SK7292002A3 - Pharmaceutical composition with controlled release for increasing the dose or system exposure of a medicament inhibiting pde4 - Google Patents
Pharmaceutical composition with controlled release for increasing the dose or system exposure of a medicament inhibiting pde4 Download PDFInfo
- Publication number
- SK7292002A3 SK7292002A3 SK729-2002A SK7292002A SK7292002A3 SK 7292002 A3 SK7292002 A3 SK 7292002A3 SK 7292002 A SK7292002 A SK 7292002A SK 7292002 A3 SK7292002 A3 SK 7292002A3
- Authority
- SK
- Slovakia
- Prior art keywords
- drug
- dose
- pharmaceutical composition
- controlled release
- pde4
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims description 94
- 238000013270 controlled release Methods 0.000 title claims description 47
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 23
- 230000002401 inhibitory effect Effects 0.000 title claims description 12
- 101100296719 Caenorhabditis elegans pde-4 gene Proteins 0.000 title 1
- 230000036470 plasma concentration Effects 0.000 claims abstract description 27
- 229940079593 drug Drugs 0.000 claims description 81
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- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- JVTIXNMXDLQEJE-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate 2-octanoyloxypropyl octanoate Chemical compound C(CCCCCCC)(=O)OCC(C)OC(CCCCCCC)=O.C(=O)(CCCCCCCCC)OCC(C)OC(=O)CCCCCCCCC JVTIXNMXDLQEJE-UHFFFAOYSA-N 0.000 claims description 3
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- 101100296720 Dictyostelium discoideum Pde4 gene Proteins 0.000 claims 1
- 101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 abstract description 22
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- 238000009472 formulation Methods 0.000 description 42
- CFBUZOUXXHZCFB-OYOVHJISSA-N chembl511115 Chemical compound COC1=CC=C([C@@]2(CC[C@H](CC2)C(O)=O)C#N)C=C1OC1CCCC1 CFBUZOUXXHZCFB-OYOVHJISSA-N 0.000 description 24
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 12
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
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- HJPRDDKCXVCFOH-UHFFFAOYSA-N 1,3-dibutyl-7-(2-oxopropyl)purine-2,6-dione Chemical compound O=C1N(CCCC)C(=O)N(CCCC)C2=C1N(CC(C)=O)C=N2 HJPRDDKCXVCFOH-UHFFFAOYSA-N 0.000 description 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 1
- MRHCSNNEUHXNIC-UHFFFAOYSA-N 9-benzylpurin-6-amine Chemical class C1=NC=2C(N)=NC=NC=2N1CC1=CC=CC=C1 MRHCSNNEUHXNIC-UHFFFAOYSA-N 0.000 description 1
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- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 1
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- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 description 1
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- 101000909851 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) cAMP/cGMP dual specificity phosphodiesterase Rv0805 Proteins 0.000 description 1
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical compound O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 description 1
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- DPHDSIQHVGSITN-UHFFFAOYSA-N n-(3,5-dichloropyridin-4-yl)-2-[1-[(4-fluorophenyl)methyl]-5-hydroxyindol-3-yl]-2-oxoacetamide Chemical compound C1=C(C(=O)C(=O)NC=2C(=CN=CC=2Cl)Cl)C2=CC(O)=CC=C2N1CC1=CC=C(F)C=C1 DPHDSIQHVGSITN-UHFFFAOYSA-N 0.000 description 1
- 239000012740 non-selective inhibitor Substances 0.000 description 1
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- 230000003204 osmotic effect Effects 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 229940023488 pill Drugs 0.000 description 1
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- 230000000506 psychotropic effect Effects 0.000 description 1
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- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- HJORMJIFDVBMOB-UHFFFAOYSA-N rolipram Chemical compound COC1=CC=C(C2CC(=O)NC2)C=C1OC1CCCC1 HJORMJIFDVBMOB-UHFFFAOYSA-N 0.000 description 1
- 229950005741 rolipram Drugs 0.000 description 1
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- 102000003390 tumor necrosis factor Human genes 0.000 description 1
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- 230000003442 weekly effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16247799P | 1999-10-29 | 1999-10-29 | |
| US16264199P | 1999-11-01 | 1999-11-01 | |
| US17981700P | 2000-02-02 | 2000-02-02 | |
| PCT/US2000/029453 WO2001032165A1 (fr) | 1999-10-29 | 2000-10-26 | Procede d'administration d'un inhibiteur phosphodiesterase 4 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK7292002A3 true SK7292002A3 (en) | 2002-12-03 |
Family
ID=27388757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK729-2002A SK7292002A3 (en) | 1999-10-29 | 2000-10-26 | Pharmaceutical composition with controlled release for increasing the dose or system exposure of a medicament inhibiting pde4 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US20030212112A1 (fr) |
| EP (1) | EP1225884A4 (fr) |
| JP (1) | JP2003513038A (fr) |
| KR (1) | KR20020050249A (fr) |
| CN (1) | CN1387433A (fr) |
| AP (1) | AP2002002446A0 (fr) |
| AR (1) | AR026254A1 (fr) |
| AU (1) | AU772909B2 (fr) |
| BG (1) | BG106623A (fr) |
| BR (1) | BR0015039A (fr) |
| CA (1) | CA2389293A1 (fr) |
| CO (1) | CO5271676A1 (fr) |
| CZ (1) | CZ20021443A3 (fr) |
| DZ (1) | DZ3249A1 (fr) |
| EA (1) | EA200200502A1 (fr) |
| HK (1) | HK1049105A1 (fr) |
| HU (1) | HUP0203682A3 (fr) |
| IL (1) | IL148813A0 (fr) |
| MA (1) | MA25562A1 (fr) |
| MX (1) | MXPA02004220A (fr) |
| NO (1) | NO20021937L (fr) |
| NZ (1) | NZ518002A (fr) |
| OA (1) | OA12078A (fr) |
| PE (1) | PE20011004A1 (fr) |
| PL (1) | PL355262A1 (fr) |
| SK (1) | SK7292002A3 (fr) |
| TR (1) | TR200201150T2 (fr) |
| UY (1) | UY26422A1 (fr) |
| WO (1) | WO2001032165A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR029984A1 (es) * | 2000-07-27 | 2003-07-23 | Smithkline Beecham Corp | Metodo para reducir las exacerbaciones asociadas copd ambito |
| DE10207160A1 (de) * | 2002-02-20 | 2003-12-18 | Altana Pharma Ag | Darreichungsform enthaltend PDE 4-Hemmer als Wirkstoff |
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| ATE485821T1 (de) * | 2002-05-28 | 2010-11-15 | Nycomed Gmbh | Ophthalmologische zubereitung enthaltend roflumilast in der behandlung von krankheiten der augen |
| US6822114B1 (en) | 2002-10-08 | 2004-11-23 | Albemarle Corporation | Process for production of fluoroalkoxy-substituted benzamides and their intermediates |
| PL1606261T3 (pl) | 2003-03-10 | 2010-04-30 | Astrazeneca Ab | Nowy sposób przygotowania roflumilastu |
| WO2004096274A1 (fr) * | 2003-03-31 | 2004-11-11 | Kyowa Hakko Kogyo Co., Ltd. | Medicament administre par voie orale |
| US20050026883A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
| WO2006097456A1 (fr) | 2005-03-16 | 2006-09-21 | Nycomed Gmbh | Forme posologique a gout masque |
| JP5860811B2 (ja) * | 2009-12-03 | 2016-02-16 | オプコ ヘルス インコーポレイテッド | 高硫酸化二糖製剤 |
| KR20210033073A (ko) * | 2011-12-27 | 2021-03-25 | 암젠 (유럽) 게엠베하 | (+)-2-[1-(3-에톡시-4-메톡시-페닐)-2-메탄술포닐-에틸]-4-아세틸아미노이소인돌린-1,3-디온의 제제 |
| CN103536582A (zh) * | 2013-10-12 | 2014-01-29 | 云南龙海天然植物药业有限公司 | 罗氟司特干粉吸入剂 |
| WO2019147824A1 (fr) | 2018-01-26 | 2019-08-01 | Progenity, Inc. | Traitement d'une maladie du tractus gastro-intestinal avec un inhibiteur de pde4 |
| AU2019383976B2 (en) | 2018-11-19 | 2025-07-03 | Bt Bidco, Inc. | Methods and devices for treating a disease with biotherapeutics |
| WO2021119482A1 (fr) | 2019-12-13 | 2021-06-17 | Progenity, Inc. | Dispositif ingérable pour administrer un agent thérapeutique dans le tractus gastro-intestinal |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4684516A (en) * | 1983-08-01 | 1987-08-04 | Alra Laboratories, Inc. | Sustained release tablets and method of making same |
| MY121142A (en) * | 1999-02-23 | 2005-12-30 | Smithkline Beecham Corp | Controlled release formulation for treating copd |
| AR035987A1 (es) * | 1999-03-01 | 2004-08-04 | Smithkline Beecham Corp | Uso de un compuesto inhibidor de la pde 4 para la manufactura de un medicamento y el medicamento para tratar asma inducida por ejercicio |
-
2000
- 2000-10-26 KR KR1020027005448A patent/KR20020050249A/ko not_active Withdrawn
- 2000-10-26 CO CO00081570A patent/CO5271676A1/es not_active Application Discontinuation
- 2000-10-26 DZ DZ003249A patent/DZ3249A1/fr active
- 2000-10-26 BR BR0015039-8A patent/BR0015039A/pt not_active IP Right Cessation
- 2000-10-26 WO PCT/US2000/029453 patent/WO2001032165A1/fr not_active Ceased
- 2000-10-26 HK HK02109231.8A patent/HK1049105A1/zh unknown
- 2000-10-26 IL IL14881300A patent/IL148813A0/xx unknown
- 2000-10-26 PL PL00355262A patent/PL355262A1/xx unknown
- 2000-10-26 CA CA002389293A patent/CA2389293A1/fr not_active Abandoned
- 2000-10-26 AP APAP/P/2002/002446A patent/AP2002002446A0/en unknown
- 2000-10-26 NZ NZ518002A patent/NZ518002A/en unknown
- 2000-10-26 EP EP00975385A patent/EP1225884A4/fr not_active Withdrawn
- 2000-10-26 AU AU13445/01A patent/AU772909B2/en not_active Ceased
- 2000-10-26 JP JP2001534370A patent/JP2003513038A/ja not_active Withdrawn
- 2000-10-26 AR ARP000105644A patent/AR026254A1/es not_active Application Discontinuation
- 2000-10-26 OA OA1200200126A patent/OA12078A/en unknown
- 2000-10-26 MX MXPA02004220A patent/MXPA02004220A/es unknown
- 2000-10-26 HU HU0203682A patent/HUP0203682A3/hu unknown
- 2000-10-26 CN CN00815150A patent/CN1387433A/zh active Pending
- 2000-10-26 TR TR2002/01150T patent/TR200201150T2/xx unknown
- 2000-10-26 SK SK729-2002A patent/SK7292002A3/sk unknown
- 2000-10-26 EA EA200200502A patent/EA200200502A1/ru unknown
- 2000-10-26 CZ CZ20021443A patent/CZ20021443A3/cs unknown
- 2000-10-27 PE PE2000001157A patent/PE20011004A1/es not_active Application Discontinuation
- 2000-10-30 UY UY26422A patent/UY26422A1/es not_active Application Discontinuation
-
2002
- 2002-04-17 BG BG106623A patent/BG106623A/bg unknown
- 2002-04-24 NO NO20021937A patent/NO20021937L/no not_active Application Discontinuation
- 2002-04-26 MA MA26618A patent/MA25562A1/fr unknown
-
2003
- 2003-05-02 US US10/429,666 patent/US20030212112A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20021443A3 (cs) | 2003-01-15 |
| PE20011004A1 (es) | 2001-09-28 |
| PL355262A1 (en) | 2004-04-05 |
| EP1225884A1 (fr) | 2002-07-31 |
| US20030212112A1 (en) | 2003-11-13 |
| OA12078A (en) | 2003-05-28 |
| JP2003513038A (ja) | 2003-04-08 |
| NO20021937L (no) | 2002-05-30 |
| UY26422A1 (es) | 2001-07-31 |
| AR026254A1 (es) | 2003-02-05 |
| BR0015039A (pt) | 2002-06-25 |
| NZ518002A (en) | 2004-01-30 |
| MA25562A1 (fr) | 2002-10-01 |
| MXPA02004220A (es) | 2002-10-17 |
| DZ3249A1 (fr) | 2001-05-10 |
| HK1049105A1 (zh) | 2003-05-02 |
| AU772909B2 (en) | 2004-05-13 |
| AP2002002446A0 (en) | 2002-03-31 |
| NO20021937D0 (no) | 2002-04-24 |
| CA2389293A1 (fr) | 2001-05-10 |
| CN1387433A (zh) | 2002-12-25 |
| WO2001032165A1 (fr) | 2001-05-10 |
| IL148813A0 (en) | 2002-09-12 |
| HUP0203682A2 (hu) | 2003-04-28 |
| TR200201150T2 (tr) | 2002-09-23 |
| CO5271676A1 (es) | 2003-04-30 |
| HUP0203682A3 (en) | 2003-10-28 |
| EP1225884A4 (fr) | 2005-06-15 |
| AU1344501A (en) | 2001-05-14 |
| BG106623A (bg) | 2003-02-28 |
| KR20020050249A (ko) | 2002-06-26 |
| EA200200502A1 (ru) | 2002-10-31 |
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