SU1146047A1 - Method of treatment of vegetative vascular dystonia of paroxysmal nature - Google Patents

Abstract

METHOD OF TREATMENT OF VEGETARY-VASCULAR DISTONIUM OF PAROXISMAL 1a tt tt V / / 3 12 W 29 hh 110 tX t .AV. 9 12 16 20 24: .g ... v CHARACTER by oral administration of a dilantin to a patient, characterized in that, in order to shorten the treatment time, the patient's blood pressure, body temperature, respiratory rate are measured every 4 hours for three days. and heart rate, yes .; The mean values of these indicators and the moments of maximum deviations from them are determined later, and the dilantin is administered 10-15 minutes before the coincidence of the maximum deviations of the 2-4 studied parameters. (Lt t 3 n; b 2B g is Od O 4: Y to hGL - V 5 12 No. ha 24

Description

The invention relates to medicine, in particular to methods of treatment, and can be used in the clinic of nervous diseases. Treatment of vegetovascular diseases with a paroxysmal course is carried out using a complex of pharmacological agents of various classes, selected depending on the etiological and pathogenetic factors.

One of these drugs is dilanti (difenin), which has a direct effect on the excitability of vegetative centers and the conduction of nerve impulses.

The known method is oral dillantin two to three times a day, i.e. morning, afternoon and evening u,

. However, the known method of treatment, even in combination with a wide range of symptomatic therapy, does not always give a good clinical effect and improvement occurs within one or two months. A good and lasting effect can be obtained with treatment in 20-30% of cases, satisfactory in 55-61% and no effect in 13-25% of cases.

The aim of the invention is to reduce the duration of treatment.

The goal is achieved by the method, which includes oral administration of dilantin to a patient, first every 4 hours blood pressure, body temperature, respiratory rate and heart rate are measured every three hours, then the average values of these indicators and the moments of maximum deviations from them are determined , and dilantin is administered 10–15 minutes before the coincidence points of the maximum deviations of 2–4 studied parameters.

Measurement of blood pressure, body temperature, respiratory rate and heart rate, carried out for consecutive three days every 4 hours, allows us to clarify the individual structure of biological rhythms of the body’s physiological systems and to detect in those structure those from the normal values, the functions (both in the direction of decreasing and decreasing) are maximum. The coincidence of these points for two and four functions makes it possible to choose for the introduction of dilantin those times when the body most needs therapeutic effects.

Example 1. Ill R., 32 years old. Diagnosis: diencephalic syndrome on the basis of common osteochondrosis.

When you receive a complaint of bouts of pain in the heart area several times a day, accompanied by holoca, contraction, headache, hyperhidrosis, numbness and burning sensation in

areas between the shoulder blades and in the elbow joints. Common pains in the posture of the spine, the duration of the attack is 1 hour, after the attack, abundant urination and general weakness. He considers himself a patient for about 10 years.

Objectively: the general condition is satisfactory. From the internal organs without pathology. ECG within normal limits. The lability of the systological pressure (120-145). Horizontal nystagmus when looking in both directions. Coordination tests are performed uncertainly. Movement in all parts of the spine is limited and painful. In the interscapular region and in the paravertebral points (especially in the hypardium and in the thoracic region, at the level of Dj-B) hyperesthesi. Tension long spins c. thoracic and lumbar spine. The symptom of Lasega on the left (from the angle of 90). Osteochondrosis in the area, Dj-pg, is observed on the radiographs of the spine. Laboratory studies without deviations from the norm.

During the month, the patient received symptomatic treatment: desensitization, anti-edema and anti-inflammatory therapy, as well as vasodilator drugs, multivitamins and ganglioblokatory, and from 26.08 - twice daily dilantin, one tablet without positive

effect. The patient was studied the structure of the biorhythms of the systological and diastological blood pressure, body temperature, pulse rate and respiration, three

days p.

FIG. Figures 1-4 show daily blood pressure curves (measured on the right and left hand), body temperature, respiratory rates and heart rate. As seen in FIG. 1 (where the upper curves correspond to the systolic and the lower to the diastolic pressure measured on the right hand, - the first pair of graphs 1q and 11q, on the left arm - the second pair of graphs S and 118, on the abscissa axis - the time of day, on the ordinate axis - the value pressure in mm Hg, solid line — study curve for the first day, dotted line — for the second day, dash-dotted line — for the third day) on the first day of the study, the diastolic pressure at 20 hours turned out to be high on the right hand, as a result of which it turned out to be pulse pressure, on the second day dovani pulse pressure also was low at 20 h (by reducing the pressure ontological ICI). On the left hand, the pulse pressure was low at 16 and 20 hours on the first and second days. As seen in FIG. 2 (where temperature values are given in degrees centigrade along the ordinate axis, the rest is the same as in Fig. 1), temperature rises above the norm were noted at 8 and 20 hours on the first day and at 16 hours on the second day of the study. As seen in FIG. 3 (where the ratio of respiration rate per 1 minute) is observed on the ordinate axis; the increase in respiration rate up to 1820 per minute was observed on the first day of the study at 20 h and on the second day at 16 h. As can be seen in FIG. 4 (where the heart rate for 1 min is plotted on the ordinate axis), tachycardia is presented on the first day at 8, 12 and 16 h, on the second day at 12 and 16 h and on the third day at 12 h. Thus, the maximum deviations from Normal values of functions were noted at 20 hours according to arterial pressure curves, body temperature and 16 hours at 16 hours according to blood pressure, body temperature, respiratory rate and heart rate. Reception of dilantina is prescribed from 11.08 at 16 and 20 hours one tablet (100 milligrams). Continuous studies of the biorhythm structure for the purpose of controlling the treatment. held on October 21-24 and 17.1019 .10. The time of drug administration remained the same. A day after the appointment of the individual time of administration of dilantin, on September 13, in the second half of the day, a sharp deterioration of the condition occurred, and precariousness, dizziness, sweating developed. The patient could not get out of bed, turning the head caused nausea and increased nystagmus. Heart pain was not observed. This state lasted for about a day, and on September 15, the patient felt good. The intensity of the pain syndrome significantly decreased, coordination improved. After 2 weeks radicular phenomena have almost disappeared, bouts of pain in the heart and headache do not bother. In total, according to an individual scheme, the patient received a dilantin of 40 days. At discharge of complaints, he presented a neurological and therapeutic status without deviations from the norm. During the year, the patient felt good, in August 1979, the occurrence of coroscula pain in the cervical and thoracic regions was noted and the patient received a course of dilantin (administered at 16 and 20 hours after repeated biorhythmic research) for 2 over. therapeutic effect. Further, until February 1981, there was no deterioration. Example 2. Ill F., 28 years old. Diagnosis: post-infectious vegetative-vascular dyston with paroxysmal flow. Upon receipt of a complaint of general weakness, increased fatigue, headache of dull compressive nature, reduced mood background, uncertain chest pains. Against this background, seizures occurred 2-3 times a week, accompanied by an increase in the intensity of the headache, a sensation of hot flashes on the third day at 12 and 20 o'clock. As you can see. in fig. 6, the temperature rise above the norm is noted on the first day at 20 h, on the second day at 12 and 24 h. As can be seen on, fig. 7, an increase in respiratory rate on the first day of the study was observed at 20 h and (to a lesser extent) at 8 and 12 h, on the second day - at 16, 20 and 24 h °, on the third day - at 8 h. FIG. 8 shows that the increase in heart rate in the first. Day 511 was noted at 8, 12 and 16 h, on the second day at 12 and 16 h, on the third day at 12 h. Thus, the maximum deviations from normal values of functions were noted at 8 h according to the curves of blood pressure, respiratory rate and heart rate, at 12 o'clock on all curves of blood pressure, body temperature and respiratory rate. The patient was prescribed dclantin at 8 am, as well as at 12 and 20 h. The treatment started in the hospital is continued on an outpatient basis. In total, dilantin was given for 60 days according to an individual administration schedule. During this time, the patient did not have a single attack, no loss of consciousness, no tachycardia, and there were no vegetative-vascular crises. The first week after the introduction of the drug according to the new scheme, the patient noted an increase in general weakness, increased sweating. stiffness, fatigue and headache. Then the condition began to improve distinctly. On examination, on February 23, there were no complaints, the state of health was good, the blood pressure was 115/75 mm Hg, and the hyperhidrosis died down significantly. Comparison of the results of treatment with dilantin according to the usual and proposed regimen of administration, based on the analysis of daily curves. To compare the results, a group of 300 patients with paroxysmal vegetative-vascular dystonia of character treated with dilantin in the form of tablets (100 mg of the preparation) twice a day (at 10 and 14 hours) or three times a day (at 10, 14 and 17 h). Continued from year to 5 years. The table shows the comparative data of the therapeutic effect when using the drug dilantin according to the usual regimen of administration and according to individual regimens, when, based on the study of biorhythms, the timing of administration is chosen that are optimal for the patient.

Standard 300 13 Individual 70 O

As a result, chronotherapy can be recommended as a means of optimizing the pharmacological treatment of vegetative-vascular dystonias of a paroxysmal nature.

According to the proposed method of treating vegetative-vascular dystonias of paroxysmal character as compared with the known methods, the effect is achieved6 8

30 61

51 31

goes fast. After 1-2 weeks. patients show a distinct improvement, while with the usual method of dilantin, improvement occurs within one to two months.

In addition, a stronger and more lasting therapeutic effect is achieved.

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Claims (1)

METHOD FOR TREATING VEGETO-VASCULAR DYSTONIA OF PAROXISMAL CHARACTERISTIC by oral administration of dilantin to the patient, characterized in that, in order to reduce the treatment time, the patient is preliminarily measured every 4 hours for three days, blood pressure, body temperature, respiratory rate and heart rate, yes. ^- ; Then, the average values of these indicators and the moments of maximum deviations from them are determined, and dilantin is administered 10–15 min before the maximum deviations of 2–4 studied parameters coincide. 1a Figure 1 1 1146047