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PE20110683A1 - Tratamiento de pirfenidona para pacientes con funcion hepatica atipica - Google Patents

Tratamiento de pirfenidona para pacientes con funcion hepatica atipica

Info

Publication number
PE20110683A1
PE20110683A1 PE2011000951A PE2011000951A PE20110683A1 PE 20110683 A1 PE20110683 A1 PE 20110683A1 PE 2011000951 A PE2011000951 A PE 2011000951A PE 2011000951 A PE2011000951 A PE 2011000951A PE 20110683 A1 PE20110683 A1 PE 20110683A1
Authority
PE
Peru
Prior art keywords
pyrphenidone
day
hepatic function
atypic
patients
Prior art date
Application number
PE2011000951A
Other languages
English (en)
Inventor
Williamson Ziegler Bradford
Javier Szwarcberg
Original Assignee
Intermune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41427890&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110683(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US12/428,393 external-priority patent/US7566729B1/en
Application filed by Intermune Inc filed Critical Intermune Inc
Publication of PE20110683A1 publication Critical patent/PE20110683A1/es

Links

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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Abstract

SE REFIERE A UN METODO DE ADMINISTRACION DE PIRFENIDONA EN UN PACIENTE CON FIBROSIS PULMONAR IDIOPATICA (IPF) Y QUE HA EXHIBIDO UNA ANORMALIDAD GRADO 2 EN UNO O MAS BIOMARCADORES DE LA FUNCION HEPATICA COMO LA TRANSAMINASA ALANINA, TRANSAMINASA ASPARTATO Y BILIRRUBINA, DESPUES DE LA ADMINISTRACION DE PIRFENIDONA, EN DONDE DICHO METODO COMPRENDE: A) ADMINISTRAR 800 MG/DIA O 801 MG/DIA DE PIRFENIDONA DURANTE UNA SEMANA O HASTA QUE LOS BIOMARCADORES DE LA FUNCION HEPATICA ESTEN DENTRO DE LIMITES NORMALES; B) LUEGO, ADMINISTRAR 1600 MG/DIA O 1602 MG/DIA DE PIRFENIDONA DURANTE UNA SEMANA O HASTA QUE LOS BIOMARCADORES DE LA FUNCION HEPATICA ESTEN DENTRO DE LIMITES NORMALES; Y C) POSTERIORMENTE, ADMINISTRAR 2400 MG/DIA O 2403 MG/DIA DE PIRFENIDONA
PE2011000951A 2008-11-10 2009-11-09 Tratamiento de pirfenidona para pacientes con funcion hepatica atipica PE20110683A1 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11310708P 2008-11-10 2008-11-10
US12/428,393 US7566729B1 (en) 2008-11-10 2009-04-22 Modifying pirfenidone treatment for patients with atypical liver function
US48822809A 2009-06-19 2009-06-19
US22894309P 2009-07-27 2009-07-27
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