SU1392872A1 - 2-imino-4-hydroxyethylamino-5, 5-dimethyl-2,5-dihydrofuran showing antiinflammatory and analgetic activity - Google Patents
2-imino-4-hydroxyethylamino-5, 5-dimethyl-2,5-dihydrofuran showing antiinflammatory and analgetic activityInfo
- Publication number
- SU1392872A1 SU1392872A1 SU4013774/04A SU4013774A SU1392872A1 SU 1392872 A1 SU1392872 A1 SU 1392872A1 SU 4013774/04 A SU4013774/04 A SU 4013774/04A SU 4013774 A SU4013774 A SU 4013774A SU 1392872 A1 SU1392872 A1 SU 1392872A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- hydroxyethylamino
- dihydrofuran
- imino
- dimethyl
- activity
- Prior art date
Links
- KITXZSWUUDKJRA-UHFFFAOYSA-N CC1(C)OC(=N)C=C1NCCO Chemical compound CC1(C)OC(=N)C=C1NCCO KITXZSWUUDKJRA-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000202 analgesic effect Effects 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- 230000000694 effects Effects 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 239000007795 chemical reaction product Substances 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 1
- LAHLMBPINRTSLN-UHFFFAOYSA-N 4-hydroxy-4-methylpent-2-ynenitrile Chemical compound CC(C)(O)C#CC#N LAHLMBPINRTSLN-UHFFFAOYSA-N 0.000 abstract 1
- 150000002240 furans Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 231100001274 therapeutic index Toxicity 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
FIELD: organic chemistry, furan derivatives. SUBSTANCE: synthesis of 2-imino-4-hydroxyethylamino-5,5-dimethyl-2,5-dihydrofuran is carried out from aminoethanol and 3-hydroxy-3-methyl-1-butyne-1-carbonitrile in ethanol medium. The yield is 90%, m. p. is 144-146 C, empirical formula is CHNO. The end product shows activity that is identical with the known analgetics and its antiinflammatory activity exceeds that of brufen (therapeutic index is 8.7 as compared with 6.2). Toxicity of the end product and brufen: 435 and 282 mg/kg, respectively. EFFECT: improved method of synthesis, increased yield and enhanced activity. 2 tbl
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU4013774/04A SU1392872A1 (en) | 1986-01-28 | 1986-01-28 | 2-imino-4-hydroxyethylamino-5, 5-dimethyl-2,5-dihydrofuran showing antiinflammatory and analgetic activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU4013774/04A SU1392872A1 (en) | 1986-01-28 | 1986-01-28 | 2-imino-4-hydroxyethylamino-5, 5-dimethyl-2,5-dihydrofuran showing antiinflammatory and analgetic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1392872A1 true SU1392872A1 (en) | 1998-04-10 |
Family
ID=60533850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU4013774/04A SU1392872A1 (en) | 1986-01-28 | 1986-01-28 | 2-imino-4-hydroxyethylamino-5, 5-dimethyl-2,5-dihydrofuran showing antiinflammatory and analgetic activity |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU1392872A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7417150B2 (en) | 2001-04-20 | 2008-08-26 | Bayer Cropscience Ag | Azoles having an insecticidal action |
-
1986
- 1986-01-28 SU SU4013774/04A patent/SU1392872A1/en active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7417150B2 (en) | 2001-04-20 | 2008-08-26 | Bayer Cropscience Ag | Azoles having an insecticidal action |
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