TN2010000060A1 - Proteasome inhibitors - Google Patents

Proteasome inhibitors

Info

Publication number: TN2010000060A1
Authority: TN; Tunisia
Prior art keywords: proteasome inhibitors; compositions; treatment; methods; various diseases
Prior art date: 2007-08-06

Application number

TNP2010000060A

Other languages

English (en)

Inventor

Edward J Olhava

Miheala D Danca

Original Assignee

Millennium Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-06

Filing date

2010-02-05

Publication date

2011-09-26

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38691782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2010000060(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-02-05 Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc

2011-09-26 Publication of TN2010000060A1 publication Critical patent/TN2010000060A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Toxicology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

TNP2010000060A 2007-08-06 2010-02-05 Proteasome inhibitors TN2010000060A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2007/017440 WO2009020448A1 (fr)	2007-08-06	2007-08-06	Inhibiteurs de protéasomes

Publications (1)

Publication Number	Publication Date
TN2010000060A1 true TN2010000060A1 (en)	2011-09-26

Family

ID=38691782

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TNP2010000060A TN2010000060A1 (en)	2007-08-06	2010-02-05	Proteasome inhibitors

Country Status (32)

Country	Link
EP (3)	EP2178888B1 (fr)
JP (1)	JP5261488B2 (fr)
KR (6)	KR101831674B1 (fr)
CN (1)	CN101772507B (fr)
AU (1)	AU2007357338B2 (fr)
BR (1)	BRPI0721905B8 (fr)
CA (1)	CA2695082C (fr)
CY (2)	CY1113386T1 (fr)
DK (1)	DK2178888T3 (fr)
EA (1)	EA028622B1 (fr)
EC (1)	ECSP10010015A (fr)
ES (1)	ES2390606T3 (fr)
FR (1)	FR17C1011I2 (fr)
GE (1)	GEP20125599B (fr)
HR (1)	HRP20120745T1 (fr)
HU (1)	HUS1700018I1 (fr)
IL (4)	IL203641A (fr)
LT (1)	LTC2178888I2 (fr)
LU (1)	LUC00013I2 (fr)
MY (1)	MY161991A (fr)
NL (1)	NL300871I2 (fr)
NZ (1)	NZ582693A (fr)
PH (1)	PH12014500053A1 (fr)
PL (1)	PL2178888T3 (fr)
PT (1)	PT2178888E (fr)
RS (1)	RS52435B (fr)
SG (1)	SG10201508712QA (fr)
SI (1)	SI2178888T1 (fr)
TN (1)	TN2010000060A1 (fr)
UA (1)	UA97536C2 (fr)
WO (1)	WO2009020448A1 (fr)
ZA (1)	ZA201000348B (fr)

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US7576206B2 (en) †	2003-08-14	2009-08-18	Cephalon, Inc.	Proteasome inhibitors and methods of using the same
US7468383B2 (en)	2005-02-11	2008-12-23	Cephalon, Inc.	Proteasome inhibitors and methods of using the same
LT2623113T (lt)	2005-11-09	2017-07-10	Onyx Therapeutics, Inc.	Junginiai, skirti fermentų slopinimui
PL2041158T3 (pl)	2006-06-19	2013-08-30	Onyx Therapeutics Inc	Peptydowe epoksyketony do hamowania proteasomu
US7442830B1 (en)	2007-08-06	2008-10-28	Millenium Pharmaceuticals, Inc.	Proteasome inhibitors
ES2684340T3 (es)	2007-10-04	2018-10-02	Onyx Therapeutics, Inc.	Inhibidores de proteasa epoxi cetona de péptidos cristalinos y síntesis de cetoepóxidos de aminoácidos
CN102066386A (zh)	2008-06-17	2011-05-18	米伦纽姆医药公司	硼酸酯化合物及其医药组合物
AR075090A1 (es)	2008-09-29	2011-03-09	Millennium Pharm Inc	Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
EP2349313A4 (fr)	2008-10-21	2012-08-29	Onyx Therapeutics Inc	Thérapie de combinaison avec des peptides époxycétones
TWI504598B (zh)	2009-03-20	2015-10-21	Onyx Therapeutics Inc	結晶性三肽環氧酮蛋白酶抑制劑
WO2011060179A1 (fr)	2009-11-13	2011-05-19	Onyx Therapeutics, Inc	Utilisation de peptides epoxycetones pour la suppression de la metastase
WO2011087822A1 (fr)	2009-12-22	2011-07-21	Cephalon, Inc.	Inhibiteurs du protéasome et leurs procédés de préparation, d'épuration et d'utilisation
EA201290844A1 (ru)	2010-03-01	2013-03-29	Оникс Терапьютикс, Инк.	Соединения для ингибирования иммунопротеасом
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CN103570806B (zh) *	2012-07-26	2020-04-07	圣特莱国际公司	多肽环氧酮化合物
JP2013006855A (ja) *	2012-09-03	2013-01-10	Millennium Pharmaceuticals Inc	プロテアソーム阻害剤
BR112015012909A2 (pt) *	2012-12-03	2017-07-11	Hoffmann La Roche	compostos de ácido borônico de triazol substituído
BR112016007237A2 (pt) *	2013-10-03	2017-09-12	Millennium Pharm Inc	método para a profilaxia ou tratamento do lúpus eritematoso sistêmico e/ou nefrite lúpica
CR20160577A (es)	2014-05-20	2017-01-06	Millennium Pharm Inc	Inhibidores de proteasoma que contienen boro para usarse despues de una terapia de cancer primaria
EP3177292B1 (fr)	2014-08-07	2020-11-25	Mayo Foundation for Medical Education and Research	Composés et méthodes de traitement du cancer
MA41555A (fr) *	2015-02-17	2017-12-26	Millennium Pharm Inc	Polythérapie pour le traitement du cancer
WO2016205790A2 (fr)	2015-06-19	2016-12-22	Hanlin Scientific, Inc.	Composés spécifiques chiraux à base de bore et leur utilisation dans le traitement du cancer ou de l'amyloïdose
CN106608883A (zh) *	2015-10-21	2017-05-03	北京大学	蛋白酶体抑制剂mln9708的合成方法
WO2017198194A1 (fr) *	2016-05-19	2017-11-23	成都奥璟生物科技有限公司	Acide boronique et composé ester borate et ses applications
CN106008572B (zh) *	2016-05-23	2018-08-17	成都千禧莱医药科技有限公司	一类二肽硼酸化合物及制备方法和用途
JP7164521B2 (ja)	2016-06-21	2022-11-01	オリオン・オフサルモロジー・エルエルシー	炭素環式プロリンアミド誘導体
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CN108440583B (zh) *	2017-01-23	2020-12-04	成都奥璟生物科技有限公司	一种新的硼酸衍生物及其药物组合物
EP4606431A3 (fr)	2017-02-28	2025-11-19	Mayo Foundation for Medical Education and Research	Composés et méthodes de traitement du cancer
CN108794516A (zh) *	2017-04-26	2018-11-13	上海时莱生物技术有限公司	硼酸和硼酸酯类化合物及其制备方法和用途
US11414437B2 (en)	2017-07-28	2022-08-16	Chengdu Origin Biotechnology Limited Company	Borate compound, and synthesis method therefor and uses thereof
US20200199159A1 (en)	2017-08-25	2020-06-25	Synthon B.V.	Process for making ixazomib or intermediates therefor
JP2018024694A (ja) *	2017-10-03	2018-02-15	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	プロテアソーム阻害剤
US11243207B2 (en)	2018-03-29	2022-02-08	Mayo Foundation For Medical Education And Research	Assessing and treating cancer
CN115403603A (zh) *	2018-09-14	2022-11-29	成都奥璟生物科技有限公司	一种硼酸酯类药物及其用途
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CN110950897B (zh) *	2019-12-12	2021-05-28	山东大学	一种组蛋白去乙酰化酶、蛋白酶体双靶点抑制剂及其制备方法和应用

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2007
- 2007-08-06 KR KR1020167036758A patent/KR101831674B1/ko active Active
- 2007-08-06 GE GEAP200711714A patent/GEP20125599B/en unknown
- 2007-08-06 AU AU2007357338A patent/AU2007357338B2/en active Active
- 2007-08-06 CA CA2695082A patent/CA2695082C/fr active Active
- 2007-08-06 KR KR1020167008358A patent/KR20160040735A/ko not_active Ceased
- 2007-08-06 PT PT07811087T patent/PT2178888E/pt unknown
- 2007-08-06 PL PL07811087T patent/PL2178888T3/pl unknown
- 2007-08-06 KR KR1020147007078A patent/KR20140042933A/ko not_active Abandoned
- 2007-08-06 EA EA201070247A patent/EA028622B1/ru not_active IP Right Cessation
- 2007-08-06 SI SI200731030T patent/SI2178888T1/sl unknown
- 2007-08-06 EP EP07811087A patent/EP2178888B1/fr active Active
- 2007-08-06 EP EP16201780.0A patent/EP3210987A1/fr active Pending
- 2007-08-06 EP EP12171220A patent/EP2527347A1/fr not_active Withdrawn
- 2007-08-06 RS RS20120405A patent/RS52435B/sr unknown
- 2007-08-06 HR HRP20120745TT patent/HRP20120745T1/hr unknown
- 2007-08-06 UA UAA201002409A patent/UA97536C2/ru unknown
- 2007-08-06 CN CN2007801001423A patent/CN101772507B/zh active Active
- 2007-08-06 KR KR1020107003809A patent/KR101474831B1/ko active Active
- 2007-08-06 WO PCT/US2007/017440 patent/WO2009020448A1/fr not_active Ceased
- 2007-08-06 NZ NZ582693A patent/NZ582693A/en unknown
- 2007-08-06 BR BRPI0721905A patent/BRPI0721905B8/pt active IP Right Grant
- 2007-08-06 MY MYPI2010000270A patent/MY161991A/en unknown
- 2007-08-06 ES ES07811087T patent/ES2390606T3/es active Active
- 2007-08-06 KR KR1020147007077A patent/KR20140042932A/ko not_active Ceased
- 2007-08-06 KR KR1020157000064A patent/KR20150010802A/ko not_active Ceased
- 2007-08-06 SG SG10201508712QA patent/SG10201508712QA/en unknown
- 2007-08-06 JP JP2010519898A patent/JP5261488B2/ja active Active
- 2007-08-06 DK DK07811087.1T patent/DK2178888T3/da active
2010
- 2010-01-18 ZA ZA2010/00348A patent/ZA201000348B/en unknown
- 2010-02-01 IL IL203641A patent/IL203641A/en active Protection Beyond IP Right Term
- 2010-02-05 TN TNP2010000060A patent/TN2010000060A1/fr unknown
- 2010-03-04 EC EC2010010015A patent/ECSP10010015A/es unknown
2012
- 2012-09-17 CY CY20121100845T patent/CY1113386T1/el unknown
2014
- 2014-01-06 PH PH12014500053A patent/PH12014500053A1/en unknown
2015
- 2015-10-26 IL IL242292A patent/IL242292A/en active IP Right Grant
- 2015-10-26 IL IL242290A patent/IL242290A/en active IP Right Grant
- 2015-10-26 IL IL242291A patent/IL242291A/en active IP Right Grant
2017
- 2017-04-05 LU LU00013C patent/LUC00013I2/fr unknown
- 2017-04-06 LT LTPA2017010C patent/LTC2178888I2/lt unknown
- 2017-04-14 FR FR17C1011C patent/FR17C1011I2/fr active Active
- 2017-04-26 CY CY2017016C patent/CY2017016I1/el unknown
- 2017-05-03 HU HUS1700018C patent/HUS1700018I1/hu unknown
- 2017-05-05 NL NL300871C patent/NL300871I2/nl unknown

Also Published As

Publication number	Publication date
PT2178888E (pt)	2012-10-04
PH12014500053B1 (en)	2015-03-30
ZA201000348B (en)	2011-03-30
IL242290A (en)	2017-12-31
KR20150010802A (ko)	2015-01-28
CY1113386T1 (el)	2016-06-22
IL242291A (en)	2017-12-31
KR20140042933A (ko)	2014-04-07
JP2010535759A (ja)	2010-11-25
EA028622B1 (ru)	2017-12-29
JP5261488B2 (ja)	2013-08-14
EP2178888A1 (fr)	2010-04-28
HRP20120745T1 (hr)	2012-10-31
BRPI0721905B8 (pt)	2021-05-25
UA97536C2 (en)	2012-02-27
IL203641A (en)	2015-11-30
HUS1700018I1 (hu)	2017-05-29
RS52435B (sr)	2013-02-28
KR20160040735A (ko)	2016-04-14
KR20140042932A (ko)	2014-04-07
SG10201508712QA (en)	2015-11-27
BRPI0721905B1 (pt)	2020-11-17
EP3210987A1 (fr)	2017-08-30
HK1143595A1 (en)	2011-01-07
FR17C1011I2 (fr)	2018-04-27
CY2017016I2 (el)	2017-07-12
NL300871I2 (nl)	2017-12-07
FR17C1011I1 (fr)	2017-05-26
BRPI0721905A2 (pt)	2014-02-25
SI2178888T1 (sl)	2012-11-30
AU2007357338A1 (en)	2009-02-12
LUC00013I2 (fr)	2017-06-19
EP2178888B1 (fr)	2012-07-04
EA201070247A1 (ru)	2010-06-30
LTC2178888I2 (lt)	2018-03-12
ECSP10010015A (es)	2010-04-30
KR101831674B1 (ko)	2018-02-23
ES2390606T3 (es)	2012-11-14
HK1182924A1 (zh)	2013-12-13
CN101772507A (zh)	2010-07-07
IL242290A0 (en)	2015-11-30
LUC00013I1 (fr)	2017-04-06
CA2695082C (fr)	2015-07-28
MY161991A (en)	2017-05-31
LTPA2017010I1 (lt)	2017-05-10
CY2017016I1 (el)	2017-07-12
AU2007357338B2 (en)	2014-03-20
IL242291A0 (en)	2015-11-30
NZ582693A (en)	2012-01-12
KR20170004031A (ko)	2017-01-10
KR101474831B1 (ko)	2014-12-19
PL2178888T3 (pl)	2012-11-30
IL242292A0 (en)	2015-11-30
DK2178888T3 (da)	2012-10-01
IL242292A (en)	2017-12-31
PH12014500053A1 (en)	2015-03-30
EP2527347A1 (fr)	2012-11-28
KR20100059811A (ko)	2010-06-04
CA2695082A1 (fr)	2009-02-12
GEP20125599B (en)	2012-08-10
CN101772507B (zh)	2012-12-12
WO2009020448A1 (fr)	2009-02-12

Publication	Publication Date	Title
PH12014500053A1 (en)	2015-03-30	Proteasome inhibitors
PH12015501191A1 (en)	2016-01-11	Boronate ester compounds and pharmaceutical compositions thereof
MY166653A (en)	2018-07-18	Derivatives of 1-amino-2-cyclobutylethylboronic acid
TN2012000465A1 (en)	2014-01-30	Derivatives of 1-amino-2-cyclopropylethylboronic acid
MX2009006706A (es)	2009-07-02	Compuestos heterociclicos biciclicos como inhibidores del receptor del factor de crecimiento de fibroblastos.
MX2009006704A (es)	2009-06-30	Derivados de amina triciclicos como inhibidores de proteina de tirosina cinasa.
IN2012DN00971A (fr)	2015-04-10
TW200602052A (en)	2006-01-16	Azaindoles useful as inhibitors of JAK and other protein kinases
TW200714590A (en)	2007-04-16	Heterocyclic inhibitors of MEK and methods of use thereof
MY163275A (en)	2017-08-30	Ibat inhibitors for the treatment of liver diseases
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