SK8472003A3 - Use of SARP-1 for the treatment and/or prevention of scleroderma - Google Patents

Use of SARP-1 for the treatment and/or prevention of scleroderma Download PDF

Info

Publication number: SK8472003A3
Authority: SK; Slovakia
Prior art keywords: sarp; scleroderma; polypeptide; seq; amino acids
Prior art date: 2000-12-06

Application number

SK847-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Christine Plater-Zyberk

Christine Power

Jacques Colinge

Original Assignee

Applied Research Systems

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-06

Filing date

2001-11-30

Publication date

2003-10-07

2001-11-30 Application filed by Applied Research Systems filed Critical Applied Research Systems

2003-10-07 Publication of SK8472003A3 publication Critical patent/SK8472003A3/sk

Links

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Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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SK847-2003A 2000-12-06 2001-11-30 Use of SARP-1 for the treatment and/or prevention of scleroderma SK8472003A3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP00126771		2000-12-06
EP01118888		2001-08-17
PCT/EP2001/013992 WO2002046225A2 (en)	2000-12-06	2001-11-30	Use of sarp-1 for the treatment and/or prevention of scleroderma

Publications (1)

Publication Number	Publication Date
SK8472003A3 true SK8472003A3 (en)	2003-10-07

Family

ID=26071647

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK847-2003A SK8472003A3 (en)	2000-12-06	2001-11-30	Use of SARP-1 for the treatment and/or prevention of scleroderma

Country Status (29)

Country	Link
US (2)	US7341995B2 (no)
EP (2)	EP1411970B1 (no)
JP (1)	JP2004525869A (no)
KR (1)	KR100804885B1 (no)
CN (1)	CN1323716C (no)
AT (1)	ATE359808T1 (no)
AU (2)	AU2002226366B2 (no)
BG (1)	BG107941A (no)
BR (1)	BR0115983A (no)
CA (1)	CA2428092A1 (no)
CY (1)	CY1107687T1 (no)
CZ (1)	CZ20031855A3 (no)
DE (1)	DE60128009T2 (no)
DK (1)	DK1411970T3 (no)
EA (1)	EA005973B1 (no)
EE (1)	EE200300213A (no)
ES (1)	ES2281463T3 (no)
HR (1)	HRP20030426A2 (no)
HU (1)	HUP0302738A3 (no)
IL (1)	IL156069A0 (no)
MX (1)	MXPA03005027A (no)
NO (1)	NO20032597D0 (no)
NZ (1)	NZ525774A (no)
PL (1)	PL365316A1 (no)
PT (1)	PT1411970E (no)
SK (1)	SK8472003A3 (no)
UA (1)	UA83790C2 (no)
WO (1)	WO2002046225A2 (no)
YU (1)	YU45103A (no)

Families Citing this family (11)

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Publication number	Priority date	Publication date	Assignee	Title
EP0954580B1 (en) *	1997-02-06	2003-12-17	Genetics Institute, LLC	Human sdf-5 protein and compositions
CN1658895A (zh) *	2002-04-10	2005-08-24	应用研究系统Ars股份公司	护骨素在治疗和／或预防纤维变性疾病中的应用
US7585840B2 (en)	2002-04-10	2009-09-08	Merck Serono S.A.	Use of osteoprotegerin for the treatment and/or prevention of fibrotic disease
US9046537B2 (en) *	2003-09-22	2015-06-02	Enzo Biochem, Inc.	Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain
SE0400489D0 (sv) *	2004-02-27	2004-02-27	Biovitrum Ab	Therapeutic proteins
PT3520815T (pt)	2005-02-08	2022-02-02	Genzyme Corp	Anticorpos contra tgfbeta
JP5025646B2 (ja) *	2005-11-08	2012-09-12	公益財団法人先端医療振興財団	虚血性心疾患の治療方法
CA2707735A1 (en) *	2007-12-13	2009-06-18	Gabriela Saborio	Sarp-1 fusion proteins and uses thereof
CA2829593A1 (en) *	2011-03-11	2012-09-20	Celgene Corporation	Use of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl)piperidine-2,6-dione in treatment of immune-related and inflammatory diseases
WO2022217037A1 (en)	2021-04-09	2022-10-13	Board Of Regents, The University Of Texas System	Compositions and methods for treatment of chronic lung diseases
CN117756910A (zh) *	2023-12-22	2024-03-26	首都医科大学附属北京口腔医院	Sfrp2功能多肽及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2855189A (en) *	1988-01-25	1989-07-27	Baker Cummins Dermatologicals, Inc.	Method of treating fibrotic disorders
US5266575A (en) *	1991-11-06	1993-11-30	Minnesota Mining And Manufacturing Company	2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines
US5747639A (en) *	1996-03-06	1998-05-05	Amgen Boulder Inc.	Use of hydrophobic interaction chromatography to purify polyethylene glycols
TW555765B (en) *	1996-07-09	2003-10-01	Amgen Inc	Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
PT932678E (pt) *	1996-09-24	2006-07-31	Tanox Inc	Familia de genes que codificam peptidos relacionados com apoptose, peptidos por eles codificados e metodos para sua utilizacao
US5858715A (en) *	1997-01-29	1999-01-12	Incyte Pharmaceuticals, Inc.	Human apoptosis-associated protein
EP0954580B1 (en) *	1997-02-06	2003-12-17	Genetics Institute, LLC	Human sdf-5 protein and compositions
ES2265693T3 (es) *	1998-10-16	2007-02-16	Biogen Idec Ma Inc.	Proteinas de fusion con interferon-beta y usos.

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Also Published As

Publication number	Publication date
KR100804885B1 (ko)	2008-02-20
UA83790C2 (ru)	2008-08-26
CZ20031855A3 (cs)	2003-09-17
US7655628B2 (en)	2010-02-02
DE60128009T2 (de)	2007-08-23
HUP0302738A2 (hu)	2003-11-28
CY1107687T1 (el)	2012-05-23
EE200300213A (et)	2003-08-15
US20080107627A1 (en)	2008-05-08
EA005973B1 (ru)	2005-08-25
DK1411970T3 (da)	2007-06-04
ES2281463T3 (es)	2007-10-01
PT1411970E (pt)	2007-05-31
IL156069A0 (en)	2003-12-23
US7341995B2 (en)	2008-03-11
EP1806144A2 (en)	2007-07-11
US20050113291A1 (en)	2005-05-26
WO2002046225A2 (en)	2002-06-13
NZ525774A (en)	2006-03-31
EP1411970B1 (en)	2007-04-18
NO20032597L (no)	2003-06-06
ATE359808T1 (de)	2007-05-15
EP1806144A3 (en)	2008-04-23
HK1068106A1 (zh)	2005-04-22
EP1411970A2 (en)	2004-04-28
BG107941A (bg)	2004-01-30
NO20032597D0 (no)	2003-06-06
HUP0302738A3 (en)	2010-01-28
BR0115983A (pt)	2003-12-30
AU2636602A (en)	2002-06-18
CN1323716C (zh)	2007-07-04
PL365316A1 (en)	2004-12-27
EA200300639A1 (ru)	2003-12-25
DE60128009D1 (de)	2007-05-31
CA2428092A1 (en)	2002-06-13
AU2002226366B2 (en)	2007-03-22
HRP20030426A2 (en)	2005-04-30
WO2002046225A3 (en)	2004-01-08
MXPA03005027A (es)	2003-09-05
KR20030076585A (ko)	2003-09-26
JP2004525869A (ja)	2004-08-26
CN1553806A (zh)	2004-12-08
YU45103A (sh)	2006-08-17

Publication	Publication Date	Title
US7655628B2 (en)	2010-02-02	Method for treating liver cirrhosis or interstitial pulmonary fibrosis
JP4430403B2 (ja)	2010-03-10	線維化疾患の治療および／または予防のためのオステオプロテゲリンの使用
US7655761B2 (en)	2010-02-02	IL-17-like cytokine binding compounds and antibodies
ZA200104415B (en)	2002-08-29	Interleukin-17 related mammalian cytokines. Polynucleotides encoding them. Uses.
AU2002226366A1 (en)	2002-08-22	Use of SARP-1 for the treatment and/or prevention of scleroderma
WO2002005833A1 (en)	2002-01-24	MANNAN-BINDING LECTIN (MBL) TREATMENT OF INFECTIONS IN INDIVIDUALS TREATED WITH TNF-αinhibitors
US7585840B2 (en)	2009-09-08	Use of osteoprotegerin for the treatment and/or prevention of fibrotic disease
ZA200303508B (en)	2004-08-10	Use of SARP-1 for the treatment and/or prevention of scleroderma.
US20070104723A1 (en)	2007-05-10	Treatment of fibrotic disease
IL165485A (en)	2012-02-29	Use of osteoprotegerin in the preparation of medicaments
HK1068106B (en)	2007-10-26	Use of sarp-1 for the treatment and/or prevention of scleroderma

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