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FR17C1011I1 - - Google Patents

Info

Publication number
FR17C1011I1
FR17C1011I1 FR17C1011C FR17C1011I1 FR 17C1011 I1 FR17C1011 I1 FR 17C1011I1 FR 17C1011 C FR17C1011 C FR 17C1011C FR 17C1011 I1 FR17C1011 I1 FR 17C1011I1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38691782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR17C1011(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of FR17C1011I1 publication Critical patent/FR17C1011I1/fr
Application granted granted Critical
Publication of FR17C1011I2 publication Critical patent/FR17C1011I2/fr
Active legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR17C1011C 2007-08-06 2017-04-14 Inhibiteurs de proteasomes Active FR17C1011I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2007/017440 WO2009020448A1 (fr) 2007-08-06 2007-08-06 Inhibiteurs de protéasomes

Publications (2)

Publication Number Publication Date
FR17C1011I1 true FR17C1011I1 (fr) 2017-05-26
FR17C1011I2 FR17C1011I2 (fr) 2018-04-27

Family

ID=38691782

Family Applications (1)

Application Number Title Priority Date Filing Date
FR17C1011C Active FR17C1011I2 (fr) 2007-08-06 2017-04-14 Inhibiteurs de proteasomes

Country Status (32)

Country Link
EP (3) EP2527347A1 (fr)
JP (1) JP5261488B2 (fr)
KR (6) KR101831674B1 (fr)
CN (1) CN101772507B (fr)
AU (1) AU2007357338B2 (fr)
BR (1) BRPI0721905B8 (fr)
CA (1) CA2695082C (fr)
CY (2) CY1113386T1 (fr)
DK (1) DK2178888T3 (fr)
EA (1) EA028622B1 (fr)
EC (1) ECSP10010015A (fr)
ES (1) ES2390606T3 (fr)
FR (1) FR17C1011I2 (fr)
GE (1) GEP20125599B (fr)
HR (1) HRP20120745T1 (fr)
HU (1) HUS1700018I1 (fr)
IL (4) IL203641A (fr)
LT (1) LTC2178888I2 (fr)
LU (1) LUC00013I2 (fr)
MY (1) MY161991A (fr)
NL (1) NL300871I2 (fr)
NZ (1) NZ582693A (fr)
PH (1) PH12014500053B1 (fr)
PL (1) PL2178888T3 (fr)
PT (1) PT2178888E (fr)
RS (1) RS52435B (fr)
SG (1) SG10201508712QA (fr)
SI (1) SI2178888T1 (fr)
TN (1) TN2010000060A1 (fr)
UA (1) UA97536C2 (fr)
WO (1) WO2009020448A1 (fr)
ZA (1) ZA201000348B (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
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US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7468383B2 (en) 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7687456B2 (en) 2005-11-09 2010-03-30 Proteolix, Inc. Compounds for enzyme inhibition
EP2484688B1 (fr) 2006-06-19 2016-06-08 Onyx Therapeutics, Inc. Peptide époxycétones destinées à l'inhibition de proteasome
US7442830B1 (en) 2007-08-06 2008-10-28 Millenium Pharmaceuticals, Inc. Proteasome inhibitors
MX2010003732A (es) 2007-10-04 2010-08-09 Onyx Therapeutics Inc Inhibidores de peptido cetona epoxi de proteasa cristalina y la sintesis de ceto-epoxidos de aminoacido.
BR122014008753A2 (pt) 2008-06-17 2015-12-29 Millennium Pharm Inc compostos de éster boronato e composições farmacêuticas dos mesmos
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
PE20120059A1 (es) 2008-10-21 2012-02-27 Onyx Therapeutics Inc Combinaciones farmaceuticas con epoxicetonas peptidicas
TWI504598B (zh) 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
US8853147B2 (en) 2009-11-13 2014-10-07 Onyx Therapeutics, Inc. Use of peptide epoxyketones for metastasis suppression
CN102725300B (zh) 2009-12-22 2015-03-11 赛福伦公司 蛋白酶体抑制剂及其制备、纯化、和应用的方法
US9359398B2 (en) 2010-03-01 2016-06-07 Onyx Therapeutics, Inc. Compounds for immunoproteasome inhibition
CN106008570A (zh) 2010-03-31 2016-10-12 米伦纽姆医药公司 1-氨基-2-环丙基乙硼酸衍生物
MX2013015308A (es) * 2011-06-22 2014-05-20 Cephalon Inc Inhibidores de proteasoma y procesos para su preparacion, purificacion y uso.
HUE060305T2 (hu) * 2011-08-30 2023-02-28 Tufts College FAP-aktivált proteaszóma inhibitorok a szolid tumorok kezelésére
SG10201605152SA (en) * 2011-12-22 2016-08-30 Ares Trading Sa Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors
EP2812338A4 (fr) * 2012-01-24 2015-09-23 Millennium Pharm Inc Méthode de traitement d'un cancer nasopharyngé
CA2862492A1 (fr) * 2012-01-24 2013-08-01 Millennium Pharmaceuticals, Inc. Methodes de traitement du cancer
US9309283B2 (en) 2012-07-09 2016-04-12 Onyx Therapeutics, Inc. Prodrugs of peptide epoxy ketone protease inhibitors
CN109096370B (zh) * 2012-07-26 2022-03-18 圣特莱国际公司 多肽环氧酮化合物
JP2013006855A (ja) * 2012-09-03 2013-01-10 Millennium Pharmaceuticals Inc プロテアソーム阻害剤
JP6018319B2 (ja) * 2012-12-03 2016-11-02 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 置換トリアゾールボロン酸化合物
KR20160058886A (ko) * 2013-10-03 2016-05-25 밀레니엄 파머슈티컬스 인코퍼레이티드 전신 홍반성 낭창 및/또는 낭창성 신염의 예방 또는 치료 방법
CN106659761A (zh) 2014-05-20 2017-05-10 千年药物公司 初级癌症疗法后使用的含硼蛋白酶体抑制剂
EP3808349B1 (fr) 2014-08-07 2022-10-05 Mayo Foundation for Medical Education and Research Composés et procédés pour le traitement du cancer
MA41555A (fr) * 2015-02-17 2017-12-26 Millennium Pharm Inc Polythérapie pour le traitement du cancer
US10144761B2 (en) 2015-06-19 2018-12-04 Hanlin Scientific Inc. Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis
CN106608883A (zh) * 2015-10-21 2017-05-03 北京大学 蛋白酶体抑制剂mln9708的合成方法
CN107400142B (zh) * 2016-05-19 2019-11-19 成都奥璟生物科技有限公司 一种硼酸和硼酸酯类化合物及其应用
CN106008572B (zh) * 2016-05-23 2018-08-17 成都千禧莱医药科技有限公司 一类二肽硼酸化合物及制备方法和用途
MX392422B (es) 2016-06-21 2025-03-24 Orion Ophthalmology LLC Derivados de prolinamida heterociclica
JP7164521B2 (ja) 2016-06-21 2022-11-01 オリオン・オフサルモロジー・エルエルシー 炭素環式プロリンアミド誘導体
JP6802899B2 (ja) * 2016-07-25 2020-12-23 深▲セン▼市塔吉瑞生物医▲薬▼有限公司Shenzhen TargetRx,Inc. 置換ボロン酸化合物、該化合物を含む医薬組成物およびその使用
CN108440583B (zh) * 2017-01-23 2020-12-04 成都奥璟生物科技有限公司 一种新的硼酸衍生物及其药物组合物
ES3036483T3 (en) 2017-02-28 2025-09-19 Mayo Found Medical Education & Res Combinations for use in the treatment of cancer
CN108794516A (zh) * 2017-04-26 2018-11-13 上海时莱生物技术有限公司 硼酸和硼酸酯类化合物及其制备方法和用途
US11414437B2 (en) 2017-07-28 2022-08-16 Chengdu Origin Biotechnology Limited Company Borate compound, and synthesis method therefor and uses thereof
US20200199159A1 (en) 2017-08-25 2020-06-25 Synthon B.V. Process for making ixazomib or intermediates therefor
JP2018024694A (ja) * 2017-10-03 2018-02-15 ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. プロテアソーム阻害剤
US11243207B2 (en) 2018-03-29 2022-02-08 Mayo Foundation For Medical Education And Research Assessing and treating cancer
CN115403603A (zh) * 2018-09-14 2022-11-29 成都奥璟生物科技有限公司 一种硼酸酯类药物及其用途
CN110357787A (zh) * 2019-08-02 2019-10-22 苏州艾和医药科技有限公司 依沙佐米合成工艺研究
US20220362268A1 (en) * 2019-10-07 2022-11-17 Cornell University Antimicrobial and antiviral effects of c2-c7 alkyl boronic acids
CN110950897B (zh) * 2019-12-12 2021-05-28 山东大学 一种组蛋白去乙酰化酶、蛋白酶体双靶点抑制剂及其制备方法和应用

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US4499082A (en) 1983-12-05 1985-02-12 E. I. Du Pont De Nemours And Company α-Aminoboronic acid peptides
US5250720A (en) 1987-06-05 1993-10-05 The Dupont Merck Pharmaceutical Company Intermediates for preparing peptide boronic acid inhibitors of trypsin-like proteases
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
US5242904A (en) 1987-06-05 1993-09-07 The Dupont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0315574A3 (fr) 1987-11-05 1990-08-22 Hoechst Aktiengesellschaft Inhibiteurs de la rénine
US5106948A (en) 1988-05-27 1992-04-21 Mao Foundation For Medical Education And Research Cytotoxic boronic acid peptide analogs
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EP2251344B2 (fr) * 2001-01-25 2024-04-24 THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Formulation des composes d'acide boronique
WO2002096933A1 (fr) 2001-05-30 2002-12-05 Novartis Ag Derives d'acide 2-{[n-(2-amino-3-(heteroaryl ou aryl)propionyl)-aminoacyl]-amino}-alkylboronique
CN1867572B (zh) * 2003-08-14 2012-03-28 赛福伦公司 蛋白酶体抑制剂及其使用方法
US7576206B2 (en) * 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7223745B2 (en) 2003-08-14 2007-05-29 Cephalon, Inc. Proteasome inhibitors and methods of using the same
PL4008721T3 (pl) * 2004-03-30 2024-05-13 Millennium Pharmaceuticals, Inc. Synteza związków estrów i kwasów boronowych
WO2006008660A2 (fr) 2004-07-20 2006-01-26 Affinium Pharmaceuticals, Inc. Nouveaux polypeptides purifies derives de streptococcus pneumoniae
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GB0513349D0 (en) 2005-06-29 2005-08-03 Torres Manel Non-woven fabric
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Also Published As

Publication number Publication date
BRPI0721905A2 (pt) 2014-02-25
PT2178888E (pt) 2012-10-04
EP2527347A1 (fr) 2012-11-28
DK2178888T3 (da) 2012-10-01
CY2017016I2 (el) 2017-07-12
WO2009020448A1 (fr) 2009-02-12
GEP20125599B (en) 2012-08-10
EP3210987A1 (fr) 2017-08-30
EP2178888A1 (fr) 2010-04-28
KR20150010802A (ko) 2015-01-28
IL203641A (en) 2015-11-30
EP2178888B1 (fr) 2012-07-04
KR20170004031A (ko) 2017-01-10
ZA201000348B (en) 2011-03-30
KR20140042932A (ko) 2014-04-07
CY2017016I1 (el) 2017-07-12
TN2010000060A1 (en) 2011-09-26
IL242291A0 (en) 2015-11-30
LUC00013I1 (fr) 2017-04-06
HK1182924A1 (zh) 2013-12-13
EA028622B1 (ru) 2017-12-29
PH12014500053A1 (en) 2015-03-30
ES2390606T3 (es) 2012-11-14
IL242290A0 (en) 2015-11-30
HRP20120745T1 (hr) 2012-10-31
PH12014500053B1 (en) 2015-03-30
FR17C1011I2 (fr) 2018-04-27
CN101772507A (zh) 2010-07-07
KR101474831B1 (ko) 2014-12-19
HUS1700018I1 (hu) 2017-05-29
NL300871I2 (nl) 2017-12-07
CN101772507B (zh) 2012-12-12
SI2178888T1 (sl) 2012-11-30
SG10201508712QA (en) 2015-11-27
NZ582693A (en) 2012-01-12
KR101831674B1 (ko) 2018-02-23
KR20140042933A (ko) 2014-04-07
CY1113386T1 (el) 2016-06-22
KR20160040735A (ko) 2016-04-14
CA2695082C (fr) 2015-07-28
BRPI0721905B8 (pt) 2021-05-25
CA2695082A1 (fr) 2009-02-12
PL2178888T3 (pl) 2012-11-30
EA201070247A1 (ru) 2010-06-30
IL242290A (en) 2017-12-31
UA97536C2 (en) 2012-02-27
JP5261488B2 (ja) 2013-08-14
BRPI0721905B1 (pt) 2020-11-17
JP2010535759A (ja) 2010-11-25
MY161991A (en) 2017-05-31
LTPA2017010I1 (lt) 2017-05-10
LUC00013I2 (fr) 2017-06-19
KR20100059811A (ko) 2010-06-04
ECSP10010015A (es) 2010-04-30
IL242291A (en) 2017-12-31
HK1143595A1 (en) 2011-01-07
IL242292A0 (en) 2015-11-30
AU2007357338A1 (en) 2009-02-12
LTC2178888I2 (lt) 2018-03-12
RS52435B (sr) 2013-02-28
IL242292A (en) 2017-12-31
AU2007357338B2 (en) 2014-03-20

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