SK7412002A3 - Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents - Google Patents

Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents Download PDF

Info

Publication number: SK7412002A3
Authority: SK; Slovakia
Prior art keywords: alkyl; alkoxy; amino; halogen; independently selected
Prior art date: 1999-12-03

Application number

SK741-2002A

Other languages

English (en)

Slovak (sk)

Inventor

Hengmiao Cheng

Jin Li

Kristin Marie Lundy

Martha Lou Minich

Subas Man Sakya

Chikara Uchida

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-03

Filing date

2000-11-24

Publication date

2003-08-05

2000-11-24 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2003-08-05 Publication of SK7412002A3 publication Critical patent/SK7412002A3/sk

Links

230000003110 anti-inflammatory effect Effects 0.000 title description 6
239000000730 antalgic agent Substances 0.000 title description 3
239000002260 anti-inflammatory agent Substances 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims abstract description 268
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 33
238000011282 treatment Methods 0.000 claims abstract description 30
241000124008 Mammalia Species 0.000 claims abstract description 20
208000035475 disorder Diseases 0.000 claims abstract description 14
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 8
-1 formamidyl Chemical group 0.000 claims description 416
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 313
229920006395 saturated elastomer Polymers 0.000 claims description 189
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 170
125000001424 substituent group Chemical group 0.000 claims description 159
125000000217 alkyl group Chemical group 0.000 claims description 133
229910052736 halogen Inorganic materials 0.000 claims description 125
229910052739 hydrogen Inorganic materials 0.000 claims description 125
150000002367 halogens Chemical class 0.000 claims description 118
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 113
239000001257 hydrogen Substances 0.000 claims description 111
125000003118 aryl group Chemical group 0.000 claims description 102
229910052757 nitrogen Inorganic materials 0.000 claims description 101
125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 97
125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 97
125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 93
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 93
125000003368 amide group Chemical group 0.000 claims description 84
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 81
125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims description 70
125000001960 7 membered carbocyclic group Chemical group 0.000 claims description 63
125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 54
238000006243 chemical reaction Methods 0.000 claims description 52
125000003282 alkyl amino group Chemical group 0.000 claims description 51
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125000003545 alkoxy group Chemical group 0.000 claims description 47
125000005100 aryl amino carbonyl group Chemical group 0.000 claims description 46
238000000034 method Methods 0.000 claims description 44
150000003839 salts Chemical class 0.000 claims description 44
125000004104 aryloxy group Chemical group 0.000 claims description 39
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125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 34
125000004457 alkyl amino carbonyl group Chemical group 0.000 claims description 33
125000000041 C6-C10 aryl group Chemical group 0.000 claims description 32
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239000008247 solid mixture Substances 0.000 description 1
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229940063683 taxotere Drugs 0.000 description 1
210000002435 tendon Anatomy 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
WHRNULOCNSKMGB-UHFFFAOYSA-N tetrahydrofuran thf Chemical compound C1CCOC1.C1CCOC1 WHRNULOCNSKMGB-UHFFFAOYSA-N 0.000 description 1
125000004192 tetrahydrofuran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
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CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
PHCBRBWANGJMHS-UHFFFAOYSA-J tetrasodium;disulfate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O PHCBRBWANGJMHS-UHFFFAOYSA-J 0.000 description 1
238000010257 thawing Methods 0.000 description 1
125000001113 thiadiazolyl group Chemical group 0.000 description 1
150000007970 thio esters Chemical class 0.000 description 1
MIQPIUSUKVNLNT-UHFFFAOYSA-N tolcapone Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC(O)=C(O)C([N+]([O-])=O)=C1 MIQPIUSUKVNLNT-UHFFFAOYSA-N 0.000 description 1
238000012546 transfer Methods 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
150000008648 triflates Chemical class 0.000 description 1
239000002447 tumor necrosis factor alpha converting enzyme inhibitor Substances 0.000 description 1
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229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 description 1
102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
210000003606 umbilical vein Anatomy 0.000 description 1
230000008347 uteroplacental blood flow Effects 0.000 description 1
210000001215 vagina Anatomy 0.000 description 1
229910052720 vanadium Inorganic materials 0.000 description 1
229960003048 vinblastine Drugs 0.000 description 1
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
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239000008215 water for injection Substances 0.000 description 1
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239000011995 wilkinson's catalyst Substances 0.000 description 1
239000008096 xylene Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
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UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1

Classifications

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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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SK741-2002A 1999-12-03 2000-11-24 Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents SK7412002A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US16870199P	1999-12-03	1999-12-03
PCT/IB2000/001748 WO2001040216A1 (en)	1999-12-03	2000-11-24	Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents

Publications (1)

Publication Number	Publication Date
SK7412002A3 true SK7412002A3 (en)	2003-08-05

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ID=22612589

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK741-2002A SK7412002A3 (en)	1999-12-03	2000-11-24	Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents

Country Status (34)

Country	Link
US (2)	US6531492B1 (es)
EP (1)	EP1233959B1 (es)
JP (1)	JP2003517475A (es)
KR (1)	KR20020058074A (es)
CN (1)	CN1423646A (es)
AP (1)	AP2002002532A0 (es)
AR (1)	AR026711A1 (es)
AT (1)	ATE291019T1 (es)
AU (1)	AU783359B2 (es)
BG (1)	BG106694A (es)
BR (1)	BR0016031A (es)
CA (1)	CA2392931A1 (es)
CO (1)	CO5261496A1 (es)
DE (1)	DE60018792T2 (es)
DZ (1)	DZ3246A1 (es)
EA (1)	EA200200520A1 (es)
ES (1)	ES2238324T3 (es)
GT (1)	GT200000204A (es)
HK (1)	HK1052701A1 (es)
HU (1)	HUP0300157A3 (es)
IL (1)	IL149581A0 (es)
IS (1)	IS6376A (es)
MA (1)	MA26848A1 (es)
MX (1)	MXPA02005539A (es)
NO (1)	NO20022624L (es)
OA (1)	OA12100A (es)
PA (1)	PA8508201A1 (es)
PE (1)	PE20010962A1 (es)
PL (1)	PL356669A1 (es)
SK (1)	SK7412002A3 (es)
TN (1)	TNSN00235A1 (es)
WO (1)	WO2001040216A1 (es)
YU (1)	YU35102A (es)
ZA (1)	ZA200204285B (es)

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ATE291019T1 (de) *	1999-12-03	2005-04-15	Pfizer Prod Inc	Heterocyclo-alkylsulfonylpyrazolderivate zur verwendung als anti-imflammatorische oder analgetische verbindungen
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GT200200183A (es)	2001-09-28	2003-05-23		Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol
YU67702A (sh) *	2001-09-28	2004-12-31	Pfizer Products Inc.	Postupak za dobijanje alkansulfonil piridina
US20050043409A1 (en) *	2001-10-25	2005-02-24	Chen Ying-Nan Pan	Combinations comprising a selective cyclooxygenase-2 inhibitor
WO2003037330A1 (en) *	2001-11-02	2003-05-08	Pfizer Products Inc.	Sulfonyl-and sulfonylheteroaryl-pyrazoles with a hydrazinyl or nitrogen oxide substituent at the 5-position for use as cyclooxygenase inhibitors
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EP1440062A1 (en)	2001-11-02	2004-07-28	Pfizer Products Inc.	An efficient synthesis of 5-heteroatom-containing-pyrazoles
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WO2003037351A1 (en) *	2001-11-02	2003-05-08	Pfizer Products Inc.	Heterocyclo-alkylsulfonyl pyrazoles and their use as cox-2 inhibitors
KR100686537B1 (ko) *	2001-12-28	2007-02-27	씨제이 주식회사	사이클로옥시게나제-2 의 저해제로서 선택성이 뛰어난디아릴 1,2,4-트리아졸 유도체
TW200403072A (en) *	2002-01-23	2004-03-01	Upjohn Co	Combination therapy for the treatment of bacterial infections
KR100470076B1 (ko) *	2002-11-27	2005-02-05	씨제이 주식회사	1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
US7247628B2 (en) *	2002-12-12	2007-07-24	Pfizer, Inc.	Cannabinoid receptor ligands and uses thereof
KR20050096956A (ko)	2003-02-07	2005-10-06	다이이찌 세이야꾸 가부시기가이샤	피라졸 유도체
RU2379292C2 (ru)	2003-04-18	2010-01-20	Мемори Фармасьютиклз Корпорейшн	Производные пиразола в качестве ингибиторов фосфодиэстеразы 4
US20050107350A1 (en) *	2003-08-22	2005-05-19	Pharmacia Corporation	Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith
JP2008516964A (ja) *	2004-10-15	2008-05-22	メモリーファーマシューティカルスコーポレーション	ホスホジエステラーゼ４阻害剤としてのピラゾール誘導体
CN109438365B (zh) *	2018-12-06	2022-04-05	华南师范大学	N-(3-((4-三氟甲基)-2-嘧啶基)氨基苯基)-2,6-二氟苯磺酰胺衍生物

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2000
- 2000-11-24 AT AT00974741T patent/ATE291019T1/de not_active IP Right Cessation
- 2000-11-24 CN CN00818329A patent/CN1423646A/zh active Pending
- 2000-11-24 HK HK03104988.3A patent/HK1052701A1/zh unknown
- 2000-11-24 BR BR0016031-8A patent/BR0016031A/pt not_active IP Right Cessation
- 2000-11-24 WO PCT/IB2000/001748 patent/WO2001040216A1/en not_active Ceased
- 2000-11-24 DE DE60018792T patent/DE60018792T2/de not_active Expired - Fee Related
- 2000-11-24 CA CA002392931A patent/CA2392931A1/en not_active Abandoned
- 2000-11-24 EP EP00974741A patent/EP1233959B1/en not_active Expired - Lifetime
- 2000-11-24 JP JP2001541900A patent/JP2003517475A/ja active Pending
- 2000-11-24 ES ES00974741T patent/ES2238324T3/es not_active Expired - Lifetime
- 2000-11-24 HU HU0300157A patent/HUP0300157A3/hu unknown
- 2000-11-24 KR KR1020027007082A patent/KR20020058074A/ko not_active Ceased
- 2000-11-24 DZ DZ003246A patent/DZ3246A1/fr active
- 2000-11-24 OA OA1200200159A patent/OA12100A/en unknown
- 2000-11-24 AU AU12953/01A patent/AU783359B2/en not_active Ceased
- 2000-11-24 EA EA200200520A patent/EA200200520A1/ru unknown
- 2000-11-24 PL PL00356669A patent/PL356669A1/xx not_active Application Discontinuation
- 2000-11-24 IL IL14958100A patent/IL149581A0/xx unknown
- 2000-11-24 SK SK741-2002A patent/SK7412002A3/sk unknown
- 2000-11-24 AP APAP/P/2002/002532A patent/AP2002002532A0/en unknown
- 2000-11-24 MX MXPA02005539A patent/MXPA02005539A/es unknown
- 2000-11-24 YU YU35102A patent/YU35102A/sh unknown
- 2000-11-28 US US09/724,446 patent/US6531492B1/en not_active Expired - Fee Related
- 2000-12-01 TN TNTNSN00235A patent/TNSN00235A1/fr unknown
- 2000-12-01 PE PE2000001289A patent/PE20010962A1/es not_active Application Discontinuation
- 2000-12-04 GT GT200000204A patent/GT200000204A/es unknown
- 2000-12-04 AR ARP000106402A patent/AR026711A1/es unknown
- 2000-12-04 CO CO00092095A patent/CO5261496A1/es not_active Application Discontinuation
- 2000-12-04 PA PA20008508201A patent/PA8508201A1/es unknown
2002
- 2002-05-10 IS IS6376A patent/IS6376A/is unknown
- 2002-05-13 BG BG106694A patent/BG106694A/xx unknown
- 2002-05-29 ZA ZA200204285A patent/ZA200204285B/en unknown
- 2002-05-31 MA MA26662A patent/MA26848A1/fr unknown
- 2002-06-03 NO NO20022624A patent/NO20022624L/no unknown
2003
- 2003-01-14 US US10/342,666 patent/US20030236258A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1233959A1 (en)	2002-08-28
AU1295301A (en)	2001-06-12
PL356669A1 (en)	2004-06-28
DZ3246A1 (fr)	2001-06-07
HK1052701A1 (zh)	2003-09-26
KR20020058074A (ko)	2002-07-12
AU783359B2 (en)	2005-10-20
HUP0300157A2 (hu)	2003-06-28
EA200200520A1 (ru)	2002-10-31
CA2392931A1 (en)	2001-06-07
CO5261496A1 (es)	2003-03-31
DE60018792T2 (de)	2006-01-26
TNSN00235A1 (fr)	2002-05-30
PA8508201A1 (es)	2005-08-04
AP2002002532A0 (en)	2002-06-30
BG106694A (en)	2003-03-31
PE20010962A1 (es)	2001-09-22
IL149581A0 (en)	2002-11-10
EP1233959B1 (en)	2005-03-16
AR026711A1 (es)	2003-02-26
NO20022624D0 (no)	2002-06-03
YU35102A (sh)	2005-03-15
DE60018792D1 (de)	2005-04-21
ATE291019T1 (de)	2005-04-15
HUP0300157A3 (en)	2006-01-30
US20030236258A1 (en)	2003-12-25
CN1423646A (zh)	2003-06-11
GT200000204A (es)	2002-05-28
WO2001040216A1 (en)	2001-06-07
IS6376A (is)	2002-05-10
US6531492B1 (en)	2003-03-11
MA26848A1 (fr)	2004-12-20
MXPA02005539A (es)	2002-09-02
NO20022624L (no)	2002-07-30
ZA200204285B (en)	2003-05-29
ES2238324T3 (es)	2005-09-01
OA12100A (en)	2006-05-04
JP2003517475A (ja)	2003-05-27
BR0016031A (pt)	2002-07-23

Publication	Publication Date	Title
SK7412002A3 (en)	2003-08-05	Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents
EP1104758B1 (en)	2003-07-23	Acetylene derivatives as anti-inflammatory/analgesic agents
AU2001232175B2 (en)	2005-07-07	Pyrazole ether derivatives as anti-inflammatory/analgesic agents
US6900230B2 (en)	2005-05-31	Heterocyclo-alkylsulfonyl pyrazoles as anti-inflammatory/analgesic agents
AU2001232175A1 (en)	2001-11-22	Pyrazole ether derivatives as anti-inflammatory/analgesic agents
JP2001316387A (ja)	2001-11-13	抗炎症または鎮痛薬としてのピラゾール誘導体
US6753332B2 (en)	2004-06-22	Sulfonyl heteroaryl triazoles as anti-inflammatory/analgesic agents
MXPA02006722A (es)	2003-01-23	Sulfonilaril triazoles como agentes antiinflamatorios / analgesicos.