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SV1994000031A - Derivados de 1,5 benzodiacepina ref. 1160ch/sv - Google Patents

Derivados de 1,5 benzodiacepina ref. 1160ch/sv

Info

Publication number
SV1994000031A
SV1994000031A SV1994000031A SV1994000031A SV1994000031A SV 1994000031 A SV1994000031 A SV 1994000031A SV 1994000031 A SV1994000031 A SV 1994000031A SV 1994000031 A SV1994000031 A SV 1994000031A SV 1994000031 A SV1994000031 A SV 1994000031A
Authority
SV
El Salvador
Prior art keywords
carbon
atoms
rent
hydroxy
replaced
Prior art date
Application number
SV1994000031A
Other languages
English (en)
Inventor
Daniele Donati
Antonella Ursini
Mauro Corsi
Original Assignee
Glaxo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Spa filed Critical Glaxo Spa
Publication of SV1994000031A publication Critical patent/SV1994000031A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/121,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

EL PRESENTE INVENTO SE RELACIONA CON UN COMPUESTO DE LA FORMULA GENERAL I, VER FORMULA, CARACTERIZADO PORQUE R1 REPRESENTA UN GRUPO FENILO, CICLOAQUILO CON 3 A 7 ATOMOS DE CARBONO, CICLOALQUILO CON 7 A 11 ATOMOS DE CARBONO, UNIDO POR MEDIO DE UN PUENTE O ALQUILO CON 1 A 6 ATOMOS DE CARBONO, TAL GRUPO ALQUILO PUEDE ESTAR SUSTITUIDO POR UN GRUPO HIDROXI, FENILO, ALCOXICARBONILO CON 1 A 6 ATOMOS DE CARBONO, CICLOALQUILO CON 3 A 7 ATOMOS DE CARBONO, O CICLOAQUILO CON 7 A 11 ATOMOS DE CARBONO, UNIDO POR MEDIOS DE UN PUENTE; R2 REPRESENTA UN GRUPO FENILO OPCIONALMENTE SUSTITUIDO POR 1 ó 2 SUSTITUYENTES SELECCIONADOS DE HOLOGENO, ALQUILO CON 1 A 4 ATOMOS DE CARBONO, ALQUILTIO CON 1 A 4 ATOMOS DE CARBONO, CIANO, NITRO, TRIFLUOROETILO, TRIFLUOROMETOXI, (CH2)nR4 U O(CH2)pR4, DONDE R4 REPRESENTA HIDROXI, ALCOXI CON 1 A 4 ATOMOSD E CARBONO, CO2R5 O NR6R7; N ES CERO ó 1; p ES UN ENTERO DESD4E 1 HASTA 4; R3 REPRESENTA EL GRUPO ALqNR8R9; R5 REPRESENTA HIDROGENO O ALQUILO CON 1 A 4 ATOMOS DE CARBONO; R6 REPRESENTA HIDROGENO O ALQUILO CON 1 A 4 ATOMOS DE CARBONO; R7 REPRESENTA HIDROGENO, ALQUILO CON 1 A 4 ATOMOS DE CARBONO, ACILO, O ALQUILO CON 2 A 6 ATOMOS DE CARBONO, SUSTITUIDO POR UNO O MAS GRUPOS HIDROXI, CARBOXILO Y/O AMINO R6 Y R7 JUNTO CON EL ATOMO DE NITROGENO AL CUAL LOS MISMOS ESTAN UNIDOS, FORMAN UN ANILLO HETEROCICLICO SATURADO CON 5-7 ELEMENTOS, EL CUAL CONTIENE UN HETEROATOMO ADICIONAL SELECCIONADO DE OXIGENO, AZUFRE O NITROGENO Y/O PUEDE ESTAR SUSTITUIDO POR 1 ó 2 GRUPOS HIDROXI O ALQUILO CON 1 A 4 ATOMOS DE CARBONO; R8 Y R9 REPRESENTAN INDEPENDIENTEMENTE HIDROGENO, ALQUILO CON 1 A 4 ATOMOS DE CARBONO O ALQUILO CON 2 A 6 ATOMOS DE CARBONO, SUSTITUIDO POR UNO O MAS GRUPOS HIDROXI, CARBOXILO Y/O AMINO O R8 Y R9 JUNTO CON EL ATOMO DE NITROGENO AL CUAL LOS MISMOS ESTAN UNIDOS, REPRESENTAN UN ANILLO HETEROCICLICO SATURADO CON 5-7 ELEMENTOS, EL CUAL PUEDE CONTENER UN HETEROATOMO ADICIONAL SELECCIOANDO DE OXIGENO, AZUFRE O NITROGENO Y/O PUEDE ESTAR SUSTITUIDO POR 1 ó 2 GRUOS HIDROXI O ALQUILO CON 1 A 4 ATOMOS DE CARBONO, ALq REPRESETA UNA CADENA DE ALQUILENO CON 2 A 6 ATOMOS DE CARBONO, RECTA O RAMIFICADA, SUSTITUIDA OPCIONALMENTE POR UN HIDROXILO; R10 REPRESENTA HIDROGENO O UN ATOMO DE HALOGENO, M ES CERO, 1 ó 2; X ES OXIGENO O NH; Y SUS SALES ACEPTABLES FARMACEUTICAMENTE Y/O ESTERES METABOLICAMENTE LABILES DE LOS MISMOS.
SV1994000031A 1993-07-20 1994-07-19 Derivados de 1,5 benzodiacepina ref. 1160ch/sv SV1994000031A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939314981A GB9314981D0 (en) 1993-07-20 1993-07-20 Chemical compounds

Publications (1)

Publication Number Publication Date
SV1994000031A true SV1994000031A (es) 1995-10-04

Family

ID=10739096

Family Applications (1)

Application Number Title Priority Date Filing Date
SV1994000031A SV1994000031A (es) 1993-07-20 1994-07-19 Derivados de 1,5 benzodiacepina ref. 1160ch/sv

Country Status (32)

Country Link
US (1) US5716953A (es)
EP (1) EP0710230B1 (es)
JP (1) JP3587849B2 (es)
KR (1) KR100347287B1 (es)
CN (1) CN1050835C (es)
AP (1) AP492A (es)
AT (1) ATE171167T1 (es)
AU (1) AU687858B2 (es)
CA (1) CA2167308A1 (es)
CO (1) CO4290299A1 (es)
CZ (1) CZ290472B6 (es)
DE (1) DE69413405T2 (es)
DK (1) DK0710230T3 (es)
EC (1) ECSP941120A (es)
ES (1) ES2123812T3 (es)
FI (1) FI960223A7 (es)
GB (1) GB9314981D0 (es)
HR (1) HRP940411B1 (es)
HU (1) HU222439B1 (es)
IL (1) IL110366A (es)
IS (1) IS4190A (es)
MY (1) MY118638A (es)
NO (1) NO313288B1 (es)
NZ (1) NZ271075A (es)
PE (1) PE8295A1 (es)
PL (1) PL175609B1 (es)
RU (1) RU2135485C1 (es)
SI (1) SI0710230T1 (es)
SV (1) SV1994000031A (es)
TW (1) TW290542B (es)
WO (1) WO1995003285A1 (es)
ZA (1) ZA945238B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5739129A (en) * 1994-04-14 1998-04-14 Glaxo Wellcome Inc. CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines
PE27497A1 (es) * 1994-04-15 1997-08-07 Glaxo Inc Derivados de 1,5 benzodiazepina
WO1998002419A1 (en) * 1996-07-12 1998-01-22 Chugai Seiyaku Kabushiki Kaisha Cancer cell proliferation inhibitors
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US6569851B1 (en) * 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
DE60009116T2 (de) 1999-10-15 2005-02-17 F. Hoffmann-La Roche Ag Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten
US20050192265A1 (en) * 2003-03-20 2005-09-01 Thompson Richard C. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
MXPA06003870A (es) * 2003-10-06 2006-07-03 Hoffmann La Roche Derivados de dibenzo-azepina y benzo-diazepina substituidas utiles como inhibidores de gama-secretasa.
EP1722711A4 (en) * 2004-02-27 2009-12-02 Aortx Inc SYSTEMS AND METHOD FOR STORING ARTIFICIAL HEART FLAPS
EP2137167B1 (en) * 2007-04-19 2011-08-10 F. Hoffmann-La Roche AG Dihydro-benzo[b][1,4]diazepin-2-one sulfonamide derivatives
RU2540464C2 (ru) * 2012-05-28 2015-02-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации Водорастворимое производное амида салициловой кислоты, обладающее транквилизирующей, ноотропной и анальгезирующей активностью
CN103435562B (zh) * 2013-08-26 2016-02-24 华东理工大学 6-取代苯并二氮卓-2,4-二酮类化合物及其用途
RU2702359C1 (ru) * 2019-06-04 2019-10-08 Федеральное государственное бюджетное научное учреждение Уфимский федеральный исследовательский центр Российской академии наук Способ получения 2,2,4-триалкил-2,3-дигидро-1Н-1,5-бензодиазепинов

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2103745A1 (de) * 1971-01-27 1972-08-10 CH. Boehringer Sohn, 6507 Ingelheim Neue 5-AryJ-(bzw. Heteroaryl)-3-hydroxylH-l,5-benzodiazepin-2,4-(3H,5H)-dioneund Verfahren zu ihrer Herstellung
FR2641280B1 (fr) * 1988-12-29 1994-01-21 Roussel Uclaf Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments
CA2068355A1 (en) * 1991-05-14 1992-11-15 Mark S. Chambers Benzodiazephine derivatives, compositions containing them and their use in therapy
GEP20001968B (en) * 1992-01-21 2000-03-05 Glaxo Spa Arilthio Compounds as Antibacterial and Antiviral Agents
GB9201181D0 (en) * 1992-01-21 1992-03-11 Glaxo Spa Chemical compounds
GB9225492D0 (en) * 1992-12-05 1993-01-27 Glaxo Group Ltd Amine derivatives

Also Published As

Publication number Publication date
HRP940411A2 (en) 1997-04-30
EP0710230B1 (en) 1998-09-16
RU2135485C1 (ru) 1999-08-27
CO4290299A1 (es) 1996-04-17
US5716953A (en) 1998-02-10
ZA945238B (en) 1995-02-09
CN1138853A (zh) 1996-12-25
ATE171167T1 (de) 1998-10-15
FI960223A0 (fi) 1996-01-17
EP0710230A1 (en) 1996-05-08
FI960223A7 (fi) 1996-03-19
AU7458994A (en) 1995-02-20
PL312659A1 (en) 1996-04-29
PL175609B1 (pl) 1999-01-29
KR100347287B1 (ko) 2002-12-06
HU222439B1 (hu) 2003-07-28
WO1995003285A1 (en) 1995-02-02
DE69413405T2 (de) 1999-04-15
ES2123812T3 (es) 1999-01-16
IL110366A0 (en) 1994-10-21
PE8295A1 (es) 1995-04-20
CA2167308A1 (en) 1995-02-02
NO313288B1 (no) 2002-09-09
IL110366A (en) 1999-01-26
DK0710230T3 (da) 1999-06-14
CN1050835C (zh) 2000-03-29
CZ290472B6 (cs) 2002-07-17
HUT73499A (en) 1996-08-28
HRP940411B1 (en) 2000-12-31
IS4190A (is) 1995-01-21
AP492A (en) 1996-05-13
DE69413405D1 (de) 1998-10-22
AP9400657A0 (en) 1994-07-31
CZ17396A3 (en) 1996-07-17
JPH09502428A (ja) 1997-03-11
ECSP941120A (es) 1995-01-16
SI0710230T1 (en) 1999-02-28
HU9600124D0 (en) 1996-03-28
TW290542B (es) 1996-11-11
MY118638A (en) 2004-12-31
GB9314981D0 (en) 1993-09-01
NO960237D0 (no) 1996-01-19
NZ271075A (en) 1998-06-26
NO960237L (no) 1996-03-19
AU687858B2 (en) 1998-03-05
JP3587849B2 (ja) 2004-11-10

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