SK6962002A3 - A process for the coating of tablet cores and tablets obtained by this process - Google Patents

A process for the coating of tablet cores and tablets obtained by this process Download PDF

Info

Publication number: SK6962002A3
Authority: SK; Slovakia
Prior art keywords: starch; coating; tablet; sugar; tablets
Prior art date: 1999-11-23

Application number

SK696-2002A

Other languages

English (en)

Slovak (sk)

Inventor

Reinhard Entner

Herwig Jennewein

Original Assignee

Biochemie Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-23

Filing date

2000-11-21

Publication date

2002-10-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3525424&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK6962002(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-11-21 Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh

2002-10-08 Publication of SK6962002A3 publication Critical patent/SK6962002A3/sk

Links

238000000576 coating method Methods 0.000 title claims abstract description 51
239000011248 coating agent Substances 0.000 title claims abstract description 50
238000000034 method Methods 0.000 title claims abstract description 19
229920002472 Starch Polymers 0.000 claims abstract description 55
235000019698 starch Nutrition 0.000 claims abstract description 55
239000008107 starch Substances 0.000 claims abstract description 49
239000000203 mixture Substances 0.000 claims abstract description 39
150000001875 compounds Chemical class 0.000 claims abstract description 32
235000000346 sugar Nutrition 0.000 claims abstract description 32
239000000725 suspension Substances 0.000 claims abstract description 23
238000005507 spraying Methods 0.000 claims abstract description 16
239000003795 chemical substances by application Substances 0.000 claims abstract description 10
239000003826 tablet Substances 0.000 claims description 121
KEJCWVGMRLCZQQ-YJBYXUATSA-N Cefuroxime axetil Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(=O)OC(C)OC(C)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 KEJCWVGMRLCZQQ-YJBYXUATSA-N 0.000 claims description 28
229960002620 cefuroxime axetil Drugs 0.000 claims description 28
239000008199 coating composition Substances 0.000 claims description 24
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 21
229930195725 Mannitol Natural products 0.000 claims description 21
239000000594 mannitol Substances 0.000 claims description 21
235000010355 mannitol Nutrition 0.000 claims description 21
LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims description 20
KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 claims description 20
239000007919 dispersible tablet Substances 0.000 claims description 19
229960003022 amoxicillin Drugs 0.000 claims description 18
LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims description 18
229960003708 sumatriptan Drugs 0.000 claims description 17
KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 claims description 14
229960005017 olanzapine Drugs 0.000 claims description 14
239000000126 substance Substances 0.000 claims description 14
150000008163 sugars Chemical class 0.000 claims description 11
229950000033 proxetil Drugs 0.000 claims description 10
239000000796 flavoring agent Substances 0.000 claims description 9
235000013355 food flavoring agent Nutrition 0.000 claims description 9
239000003765 sweetening agent Substances 0.000 claims description 9
235000003599 food sweetener Nutrition 0.000 claims description 8
239000003906 humectant Substances 0.000 claims description 7
239000003755 preservative agent Substances 0.000 claims description 7
150000005846 sugar alcohols Chemical class 0.000 claims description 7
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 6
239000003086 colorant Substances 0.000 claims description 6
239000008101 lactose Substances 0.000 claims description 6
239000000049 pigment Substances 0.000 claims description 6
230000000181 anti-adherent effect Effects 0.000 claims description 5
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 4
229920000858 Cyclodextrin Polymers 0.000 claims description 3
229920001353 Dextrin Polymers 0.000 claims description 3
239000004375 Dextrin Substances 0.000 claims description 3
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
229930006000 Sucrose Natural products 0.000 claims description 3
239000000853 adhesive Substances 0.000 claims description 3
235000019425 dextrin Nutrition 0.000 claims description 3
229920001592 potato starch Polymers 0.000 claims description 3
239000005720 sucrose Substances 0.000 claims description 3
229920000881 Modified starch Polymers 0.000 claims description 2
235000019426 modified starch Nutrition 0.000 claims description 2
238000002360 preparation method Methods 0.000 claims description 2
239000013543 active substance Substances 0.000 claims 1
239000000975 dye Substances 0.000 claims 1
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 1
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 23
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 20
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 18
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 18
108010011485 Aspartame Proteins 0.000 description 16
239000000605 aspartame Substances 0.000 description 16
235000010357 aspartame Nutrition 0.000 description 16
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 16
229960003438 aspartame Drugs 0.000 description 16
239000000454 talc Substances 0.000 description 16
229910052623 talc Inorganic materials 0.000 description 16
229940033134 talc Drugs 0.000 description 16
239000000243 solution Substances 0.000 description 13
239000004408 titanium dioxide Substances 0.000 description 11
LTINZAODLRIQIX-ZFEISNGRSA-N 1-propan-2-yloxycarbonyloxyethyl (6r,7r)-7-[[(2e)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Chemical compound N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC)C(=O)OC(C)OC(=O)OC(C)C)C(=O)C(=N\OC)\C1=CSC(N)=N1 LTINZAODLRIQIX-ZFEISNGRSA-N 0.000 description 9
235000019359 magnesium stearate Nutrition 0.000 description 9
229960004797 cefpodoxime proxetil Drugs 0.000 description 8
239000000463 material Substances 0.000 description 8
239000010408 film Substances 0.000 description 7
229910002016 Aerosil® 200 Inorganic materials 0.000 description 6
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 6
239000007941 film coated tablet Substances 0.000 description 6
239000007788 liquid Substances 0.000 description 6
229920000642 polymer Polymers 0.000 description 6
235000019333 sodium laurylsulphate Nutrition 0.000 description 6
239000002904 solvent Substances 0.000 description 6
235000019640 taste Nutrition 0.000 description 6
229920000168 Microcrystalline cellulose Polymers 0.000 description 5
229960001375 lactose Drugs 0.000 description 5
229940016286 microcrystalline cellulose Drugs 0.000 description 5
235000019813 microcrystalline cellulose Nutrition 0.000 description 5
239000008108 microcrystalline cellulose Substances 0.000 description 5
150000003839 salts Chemical class 0.000 description 5
229920002261 Corn starch Polymers 0.000 description 4
239000005913 Maltodextrin Substances 0.000 description 4
229920002774 Maltodextrin Polymers 0.000 description 4
108010009736 Protein Hydrolysates Proteins 0.000 description 4
229940035034 maltodextrin Drugs 0.000 description 4
229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
239000001267 polyvinylpyrrolidone Substances 0.000 description 4
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
239000000377 silicon dioxide Substances 0.000 description 4
239000012453 solvate Substances 0.000 description 4
HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 description 3
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
239000001768 carboxy methyl cellulose Substances 0.000 description 3
229960003324 clavulanic acid Drugs 0.000 description 3
HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 description 3
239000008119 colloidal silica Substances 0.000 description 3
239000008120 corn starch Substances 0.000 description 3
AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 description 3
239000000428 dust Substances 0.000 description 3
-1 fatty acid esters Chemical class 0.000 description 3
230000035515 penetration Effects 0.000 description 3
239000000546 pharmaceutical excipient Substances 0.000 description 3
229940083037 simethicone Drugs 0.000 description 3
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 3
238000010561 standard procedure Methods 0.000 description 3
238000012360 testing method Methods 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 2
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
238000005299 abrasion Methods 0.000 description 2
239000003463 adsorbent Substances 0.000 description 2
229960004920 amoxicillin trihydrate Drugs 0.000 description 2
238000007906 compression Methods 0.000 description 2
230000006835 compression Effects 0.000 description 2
229960000913 crospovidone Drugs 0.000 description 2
229940097362 cyclodextrins Drugs 0.000 description 2
235000014113 dietary fatty acids Nutrition 0.000 description 2
239000000194 fatty acid Substances 0.000 description 2
229930195729 fatty acid Natural products 0.000 description 2
239000007888 film coating Substances 0.000 description 2
238000009501 film coating Methods 0.000 description 2
239000008187 granular material Substances 0.000 description 2
238000005469 granulation Methods 0.000 description 2
230000003179 granulation Effects 0.000 description 2
229960001021 lactose monohydrate Drugs 0.000 description 2
239000010410 layer Substances 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
238000002156 mixing Methods 0.000 description 2
238000012986 modification Methods 0.000 description 2
230000004048 modification Effects 0.000 description 2
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
229940068968 polysorbate 80 Drugs 0.000 description 2
229920000053 polysorbate 80 Polymers 0.000 description 2
235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 2
229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 2
239000007921 spray Substances 0.000 description 2
229960000658 sumatriptan succinate Drugs 0.000 description 2
229960005196 titanium dioxide Drugs 0.000 description 2
229910002012 Aerosil® Inorganic materials 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
235000019759 Maize starch Nutrition 0.000 description 1
239000004594 Masterbatch (MB) Substances 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
229920001214 Polysorbate 60 Polymers 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
230000002411 adverse Effects 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000002460 anti-migrenic effect Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
230000004888 barrier function Effects 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
235000019658 bitter taste Nutrition 0.000 description 1
229960001668 cefuroxime Drugs 0.000 description 1
JFPVXVDWJQMJEE-IZRZKJBUSA-N cefuroxime Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 JFPVXVDWJQMJEE-IZRZKJBUSA-N 0.000 description 1
229940075614 colloidal silicon dioxide Drugs 0.000 description 1
238000004040 coloring Methods 0.000 description 1
230000003750 conditioning effect Effects 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
239000007884 disintegrant Substances 0.000 description 1
239000004815 dispersion polymer Substances 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
230000035622 drinking Effects 0.000 description 1
238000007908 dry granulation Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
239000000945 filler Substances 0.000 description 1
210000004051 gastric juice Anatomy 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
229960001855 mannitol Drugs 0.000 description 1
239000003607 modifier Substances 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
238000003825 pressing Methods 0.000 description 1
210000003296 saliva Anatomy 0.000 description 1
238000007873 sieving Methods 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000007962 solid dispersion Substances 0.000 description 1
239000006104 solid solution Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
235000021092 sugar substitutes Nutrition 0.000 description 1
238000010998 test method Methods 0.000 description 1
239000010409 thin film Substances 0.000 description 1
OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
238000005550 wet granulation Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
- A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2813—Inorganic compounds

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Oncology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)
Glanulating (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

SK696-2002A 1999-11-23 2000-11-21 A process for the coating of tablet cores and tablets obtained by this process SK6962002A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AT0198899A AT500063A1 (de)	1999-11-23	1999-11-23	Beschichtete tablettenkerne
PCT/EP2000/011590 WO2001037816A2 (en)	1999-11-23	2000-11-21	Coating of tablet cores

Publications (1)

Publication Number	Publication Date
SK6962002A3 true SK6962002A3 (en)	2002-10-08

Family

ID=3525424

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK696-2002A SK6962002A3 (en)	1999-11-23	2000-11-21	A process for the coating of tablet cores and tablets obtained by this process

Country Status (29)

Country	Link
US (1)	US8652517B2 (es)
EP (1)	EP1231903B1 (es)
JP (1)	JP2003514848A (es)
KR (1)	KR20020059771A (es)
CN (1)	CN1391465A (es)
AR (1)	AR026560A1 (es)
AT (2)	AT500063A1 (es)
AU (1)	AU776662B2 (es)
BR (1)	BR0015449A (es)
CA (1)	CA2387575A1 (es)
CO (1)	CO5261638A1 (es)
CZ (1)	CZ20021765A3 (es)
DE (1)	DE60025536T2 (es)
EC (1)	ECSP003781A (es)
ES (1)	ES2255521T3 (es)
HK (1)	HK1049786A1 (es)
HU (1)	HUP0204072A3 (es)
IL (1)	IL149189A0 (es)
MX (1)	MXPA02005195A (es)
NO (1)	NO20022362L (es)
NZ (1)	NZ518524A (es)
PE (1)	PE20011009A1 (es)
PL (1)	PL354456A1 (es)
RU (1)	RU2002116225A (es)
SK (1)	SK6962002A3 (es)
TR (1)	TR200201028T2 (es)
TW (1)	TW579298B (es)
WO (1)	WO2001037816A2 (es)
ZA (1)	ZA200203654B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20030087009A (ko) *	2001-02-27	2003-11-12	랜박시 래보러터리스 리미티드	세프포독심 프록세틸의 경구용 약학 조성물
US20030072729A1 (en) *	2001-05-15	2003-04-17	Christopher Szymczak	Simethicone as weight gain enhancer
GB2380936B (en) *	2001-10-18	2003-07-09	Reckitt Benckiser Healthcare	Improvements in or relating to compositions
TW200404550A (en) *	2002-07-08	2004-04-01	Sankyo Co	Cepharospolin formulation for oral use
JP4526247B2 (ja) *	2002-07-08	2010-08-18	第一三共株式会社	経口用セファロスポリン製剤
EP1524978A2 (en) *	2002-07-19	2005-04-27	Ranbaxy Laboratories, Ltd.	Taste masked sumatriptan tablets and processes for their preparation
KR20040011087A (ko) *	2002-07-27	2004-02-05	주식회사 씨티씨바이오	불쾌한 맛과 향을 차폐할 수 있는 록시스로마이신 과립의제조방법
KR100523082B1 (ko) *	2002-09-11	2005-10-20	(주)다산메디켐	쓴 맛이 은폐된 세푸록심악세틸 제제의 제약조성물 및 그의 제조방법
DE10249552A1 (de)	2002-10-23	2004-05-13	Vifor (International) Ag	Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel
GB2407498B (en) *	2003-10-30	2008-06-11	Cipla Ltd	Oral formulations for 5-HT receptor agonists with reduced degradation of active ingredient
GB0403628D0 (en) *	2004-02-18	2004-03-24	Arrow Group Ltd	Compression-coated tablets and the manufacture thereof
PE20070077A1 (es) *	2005-06-10	2007-02-07	Takeda Pharmaceutical	Comprimido con recubierta con azucar
WO2007049304A2 (en) *	2005-10-27	2007-05-03	Jubilant Organosys Limited	Stable coated pharmaceutical formulation of olanzapine and process for preparing the same
CA2953964A1 (en)	2006-01-06	2007-07-19	Luitpold Pharmaceuticals, Inc.	Methods and compositions for administration of iron
WO2007148772A1 (ja) *	2006-06-23	2007-12-27	Shionogi & Co., Ltd.	マクロライド系抗生物質の糖類被覆製剤
EP2042164A4 (en) *	2006-06-23	2010-10-13	Takeda Pharmaceutical	STABILIZED SOLID PREPARATION
WO2008057058A1 (en) *	2006-11-10	2008-05-15	Nobel Ilac Sanayii Ve Ticaret As	Oral pharmaceutical compositions
JP5248060B2 (ja) *	2007-08-17	2013-07-31	興和株式会社	シリコーンを配合した糖衣製剤およびその製造方法
DE202009007393U1 (de)	2009-02-25	2010-07-22	Sensient Food Colors Germany Gmbh	Dragiermittel zum Dragieren von Arzneimitteln und Lebensmitteln
CN102266304B (zh) *	2010-06-04	2012-12-26	瑞阳制药有限公司	苯唑西林薄膜衣片的制备方法
JP5806490B2 (ja) *	2011-03-31	2015-11-10	エスエス製薬株式会社	フィルムコーティング用組成物
EP2833873A1 (en) *	2012-04-04	2015-02-11	Mahmut Bilgic	Film tablet formulations comprising cefuroxime axetil and clavulanic acid
EP2882423A1 (en)	2012-08-07	2015-06-17	Sandoz AG	Uncoated tablet comprising granules including a -lactam antibiotic and highly dispersed silicone dioxide
JP2014227406A (ja) *	2013-05-27	2014-12-08	株式会社ウメケン	苦味生薬含有粒状物
JP6031730B2 (ja) *	2014-12-19	2016-11-24	株式会社東洋新薬	経口剤、経口剤の製造方法、経口固形剤のコーティング用組成物
CN108815130A (zh) *	2018-08-27	2018-11-16	邓倩	一种头孢泊肟酯药片及其生产工艺
FR3089756B1 (fr) *	2018-12-17	2021-02-19	Roquette Freres	Formes solides dragéifiées présentant une stabilité améliorée
EP3766483A1 (en)	2019-07-19	2021-01-20	BioPharma Synergies, S. L.	Orodispersible powder composition comprising a triptan
JP7698962B2 (ja) *	2021-03-19	2025-06-26	三栄源エフ・エフ・アイ株式会社	不快風味のマスキング方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB407919A (en) *	1932-06-24	1934-03-29	Ig Farbenindustrie Ag	Improvements in or relating to the manufacture of shaped medicinal preparations
US3185628A (en) *	1960-03-18	1965-05-25	Nopco Chem Co	Sunscreening dihydroxy-diphenylsulfone derivatives
US3185626A (en) *	1963-03-06	1965-05-25	Sterling Drug Inc	Tablet coating method
US3361631A (en)	1963-09-30	1968-01-02	Sandoz Ag	Method of sugar coating pharmaceutical tablets
JPS4837815B1 (es) *	1970-09-25	1973-11-14	Yamanouchi Pharma Co Ltd
GB1318757A (en)	1970-11-16	1973-05-31	Yamanouchi Pharma Co Ltd	Method of sugar coating tablets
US3751277A (en) *	1971-03-24	1973-08-07	Dow Chemical Co	Tablet coating process and composition
US3753767A (en) *	1971-08-02	1973-08-21	Colgate Palmolive Co	Method of sugar-coating tablets
US4238510A (en) *	1979-02-21	1980-12-09	Life Savers, Inc.	Sugarless coating for chewing gum and confections and method
JPS5850968B2 (ja) *	1979-04-12	1983-11-14	フロイント産業株式会社	糖衣の製法
DE2936040C2 (de) *	1979-09-06	1982-05-19	Meggle Milchindustrie Gmbh & Co Kg, 8094 Reitmehring	Dragierverfahren und Mittel zur Durchführung des Verfahrens, bestehend im wesentlichen aus Saccharose, wenigstens einem weiteren Zucker und Wasser
DE3066710D1 (en) *	1979-10-17	1984-03-29	Roquette Freres	Process for hard coating with sorbitol
JPS57134414A (en) *	1981-02-13	1982-08-19	Nikken Kagaku Kk	Preparation of sugar-coated tablet
IT1214875B (it) *	1984-06-21	1990-01-18	Ferrero Spa	Prodotto confettato e procedimento per la sua fabbricazione
US4643894A (en)	1984-07-24	1987-02-17	Colorcon, Inc.	Maltodextrin coating
GB8419575D0 (en)	1984-08-01	1984-09-05	Glaxo Group Ltd	Chemical compounds
FR2580904B1 (fr) *	1985-04-30	1990-08-10	Roquette Freres	Produit de confiserie ou pharmaceutique a revetement sans sucre obtenu par drageification dure et son procede de preparation.
JPS625910A (ja) *	1985-07-02	1987-01-12	Shin Etsu Chem Co Ltd	薄層糖衣錠の製造方法
GB8524001D0 (en) *	1985-09-30	1985-11-06	Glaxo Group Ltd	Pharmaceutical composition
ZA881301B (en) *	1987-02-27	1989-10-25	Lilly Co Eli	Sustained release matrix formulations
NL193682C (nl) *	1987-05-14	2000-07-04	Glaxo Group Ltd	Beklede cefuroximaxetilsamenstelling.
DD273000A1 (de) *	1988-06-20	1989-11-01	Univ Halle Wittenberg	Verfahren zur herstellung von ueberzuegen auf arzneiformen
GB9104890D0 (en)	1991-03-08	1991-04-24	Glaxo Group Ltd	Compositions
US5224989A (en) *	1991-11-18	1993-07-06	Eva Likarova	Film-forming dispersion for a protective coating of drug and food containing articles and objects
DE4236025A1 (de)	1992-10-24	1994-04-28	Merck Patent Gmbh	Orale Arzneiformen
US5759577A (en)	1995-01-17	1998-06-02	American Home Products Corporation	Controlled release of steroids from sugar coatings
US5547948A (en)	1995-01-17	1996-08-20	American Home Products Corporation	Controlled release of steroids from sugar coatings
DE19503670C2 (de) *	1995-01-25	1997-07-31	Lichtwer Pharma Gmbh	Dragiersuspension und Verfahren zur Herstellung der Dragees
US5882707A (en) *	1996-01-05	1999-03-16	Bpsi Holdings, Inc.	Method of coating an edible substrate with sugar/syrup or sugarless solutions containing dry color concentrate
WO1998030341A1 (en) *	1997-01-06	1998-07-16	Berwind Pharmaceutical Services, Inc.	Film coatings and film coating compositions based on dextrin
US6221402B1 (en) *	1997-11-20	2001-04-24	Pfizer Inc.	Rapidly releasing and taste-masking pharmaceutical dosage form
KR20010042347A (ko) *	1998-04-02	2001-05-25	마가렛 에이.혼	개질된 전분 피복물
DE19826517B4 (de)	1998-06-15	2006-03-23	Baxter Healthcare S.A.	Verfahren zur Herstellung von Filmtabletten mit Cyclophosphamid als Wirkstoff und daraus hergestellte Cyclophosphamid-Filmtablette

1999
- 1999-11-23 AT AT0198899A patent/AT500063A1/de not_active Application Discontinuation
2000
- 2000-11-17 TW TW089124406A patent/TW579298B/zh not_active IP Right Cessation
- 2000-11-21 CZ CZ20021765A patent/CZ20021765A3/cs unknown
- 2000-11-21 WO PCT/EP2000/011590 patent/WO2001037816A2/en not_active Ceased
- 2000-11-21 HK HK03100426.1A patent/HK1049786A1/zh unknown
- 2000-11-21 PL PL00354456A patent/PL354456A1/xx not_active Application Discontinuation
- 2000-11-21 CA CA002387575A patent/CA2387575A1/en not_active Abandoned
- 2000-11-21 AU AU23585/01A patent/AU776662B2/en not_active Ceased
- 2000-11-21 CN CN00816065A patent/CN1391465A/zh active Pending
- 2000-11-21 AT AT00987277T patent/ATE315383T1/de not_active IP Right Cessation
- 2000-11-21 JP JP2001539431A patent/JP2003514848A/ja not_active Withdrawn
- 2000-11-21 RU RU2002116225/15A patent/RU2002116225A/ru not_active Application Discontinuation
- 2000-11-21 AR ARP000106139A patent/AR026560A1/es not_active Application Discontinuation
- 2000-11-21 KR KR1020027006544A patent/KR20020059771A/ko not_active Withdrawn
- 2000-11-21 BR BR0015449-0A patent/BR0015449A/pt not_active IP Right Cessation
- 2000-11-21 MX MXPA02005195A patent/MXPA02005195A/es unknown
- 2000-11-21 EP EP00987277A patent/EP1231903B1/en not_active Revoked
- 2000-11-21 HU HU0204072A patent/HUP0204072A3/hu unknown
- 2000-11-21 DE DE60025536T patent/DE60025536T2/de not_active Expired - Lifetime
- 2000-11-21 ES ES00987277T patent/ES2255521T3/es not_active Expired - Lifetime
- 2000-11-21 NZ NZ518524A patent/NZ518524A/en unknown
- 2000-11-21 IL IL14918900A patent/IL149189A0/xx unknown
- 2000-11-21 TR TR2002/01028T patent/TR200201028T2/xx unknown
- 2000-11-21 SK SK696-2002A patent/SK6962002A3/sk unknown
- 2000-11-22 PE PE2000001245A patent/PE20011009A1/es not_active Application Discontinuation
- 2000-11-22 CO CO00088901A patent/CO5261638A1/es not_active Application Discontinuation
- 2000-11-23 EC EC2000003781A patent/ECSP003781A/es unknown
2002
- 2002-05-08 ZA ZA200203654A patent/ZA200203654B/en unknown
- 2002-05-16 NO NO20022362A patent/NO20022362L/no not_active Application Discontinuation
2005
- 2005-09-22 US US11/233,121 patent/US8652517B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU2358501A (en)	2001-06-04
KR20020059771A (ko)	2002-07-13
CZ20021765A3 (cs)	2002-08-14
TW579298B (en)	2004-03-11
ATE315383T1 (de)	2006-02-15
AU776662B2 (en)	2004-09-16
JP2003514848A (ja)	2003-04-22
PE20011009A1 (es)	2001-10-18
NZ518524A (en)	2004-04-30
BR0015449A (pt)	2002-07-09
HK1049786A1 (zh)	2003-05-30
TR200201028T2 (tr)	2002-10-21
HUP0204072A3 (en)	2004-06-28
NO20022362L (no)	2002-07-11
ZA200203654B (en)	2003-06-05
AT500063A1 (de)	2005-10-15
HUP0204072A2 (en)	2003-05-28
CA2387575A1 (en)	2001-05-31
CO5261638A1 (es)	2003-03-31
ES2255521T3 (es)	2006-07-01
MXPA02005195A (es)	2003-01-28
DE60025536D1 (de)	2006-04-06
DE60025536T2 (de)	2006-08-10
EP1231903B1 (en)	2006-01-11
EP1231903A2 (en)	2002-08-21
CN1391465A (zh)	2003-01-15
WO2001037816A3 (en)	2001-11-29
ECSP003781A (es)	2002-04-23
US20060034917A1 (en)	2006-02-16
RU2002116225A (ru)	2004-01-20
AR026560A1 (es)	2003-02-19
US8652517B2 (en)	2014-02-18
NO20022362D0 (no)	2002-05-16
IL149189A0 (en)	2002-11-10
WO2001037816A2 (en)	2001-05-31
PL354456A1 (en)	2004-01-12

Publication	Publication Date	Title
SK6962002A3 (en)	2002-10-08	A process for the coating of tablet cores and tablets obtained by this process
KR100767928B1 (ko)	2007-10-17	활성 성분의 맛이 차폐되고 활성 성분이 즉시 방출되는 코팅된 과립의 제조 방법
JP4743321B2 (ja)	2011-08-10	フェソテロジンを含む安定した医薬組成物
AU731276B2 (en)	2001-03-29	Granulate for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug
HU196304B (en)	1988-11-28	Process for production of granulates of medical active substances with delaying effect
KR100421347B1 (ko)	2004-03-06	약학 혼합 제제
JP2003531099A (ja)	2003-10-21	改良された水溶解度をもつ医薬製剤
HU203200B (en)	1991-06-28	Process for producing oral pharmaceutical compositions comprising acid-sensitive benzimidazole derivatives
AU759517B2 (en)	2003-04-17	Compositions comprising cefuroxime axetil
HUP0104394A2 (hu)	2002-03-28	Granulált kristályos ibuprofént tartalmazó, bevont szemcsék
PL186386B1 (pl)	2004-01-30	Sposób wytwarzania granulatu zawierającego aktywny przy podawaniu drogą doustną antybiotyk beta-laktamowy oraz sposób wytwarzania szybko rozpadającejsię postaci dawkowania zawierającej aktywny przy podawaniu drogą doustną antybiotyk beta-laktamowy
PL188839B1 (pl)	2005-05-31	Powlekana tabletka maleinianu trymebutyny oraz sposób jej wytwarzania
JPH10504295A (ja)	1998-04-28	医薬処方
JP2000516601A (ja)	2000-12-12	水溶性化合物及びセルロースを含有する粒状物
GB2155330A (en)	1985-09-25	Solvent granulation technique for forming solid formulation of nystatin
HUT67577A (en)	1995-04-28	Process for production of adsorbate comprising adjuvant-mixture and non-solid active agent using production of preparations
MXPA01005274A (es)	2002-03-26	Composiciones que comprenden cefuroxima-axetil