[go: up one dir, main page]

SMT202000138T1 - Raccordi per coniugati anticorpo-farmaco - Google Patents

Raccordi per coniugati anticorpo-farmaco

Info

Publication number
SMT202000138T1
SMT202000138T1 SM20200138T SMT202000138T SMT202000138T1 SM T202000138 T1 SMT202000138 T1 SM T202000138T1 SM 20200138 T SM20200138 T SM 20200138T SM T202000138 T SMT202000138 T SM T202000138T SM T202000138 T1 SMT202000138 T1 SM T202000138T1
Authority
SM
San Marino
Prior art keywords
linkers
antibody
drug conjugates
conjugates
drug
Prior art date
Application number
SM20200138T
Other languages
English (en)
Inventor
Takeshi Masuda
Hiroyuki Naito
Takashi Nakada
Masao Yoshida
Shinji Ashida
Hideki Miyazaki
Yuji Kasuya
Koji Morita
Yuki Abe
Yusuke Ogitani
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50477169&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMT202000138(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of SMT202000138T1 publication Critical patent/SMT202000138T1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68037—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a camptothecin [CPT] or derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SM20200138T 2012-10-11 2013-10-10 Raccordi per coniugati anticorpo-farmaco SMT202000138T1 (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012225887 2012-10-11
EP18152381.2A EP3342785B1 (en) 2012-10-11 2013-10-10 Linkers for antibody-drug conjugates

Publications (1)

Publication Number Publication Date
SMT202000138T1 true SMT202000138T1 (it) 2020-05-08

Family

ID=50477169

Family Applications (2)

Application Number Title Priority Date Filing Date
SM20200138T SMT202000138T1 (it) 2012-10-11 2013-10-10 Raccordi per coniugati anticorpo-farmaco
SM20180344T SMT201800344T1 (it) 2012-10-11 2013-10-10 Coniugato anticorpo-farmaco

Family Applications After (1)

Application Number Title Priority Date Filing Date
SM20180344T SMT201800344T1 (it) 2012-10-11 2013-10-10 Coniugato anticorpo-farmaco

Country Status (30)

Country Link
US (6) US10195288B2 (it)
EP (3) EP3632471A1 (it)
JP (9) JP5953378B2 (it)
KR (15) KR101841818B1 (it)
CN (4) CN104755494B (it)
AU (5) AU2013328111B2 (it)
BR (3) BR112015006521B1 (it)
CA (2) CA2885800C (it)
CY (2) CY1120363T1 (it)
DK (2) DK2907824T3 (it)
ES (2) ES2773710T3 (it)
HR (2) HRP20180870T1 (it)
HU (2) HUE039000T2 (it)
IL (5) IL294622B2 (it)
LT (2) LT3342785T (it)
MX (3) MX364484B (it)
MY (1) MY170251A (it)
NZ (4) NZ746440A (it)
PH (2) PH12015500667B1 (it)
PL (2) PL3342785T3 (it)
PT (2) PT2907824T (it)
RS (2) RS60000B1 (it)
RU (1) RU2664465C2 (it)
SG (2) SG10201804788XA (it)
SI (2) SI3342785T1 (it)
SM (2) SMT202000138T1 (it)
TR (1) TR201809636T4 (it)
TW (14) TWI696611B (it)
WO (1) WO2014057687A1 (it)
ZA (2) ZA201501825B (it)

Families Citing this family (208)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104755494B (zh) 2012-10-11 2018-09-07 第一三共株式会社 抗体－药物偶联物
WO2014061277A1 (ja) 2012-10-19 2014-04-24 第一三共株式会社 親水性構造を含むリンカーで結合させた抗体－薬物コンジュゲート
HRP20190056T1 (hr) 2013-12-25 2019-02-22 Daiichi Sankyo Company, Limited Konjugat anti-trop2 antitijelo-lijek
SMT202500030T1 (it) * 2014-01-31 2025-03-12 Daiichi Sankyo Co Ltd Coniugato anticorpo anti-her2-farmaco
JP2017114763A (ja) * 2014-03-26 2017-06-29 第一三共株式会社 抗ｃｄ９８抗体−薬物コンジュゲート
ES2754348T3 (es) * 2014-04-10 2020-04-17 Daiichi Sankyo Co Ltd Conjugado de (anticuerpo anti-HER2)-fármaco
DK3129063T3 (da) * 2014-04-10 2021-04-06 Daiichi Sankyo Co Ltd Anti-her3-antistof-lægemiddelkonjugat
US11173213B2 (en) * 2015-06-29 2021-11-16 Daiichi Sankyo Company, Limited Method for selectively manufacturing antibody-drug conjugate
EP3395910A1 (en) * 2015-12-24 2018-10-31 AGC Inc. Resin composition, substrate, and cell culture method
MY198114A (en) * 2016-04-15 2023-08-04 Macrogenics Inc Novel b7-h3-binding molecules, antibody drug conjugates thereof and methods of use thereof
CN109963870B (zh) * 2016-06-08 2023-07-28 艾伯维公司 抗b7-h3抗体和抗体药物偶联物
CN109563167A (zh) * 2016-06-08 2019-04-02 艾伯维公司 抗b7-h3抗体和抗体药物偶联物
TW201825524A (zh) * 2016-09-20 2018-07-16 中國大陸商上海藥明生物技術有限公司 新型抗-pcsk9抗體
SG10201912575RA (en) 2016-12-12 2020-02-27 Daiichi Sankyo Co Ltd Combination of antibody-drug conjugate and immune checkpoint inhibitor
BR112019012847A2 (pt) * 2017-01-17 2019-12-10 Daiichi Sankyo Co Ltd anticorpo ou fragmento funcional do anticorpo, polinucleotídeo, vetor de expressão, células hospedeiras, método para produção de um anticorpo de interesse ou de um fragmento funcional do anticorpo e para produção de um conjugado de anticorpo-fármaco, conjugado de anticorpo-fármaco, composição farmacêutica, fármaco antitumoral, e, método de tratamento de um tumor.
US20200061031A1 (en) 2017-02-28 2020-02-27 Kinki University Method for treating egfr-tki-resistant non-small cell lung cancer by administration of anti-her3 antibody-drug conjugate
TW202532101A (zh) 2017-05-15 2025-08-16 日商第一三共股份有限公司 抗體－藥物結合物及其用途
CN109963591B (zh) * 2017-08-04 2023-04-04 江苏恒瑞医药股份有限公司 B7h3抗体-药物偶联物及其医药用途
WO2019034176A1 (zh) * 2017-08-18 2019-02-21 四川百利药业有限责任公司 一种喜树碱-抗体偶联物
US20210128741A1 (en) 2017-08-23 2021-05-06 Daiichi Sankyo Company, Limited Antibody-drug conjugate preparation and lyophilization for same
JP7248578B2 (ja) * 2017-08-31 2023-03-29 第一三共株式会社 抗体－薬物コンジュゲートの新規製造方法
US11945882B2 (en) * 2017-08-31 2024-04-02 Daiichi Sankyo Company, Limited Method for producing antibody-drug conjugate
IL273471B2 (en) 2017-09-29 2023-09-01 Daiichi Sankyo Co Ltd Conjugation of an antibody with a pyrrolobenzodiazepine derivative
CN111542324B (zh) * 2018-02-11 2023-09-12 四川科伦博泰生物医药股份有限公司 细胞毒性剂及其偶联物、其制备方法及用途
JP7430643B2 (ja) * 2018-04-06 2024-02-13 シージェン インコーポレイテッド カンプトテシンペプチドコンジュゲート
AU2019270459B2 (en) 2018-05-18 2025-08-28 Daiichi Sankyo Co., Ltd. Anti-MUC1 antibody-drug conjugate
US20210251994A1 (en) 2018-06-15 2021-08-19 Flagship Pioneering Innovations V, Inc. Increasing immune activity through modulation of postcellular signaling factors
EP3828206A4 (en) 2018-07-25 2022-04-20 Daiichi Sankyo Company, Limited METHOD OF PREPARING AN ANTIBODY DRUG CONJUGATE
KR102899298B1 (ko) 2018-07-27 2025-12-12 다이이찌 산쿄 가부시키가이샤 항체-약물 콘주게이트의 약물 부위를 인식하는 단백질
EA202190403A1 (ru) * 2018-07-31 2021-05-24 Дайити Санкио Компани, Лимитед Лечение метастатической опухоли головного мозга путем введения конъюгата антитело-лекарственное средство
EP3834843A4 (en) 2018-08-06 2022-05-11 Daiichi Sankyo Company, Limited COMBINATION OF ANTIBODY-DRUG CONJUGATE AND TUBULIN INHIBITOR
JP7481255B2 (ja) 2018-08-23 2024-05-10 第一三共株式会社 抗体薬物複合体の感受性マーカー
DK3848054T3 (da) 2018-09-06 2025-04-14 Daiichi Sankyo Co Ltd Antistof-lægemiddelkonjugater af cykliske dinukleotidderivater
TW202024133A (zh) 2018-09-20 2020-07-01 日商第一三共股份有限公司 利用投予抗her3抗體-藥物結合物之her3突變癌之治療
CA3114137A1 (en) * 2018-09-26 2020-04-02 Jiangsu Hengrui Medicine Co., Ltd. Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof
WO2020063673A1 (zh) 2018-09-30 2020-04-02 江苏恒瑞医药股份有限公司 抗b7h3抗体-依喜替康类似物偶联物及其医药用途
TW202031298A (zh) 2018-11-14 2020-09-01 日商第一三共股份有限公司 抗ｃｄｈ６抗體－吡咯并苯二氮呯衍生物結合物
EA202191641A1 (ru) * 2018-12-11 2021-09-13 Дайити Санкио Компани, Лимитед Комбинация конъюгата антитело-лекарственное средство с ингибитором parp
BR112021011894A2 (pt) 2018-12-21 2021-09-08 Daiichi Sankyo Company, Limited Composição farmacêutica
JP7682797B2 (ja) 2019-03-20 2025-05-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア クローディン６二重特異性抗体
JP7682798B2 (ja) 2019-03-20 2025-05-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア クローディン６抗体及び薬物複合体
WO2020200880A1 (en) * 2019-03-29 2020-10-08 Medimmune Limited Compounds and conjugates thereof
EP3962493A2 (en) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V, Inc. Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor
CN111689980A (zh) * 2019-05-26 2020-09-22 四川百利药业有限责任公司 一种喜树碱药物及其抗体偶联物
KR20220025861A (ko) * 2019-06-28 2022-03-03 상하이 후단-장지앙 바이오-파마슈티컬 컴퍼니 리미티드 항체 약물 복합체, 이의 중간체, 제조 방법 및 용도
CN117731798A (zh) * 2019-06-28 2024-03-22 泰州复旦张江药业有限公司 抗体偶联药物、其中间体、制备方法及应用
PE20220485A1 (es) 2019-07-10 2022-04-04 Cybrexa 3 Inc Conjugados peptidicos de agentes dirigidos a microtubulos como terapeuticos
PE20220563A1 (es) 2019-07-10 2022-04-13 Cybrexa 2 Inc Conjugados peptidicos de citotoxinas como terapeuticos
WO2021052402A1 (zh) * 2019-09-18 2021-03-25 四川百利药业有限责任公司 一种喜树碱衍生物及其偶联物
CN114650845B (zh) * 2019-12-12 2024-04-16 江苏恒瑞医药股份有限公司 抗密蛋白抗体药物偶联物及其医药用途
MY209735A (en) * 2019-12-16 2025-07-31 Shanghai hengrui pharmaceutical co ltd Anti-cea antibody-exatecan analog conjugate and pharmaceutical use thereof
EP4076434A1 (en) 2019-12-17 2022-10-26 Flagship Pioneering Innovations V, Inc. Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly
CN114845739B (zh) 2020-01-22 2024-07-16 上海森辉医药有限公司 艾日布林衍生物的药物偶联物、其制备方法及其在医药上的应用
CN118873679A (zh) 2020-01-22 2024-11-01 江苏恒瑞医药股份有限公司 抗trop-2抗体-依喜替康类似物偶联物及其医药用途
BR112022017064A2 (pt) 2020-02-25 2022-11-16 Mediboston Inc Derivados da camptotecina e seus conjugados
JPWO2021177438A1 (it) 2020-03-06 2021-09-10
CN115298220B (zh) * 2020-03-24 2024-12-20 上海翰森生物医药科技有限公司 抗体-药物偶联物及其医药用途
CA3177279A1 (en) * 2020-03-25 2021-09-30 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Anti-psma antibody-exatecan analogue conjugate and medical use thereof
CA3175048A1 (en) * 2020-03-25 2021-09-30 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Preparation method for antibody medicament conjugate
BR112022019073A2 (pt) * 2020-03-25 2022-11-08 Jiangsu Hengrui Pharmaceuticals Co Ltd Composição farmacêutica que compreende conjugado anticorpo-fármaco e uso da mesma
CA3173263A1 (en) * 2020-03-30 2021-10-07 Yasuhiro Matsumura Antibody drug conjugate
BR112022024930A2 (pt) * 2020-06-08 2022-12-27 Baili Bio Chengdu Pharmaceutical Co Ltd Fármaco de camptotecina possuindo unidade de conexão hidrofílica de alta estabilidade e conjugado do mesmo
CN116194109A (zh) 2020-06-24 2023-05-30 阿斯利康(英国)有限公司 抗体-药物缀合物和atm抑制剂的组合
WO2021260583A1 (en) 2020-06-24 2021-12-30 Astrazeneca Uk Limited Combination of antibody-drug conjugate and dna-pk inhibitor
CN116615248A (zh) 2020-06-24 2023-08-18 阿斯利康(英国)有限公司 抗体-药物缀合物和cdk9抑制剂的组合
AU2021298251A1 (en) 2020-06-24 2023-02-02 Astrazeneca Uk Limited Combination of antibody-drug conjugate and ATR inhibitor
WO2021260582A1 (en) 2020-06-24 2021-12-30 Astrazeneca Uk Limited Combination of antibody-drug conjugate and aurora b inhibitor
CN116096906A (zh) 2020-06-29 2023-05-09 旗舰创业创新五公司 工程化以促进萨诺传递的病毒及其在治疗癌症中的用途
US10997243B1 (en) 2020-06-30 2021-05-04 Snowflake Inc. Supporting unstructured, semi-structured, and structured files
US11423081B1 (en) 2020-06-30 2022-08-23 Snowflake Inc. Accessing files in a database stage using a user defined function
US11361026B2 (en) 2020-06-30 2022-06-14 Snowflake Inc. Accessing files in a database stage using a user defined function
IL299184A (en) 2020-07-06 2023-02-01 Byondis Bv Anti-folic acid drugs and antibody-conjugated drugs
WO2022011075A1 (en) * 2020-07-10 2022-01-13 VelosBio Inc. Novel ror1 antibody immunoconjugates
AU2021308190A1 (en) * 2020-07-13 2023-02-02 Regeneron Pharmaceuticals, Inc. Camptothecin analogs conjugated to a glutamine residue in a protein, and their use
BR112023000711A2 (pt) 2020-07-17 2023-01-31 Daiichi Sankyo Co Ltd Método para produzir uma composição de conjugado de anticorpo-fármaco, e, composição de conjugado de anticorpo-fármaco
CN119792568A (zh) * 2020-08-13 2025-04-11 正大天晴药业集团股份有限公司 抗体药物偶联物
KR20230050378A (ko) 2020-08-13 2023-04-14 이나뜨 파르마 에스.에이. 항-cd73 항체를 사용하여 암을 치료하는 방법
CA3191395A1 (en) 2020-09-02 2022-03-10 Daiichi Sankyo Company, Limited Novel endo-.beta.-n-acetylglucosaminidase
EP4223318A4 (en) 2020-09-30 2024-12-18 Duality Biologics (Suzhou) Co., Ltd. Antitumor compound, and preparation method therefor and use thereof
AU2021356762A1 (en) 2020-10-09 2023-05-25 Astrazeneca Uk Limited Combination of antibody-drug conjugate and parp1 selective inhibitor
WO2022078259A1 (zh) * 2020-10-12 2022-04-21 四川百利药业有限责任公司 一种氘代的喜树碱衍生物及其抗体药物偶联物
JP2023545581A (ja) * 2020-10-12 2023-10-30 シーチュアン バイリ ファーム シーオー． エルティーディー カンプトテシン系誘導体及びそのリガンド－薬物複合体
TW202227140A (zh) 2020-11-11 2022-07-16 日商第一三共股份有限公司 抗體-藥物結合物及抗SIRPα抗體之組合
WO2022099762A1 (zh) * 2020-11-12 2022-05-19 博瑞生物医药（苏州）股份有限公司 一种抗体偶联物中间体及其制备方法
US20230398230A1 (en) * 2020-11-12 2023-12-14 Daiichi Sankyo Company, Limited Treatment of mesothelioma by administration of anti-b7-h3 antibody-drug conjugate
US20240058463A1 (en) * 2020-12-18 2024-02-22 Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. B7-h3 targeting antibody-drug conjugate, and preparation method therefor and use thereof
US20240050584A1 (en) * 2020-12-18 2024-02-15 Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. Trop2 targeting antibody-drug conjugate, and preparation method and use therefor
TW202241897A (zh) * 2020-12-23 2022-11-01 大陸商上海偌妥生物科技有限公司 抗體藥物結合物、醫藥組合物及治療應用
TW202245844A (zh) * 2021-01-13 2022-12-01 紀念斯隆凱特琳癌症中心 抗dll3抗體-藥物結合物
CN114805377A (zh) * 2021-01-29 2022-07-29 明慧医药（杭州）有限公司 适用于抗体-药物偶联物的毒素分子
TW202241454A (zh) 2021-02-01 2022-11-01 日商第一三共股份有限公司 抗體－免疫賦活化劑共軛物之新穎製造方法
TW202241521A (zh) 2021-02-09 2022-11-01 大陸商蘇州宜聯生物醫藥有限公司 生物活性物偶聯物及其製備方法和用途
IL305816A (en) 2021-03-12 2023-11-01 Daiichi Sankyo Co Ltd Glycan and a method for preparing a medicine containing it
TW202300148A (zh) * 2021-03-17 2023-01-01 大陸商江蘇恒瑞醫藥股份有限公司 喜樹鹼衍生物的製備方法
AU2022238571A1 (en) 2021-03-18 2023-09-14 Seagen Inc. Selective drug release from internalized conjugates of biologically active compounds
CA3214085A1 (en) 2021-03-31 2022-10-06 Darby Rye Schmidt Thanotransmission polypeptides and their use in treating cancer
CN115197234A (zh) * 2021-04-02 2022-10-18 江苏恒瑞医药股份有限公司 一种喜树碱衍生物中间体的制备方法
EP4319820A1 (en) 2021-04-10 2024-02-14 Profoundbio Us Co. Folr1 binding agents, conjugates thereof and methods of using the same
WO2022218331A1 (en) * 2021-04-14 2022-10-20 Genequantum Healthcare (Suzhou) Co., Ltd. Linkers, conjugates and applications thereof
EP4079327A1 (en) 2021-04-22 2022-10-26 Centaurus Polytherapeutics Payloads for drug-conjugates and their use for treating cancer
TW202308699A (zh) 2021-04-23 2023-03-01 美商普方生物製藥美國公司 Ｃｄ７０結合劑、其結合物及其使用方法
EP4332117A4 (en) * 2021-04-26 2024-10-30 Jiangsu Hengrui Pharmaceuticals Co., Ltd. ANTI-NECTIN-4 ANTIBODIES AND ANTI-NECTIN-4 ANTIBODY-DRUG CONJUGATE AND MEDICAL USERS THEREOF
CN113816969B (zh) * 2021-04-30 2024-01-16 联宁（苏州）生物制药有限公司 依喜替康类化合物、其抗体药物偶联物及其应用
US11645243B2 (en) 2021-06-07 2023-05-09 Snowflake Inc. Accessing files in a database stage using a user defined function
US20240358848A1 (en) * 2021-06-17 2024-10-31 Minghui Pharmaceutical (Hangzhou) Limited Antitumor compound and use thereof
KR20240027761A (ko) 2021-06-28 2024-03-04 비온디스 비.브이. 인항원을 포함하는 접합체 및 요법에서의 이의 용도
EP4363059A1 (en) 2021-06-29 2024-05-08 Flagship Pioneering Innovations V, Inc. Immune cells engineered to promote thanotransmission and uses thereof
CN113402584A (zh) * 2021-07-06 2021-09-17 联宁（苏州）生物制药有限公司 一种抗体偶联药物连接子的中间体lnd1067-l1的合成方法
TW202320857A (zh) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 連接子、藥物連接子及其結合物及其使用方法
CN113527418B (zh) * 2021-07-16 2022-05-03 成都普康唯新生物科技有限公司 一种ADC linker的制备方法
US20230123041A1 (en) * 2021-07-19 2023-04-20 Recurium Ip Holdings, Llc Immunoconjugates and methods
US11806405B1 (en) 2021-07-19 2023-11-07 Zeno Management, Inc. Immunoconjugates and methods
CN117715913A (zh) * 2021-07-19 2024-03-15 芝诺管理公司 免疫缀合物和方法
TW202320859A (zh) 2021-07-21 2023-06-01 大陸商江蘇恆瑞醫藥股份有限公司 一種含抗ｔｒｏｐ２抗體藥物偶聯物的醫藥組成物及其用途
EP4401791A1 (en) 2021-09-15 2024-07-24 Daiichi Sankyo Company, Limited Antibody-drug conjugate for use in methods of treating chemotherapy-resistant cancer
EP4410830A1 (en) 2021-09-30 2024-08-07 Ajinomoto Co., Inc. Conjugate of antibody and functional substance or salt thereof, and antibody derivative and compound or salts thereof to be used in producing conjugate or salt thereof
TW202330041A (zh) 2021-10-18 2023-08-01 日商第一三共股份有限公司 抗cd37抗體-藥物結合物
AU2021362997A1 (en) 2021-11-03 2024-05-16 Hangzhou Dac Biotech Co., Ltd. Specific conjugation of an antibody
PE20250759A1 (es) 2021-11-15 2025-03-13 Systimmune Inc Conjugado de anticuerpo bispecifico-farmaco de camptotecina y uso farmaceutico de este
US11814394B2 (en) 2021-11-16 2023-11-14 Genequantum Healthcare (Suzhou) Co., Ltd. Exatecan derivatives, linker-payloads, and conjugates and thereof
MX2024006039A (es) 2021-11-18 2024-06-04 Astrazeneca Uk Ltd Combinacion de conjugado de anticuerpo-farmaco e inhibidor selectivo de poli(adenosina-5'-difosfato-ribosa) polimerasa 1 (parp1).
EP4433096A1 (en) 2021-11-19 2024-09-25 Ardeagen Corporation Gpc3 binding agents, conjugates thereof and methods of using the same
WO2023100829A1 (ja) 2021-11-30 2023-06-08 第一三共株式会社 プロテアーゼ分解性マスク抗体
MX2024006732A (es) 2021-12-03 2024-07-22 Systimmune Inc Conjugado de anticuerpo anti-trop2 humano - fármaco de camptotecina y uso médico del mismo.
KR20240125958A (ko) 2021-12-23 2024-08-20 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 항-dll3 항체, 이의 항체-약물 접합체 및 이의 의약적 용도
WO2023116911A1 (zh) * 2021-12-24 2023-06-29 百奥泰生物制药股份有限公司 抗FRα抗体及其抗体药物偶联物和用途
US20250161305A1 (en) 2021-12-28 2025-05-22 Astrazeneca Uk Limited Combination of antibody-drug conjugate and rasg12c inhibitor
US20250064967A1 (en) 2021-12-28 2025-02-27 Astrazeneca Uk Limited Combination of antibody-drug conjugate and atr inhibitor
IL313806A (en) 2021-12-30 2024-08-01 Byondis Bv Antifolate linker-drugs and antibody-drug conjugates
WO2023138635A1 (zh) * 2022-01-18 2023-07-27 甘李药业股份有限公司 一种依喜替康衍生物-抗体偶联物及其医药用途
CA3243294A1 (en) 2022-01-25 2025-02-28 Medilink Therapeutics (Suzhou) Co., Ltd. Antibody against her3, conjugate, and use thereof
WO2023153442A1 (ja) 2022-02-09 2023-08-17 第一三共株式会社 環境応答性マスク抗体及びその利用
EP4487874A1 (en) 2022-02-28 2025-01-08 UBE Corporation Antibody-drug conjugate precursor and intermediate for synthesis thereof
CA3252358A1 (en) 2022-02-28 2025-03-04 Ube Corporation ANTIBODY-DRUG CONJUGATE
TW202346322A (zh) 2022-03-02 2023-12-01 日商第一三共股份有限公司 含Ｆｃ分子之製造方法
EP4489790A1 (en) 2022-03-10 2025-01-15 Vivasor, Inc. Antibody-drug conjugates and uses thereof
CA3255700A1 (en) 2022-03-16 2023-09-21 Astrazeneca Uk Limited RATING METHOD FOR ANTI-TROP2 ANTIBODY-DRUG CONJUGATE THERAPY
CN118613286A (zh) 2022-03-18 2024-09-06 映恩生物制药（苏州）有限公司 Gpc3抗体药物偶联物及其用途
IL316221A (en) 2022-04-12 2024-12-01 Minerva Biotechnologies Corp Anti-MUC1* variant antibodies and their uses
TW202400140A (zh) 2022-04-27 2024-01-01 日商第一三共股份有限公司 抗體-藥物結合物與ezh1及/或ezh2抑制劑之組合
JP2025517656A (ja) 2022-05-11 2025-06-10 第一三共株式会社 腫瘍抗原に特異的である抗体と、ｃｄ４７阻害剤との組合せ
EP4531927A1 (en) 2022-05-24 2025-04-09 Daiichi Sankyo Company, Limited Dosage regimen of an anti-cdh6 antibody-drug conjugate
JPWO2023234426A1 (it) 2022-06-03 2023-12-07
JPWO2023234427A1 (it) 2022-06-03 2023-12-07
CA3254691A1 (en) 2022-06-07 2025-03-18 Duality Biologics (Suzhou) Co., Ltd. ANTIBODY-DRUG CONJUGATE ANTI-3 APPROVED B7 AND ITS USE
KR20250020660A (ko) * 2022-06-09 2025-02-11 베이진 엘티디 항체 약물 접합체
CA3258214A1 (en) 2022-06-15 2025-03-18 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. PHARMACEUTICAL COMPOSITION COMPRISING AN ANTIBODY-DRUG CONJUGATE AND ITS USE
CN115160403B (zh) * 2022-07-05 2025-06-27 博石丰生命科技(南通)有限公司 特异性拓扑异构酶抑制剂和可用于抗体药物偶联物及其制备方法
CN118955615A (zh) * 2022-07-05 2024-11-15 上海药明合联生物技术有限公司 偶联连接子
CN119677750A (zh) 2022-07-11 2025-03-21 匹诺生物股份有限公司 与ddx5蛋白结合的喜树碱衍生物及其前药
JP2025523090A (ja) 2022-07-14 2025-07-17 メディリンク セラピューティクス（スーチョウ）カンパニー，リミティド 抗体薬物複合体及びその製造方法と使用
MA71455A (fr) 2022-07-15 2025-04-30 Genequantum Healthcare (Suzhou) Co., Ltd. Anticorps, lieurs, charge utile, conjugués et leurs applications
EP4558506A1 (en) * 2022-07-22 2025-05-28 NJ Bio, Inc. Hexacyclic topoisomerase inhibitors having cytotoxic activity on cancer cells
WO2024022372A1 (zh) 2022-07-27 2024-02-01 明慧医药（杭州）有限公司 抗体药物偶联物及其应用
AU2023313120A1 (en) 2022-07-28 2025-02-06 Astrazeneca Uk Limited Combination of antibody-drug conjugate and bispecific checkpoint inhibitor
CN117510515A (zh) * 2022-07-28 2024-02-06 明慧医药（杭州）有限公司 适用于抗体-药物偶联物的毒素分子
TW202415409A (zh) 2022-08-02 2024-04-16 中國商諾納生物（蘇州）有限公司 Msln抗體藥物複合體
JP2025531032A (ja) 2022-08-25 2025-09-19 ジーンクアンタム ヘルスケア （スーチョウ） シーオー．， エルティーディー． 抗体薬物複合体の医薬組成物
TW202417056A (zh) 2022-08-29 2024-05-01 日商第一三共股份有限公司 包含變異Fc區域的抗體藥物結合物
JP2025511436A (ja) 2022-09-02 2025-04-16 メルク・シャープ・アンド・ドーム・エルエルシー エキサテカン由来トポイソメラーゼ－１阻害薬医薬組成物及びその使用
JPWO2024053574A1 (it) 2022-09-09 2024-03-14
CN117752813A (zh) 2022-09-26 2024-03-26 成都百利多特生物药业有限责任公司 抗cd33抗体和抗cd33抗体-药物偶联物及其用途
EP4593819A2 (en) * 2022-09-26 2025-08-06 Solve Therapeutics, Inc. Compositions and uses thereof
IL319866A (en) * 2022-09-30 2025-05-01 Beigene Switzerland Gmbh Ligand-drug conjugates of exatacan analogs and their medical use
US20240174732A1 (en) 2022-10-05 2024-05-30 Flagship Pioneering Innovations V, Inc. Nucleic acid molecules encoding trif and additional polypeptides and their use in treating cancer
IL320161A (en) 2022-10-09 2025-06-01 Lanova Medicines Ltd Compounds, compositions and methods
TW202432099A (zh) 2022-10-25 2024-08-16 美商默沙東有限責任公司 源自依克沙替康(exatecan)之adc連接子-載藥(payload)、醫藥組合物及其用途
KR20250111207A (ko) 2022-11-24 2025-07-22 비원 메디슨즈 아이 게엠베하 항체 약물 접합체
EP4623937A1 (en) * 2022-11-25 2025-10-01 Minghui Pharmaceutical (Hangzhou) Limited Anti-tumor compound and use thereof
CN118105508A (zh) * 2022-11-29 2024-05-31 四川科伦博泰生物医药股份有限公司 药物连接子化合物及其制备方法和用途
TW202440169A (zh) 2022-11-30 2024-10-16 日商第一三共股份有限公司 抗體-藥物結合物與dnmt抑制劑之組合
US20240269251A1 (en) 2023-01-09 2024-08-15 Flagship Pioneering Innovations V, Inc. Genetic switches and their use in treating cancer
CN116621927B (zh) * 2023-01-09 2024-03-26 联宁（苏州）生物制药有限公司 带有伊喜替康和C-lock定点偶联基团的抗体偶联中间体、偶联方法及抗体偶联药物
AR131815A1 (es) 2023-02-09 2025-05-07 Beigene Ltd Conjugados de enlace autoestabilizantes
WO2024179470A1 (zh) * 2023-02-27 2024-09-06 苏州盛迪亚生物医药有限公司 抗dll3抗体、其抗体-药物偶联物及其医药用途
JPWO2024190815A1 (it) 2023-03-14 2024-09-19
CN118666946A (zh) * 2023-03-15 2024-09-20 上海亲合力生物医药科技股份有限公司 连接子及使用其的偶联药物、抗体偶联药物及其应用
AR132196A1 (es) * 2023-03-23 2025-06-04 Beigene Switzerland Gmbh Conjugado bioactivo, método de preparación del mismo y uso del mismo
KR20250164708A (ko) 2023-03-29 2025-11-25 다이이찌 산쿄 가부시키가이샤 항 cd25 항체 및 항 cd25 항체-약물 콘주게이트
TW202444427A (zh) 2023-03-31 2024-11-16 日商第一三共股份有限公司 抗CDH6抗體-藥物結合物與HIF-2α抑制劑之組合
CN120917041A (zh) 2023-04-04 2025-11-07 味之素株式会社 抗体和功能性物质的缀合物、抗体衍生物以及化合物或它们的盐
WO2024210178A1 (ja) 2023-04-05 2024-10-10 味の素株式会社 抗体および機能性物質のコンジュゲートまたはその塩、ならびにチオール基を有する抗体中間体またはその塩
WO2024211235A1 (en) 2023-04-05 2024-10-10 Sorrento Therapeutics, Inc. Antibody-drug conjugates and uses thereof
TW202506190A (zh) 2023-04-05 2025-02-16 日商第一三共股份有限公司 利用抗ｍｕｃ１抗體－藥物結合物投予的藥劑低敏感性癌之治療方法
WO2024211234A1 (en) 2023-04-05 2024-10-10 Sorrento Therapeutics, Inc. Antibody-drug conjugates and uses thereof
WO2024211236A2 (en) 2023-04-05 2024-10-10 Sorrento Therapeutics, Inc. Antibody-drug conjugates and uses thereof
TW202446421A (zh) 2023-04-10 2024-12-01 日商第一三共股份有限公司 抗ｂ７－ｈ３抗體－藥物結合物與ａｔｒ抑制劑或ａｔｍ抑制劑之組合
AU2024252499A1 (en) 2023-04-13 2025-10-23 Genequantum Healthcare (Suzhou) Co., Ltd. Combination of antibody-drug conjugate and anti-pd-1 antibody, and use thereof
CN121057735A (zh) * 2023-05-06 2025-12-02 上海齐鲁制药研究中心有限公司 一种氘代喜树碱化合物及其制备和应用
WO2024230752A1 (zh) 2023-05-08 2024-11-14 甘李药业股份有限公司 喜树碱衍生物、接头、配体-药物偶联物及其医药用途
WO2024235071A1 (en) * 2023-05-16 2024-11-21 Nanjing University Conjugate and the preparation thereof
CN119522111A (zh) * 2023-05-16 2025-02-25 石药集团巨石生物制药有限公司 一种抗体药物偶联物的药物组合物
CN121219016A (zh) 2023-06-02 2025-12-26 第一三共株式会社 抗-her3抗体-药物缀合物和rasg12c抑制剂的组合
CN119546347A (zh) * 2023-06-29 2025-02-28 石药集团巨石生物制药有限公司 抗体-药物偶联物及其用途
WO2025005240A1 (ja) * 2023-06-30 2025-01-02 第一三共株式会社 活性炭材料を使用する精製工程を含む抗体－薬物コンジュゲートの製造方法
CN119490559A (zh) * 2023-08-16 2025-02-21 中山康方生物医药有限公司 化合物以及含有该化合物的抗体偶联药物
AR133955A1 (es) 2023-09-26 2025-11-19 Profoundbio Us Co Agentes de unión a ptk7, conjugados de éstos y métodos de uso de los mismos
WO2025088496A1 (en) 2023-10-24 2025-05-01 Astrazeneca Uk Limited Combination of antibody-drug conjugate and anti-pd-1/tim-3 bispecific binding protein
WO2025106278A1 (en) 2023-11-17 2025-05-22 Mersana Therapeutics, Inc. Treatment of cancer using b7-h4-targeted antibody-drug conjugates
WO2025120513A1 (en) 2023-12-05 2025-06-12 Astrazeneca Uk Limited Combination of antibody-drug conjugate and blood brain barrier-penetrant parp1 selective inhibitor
WO2025141153A1 (en) 2023-12-29 2025-07-03 Oncomatryx Biopharma, S.L. Endo180 targeted antibody-drug conjugates
WO2025146131A1 (en) 2024-01-05 2025-07-10 Beigene, Ltd. ANTI-FGFR2b ANTIBODIES, CONJUGATES AND METHODS OF USE
WO2025149661A1 (en) 2024-01-10 2025-07-17 Genmab A/S Slitrk6 binding agents, conjugates thereof and methods of using the same
US20250381289A1 (en) 2024-02-29 2025-12-18 Genmab A/S Egfr and c-met bispecific binding agents, conjugates thereof and methods of using the same
WO2025185559A1 (zh) * 2024-03-04 2025-09-12 杭州中美华东制药有限公司 抗FGFR2b抗体、其抗体药物偶联物及其用途
WO2025186213A1 (en) 2024-03-04 2025-09-12 Debiopharm International S.A. Combination of a wee1 inhibitor and a topoisomerase 1 inhibitor
WO2025238587A1 (en) 2024-05-16 2025-11-20 Daiichi Sankyo Company, Limited Combination of anti-b7-h3 antibody-drug conjugate and androgen receptor signaling inhibitor
WO2025241867A1 (zh) * 2024-05-24 2025-11-27 明慧医药（杭州）有限公司 抗b7-h4抗体药物偶联物及其应用

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
EP0585287B1 (en) 1990-07-10 1999-10-13 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
JP3008226B2 (ja) 1991-01-16 2000-02-14 第一製薬株式会社 六環性化合物
US5658920A (en) 1991-01-16 1997-08-19 Daiichi Pharmaceutical Co., Ltd. Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound
JPH0559061U (ja) 1991-04-18 1993-08-03 株式会社ケイヴイシー ボールバルブ
EP0605522B1 (en) 1991-09-23 1999-06-23 Medical Research Council Methods for the production of humanized antibodies
WO1993011236A1 (en) 1991-12-02 1993-06-10 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
CA2131151A1 (en) 1992-03-24 1994-09-30 Kevin S. Johnson Methods for producing members of specific binding pairs
JP3359955B2 (ja) 1992-07-16 2002-12-24 第一製薬株式会社 抗腫瘍剤
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
JPH0687746U (ja) 1993-06-02 1994-12-22 株式会社ユニシアジェックス 液圧緩衝器のリザーバチューブ構造
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
AU690171B2 (en) 1993-12-03 1998-04-23 Medical Research Council Recombinant binding proteins and peptides
US5773001A (en) 1994-06-03 1998-06-30 American Cyanamid Company Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
US6504029B1 (en) 1995-04-10 2003-01-07 Daiichi Pharmaceutical Co., Ltd. Condensed-hexacyclic compounds and a process therefor
JPH08337584A (ja) 1995-04-10 1996-12-24 Dai Ichi Seiyaku Co Ltd 縮合六環式アミノ化合物、これを含有する医薬及びその製法
SG50747A1 (en) 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
JPH1095802A (ja) 1995-12-28 1998-04-14 Tanabe Seiyaku Co Ltd カンプトテシン誘導体
CA2192725C (en) 1995-12-28 2004-04-20 Kenji Tsujihara Camptothecin derivatives
TW409058B (en) 1996-06-06 2000-10-21 Daiichi Seiyaku Co Method for preparation of a drug complex
TW527183B (en) 1996-06-06 2003-04-11 Daiichi Seiyaku Co Drug complex
JPH1171280A (ja) 1997-06-26 1999-03-16 Tanabe Seiyaku Co Ltd 医薬組成物
JPH1192405A (ja) * 1997-09-19 1999-04-06 Dai Ichi Seiyaku Co Ltd 薬物複合体
PT1071700E (pt) 1998-04-20 2010-04-23 Glycart Biotechnology Ag Modificação por glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos
TWI253935B (en) * 1998-05-22 2006-05-01 Daiichi Seiyaku Co Drug complex
EP1619210A1 (en) 1998-10-30 2006-01-25 Daiichi Pharmaceutical Co., Ltd. DDS compounds and method for assaying the same
EP2278003B2 (en) 1999-04-09 2020-08-05 Kyowa Kirin Co., Ltd. Method for controlling the activity of immunologically functional molecule
JP2002060351A (ja) 2000-03-22 2002-02-26 Dai Ichi Seiyaku Co Ltd 水酸基を有する薬物を含むｄｄｓ化合物
KR20030031502A (ko) * 2000-06-29 2003-04-21 다이이찌 세이야꾸 가부시기가이샤 디디에스 화합물 및 그의 제조방법
KR20030023697A (ko) 2000-07-13 2003-03-19 다이이찌 세이야꾸 가부시기가이샤 Ｄｄｓ 화합물을 함유하는 의약 조성물
EA013563B1 (ru) 2000-10-06 2010-06-30 Киова Хакко Кирин Ко., Лтд. Трансгенное животное, продуцирующее антитела с измененными углеводными цепями, способ получения антител и содержащее антитела лекарственное средство
US7090843B1 (en) 2000-11-28 2006-08-15 Seattle Genetics, Inc. Recombinant anti-CD30 antibodies and uses thereof
TWI313609B (en) * 2001-08-21 2009-08-21 Mitsubishi Tanabe Pharma Corp Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor
NZ533164A (en) 2001-11-01 2008-09-26 Uab Research Foundation Combinations of antibodies selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and other therapeutic agents
AU2002363939A1 (en) 2001-11-20 2003-06-10 Seattle Genetics, Inc. Treatment of immunological disorders using anti-cd30 antibodies
US8877901B2 (en) 2002-12-13 2014-11-04 Immunomedics, Inc. Camptothecin-binding moiety conjugates
CN101264325B (zh) 2002-03-01 2017-03-01 免疫医疗公司 Rs7抗体
AU2003288467A1 (en) 2002-12-13 2004-07-09 Immunomedics, Inc. Immunoconjugates with an intracellularly-cleavable linkage
US20040202666A1 (en) 2003-01-24 2004-10-14 Immunomedics, Inc. Anti-cancer anthracycline drug-antibody conjugates
BRPI0508233A (pt) 2004-02-26 2007-07-17 Inotek Pharmaceuticals Corp derivados de isoquinolina e métodos para emprego destes
US7837980B2 (en) 2004-03-02 2010-11-23 Seattle Genetics, Inc. Partially loaded antibodies and methods of their conjugation
CA2564076C (en) * 2004-05-19 2014-02-18 Medarex, Inc. Chemical linkers and conjugates thereof
RU2404810C9 (ru) 2004-06-01 2015-06-20 Дженентек, Инк. Конъюгаты антитело-лекарственное средство и способы
EP1817341A2 (en) 2004-11-29 2007-08-15 Seattle Genetics, Inc. Engineered antibodies and immunoconjugates
DE102005009099A1 (de) 2005-02-28 2006-08-31 Ktb Tumorforschungsgesellschaft Mbh Proteinbindende Camptothecin-Peptid-Derivate und diese enthaltende Arzneimittel
DE102005009084A1 (de) 2005-02-28 2006-08-31 Ktb Tumorforschungsgesellschaft Mbh Proteinbindende Anthrazyklin-Peptid-Derivate und diese enthaltende Arzneimittel
EP2511299A1 (en) 2005-04-19 2012-10-17 Seattle Genetics, Inc. Humanized anti-CD70 binding agents and uses thereof
US7833979B2 (en) 2005-04-22 2010-11-16 Amgen Inc. Toxin peptide therapeutic agents
JP2006316040A (ja) 2005-05-13 2006-11-24 Genentech Inc Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法
PT2032606E (pt) 2006-05-30 2014-02-05 Genentech Inc Anticorpos e imunoconjugados e respetivas utilizações
UA95958C2 (en) * 2006-05-30 2011-09-26 Дженентек, Инк. Antibody that binds to cd22, immunoconjugates and uses therefor
WO2007145306A1 (ja) 2006-06-15 2007-12-21 National University Corporation Hokkaido University 腫瘍組織で選択的に分解性を示す血中滞留性素子
ITMI20061473A1 (it) 2006-07-26 2008-01-27 Indena Spa Derivati della camptotecina ad attivita antitumorale
CA2673410A1 (en) 2006-12-21 2008-07-03 Schering Corporation Pyrrolo [3, 2-a] pyridine derivatives for inhibiting ksp kinesin activity
WO2008116219A2 (en) * 2007-03-22 2008-09-25 Sloan-Kettering Institute For Cancer Research Uses of monoclonal antibody 8h9
KR20230003298A (ko) 2008-04-30 2023-01-05 이뮤노젠 아이엔씨 가교제 및 그 용도
US8715662B2 (en) 2009-02-05 2014-05-06 Oncoxx Biotech S.R.L. Anti-trop-2 monoclonal antibodies and uses thereof in the treatment and diagnosis of tumors
CA2749501C (en) 2009-02-13 2017-01-10 Immunomedics, Inc. Immunoconjugates with an intracellularly-cleavable linkage
WO2011021397A1 (ja) 2009-08-20 2011-02-24 国立大学法人千葉大学 コルヒチン誘導体
CA2775350A1 (en) 2009-09-24 2011-03-31 Seattle Genetics, Inc. Dr5 ligand drug conjugates
CN103079587B (zh) 2010-05-13 2016-05-11 印第安纳大学研究及科技有限公司 呈现核激素受体活性的胰高血糖素超家族肽
EP2571525A4 (en) 2010-05-18 2016-04-27 Cerulean Pharma Inc Compositions and methods for treating autoimmune and other diseases
BR112013000951A2 (pt) 2010-07-12 2016-05-17 Covx Technologies Ireland Ltd conjungados de anticorpo multifuncionais
CN103313990B (zh) 2010-11-17 2016-07-20 基因泰克公司 丙氨酰美登醇抗体偶联物
CN104053672A (zh) 2011-11-11 2014-09-17 瑞纳神经科学公司 Trop-2特异性抗体及其用途
JP2015505850A (ja) 2011-12-14 2015-02-26 シアトル ジェネティックス， インコーポレイテッド 新規な抗体薬物コンジュゲート（ａｄｃ）およびそれらの使用
US20130280282A1 (en) 2012-04-24 2013-10-24 Daiichi Sankyo Co., Ltd. Dr5 ligand drug conjugates
WO2013188740A1 (en) 2012-06-14 2013-12-19 Ambrx, Inc. Anti-psma antibodies conjugated to nuclear receptor ligand polypeptides
US9517522B2 (en) * 2012-09-05 2016-12-13 Illinois Tool Works Inc. Self-aligning wire feeder assembly
CN104755494B (zh) * 2012-10-11 2018-09-07 第一三共株式会社 抗体－药物偶联物
WO2014061277A1 (ja) 2012-10-19 2014-04-24 第一三共株式会社 親水性構造を含むリンカーで結合させた抗体－薬物コンジュゲート
US9814784B2 (en) 2013-01-03 2017-11-14 Celltrion, Inc. Antibody-linker-drug conjugate, preparation method therefor, and anticancer drug composition containing same
CN103313390B (zh) 2013-07-05 2016-01-20 江苏大学 一种基于双移动信标的wsn定位方法
SMT202500030T1 (it) * 2014-01-31 2025-03-12 Daiichi Sankyo Co Ltd Coniugato anticorpo anti-her2-farmaco
ES2754348T3 (es) 2014-04-10 2020-04-17 Daiichi Sankyo Co Ltd Conjugado de (anticuerpo anti-HER2)-fármaco
WO2018155976A1 (ko) 2017-02-24 2018-08-30 장길훈 대화형 애플리케이션의 메시지 공유 시스템과 방법

Also Published As

Publication number Publication date
TW202448522A (zh) 2024-12-16
MX2020010964A (es) 2020-11-09
AU2022203560A1 (en) 2022-06-16
IL271760A (en) 2020-02-27
TW201920098A (zh) 2019-06-01
TW202448523A (zh) 2024-12-16
US10195288B2 (en) 2019-02-05
CN115960111A (zh) 2023-04-14
TW202033499A (zh) 2020-09-16
SG11201502887WA (en) 2015-05-28
IL302494A (en) 2023-06-01
EP3632471A1 (en) 2020-04-08
US20240082413A1 (en) 2024-03-14
HRP20200353T1 (hr) 2020-06-12
US12186310B2 (en) 2025-01-07
KR20230086800A (ko) 2023-06-15
TWI879659B (zh) 2025-04-01
ES2671644T3 (es) 2018-06-07
EP2907824A1 (en) 2015-08-19
KR102052319B1 (ko) 2019-12-05
HRP20180870T1 (hr) 2018-07-13
US10973924B2 (en) 2021-04-13
CN104755494B (zh) 2018-09-07
TWI615152B (zh) 2018-02-21
ES2773710T3 (es) 2020-07-14
SG10201804788XA (en) 2018-07-30
AU2018200308A1 (en) 2018-02-01
CA2885800C (en) 2018-12-04
US20160279259A1 (en) 2016-09-29
LT2907824T (lt) 2018-06-11
IL271760B (en) 2022-08-01
TWI870276B (zh) 2025-01-11
IL238143B (en) 2020-01-30
BR112015006521A2 (it) 2017-09-05
NZ740948A (en) 2019-11-29
AU2018200308B2 (en) 2019-11-07
KR20220029776A (ko) 2022-03-08
TWI879658B (zh) 2025-04-01
CN113929738B (zh) 2024-05-17
MY170251A (en) 2019-07-13
EP3342785A1 (en) 2018-07-04
MX364484B (es) 2019-04-29
JP6030267B1 (ja) 2016-11-24
AU2013328111B2 (en) 2017-11-02
PH12015500667B1 (en) 2019-03-06
KR20180105271A (ko) 2018-09-27
KR20210132240A (ko) 2021-11-03
PH12015500667A1 (en) 2015-05-18
SMT201800344T1 (it) 2018-09-13
TWI696611B (zh) 2020-06-21
WO2014057687A1 (ja) 2014-04-17
TW202448521A (zh) 2024-12-16
TR201809636T4 (tr) 2018-07-23
JP2022008581A (ja) 2022-01-13
PT3342785T (pt) 2020-02-25
KR20250130442A (ko) 2025-09-01
CA3021435C (en) 2021-10-12
CN109081871B (zh) 2023-07-14
KR20150067149A (ko) 2015-06-17
KR101901558B1 (ko) 2018-09-21
US20200282073A1 (en) 2020-09-10
IL294622B2 (en) 2023-10-01
RU2664465C2 (ru) 2018-08-17
KR20200026323A (ko) 2020-03-10
SI2907824T1 (en) 2018-06-29
TWI879656B (zh) 2025-04-01
JP2020180124A (ja) 2020-11-05
KR102087017B1 (ko) 2020-03-10
RS60000B1 (sr) 2020-04-30
KR102456726B1 (ko) 2022-10-20
PT2907824T (pt) 2018-06-07
ZA201900820B (en) 2022-08-31
RS57278B1 (sr) 2018-08-31
SI3342785T1 (sl) 2020-02-28
JP6371452B2 (ja) 2018-08-08
TWI870275B (zh) 2025-01-11
EP2907824B1 (en) 2018-04-11
HK1210477A1 (en) 2016-04-22
DK3342785T3 (da) 2020-03-23
US11633493B2 (en) 2023-04-25
CA3021435A1 (en) 2014-04-17
NZ746439A (en) 2019-11-29
TW202448462A (zh) 2024-12-16
PH12018501433A1 (en) 2019-02-27
PL3342785T3 (pl) 2020-09-07
AU2020200548A1 (en) 2020-02-13
LT3342785T (lt) 2020-02-10
RU2018128384A (ru) 2018-10-02
PL2907824T3 (pl) 2018-08-31
TW202444366A (zh) 2024-11-16
CA2885800A1 (en) 2014-04-17
RU2015113767A (ru) 2016-12-10
JP5953378B2 (ja) 2016-07-20
JP2018188455A (ja) 2018-11-29
JP6715888B2 (ja) 2020-07-01
HUE048748T2 (hu) 2020-08-28
US20150297748A1 (en) 2015-10-22
TW201811746A (zh) 2018-04-01
KR102540419B1 (ko) 2023-06-05
BR112015006521B1 (pt) 2022-03-03
CN109081871A (zh) 2018-12-25
JPWO2014057687A1 (ja) 2016-09-05
KR102320907B1 (ko) 2021-11-02
IL302494B2 (en) 2024-11-01
JP6952835B2 (ja) 2021-10-27
HK1256631A1 (en) 2019-09-27
JP2024147681A (ja) 2024-10-16
US20250049782A1 (en) 2025-02-13
CY1120363T1 (el) 2019-07-10
NZ705394A (en) 2018-10-26
US9808537B2 (en) 2017-11-07
JP2016196484A (ja) 2016-11-24
AU2013328111A1 (en) 2015-03-12
KR20190135559A (ko) 2019-12-06
IL313147A (en) 2024-07-01
ZA201501825B (en) 2022-05-25
KR102498405B1 (ko) 2023-02-09
TW202444429A (zh) 2024-11-16
KR102584005B1 (ko) 2023-09-27
BR122021014396B1 (pt) 2022-07-05
KR102853456B1 (ko) 2025-09-01
CY1122789T1 (el) 2021-05-05
IL294622B1 (en) 2023-06-01
JP2018008982A (ja) 2018-01-18
KR20220146669A (ko) 2022-11-01
IL238143A0 (en) 2015-05-31
KR101841818B1 (ko) 2018-03-26
TW202448463A (zh) 2024-12-16
KR102237639B1 (ko) 2021-04-07
IL302494B1 (en) 2024-07-01
KR20230024433A (ko) 2023-02-20
RU2018128384A3 (it) 2021-12-20
KR102417310B1 (ko) 2022-07-05
BR122021014365B1 (pt) 2022-07-05
EP3342785B1 (en) 2019-12-25
KR20230142808A (ko) 2023-10-11
KR20240144454A (ko) 2024-10-02
AU2022203560B2 (en) 2025-02-06
DK2907824T3 (en) 2018-07-23
TW202444428A (zh) 2024-11-16
TWI877062B (zh) 2025-03-11
TW201420117A (zh) 2014-06-01
JP6186045B2 (ja) 2017-08-23
TW202233186A (zh) 2022-09-01
AU2020200548B2 (en) 2022-08-25
HUE039000T2 (hu) 2018-12-28
TWI650312B (zh) 2019-02-11
AU2025202668A1 (en) 2025-07-03
KR102709509B1 (ko) 2024-09-24
TWI870274B (zh) 2025-01-11
TW202448464A (zh) 2024-12-16
NZ746440A (en) 2019-11-29
CN113929738A (zh) 2022-01-14
IL294622A (en) 2022-09-01
JP2023011799A (ja) 2023-01-24
JP2017036274A (ja) 2017-02-16
MX2019004502A (es) 2019-08-21
KR102369419B1 (ko) 2022-03-02
TW202444367A (zh) 2024-11-16
KR20180030734A (ko) 2018-03-23
JP7523506B2 (ja) 2024-07-26
TWI870273B (zh) 2025-01-11
TWI879657B (zh) 2025-04-01
EP2907824A4 (en) 2016-06-08
KR20220100727A (ko) 2022-07-15
MX2015003903A (es) 2015-07-17
TWI877063B (zh) 2025-03-11
CN104755494A (zh) 2015-07-01
US20190008981A1 (en) 2019-01-10
JP7170812B2 (ja) 2022-11-14
TWI757740B (zh) 2022-03-11
KR20210038728A (ko) 2021-04-07

Similar Documents

Publication Publication Date Title
HUS2300020I1 (hu) Pirrolobenzodiazepin-antitest konjugátumok
LT3342785T (lt) Linkeriai skirti antikūno-vaisto konjugatams
SG10201605401WA (en) Antibody-drug conjugates
ZA201502523B (en) Pyrrolobenzodiazepine-anitbody conjugates
ZA201501996B (en) Drug-protein conjugates
ZA201407369B (en) Self-stabilizing linker conjugates
IL237672B (en) Drug-protein conjugates
IL238567A0 (en) Antibodies against notch3 and antibody-drug conjugates
PT2920167T (pt) Compostos de hidrazinil-indol e conjugados
HUE041274T2 (hu) Pirrolobenzodiazepin-anti-PSMA-antitest konjugátumok
LT2906251T (lt) Pirolobenzodiazepino-anti-cd22 antikūno konjugatai
LT2906252T (lt) Pirolobenzodiazepino-anti-her2 antikūno konjugatai
SG11201604191UA (en) Anti-efna4 antibody-drug conjugates
GB201310472D0 (en) Antibody-drug conjugates