (en) Methods of administering and evaluating nitrogen scavenging drugs for the treatment of hepatic encephalopathy
NZ700924A (en) Dosage regimen for a pi-3 kinase inhibitor
NZ600486A (en) Pirfenidone treatment for patients with atypical liver function
UA109944U (uk) Фармацевтична композиція для зниження рівня n-оксиду триметиламіну
NZ597675A (en) Medicament for the long term nsaid use
WO2012091425A3 (fr) Composition contenant, comme principe actif, un analogue de 4-hydroxytamoxifène ou un sel pharmaceutiquement acceptable de celui-ci, destinée à la prévention ou au traitement des maladies associées au syndrome métabolique
WO2014035828A3 (fr) Inhibition de la signalisation axl dans une thérapie anti-métastasique
UA66406U (ru) Способ лечения остеопенического синдрома у беременных с перинатальным инфицированием
MD4232B1 (en) Medicament based on troxerutin and carbazochrome for the treatment of progressive hepatic cirrhosis associated with heart failure
MD4231B1 (en) Medicament based on troxerutin and carbazochrome for the treatment of portal gastropathies in hepatic cirrhosis
UA64819U (ru) Способ лечения больных синдромом раздраженного кишечника, соединенным с хроническим некалькулезным холециститом и дисбиозом
UA45323U (ru) Способ коррекции дислипидемии у больных подагрой
UA89024U (uk) Спосіб комплексного лікування уретеролітіазу
UA89638U (ru) Способ лечения больных пожилого возраста с синдромом сосудистых умеренных когнитивных нарушений
UA53291U (ru) Способ лечения эндотелиальной дисфункции у людей пожилого возраста с хронической сердечной недостаточностью
UA48009U (ru) Способ лечения пациентов с дисфункцией сфинктера одди