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TN2010000029A1 - 2, 3-dihydrobenzo[1, 4] dioxin-2-ylmethyl derivatives as alpha2c antagonists for use in the treatment of peripheric and central nervous systeme diseases - Google Patents

2, 3-dihydrobenzo[1, 4] dioxin-2-ylmethyl derivatives as alpha2c antagonists for use in the treatment of peripheric and central nervous systeme diseases

Info

Publication number
TN2010000029A1
TN2010000029A1 TNP2010000029A TN2010000029A TN2010000029A1 TN 2010000029 A1 TN2010000029 A1 TN 2010000029A1 TN P2010000029 A TNP2010000029 A TN P2010000029A TN 2010000029 A TN2010000029 A TN 2010000029A TN 2010000029 A1 TN2010000029 A1 TN 2010000029A1
Authority
TN
Tunisia
Prior art keywords
diseases
peripheric
treatment
central nervous
systeme
Prior art date
Application number
TNP2010000029A
Other languages
English (en)
Inventor
Belle David Din
Patrik Holm
Arto Karljalainen
Arto Tolvanen
Gerd Wohlfahrt
Petteri Rummakko
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39884455&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2010000029(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Orion Corp filed Critical Orion Corp
Publication of TN2010000029A1 publication Critical patent/TN2010000029A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
TNP2010000029A 2007-07-20 2010-01-15 2, 3-dihydrobenzo[1, 4] dioxin-2-ylmethyl derivatives as alpha2c antagonists for use in the treatment of peripheric and central nervous systeme diseases TN2010000029A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95098307P 2007-07-20 2007-07-20
PCT/FI2008/000090 WO2009013390A1 (fr) 2007-07-20 2008-07-18 Dérivés de 2,3-dihydrobenzo[1,4] dioxin-2-ylméthyle utilisés en tant qu'antagonistes des alpha2c pour traiter des maladies des systèmes nerveux périphérique et central

Publications (1)

Publication Number Publication Date
TN2010000029A1 true TN2010000029A1 (en) 2011-09-26

Family

ID=39884455

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2010000029A TN2010000029A1 (en) 2007-07-20 2010-01-15 2, 3-dihydrobenzo[1, 4] dioxin-2-ylmethyl derivatives as alpha2c antagonists for use in the treatment of peripheric and central nervous systeme diseases

Country Status (31)

Country Link
US (3) US8492549B2 (fr)
EP (1) EP2176252B1 (fr)
JP (1) JP5460590B2 (fr)
KR (1) KR101535059B1 (fr)
CN (1) CN101842369B (fr)
AR (1) AR069271A1 (fr)
AU (1) AU2008278924B2 (fr)
BR (1) BRPI0814529B8 (fr)
CA (1) CA2693804C (fr)
CL (1) CL2008002114A1 (fr)
CO (1) CO6331473A2 (fr)
CY (1) CY1115789T1 (fr)
DK (1) DK2176252T3 (fr)
EA (1) EA017554B1 (fr)
ES (1) ES2502215T3 (fr)
GE (1) GEP20125538B (fr)
HR (1) HRP20141156T1 (fr)
IL (1) IL202964A (fr)
MA (1) MA31521B1 (fr)
MY (1) MY153872A (fr)
NZ (1) NZ582432A (fr)
PE (1) PE20090890A1 (fr)
PL (1) PL2176252T3 (fr)
PT (1) PT2176252E (fr)
RS (1) RS53571B1 (fr)
SI (1) SI2176252T1 (fr)
TN (1) TN2010000029A1 (fr)
TW (1) TWI457122B (fr)
UA (1) UA100695C2 (fr)
WO (1) WO2009013390A1 (fr)
ZA (1) ZA201000314B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI457122B (zh) 2007-07-20 2014-10-21 Orion Corp 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物
CN102015674B (zh) 2008-04-29 2014-10-29 Nsab神经研究瑞典公司分公司 多巴胺神经传递调节剂
RU2010141964A (ru) * 2008-04-29 2012-06-10 НСАБ, Филиаль аф НьюроСерч Свиден АБ, Сверийе (DK) Модуляторы дофаминовой нейротрансмиссии
US20110105462A1 (en) * 2008-04-29 2011-05-05 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Modulators of dopamine neurotransmission
TW201024282A (en) * 2008-11-20 2010-07-01 Orion Corp New pharmaceutical compounds
US20130267699A1 (en) 2011-06-24 2013-10-10 California Institute Of Technology Quaternary heteroatom containing compounds
US8822679B2 (en) 2011-06-24 2014-09-02 California Institute Of Technology Quaternary heteroatom containing compounds
US9518034B2 (en) 2013-10-14 2016-12-13 California Institute Of Technology Synthesis of chiral enaminones, their derivatives, and bioactivity studies thereof
US10421696B2 (en) 2014-12-18 2019-09-24 California Institute Of Technology Enantioselective synthesis of α-quaternary mannich adducts by palladium-catalyzed allylic alkylation
CN108752212B (zh) * 2015-03-06 2024-03-12 北京大学 9-脱羧迷迭香酸类似物及其合成方法和应用
CA2981041C (fr) 2015-03-27 2023-09-05 California Institute Of Technology Alkylation decarboxylative catalytique asymetrique d'alkyle au moyen de faibles concentrations de catalyseur et d'un precatalyseur robuste
TWI704145B (zh) * 2015-06-05 2020-09-11 芬蘭商奧利安公司 新醫藥化合物
EP3426391A4 (fr) 2016-03-11 2019-08-28 California Institute of Technology Compositions et procédés d'acylation de lactames
EP3478676A1 (fr) * 2016-06-29 2019-05-08 Orion Corporation Dérivés de benzodioxane et leur utilisation pharmaceutique
EP3595661A4 (fr) * 2017-03-12 2020-08-19 Xiaodong Wang Amines polycycliques utilisées comme modulateurs des récepteurs opioïdes
EP3480190B1 (fr) 2017-11-01 2023-01-04 California Institute of Technology Procédés d'alkylation allylique énantiosélective d'esters, lactones et lactames avec des alcools allyliques inactivés
GB201801130D0 (en) 2018-01-24 2018-03-07 Univ Oxford Innovation Ltd Compounds
SG11202101821TA (en) * 2018-09-25 2021-03-30 Bayer Ag a2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONISTS FOR THE TREATMENT OF SLEEP APNEA
EP3699173A1 (fr) 2018-10-18 2020-08-26 California Institute of Technology Pyrrolidines, pipérazines et diazépanes disubstitués par gem, compositions et leurs procédés de fabrication
WO2023131640A1 (fr) 2022-01-07 2023-07-13 Bayer Aktiengesellschaft ANTAGONISTES DE SOUS-TYPE C DE α2-ADRÉNOCEPTEUR POUR LE TRAITEMENT DE L'APNÉE DU SOMMEIL
KR102776660B1 (ko) * 2022-01-25 2025-03-04 재단법인 한국파스퇴르연구소 벤조다이옥세인 유도체 화합물 및 이의 의약 용도

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2056046A (en) * 1933-05-19 1936-09-29 Rhone Poulenc Sa Manufacture of bases derived from benz-dioxane
US3635982A (en) 1969-04-08 1972-01-18 American Home Prod Amino-substituted-quinoxalinyloxazolidines and -oxazines
GB1411531A (en) * 1972-10-24 1975-10-29 Lafon Labor Amino derivatives of 1,4-benzodioxan
JPS5163193A (ja) 1974-11-26 1976-06-01 Yoshitomi Pharmaceutical Tetorahidoropirazoropirijinkagobutsuno seizoho
US4039676A (en) * 1975-06-23 1977-08-02 Ciba-Geigy Corporation 2-piperidinoalkyl-1,4-benzodioxans
US4329348A (en) * 1979-02-26 1982-05-11 Ciba-Geigy Corporation N-Oxacyclic-alkylpiperidines as psychostimulants
HU181575B (en) 1980-10-03 1983-10-28 Richter Gedeon Vegyeszet Process for preparing 3-chloro-propyl-malonic acid ester and cyano-acetic acid ester derivatives
FR2525600A1 (fr) * 1982-04-21 1983-10-28 Bouchara Emile Nouvelles carboxamidoguanidines, leur procede d'obtention et les compositions pharmaceutiques en renfermant
GB2167408B (en) 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
DD250930A1 (de) 1986-06-08 1987-10-28 Isis Chemie Zwickau Veb Verfahren zur herstellung neuer tetrahydroisochinolinderivate
US4957928A (en) * 1986-06-26 1990-09-18 Ciba-Geigy Corporation Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds
AU4202589A (en) 1988-08-16 1990-03-23 E.I. Du Pont De Nemours And Company Fungicidal benzodioxane amine derivatives
CA2104873C (fr) 1991-02-26 2000-05-23 James N. Campbell Compositions et methodes pour le traitement de la douleur entretenue par le systeme sympathique
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
GB9514380D0 (en) * 1995-07-13 1995-09-13 Knoll Ag Therapeutic agents
FR2744451B1 (fr) * 1996-02-01 1998-04-24 Pf Medicament Nouvelles imidazolidinones, pyrimidinones, et 1,3-diazepin-2 -ones, leur preparation et leurs applications en therapeutique
HUP0003362A3 (en) 1997-05-06 2001-04-28 Novo Nordisk As Piperidine derivatives and pharmaceutical compositions containing them
US5902807A (en) * 1997-05-12 1999-05-11 Antti Haapalinna Method for the treatment of mental illness in mammals and a composition therefor
WO1999028300A1 (fr) 1997-12-04 1999-06-10 Allergan Sales, Inc. Derives imidazoles substitues ayant une activite de type agoniste vis a vis des recepteurs adrenergiques alpha 2b ou 2b/2c
FI20000480A0 (fi) 2000-03-01 2000-03-01 Orion Yhtymae Oyj Kinoliini- ja naftaleenijohdannaisia alfa-2 antagonisteina
AU9087301A (en) * 2000-09-11 2002-03-26 Sepracor Inc Ligands for monoamine receptors and transporters, and methods of use thereof
CA2480695A1 (fr) 2002-04-03 2003-10-09 Orion Corporation Composes polycycliques comme antagonistes puissants des recepteurs alpha2-adrenergiques
WO2004067513A1 (fr) 2003-01-27 2004-08-12 Oy Juvantia Pharma Ltd Antagonistes pour recepteurs alpha-2 adrenergiques
TWI457122B (zh) 2007-07-20 2014-10-21 Orion Corp 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物
JP5163193B2 (ja) 2008-03-13 2013-03-13 セイコーエプソン株式会社 プリンタシステム及びプリンタシステムにおける制御方法

Also Published As

Publication number Publication date
PE20090890A1 (es) 2009-07-08
CA2693804C (fr) 2015-11-24
RS53571B1 (sr) 2015-02-27
GEP20125538B (en) 2012-05-25
US20130281486A1 (en) 2013-10-24
DK2176252T3 (en) 2014-12-08
TWI457122B (zh) 2014-10-21
US8697723B2 (en) 2014-04-15
CL2008002114A1 (es) 2009-04-03
CN101842369B (zh) 2014-01-22
AU2008278924A1 (en) 2009-01-29
HRP20141156T1 (hr) 2015-01-16
EP2176252B1 (fr) 2014-09-03
BRPI0814529A2 (pt) 2015-01-27
MY153872A (en) 2015-03-31
CN101842369A (zh) 2010-09-22
IL202964A (en) 2013-12-31
PL2176252T3 (pl) 2015-04-30
MA31521B1 (fr) 2010-07-01
JP5460590B2 (ja) 2014-04-02
SI2176252T1 (sl) 2014-12-31
JP2010534197A (ja) 2010-11-04
ES2502215T3 (es) 2014-10-03
EP2176252A1 (fr) 2010-04-21
UA100695C2 (ru) 2013-01-25
EA201070169A1 (ru) 2010-06-30
US20100216836A1 (en) 2010-08-26
AR069271A1 (es) 2010-01-13
US8492549B2 (en) 2013-07-23
CO6331473A2 (es) 2011-10-20
PT2176252E (pt) 2014-12-03
KR20100044220A (ko) 2010-04-29
KR101535059B1 (ko) 2015-07-24
US8809536B2 (en) 2014-08-19
US20140179926A1 (en) 2014-06-26
AU2008278924B2 (en) 2013-09-26
HK1148530A1 (en) 2011-09-09
NZ582432A (en) 2012-03-30
WO2009013390A1 (fr) 2009-01-29
BRPI0814529B8 (pt) 2021-05-25
BRPI0814529B1 (pt) 2019-09-17
CA2693804A1 (fr) 2009-01-29
TW200908961A (en) 2009-03-01
ZA201000314B (en) 2010-10-27
US20120035210A9 (en) 2012-02-09
CY1115789T1 (el) 2017-01-25
EA017554B1 (ru) 2013-01-30

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