TN2009000291A1 - Inhibitors of mek - Google Patents
Inhibitors of mekInfo
- Publication number
- TN2009000291A1 TN2009000291A1 TNP2009000291A TN2009000291A TN2009000291A1 TN 2009000291 A1 TN2009000291 A1 TN 2009000291A1 TN P2009000291 A TNP2009000291 A TN P2009000291A TN 2009000291 A TN2009000291 A TN 2009000291A TN 2009000291 A1 TN2009000291 A1 TN 2009000291A1
- Authority
- TN
- Tunisia
- Prior art keywords
- mek
- inhibitors
- compounds
- aylamino
- treatment
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004421 aryl sulphonamide group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88584907P | 2007-01-19 | 2007-01-19 | |
| PCT/US2008/051518 WO2008089459A1 (fr) | 2007-01-19 | 2008-01-18 | Inhibiteurs de mek |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TN2009000291A1 true TN2009000291A1 (en) | 2010-12-31 |
Family
ID=39333043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNP2009000291A TN2009000291A1 (en) | 2007-01-19 | 2009-07-07 | Inhibitors of mek |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7820664B2 (fr) |
| EP (1) | EP2121620B1 (fr) |
| JP (1) | JP5491199B2 (fr) |
| KR (1) | KR20090111847A (fr) |
| CN (1) | CN101663279A (fr) |
| AU (1) | AU2008206045A1 (fr) |
| BR (1) | BRPI0806898A2 (fr) |
| CA (1) | CA2675358C (fr) |
| CO (1) | CO6210813A2 (fr) |
| CR (1) | CR10939A (fr) |
| DO (1) | DOP2009000181A (fr) |
| EA (1) | EA200900959A1 (fr) |
| EC (1) | ECSP099525A (fr) |
| ES (1) | ES2547303T3 (fr) |
| IL (1) | IL199727A0 (fr) |
| MA (1) | MA31183B1 (fr) |
| MX (1) | MX2009007661A (fr) |
| TN (1) | TN2009000291A1 (fr) |
| WO (1) | WO2008089459A1 (fr) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4834553B2 (ja) | 2004-09-17 | 2011-12-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 医薬組成物 |
| US7429667B2 (en) | 2005-01-20 | 2008-09-30 | Ardea Biosciences, Inc. | Phenylamino isothiazole carboxamidines as MEK inhibitors |
| US9095581B2 (en) | 2005-07-21 | 2015-08-04 | Ardea Biosciences, Inc. | Combinations of MEK inhibitors and Raf kinase inhibitors and uses thereof |
| US9006240B2 (en) | 2005-08-02 | 2015-04-14 | Eisai R&D Management Co., Ltd. | Method for assay on the effect of vascularization inhibitor |
| ES2556173T3 (es) | 2006-05-18 | 2016-01-13 | Eisai R&D Management Co., Ltd. | Agente antitumoral para un cáncer de tiroides |
| US8227603B2 (en) | 2006-08-01 | 2012-07-24 | Cytokinetics, Inc. | Modulating skeletal muscle |
| ES2558517T3 (es) | 2006-08-02 | 2016-02-04 | Cytokinetics, Inc. | Ciertas entidades químicas, composiciones y métodos que comprenden imidazopirimidinas |
| US8299248B2 (en) | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| EP2139478A4 (fr) * | 2007-03-30 | 2010-05-05 | Cytokinetics Inc | Entités chimiques, compositions et procédés |
| CA2924436A1 (fr) * | 2007-07-30 | 2009-02-05 | Ardea Biosciences, Inc. | Combinaisons pharmaceutiques de n-3(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide comme inhibiteurs de mek et methodes d'utilisation |
| US8044240B2 (en) | 2008-03-06 | 2011-10-25 | Ardea Biosciences Inc. | Polymorphic form of N-(S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and uses thereof |
| PE20100747A1 (es) * | 2008-04-21 | 2010-11-03 | Novartis Ag | Compuestos heterociclicos como inhibidores de mek |
| US10253020B2 (en) | 2009-06-12 | 2019-04-09 | Abivax | Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging |
| JP6041671B2 (ja) | 2009-06-12 | 2016-12-14 | アビバックス | ガンを治療する為に有用な化合物 |
| BR112012008599A2 (pt) | 2009-10-13 | 2019-09-24 | Allostem Therapeutics Llc | composto da formula (i), composto da fórmula (ia), composto da fórmula (ic), composto da fórmula (ii), composto da fórmula (iia), composto, método para tratamento de um transtorno hiperproliferativo em um mamífero, que inclui um humano, método para tratamento de uma doença, condição ou transtorno inflamatório em um mamífero, que inclui um humano, método para tratamento de um transtorno ou condição que é modulada pela cascata de meik em um mamífero, que inclui um himano, método para tratar ou prevenir câncer, composição farmacêutica e método para inibir uma enzima mek |
| MX2012004644A (es) | 2009-10-21 | 2012-05-08 | Boehringer Ingelheim Int | Compuestos de indazol y pirazolopiridina como antagonistas del receptor de ccr1. |
| US8927550B2 (en) | 2009-10-27 | 2015-01-06 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds as CCR1 receptor antagonists |
| CA2779935A1 (fr) | 2009-11-04 | 2011-05-12 | Novartis Ag | Derives sulfonamides heterocycliques utilises comme inhibiteurs de mek |
| CN102648188A (zh) * | 2009-12-08 | 2012-08-22 | 诺瓦提斯公司 | 杂环磺酰胺衍生物 |
| EP2563787B1 (fr) | 2010-04-30 | 2014-11-26 | Boehringer Ingelheim International GmbH | Composés azaindazole amides en tant qu'antagonistes des récepteurs ccr1 |
| WO2012144463A1 (fr) | 2011-04-18 | 2012-10-26 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Agent thérapeutique pour les tumeurs |
| EP2714937B1 (fr) | 2011-06-03 | 2018-11-14 | Eisai R&D Management Co., Ltd. | Biomarqueurs pour la prédiction et l'estimation de la sensibilité de sujets atteints d'un cancer de la thyroïde et du rein vis-à-vis de composés lenvatinib |
| CN103748085A (zh) | 2011-06-09 | 2014-04-23 | 诺华股份有限公司 | 杂环磺酰胺衍生物 |
| EP2718276A1 (fr) * | 2011-06-09 | 2014-04-16 | Novartis AG | Dérivés de sulfonamide hétérocyclique |
| CN109316480A (zh) | 2011-07-13 | 2019-02-12 | 赛特凯恩蒂克公司 | 组合als疗法 |
| CN103204827B (zh) * | 2012-01-17 | 2014-12-03 | 上海科州药物研发有限公司 | 作为蛋白激酶抑制剂的苯并噻二唑化合物及其制备方法和用途 |
| WO2014071183A1 (fr) | 2012-11-02 | 2014-05-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Méthode de réduction des effets secondaires chez un patient souffrant de cancer traité par un inhibiteur de la mek |
| RU2015115397A (ru) | 2012-12-21 | 2017-01-25 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Аморфная форма производного хинолина и способ его получения |
| EP2757161A1 (fr) | 2013-01-17 | 2014-07-23 | Splicos | miRNA-124 comme biomarqueur de l'infection virale |
| CA2912219C (fr) | 2013-05-14 | 2021-11-16 | Eisai R&D Management Co., Ltd. | Biomarqueurs pour predire et evaluer la reponse de sujets atteints de cancer de l'endometre a des composes a base de lenvatinib |
| MX382692B (es) | 2013-07-05 | 2025-03-13 | Abivax | Compuestos bicíclicos útiles para el tratamiento de enfermedades causadas por retrovirus. |
| CN103739550B (zh) * | 2014-01-02 | 2016-06-01 | 中国药科大学 | 2,3-二甲基-6-脲-2h-吲唑类化合物及其制备方法与应用 |
| US20160340407A1 (en) | 2014-01-14 | 2016-11-24 | Dana-Farber Camcer Institute, Inc. | Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms |
| US20170114323A1 (en) | 2014-06-19 | 2017-04-27 | Whitehead Institute For Biomedical Research | Uses of kinase inhibitors for inducing and maintaining pluripotency |
| EP2974729A1 (fr) | 2014-07-17 | 2016-01-20 | Abivax | Dérivés de quinoléine utilisés dans le traitement de maladies inflammatoires |
| CN113683564A (zh) | 2014-08-28 | 2021-11-23 | 卫材R&D管理有限公司 | 高纯度喹啉衍生物及其生产方法 |
| CN105384754B (zh) * | 2014-09-02 | 2018-04-20 | 上海科州药物研发有限公司 | 作为蛋白激酶抑制剂的杂环类化合物及其制备方法和用途 |
| US20170248603A1 (en) | 2014-10-06 | 2017-08-31 | Dana-Farber Cancer Institute, Inc. | Angiopoiten-2 biomarkers predictive of anti-immune checkpoint response |
| RU2017128583A (ru) | 2015-02-25 | 2019-03-25 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Способ ослабления горечи хинолинового производного |
| WO2016140717A1 (fr) | 2015-03-04 | 2016-09-09 | Merck Sharp & Dohme Corp. | Association d'un antagoniste de pd-1 et d'un inhibiteur des tyrosines kinases vegfr/fgfr/ret pour traiter le cancer |
| MA41866A (fr) | 2015-03-31 | 2018-02-06 | Massachusetts Gen Hospital | Molécules à auto-assemblage pour l'administration ciblée de médicaments |
| MX373231B (es) | 2015-06-16 | 2020-05-08 | Eisai R&D Man Co Ltd | Agente anticancerigeno. |
| WO2017030161A1 (fr) | 2015-08-20 | 2017-02-23 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Agent thérapeutique pour tumeur |
| WO2017033113A1 (fr) | 2015-08-21 | 2017-03-02 | Acerta Pharma B.V. | Associations thérapeutiques d'un inhibiteur de mek et d'un inhibiteur de btk |
| CN105085427B (zh) * | 2015-08-21 | 2018-06-05 | 中国科学院广州生物医药与健康研究院 | 一类苯并[d]异恶唑类化合物及其应用 |
| AU2018219637B2 (en) | 2017-02-08 | 2023-07-13 | Eisai R&D Management Co., Ltd. | Tumor-treating pharmaceutical composition |
| JP7113023B2 (ja) | 2017-03-30 | 2022-08-04 | ブリストル－マイヤーズ スクイブ カンパニー | ６－（シクロプロパンアミド）－４－（（２－メトキシ－３－（１－メチル－１ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－ｎ－（メチル－ｄ３）ピリダジン－３－カルボキシアミドの製造方法 |
| US20200197384A1 (en) | 2017-05-16 | 2020-06-25 | Eisai R&D Management Co., Ltd. | Treatment of hepatocellular carcinoma |
| MX2021003904A (es) | 2018-10-05 | 2021-10-26 | Annapurna Bio Inc | Compuestos y composiciones para el tratamiento de afecciones asociadas con la actividad del receptor apj. |
| EP3669873A1 (fr) | 2018-12-20 | 2020-06-24 | Abivax | Dérivés de quinoline destinés à être utilisés dans le traitement de maladies inflammatoires |
| MX2021009863A (es) | 2019-03-21 | 2021-11-12 | Onxeo | Una molecula dbait en combinacion con inhibidor de quinasa para el tratamiento del cancer. |
| CN110229173A (zh) * | 2019-07-17 | 2019-09-13 | 泰州职业技术学院 | 一种5-6-5氮杂三环化合物及其制备方法 |
| JP2023500906A (ja) | 2019-11-08 | 2023-01-11 | インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） | キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法 |
| WO2021148581A1 (fr) | 2020-01-22 | 2021-07-29 | Onxeo | Nouvelle molécule dbait et son utilisation |
| CN112759552A (zh) * | 2020-12-31 | 2021-05-07 | 武汉九州钰民医药科技有限公司 | 司美替尼的合成方法 |
| US12371667B2 (en) | 2021-05-13 | 2025-07-29 | Washington University | Enhanced methods for inducing and maintaining naive human pluripotent stem cells |
| JP2024521788A (ja) | 2021-05-27 | 2024-06-04 | ミラティ セラピューティクス， インコーポレイテッド | 併用療法 |
| WO2025073765A1 (fr) | 2023-10-03 | 2025-04-10 | Institut National de la Santé et de la Recherche Médicale | Méthodes de pronostic et de traitement de patients souffrant de mélanome |
| CN119019338B (zh) * | 2024-10-28 | 2025-02-18 | 合肥欧创基因生物科技有限公司 | 一种5-氯哒嗪-3-羧酸的制备方法 |
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-
2008
- 2008-01-18 EP EP08727965.9A patent/EP2121620B1/fr active Active
- 2008-01-18 MX MX2009007661A patent/MX2009007661A/es not_active Application Discontinuation
- 2008-01-18 JP JP2009546558A patent/JP5491199B2/ja not_active Expired - Fee Related
- 2008-01-18 KR KR1020097017247A patent/KR20090111847A/ko not_active Withdrawn
- 2008-01-18 CA CA2675358A patent/CA2675358C/fr not_active Expired - Fee Related
- 2008-01-18 WO PCT/US2008/051518 patent/WO2008089459A1/fr not_active Ceased
- 2008-01-18 BR BRPI0806898-4A patent/BRPI0806898A2/pt not_active IP Right Cessation
- 2008-01-18 EA EA200900959A patent/EA200900959A1/ru unknown
- 2008-01-18 CN CN200880007510A patent/CN101663279A/zh active Pending
- 2008-01-18 AU AU2008206045A patent/AU2008206045A1/en not_active Abandoned
- 2008-01-18 US US12/016,897 patent/US7820664B2/en not_active Expired - Fee Related
- 2008-01-18 ES ES08727965.9T patent/ES2547303T3/es active Active
-
2009
- 2009-07-07 IL IL199727A patent/IL199727A0/en unknown
- 2009-07-07 TN TNP2009000291A patent/TN2009000291A1/fr unknown
- 2009-07-17 EC EC2009009525A patent/ECSP099525A/es unknown
- 2009-07-17 CO CO09074929A patent/CO6210813A2/es not_active Application Discontinuation
- 2009-07-17 CR CR10939A patent/CR10939A/es unknown
- 2009-07-22 DO DO2009000181A patent/DOP2009000181A/es unknown
- 2009-08-12 MA MA32166A patent/MA31183B1/fr unknown
-
2010
- 2010-09-10 US US12/879,314 patent/US8063049B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008089459A1 (fr) | 2008-07-24 |
| EP2121620B1 (fr) | 2015-06-17 |
| EP2121620A1 (fr) | 2009-11-25 |
| ECSP099525A (es) | 2009-11-30 |
| MA31183B1 (fr) | 2010-02-01 |
| CA2675358A1 (fr) | 2008-07-24 |
| US8063049B2 (en) | 2011-11-22 |
| EA200900959A1 (ru) | 2010-02-26 |
| CN101663279A (zh) | 2010-03-03 |
| CA2675358C (fr) | 2016-01-05 |
| ES2547303T3 (es) | 2015-10-05 |
| BRPI0806898A2 (pt) | 2015-07-14 |
| IL199727A0 (en) | 2010-04-15 |
| US20080255133A1 (en) | 2008-10-16 |
| AU2008206045A1 (en) | 2008-07-24 |
| MX2009007661A (es) | 2009-12-14 |
| KR20090111847A (ko) | 2009-10-27 |
| DOP2009000181A (es) | 2010-04-30 |
| US20100331334A1 (en) | 2010-12-30 |
| JP5491199B2 (ja) | 2014-05-14 |
| US7820664B2 (en) | 2010-10-26 |
| CO6210813A2 (es) | 2010-10-20 |
| CR10939A (es) | 2009-11-13 |
| JP2010516698A (ja) | 2010-05-20 |
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