TN2009000189A1 - Tetrahydrocyclopenta [b] indole compounds as androgen receptor modulators - Google Patents

Tetrahydrocyclopenta [b] indole compounds as androgen receptor modulators

Info

Publication number: TN2009000189A1
Authority: TN; Tunisia
Prior art keywords: formula; tetrahydrocyclopenta; androgen receptor; receptor modulators; compound
Prior art date: 2006-11-20

Application number

TNP2009000189A

Other languages

English (en)

Inventor

Konstantinos Gavardinas

Jonathan Edward Green

Prabhakar Kondaji Jadhav

Donald Paul Matthews

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-11-20

Filing date

2009-05-15

Publication date

2010-10-18

2009-05-15 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2010-10-18 Publication of TN2009000189A1 publication Critical patent/TN2009000189A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Neurology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Reproductive Health (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Anesthesiology (AREA)
Hematology (AREA)
Gynecology & Obstetrics (AREA)
Psychiatry (AREA)
Immunology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

TNP2009000189A 2006-11-20 2009-05-15 Tetrahydrocyclopenta [b] indole compounds as androgen receptor modulators TN2009000189A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US86648406P	2006-11-20	2006-11-20
PCT/US2007/083745 WO2008063867A2 (fr)	2006-11-20	2007-11-06	Composés tétrahydrocyclopenta[b] indole comme modulateurs du récepteur des androgènes

Publications (1)

Publication Number	Publication Date
TN2009000189A1 true TN2009000189A1 (en)	2010-10-18

Family

ID=39415431

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TNP2009000189A TN2009000189A1 (en)	2006-11-20	2009-05-15	Tetrahydrocyclopenta [b] indole compounds as androgen receptor modulators

Country Status (36)

Country	Link
US (1)	US7968587B2 (fr)
EP (1)	EP2094658B1 (fr)
JP (1)	JP5399259B2 (fr)
KR (1)	KR101121471B1 (fr)
CN (1)	CN101541749B (fr)
AR (1)	AR063559A1 (fr)
AT (1)	ATE538091T1 (fr)
AU (1)	AU2007324046B2 (fr)
BR (1)	BRPI0719092B8 (fr)
CA (1)	CA2670340C (fr)
CL (1)	CL2007003182A1 (fr)
CO (1)	CO6190513A2 (fr)
CR (1)	CR10802A (fr)
CY (1)	CY1112284T1 (fr)
DK (1)	DK2094658T3 (fr)
EA (1)	EA015627B1 (fr)
EC (1)	ECSP099350A (fr)
ES (1)	ES2376048T3 (fr)
HR (1)	HRP20120032T1 (fr)
IL (1)	IL198410A (fr)
JO (1)	JO2800B1 (fr)
MA (1)	MA31072B1 (fr)
MX (1)	MX2009005251A (fr)
MY (1)	MY154547A (fr)
NO (1)	NO342531B1 (fr)
NZ (1)	NZ576296A (fr)
PE (1)	PE20081161A1 (fr)
PL (1)	PL2094658T3 (fr)
PT (1)	PT2094658E (fr)
RS (1)	RS52191B (fr)
SI (1)	SI2094658T1 (fr)
TN (1)	TN2009000189A1 (fr)
TW (1)	TWI398438B (fr)
UA (1)	UA98777C2 (fr)
WO (1)	WO2008063867A2 (fr)
ZA (1)	ZA200903096B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8268872B2 (en)	2008-02-22	2012-09-18	Radius Health, Inc.	Selective androgen receptor modulators
MX2010009162A (es)	2008-02-22	2010-12-21	Radius Health Inc	Moduladores selectivos del receptor de androgeno.
EA019713B1 (ru) *	2008-05-16	2014-05-30	Эли Лилли Энд Компани	ТЕТРАГИДРОЦИКЛОПЕНТА[b]ИНДОЛЬНЫЕ МОДУЛЯТОРЫ РЕЦЕПТОРОВ АНДРОГЕНОВ
AR078862A1 (es)	2009-11-13	2011-12-07	Lilly Co Eli	Ester isopropilico del acido ((s)-7-ciano-4-((2r,3s)-3-hidroxitetrahidrofuran-2-ilmetil)-1,2,3,4-tetrahidro-ciclopenta(b)indol-2-il)carbamico, composiciones farmaceuticas que lo comprenden y su uso en terapia
CA2788907A1 (fr)	2010-02-04	2011-08-11	Radius Health, Inc.	Modulateurs selectifs du recepteur des androgenes
CA2799183A1 (fr)	2010-05-12	2011-11-17	Radius Health, Inc.	Schemas therapeutiques
US8642632B2 (en)	2010-07-02	2014-02-04	Radius Health, Inc.	Selective androgen receptor modulators
WO2012047617A1 (fr)	2010-09-28	2012-04-12	Radius Health, Inc.	Modulateurs sélectifs du récepteur des androgènes
BR112013028895A2 (pt)	2011-05-10	2016-08-09	Bayer Ip Gmbh	(tio)carbonilamidinas bicíclicas
CN103265479B (zh) *	2013-06-14	2017-12-08	南开大学	一种6‑氯甲基烟酸叔丁酯的合成方法
DK3122426T3 (da)	2014-03-28	2023-04-03	Univ Duke	Behandling af brystcancer ved anvendelse af selektive østrogenreceptormodulatorer
US9421264B2 (en)	2014-03-28	2016-08-23	Duke University	Method of treating cancer using selective estrogen receptor modulators
TWI677489B (zh)	2014-06-20	2019-11-21	美商基利科學股份有限公司	多環型胺甲醯基吡啶酮化合物之合成
JOP20180072A1 (ar) *	2014-09-11	2019-01-30	Lilly Co Eli	علاج الأعراض المرتبطة بالعلاج بالحرمان من الأندروجين
PT3474841T (pt)	2016-06-22	2022-06-20	Radius Health Inc	Métodos de tratamento do cancro de mama ar+
US20180185347A1 (en)	2016-11-16	2018-07-05	Transition Therapeutics (Ireland 2) Limited	Tetrahydrocyclopenta[b]indole compounds and phosphodiesterase inhibitors for the treatment of the signs and symptoms of bhp
JP7481115B2 (ja)	2017-01-05	2024-05-10	ラジウスファーマシューティカルズ，インコーポレイテッド	Ｒａｄ１９０１－２ｈｃｌの多形性形態
KR102792490B1 (ko)	2018-07-04	2025-04-04	래디어스 파마슈티컬스, 인코포레이티드	Rad1901-2hcl의 다형 형태
WO2020167855A1 (fr)	2019-02-12	2020-08-20	Radius Pharmaceuticals, Inc.	Procédés et composés
CA3166734A1 (fr) *	2020-01-27	2021-08-05	Eirgen Pharma Ltd.	Composes de tetrahydrocyclopenta[b]indole servant au traitement de maladie renale
US11986461B1 (en) *	2023-08-24	2024-05-21	King Faisal University	3-(1-(3-(dimethylamino)propyl)-4,5-diphenyl-1H-imidazol-2-yl)pyridin-2-ol as an antitumor and antimicrobial compound

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4988820A (en) *	1986-02-21	1991-01-29	Bayer Aktiengesellschaft	Cycloalkano(1,2-B) indole-sulponamides
GB8924392D0 (en) *	1989-10-30	1989-12-20	Bayer Ag	Substituted cycloalkano/b/dihydroindole-and-indolesulphonamides
GB9008108D0 (en) *	1990-04-10	1990-06-06	Bayer Ag	Cycloalkano(b)dihydroindoles and-indolesulphonamides substituted by heterocycles
DE4027278A1 (de) *	1990-08-29	1992-03-05	Bayer Ag	Heterocyclisch substituierte indolsulfonamide
DE4131346A1 (de) *	1991-09-20	1993-03-25	Bayer Ag	Indolsulfonamid substituierte dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
ES2277853T3 (es) *	1999-10-14	2007-08-01	Kaken Pharmaceutical Co., Ltd.	Derivados de tetrahidroquinolina.
JP2005527464A (ja)	2001-08-09	2005-09-15	イーライ・リリー・アンド・カンパニー	ｓＰＬＡ２インヒビターとしてのシクロヘプタＢインドール誘導体
DE10164564B4 (de) *	2001-12-14	2007-05-16	Zentaris Gmbh	Tetrahydrocarbazolderivate als Liganden für G-Protein gekoppelte Rezeptoren (GPCR)
US7534897B2 (en) *	2002-05-16	2009-05-19	Shionogi & Co., Ltd.	Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism
US20060074124A1 (en) *	2003-09-12	2006-04-06	Andrew Napper	Methods of treating a disorder
US20050245540A1 (en) *	2003-12-09	2005-11-03	Fujisawa Pharmaceutical Co., Ltd.	New methods
US7019022B2 (en)	2003-12-15	2006-03-28	Merck Frosst Canada & Co.	Substituted tetrahydrocarbazole and cyclopentanoindole derivatives
US7728150B2 (en) *	2004-03-03	2010-06-01	Eli Lilly And Company	Bicyclic substituted indole-derivative steroid hormone nuclear receptor modulators
US20090170923A1 (en) *	2004-11-22	2009-07-02	Kristjan Gudmundsson	Hcv inhibitors
MX2007006179A (es)	2004-11-23	2007-06-20	Ptc Therapeutics Inc	Tetrahidrocarbazoles como agentes activos para inhibir la produccion del factor de crecimiento endotelial vascular por control de la traduccion.
BRPI0608353A2 (pt)	2005-02-17	2009-12-01	Wyeth Corp	derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilfundidos
JP5204650B2 (ja)	2005-06-24	2013-06-05	イーライリリーアンドカンパニー	アンドロゲン受容体調節物質として有用なテトラヒドロカルバゾール誘導体
US20090022694A1 (en)	2005-10-18	2009-01-22	Distefano Peter	Sirt1 inhibition
WO2008019825A1 (fr)	2006-08-14	2008-02-21	Santhera Pharmaceuticals (Schweiz) Ag	Utilisation de dérivés d'indole tricycliques pour le traitement de maladies musculaires
EA019713B1 (ru)	2008-05-16	2014-05-30	Эли Лилли Энд Компани	ТЕТРАГИДРОЦИКЛОПЕНТА[b]ИНДОЛЬНЫЕ МОДУЛЯТОРЫ РЕЦЕПТОРОВ АНДРОГЕНОВ

2007
- 2007-06-11 UA UAA200904819A patent/UA98777C2/ru unknown
- 2007-11-02 TW TW096141527A patent/TWI398438B/zh not_active IP Right Cessation
- 2007-11-05 AR ARP070104913A patent/AR063559A1/es active IP Right Grant
- 2007-11-05 CL CL200703182A patent/CL2007003182A1/es unknown
- 2007-11-06 CA CA2670340A patent/CA2670340C/fr active Active
- 2007-11-06 PL PL07844898T patent/PL2094658T3/pl unknown
- 2007-11-06 RS RS20120056A patent/RS52191B/sr unknown
- 2007-11-06 WO PCT/US2007/083745 patent/WO2008063867A2/fr not_active Ceased
- 2007-11-06 SI SI200730864T patent/SI2094658T1/sl unknown
- 2007-11-06 EA EA200970500A patent/EA015627B1/ru unknown
- 2007-11-06 KR KR1020097010232A patent/KR101121471B1/ko active Active
- 2007-11-06 BR BRPI0719092A patent/BRPI0719092B8/pt active IP Right Grant
- 2007-11-06 NZ NZ576296A patent/NZ576296A/en not_active IP Right Cessation
- 2007-11-06 JP JP2009537272A patent/JP5399259B2/ja active Active
- 2007-11-06 DK DK07844898.2T patent/DK2094658T3/da active
- 2007-11-06 AT AT07844898T patent/ATE538091T1/de active
- 2007-11-06 PT PT07844898T patent/PT2094658E/pt unknown
- 2007-11-06 US US12/447,693 patent/US7968587B2/en active Active
- 2007-11-06 MX MX2009005251A patent/MX2009005251A/es active IP Right Grant
- 2007-11-06 EP EP07844898A patent/EP2094658B1/fr active Active
- 2007-11-06 ES ES07844898T patent/ES2376048T3/es active Active
- 2007-11-06 HR HR20120032T patent/HRP20120032T1/hr unknown
- 2007-11-06 AU AU2007324046A patent/AU2007324046B2/en active Active
- 2007-11-06 CN CN2007800430385A patent/CN101541749B/zh active Active
- 2007-11-06 MY MYPI20092021A patent/MY154547A/en unknown
- 2007-11-08 PE PE2007001544A patent/PE20081161A1/es active IP Right Grant
- 2007-11-11 JO JO2007470A patent/JO2800B1/en active
2009
- 2009-04-27 IL IL198410A patent/IL198410A/en active IP Right Grant
- 2009-05-05 ZA ZA200903096A patent/ZA200903096B/xx unknown
- 2009-05-15 TN TNP2009000189A patent/TN2009000189A1/fr unknown
- 2009-05-18 CO CO09050693A patent/CO6190513A2/es active IP Right Grant
- 2009-05-19 CR CR10802A patent/CR10802A/es unknown
- 2009-05-20 EC EC2009009350A patent/ECSP099350A/es unknown
- 2009-05-28 NO NO20092103A patent/NO342531B1/no unknown
- 2009-06-17 MA MA32013A patent/MA31072B1/fr unknown
2012
- 2012-02-14 CY CY20121100148T patent/CY1112284T1/el unknown

Also Published As

Publication number	Publication date
EA015627B1 (ru)	2011-10-31
WO2008063867A3 (fr)	2008-07-31
IL198410A0 (en)	2010-02-17
JP5399259B2 (ja)	2014-01-29
CR10802A (es)	2009-07-13
CO6190513A2 (es)	2010-08-19
TW200827347A (en)	2008-07-01
ECSP099350A (es)	2009-06-30
MA31072B1 (fr)	2010-01-04
NO20092103L (no)	2009-05-28
CA2670340A1 (fr)	2008-05-29
JO2800B1 (en)	2014-03-15
PE20081161A1 (es)	2008-08-15
UA98777C2 (en)	2012-06-25
MY154547A (en)	2015-06-30
WO2008063867A2 (fr)	2008-05-29
NZ576296A (en)	2011-11-25
MX2009005251A (es)	2009-08-19
BRPI0719092A2 (pt)	2013-12-03
BRPI0719092B8 (pt)	2021-05-25
CA2670340C (fr)	2014-05-20
RS52191B (sr)	2012-10-31
DK2094658T3 (da)	2012-02-13
EP2094658A2 (fr)	2009-09-02
PL2094658T3 (pl)	2012-05-31
KR20090082229A (ko)	2009-07-29
NO342531B1 (no)	2018-06-11
CL2007003182A1 (es)	2008-06-27
IL198410A (en)	2013-09-30
SI2094658T1 (sl)	2012-04-30
KR101121471B1 (ko)	2012-02-28
US7968587B2 (en)	2011-06-28
ES2376048T3 (es)	2012-03-08
AU2007324046B2 (en)	2012-04-05
CN101541749A (zh)	2009-09-23
HK1134089A1 (en)	2010-04-16
EA200970500A1 (ru)	2009-10-30
AU2007324046A1 (en)	2008-05-29
TWI398438B (zh)	2013-06-11
BRPI0719092B1 (pt)	2020-08-18
ATE538091T1 (de)	2012-01-15
EP2094658B1 (fr)	2011-12-21
HRP20120032T1 (hr)	2012-02-29
PT2094658E (pt)	2012-02-22
CN101541749B (zh)	2013-03-27
CY1112284T1 (el)	2015-12-09
US20100069404A1 (en)	2010-03-18
ZA200903096B (en)	2010-07-28
AR063559A1 (es)	2009-02-04
JP2010510231A (ja)	2010-04-02

Publication	Publication Date	Title
TN2009000189A1 (en)	2010-10-18	Tetrahydrocyclopenta [b] indole compounds as androgen receptor modulators
WO2009140448A8 (fr)	2010-01-07	Modulateurs des récepteurs aux androgènes tétrahydrocyclopenta[b]indoles
SI1891038T1 (sl)	2009-04-30	Substituirani n-arilpirolodini kot selektivni modulatorji androgenskega receptorja
SI1902026T1 (sl)	2010-07-30	Derivati tetrahidrokarbazola uporabni kot modulatorji androgenskega receptorja
MX2009011816A (es)	2009-11-19	Derivados de piridina.
PL1735278T3 (pl)	2010-06-30	Związki receptora histaminowego H3, wytwarzanie i zastosowania terapeutyczne
UA86621C2 (ru)	2009-05-12	Антагонисты рецептора глюкагона, их получение и терапевтическое применение
SI1957484T1 (sl)	2010-07-30	Antagonisti glukagonskega receptorja, priprava in terapevtske uporabe
TW200626158A (en)	2006-08-01	Naphthaline derivatives
WO2008004100A3 (fr)	2011-06-16	Composés thérapeutiques
MX2009005242A (es)	2009-08-19	Derivados de 3-(hetero)arilisoquinolinamida sustituida en posición 5, 6 o 7 y uso terapeutico del mismo.
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