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SV2018005740A - Metodos para tratar la depresion con antagonistas del receptor de orexina-2 - Google Patents

Metodos para tratar la depresion con antagonistas del receptor de orexina-2

Info

Publication number
SV2018005740A
SV2018005740A SV2018005740A SV2018005740A SV2018005740A SV 2018005740 A SV2018005740 A SV 2018005740A SV 2018005740 A SV2018005740 A SV 2018005740A SV 2018005740 A SV2018005740 A SV 2018005740A SV 2018005740 A SV2018005740 A SV 2018005740A
Authority
SV
El Salvador
Prior art keywords
methods
orexina
treat depression
receiver antagonists
composite
Prior art date
Application number
SV2018005740A
Other languages
English (en)
Inventor
Justine M Kent
Wayne C Drevets
Peter De Boer
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of SV2018005740A publication Critical patent/SV2018005740A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA PRESENTE DESCRIPCIÓN ESTÁ DIRIGIDA, ENTRE OTRAS COSAS, A MÉTODOS PARA TRATAR A UN SUJETO QUE PADECE O A QUIEN SE DIAGNOSTICÓ DEPRESIÓN, QUE COMPRENDE ADMINISTRAR A UN SUJETO QUE NECESITA EL TRATAMIENTO UNA CANTIDAD EFICAZ DE UN COMPUESTO DE LA FÓRMULA (I), O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DE ESTE, EN DONDE R1 A R4 SE DESCRIBEN EN LA PRESENTE DESCRIPCIÓN Y EN DONDE EL COMPUESTO SE ADMINISTRA ANTES DE DORMIR (VER FÓRMULA)
SV2018005740A 2016-03-10 2018-09-10 Metodos para tratar la depresion con antagonistas del receptor de orexina-2 SV2018005740A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662306487P 2016-03-10 2016-03-10

Publications (1)

Publication Number Publication Date
SV2018005740A true SV2018005740A (es) 2019-03-14

Family

ID=59776691

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2018005740A SV2018005740A (es) 2016-03-10 2018-09-10 Metodos para tratar la depresion con antagonistas del receptor de orexina-2

Country Status (35)

Country Link
US (4) US10828302B2 (es)
EP (2) EP4091634A1 (es)
JP (4) JP7066622B2 (es)
KR (4) KR102448342B1 (es)
CN (2) CN108883110B (es)
AU (3) AU2017231828B2 (es)
BR (1) BR112018067906A2 (es)
CA (2) CA3016706A1 (es)
CL (1) CL2018002533A1 (es)
CO (1) CO2018009561A2 (es)
CR (1) CR20180433A (es)
CY (1) CY1125247T1 (es)
DK (1) DK3426251T3 (es)
DO (1) DOP2018000196A (es)
EA (1) EA201891930A1 (es)
ES (1) ES2913469T3 (es)
HR (1) HRP20220642T1 (es)
HU (1) HUE058759T2 (es)
IL (3) IL319248A (es)
LT (1) LT3426251T (es)
MA (2) MA43817B1 (es)
MD (1) MD3426251T2 (es)
MX (1) MX2018010852A (es)
MY (1) MY197558A (es)
NI (1) NI201800086A (es)
PH (1) PH12018501903B1 (es)
PL (1) PL3426251T3 (es)
PT (1) PT3426251T (es)
RS (1) RS63296B1 (es)
SG (1) SG11201807597UA (es)
SI (1) SI3426251T1 (es)
SM (1) SMT202200239T1 (es)
SV (1) SV2018005740A (es)
UA (1) UA125873C2 (es)
WO (1) WO2017156266A1 (es)

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KR102448342B1 (ko) * 2016-03-10 2022-09-27 얀센 파마슈티카 엔.브이. 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법
WO2020023723A1 (en) * 2018-07-27 2020-01-30 Icahn School Of Medicine At Mount Sinai Method of treating aggression with orexin receptor antagonists
BR112021009211A2 (pt) 2018-11-14 2021-08-03 Janssen Pharmaceutica N.V. métodos sintéticos aprimorados de produção de compostos heterocíclicos fundidos como moduladores de receptor de orexina
CN113631157A (zh) 2019-02-17 2021-11-09 诺拉威尔治疗公司 用于治疗抑郁症和其它病症的组合物和方法
KR102119231B1 (ko) 2019-09-05 2020-06-04 정소진 코르크칩을 이용한 신발용 밑창의 제조방법 및 그 제조방법에 의해 제조되는 신발용 밑창, 이를 포함하는 신발
WO2022122009A1 (zh) * 2020-12-11 2022-06-16 苏州晶云药物科技股份有限公司 吡咯类衍生化合物的晶型及其制备方法
TW202246274A (zh) * 2021-03-16 2022-12-01 大陸商上海翰森生物醫藥科技有限公司 含氮雜環的多環化合物及其製備方法和應用
CN113393944A (zh) * 2021-06-17 2021-09-14 中国科学院长春应用化学研究所 基于代谢组学的芪参颗粒治疗慢性心力衰竭的药代动力学-药效动力学分析方法
KR20230074653A (ko) 2021-11-19 2023-05-31 고려대학교 세종산학협력단 신규 우레아계 또는 카바메이트계 p2x7 수용체 길항제 및 이를 유효성분으로 포함하는 주요 우울 장애의 예방 또는 치료용 약학 조성물
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