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MX2007006179A - Tetrahidrocarbazoles como agentes activos para inhibir la produccion del factor de crecimiento endotelial vascular por control de la traduccion. - Google Patents

Tetrahidrocarbazoles como agentes activos para inhibir la produccion del factor de crecimiento endotelial vascular por control de la traduccion.

Info

Publication number
MX2007006179A
MX2007006179A MX2007006179A MX2007006179A MX2007006179A MX 2007006179 A MX2007006179 A MX 2007006179A MX 2007006179 A MX2007006179 A MX 2007006179A MX 2007006179 A MX2007006179 A MX 2007006179A MX 2007006179 A MX2007006179 A MX 2007006179A
Authority
MX
Mexico
Prior art keywords
tetrahydrocarbazoles
active agents
translational control
vegf production
inhibiting vegf
Prior art date
Application number
MX2007006179A
Other languages
English (en)
Inventor
Hongyan Qi
Young-Choon Moon
William Joseph Lennox
Soongyu Choi
Duck-Hyung Lee
Original Assignee
Ptc Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ptc Therapeutics Inc filed Critical Ptc Therapeutics Inc
Publication of MX2007006179A publication Critical patent/MX2007006179A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Medicinal Chemistry (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Endocrinology (AREA)
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  • Immunology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La presente invencion se refiere a metodos, compuestos y composiciones para inhibir angiogenesis; mas particularmente, la presente invencion se refiere a metodos, compuestos y composiciones para inhibir la produccion del VEGF.
MX2007006179A 2004-11-23 2005-11-23 Tetrahidrocarbazoles como agentes activos para inhibir la produccion del factor de crecimiento endotelial vascular por control de la traduccion. MX2007006179A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62988904P 2004-11-23 2004-11-23
US63373804P 2004-12-06 2004-12-06
US63928304P 2004-12-27 2004-12-27
PCT/US2005/042483 WO2006065480A2 (en) 2004-11-23 2005-11-23 Tetrahydrocarbazoles as active agents for inhibiting vegf production by translational control

Publications (1)

Publication Number Publication Date
MX2007006179A true MX2007006179A (es) 2007-06-20

Family

ID=36143248

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2007006180A MX2007006180A (es) 2004-11-23 2005-11-23 Derivados de carbazol, carbolina, e indol utiles en la inhibicion de la produccion del factor de crecimiento endotelial vascular.
MX2007006178A MX2007006178A (es) 2004-11-23 2005-11-23 Fenoles substituidos como agentes activos que inhiben la produccion del factor de crecimiento endotelial vascular.
MX2007006179A MX2007006179A (es) 2004-11-23 2005-11-23 Tetrahidrocarbazoles como agentes activos para inhibir la produccion del factor de crecimiento endotelial vascular por control de la traduccion.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2007006180A MX2007006180A (es) 2004-11-23 2005-11-23 Derivados de carbazol, carbolina, e indol utiles en la inhibicion de la produccion del factor de crecimiento endotelial vascular.
MX2007006178A MX2007006178A (es) 2004-11-23 2005-11-23 Fenoles substituidos como agentes activos que inhiben la produccion del factor de crecimiento endotelial vascular.

Country Status (6)

Country Link
US (3) US8143257B2 (es)
EP (3) EP1824821A2 (es)
JP (3) JP2008520741A (es)
CA (3) CA2588607A1 (es)
MX (3) MX2007006180A (es)
WO (3) WO2006065480A2 (es)

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