TN2010000521A1 - Synthesis of dihydrothieno [3,2-d] pyrimidine diols and similar pyrimidine diols - Google Patents
Synthesis of dihydrothieno [3,2-d] pyrimidine diols and similar pyrimidine diolsInfo
- Publication number
- TN2010000521A1 TN2010000521A1 TNP2010000521A TN2010000521A TN2010000521A1 TN 2010000521 A1 TN2010000521 A1 TN 2010000521A1 TN P2010000521 A TNP2010000521 A TN P2010000521A TN 2010000521 A TN2010000521 A TN 2010000521A TN 2010000521 A1 TN2010000521 A1 TN 2010000521A1
- Authority
- TN
- Tunisia
- Prior art keywords
- diols
- pyrimidine
- synthesis
- pyrimidine diols
- similar
- Prior art date
Links
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical class O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 101100296720 Dictyostelium discoideum Pde4 gene Proteins 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 150000002009 diols Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 208000027232 peripheral nervous system disease Diseases 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to an improved process for the preparation of dihydrothienol [3,2-α] pyrimidine diols, and similar pyrimidine diols, that is efficient, high-yielding, and does not require expensive and potentially unstable intermediates.The diols are used as intermediates in the synthesis of pyrimidine compounds which inhibit PDE4 , and are thus useful in the treatment of respiratory or gastrointestinal diseases and complaints , peripheral or central nervous system diseases and disorders, inflammatory conditions , and cancers.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2009/043068 WO2009140127A2 (en) | 2008-05-13 | 2009-05-07 | SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TN2010000521A1 true TN2010000521A1 (en) | 2012-05-24 |
Family
ID=55024615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNP2010000521A TN2010000521A1 (en) | 2009-05-07 | 2010-11-09 | Synthesis of dihydrothieno [3,2-d] pyrimidine diols and similar pyrimidine diols |
Country Status (1)
| Country | Link |
|---|---|
| TN (1) | TN2010000521A1 (en) |
-
2010
- 2010-11-09 TN TNP2010000521A patent/TN2010000521A1/en unknown
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