TN2011000070A1 - Picolinamide derivatives as kinase inhibitors - Google Patents
Picolinamide derivatives as kinase inhibitorsInfo
- Publication number
- TN2011000070A1 TN2011000070A1 TN2011000070A TN2011000070A TN2011000070A1 TN 2011000070 A1 TN2011000070 A1 TN 2011000070A1 TN 2011000070 A TN2011000070 A TN 2011000070A TN 2011000070 A TN2011000070 A TN 2011000070A TN 2011000070 A1 TN2011000070 A1 TN 2011000070A1
- Authority
- TN
- Tunisia
- Prior art keywords
- kinase
- compositions
- compounds
- kinase inhibitors
- picolinamide
- Prior art date
Links
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical class NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 title abstract 2
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 208000005623 Carcinogenesis Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000036952 cancer formation Effects 0.000 abstract 1
- 231100000504 carcinogenesis Toxicity 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 230000010469 pro-virus integration Effects 0.000 abstract 1
- 102000027426 receptor tyrosine kinases Human genes 0.000 abstract 1
- 108091008598 receptor tyrosine kinases Proteins 0.000 abstract 1
Landscapes
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
New picolinamide compounds, compositions and methods of inhibition of Provirus Integration of Maloney Kinase (PIM kinase) activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one PIM kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2009/061205 WO2010026124A1 (en) | 2008-09-02 | 2009-08-31 | Picolinamide derivatives as kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TN2011000070A1 true TN2011000070A1 (en) | 2012-09-05 |
Family
ID=55024382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TN2011000070A TN2011000070A1 (en) | 2009-08-31 | 2011-02-11 | Picolinamide derivatives as kinase inhibitors |
Country Status (1)
| Country | Link |
|---|---|
| TN (1) | TN2011000070A1 (en) |
-
2011
- 2011-02-11 TN TN2011000070A patent/TN2011000070A1/en unknown
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