SU1469517A1 - Method of simulating acute respirative distress-syndrome - Google Patents
Method of simulating acute respirative distress-syndrome Download PDFInfo
- Publication number
- SU1469517A1 SU1469517A1 SU874244511A SU4244511A SU1469517A1 SU 1469517 A1 SU1469517 A1 SU 1469517A1 SU 874244511 A SU874244511 A SU 874244511A SU 4244511 A SU4244511 A SU 4244511A SU 1469517 A1 SU1469517 A1 SU 1469517A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- syndrome
- distress
- respirative
- oleic acid
- acute
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 9
- 230000001154 acute effect Effects 0.000 title claims abstract description 4
- 208000011580 syndromic disease Diseases 0.000 title claims description 4
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims abstract description 7
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims abstract description 7
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims abstract description 7
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000005642 Oleic acid Substances 0.000 claims abstract description 7
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims abstract description 7
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims abstract description 7
- 230000009429 distress Effects 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 abstract description 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 abstract 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 abstract 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 abstract 1
- 238000004088 simulation Methods 0.000 abstract 1
- 210000003281 pleural cavity Anatomy 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 208000018875 hypoxemia Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003601 intercostal effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000007425 progressive decline Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
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- External Artificial Organs (AREA)
Abstract
Изобретение относитс к реаниматологии , пульмонологии и может быть использовано дл исследовани закономерностей развити острых дыхательных расстройств. Цель - повышение воспроизводимости способа. Животному внутрипневрально ввод т олеиновую кислоту в дозе 0,25 - 0,3 мл/100 г ткани. Способ позвол ет моделировать острый респираторный дистресс-синдром в 100%.The invention relates to resuscitation, pulmonology and can be used to study the patterns of development of acute respiratory disorders. The goal is to increase the reproducibility of the method. Oleic acid was administered intrapneurally to the animal at a dose of 0.25-0.3 ml / 100 g of tissue. The method allows the simulation of acute respiratory distress syndrome in 100%.
Description
Изобретение относитс к реаниматологии , пульмонологии и может быть использовано дл исследовани закономерностей развити острых дыхатель- ных расстройств.The invention relates to resuscitation, pulmonology and can be used to study the patterns of development of acute respiratory disorders.
Цель изобретени - повьшение воспроизводимости способа.The purpose of the invention is to increase the reproducibility of the method.
Способ осуществл етс следующим образом.The method is carried out as follows.
Крысе внутриплеврально ввод т олеиновую кислоту 0,25-0,3 мл/100 г ткани.Oleic acid 0.25-0.3 ml / 100 g of tissue was intrapleurally injected into the rat.
Пример. Крысе дают эфирный рауш- наркоз. Олеиновую кислоту набирают в 2-граммовый шприц, после чего пункционно через инъекционную иглу диаметром 0,8 мм ввод т в правую плевральную полость животного, в области 4 межреберь по передней под- мьппечной линии. Введение расчетной дозы Олеиновой кислоты Oj25 мл/100 г в плевральную полость осуществл ют прин той в торакальной хирургии пункцией с извитым трехзтапным ходом иглы , что исключает возможность попадани атмосферного воздуха в плевральную полость.Example. Rat is given ether rausch anesthesia. Oleic acid is collected in a 2 g syringe, after which the puncture needle is inserted through the injection needle with a diameter of 0.8 mm into the right pleural cavity of the animal, in the area of the 4 intercostal space along the anterior hyperemia. The introduction of the estimated dose of Oleic acid Oj25 ml / 100 g into the pleural cavity is carried out by a puncture taken in thoracic surgery with a twisted three-step needle, which excludes the possibility of atmospheric air entering the pleural cavity.
слcl
При указанном способе введени олеиновой кислоты наблюдаетс ухудшение клинического состо ни живот- ,ного, сопровождающеес быстро прогрессирующим снижением напр жени O-j, в артериальной крови, что вл етс главным функциональным критерием СОДН. Прогрессирующей артериальной гипо- ксемии сопутствуют выраженные, быстро нарастающие распространенные двусторонние изменени в легких, основные про влени которых в основном соот- ветствуют таковым в модели диспресс- синдрома, полученной в результате внутривенного введени препарата, а также соответствуют описанным типичным изменени м в легких больных с синдромом.With this method of administering oleic acid, a deterioration in the clinical condition of the animal, accompanied by a rapidly progressive decrease in the voltage O-j, in arterial blood, which is the main functional criterion of SODH, is observed. Progressive arterial hypoxemia is accompanied by pronounced, rapidly increasing widespread bilateral changes in the lungs, the main manifestations of which mainly correspond to those in the dyspress syndrome model obtained by intravenous administration of the drug, and also correspond to the described typical changes in the lungs of patients with syndrome.
4;:four;:
о: ;о елabout:; about ate
3U69517.43U69517.4
Способ позвол ет создать модельвведени олеиновой кислоты животному,The method allows to create a model for the introduction of oleic acid to an animal
в 100% случаев, тогда как в прототи-отличающийс тем, что,in 100% of the cases, whereas in protot- one, in that
пе - 40%. с целью повышени воспроизводимостиne - 40%. in order to increase reproducibility
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU874244511A SU1469517A1 (en) | 1987-05-13 | 1987-05-13 | Method of simulating acute respirative distress-syndrome |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU874244511A SU1469517A1 (en) | 1987-05-13 | 1987-05-13 | Method of simulating acute respirative distress-syndrome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1469517A1 true SU1469517A1 (en) | 1989-03-30 |
Family
ID=21304052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU874244511A SU1469517A1 (en) | 1987-05-13 | 1987-05-13 | Method of simulating acute respirative distress-syndrome |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU1469517A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2841901C1 (en) * | 2024-12-04 | 2025-06-18 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" | Method for simulating coagulation haemostasis system disorders in lungs |
-
1987
- 1987-05-13 SU SU874244511A patent/SU1469517A1/en active
Non-Patent Citations (1)
| Title |
|---|
| Симбирцев С.А., Бел ков Н.А. Микроэмболи легких. Л., 1986, c.ll8. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2841901C1 (en) * | 2024-12-04 | 2025-06-18 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" | Method for simulating coagulation haemostasis system disorders in lungs |
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