SK552004A3 - Novel 2H-pyridazine-3-one derivatives, pharmaceutical compositions containing same and a process for the preparation of the active ingredient - Google Patents
Novel 2H-pyridazine-3-one derivatives, pharmaceutical compositions containing same and a process for the preparation of the active ingredient Download PDFInfo
- Publication number
- SK552004A3 SK552004A3 SK55-2004A SK552004A SK552004A3 SK 552004 A3 SK552004 A3 SK 552004A3 SK 552004 A SK552004 A SK 552004A SK 552004 A3 SK552004 A3 SK 552004A3
- Authority
- SK
- Slovakia
- Prior art keywords
- formula
- pyridazin
- pharmaceutically acceptable
- derivative
- group
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000004480 active ingredient Substances 0.000 title claims abstract description 18
- 238000000034 method Methods 0.000 title claims abstract description 17
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- 239000001257 hydrogen Substances 0.000 claims description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
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- BQNLTXZVZWVEDX-UHFFFAOYSA-N 4-chloro-5-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethylamino]-2-methylpyridazin-3-one Chemical compound O=C1N(C)N=CC(NCCN2CCC(CC2)C=2C3=CC=C(F)C=C3ON=2)=C1Cl BQNLTXZVZWVEDX-UHFFFAOYSA-N 0.000 claims description 3
- MBNMBSVGELQSPL-UHFFFAOYSA-N 4-chloro-5-[3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propylamino]-2-methylpyridazin-3-one Chemical compound O=C1N(C)N=CC(NCCCN2CCC(CC2)C=2C3=CC=C(F)C=C3ON=2)=C1Cl MBNMBSVGELQSPL-UHFFFAOYSA-N 0.000 claims description 3
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- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
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- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 238000007281 aminoalkylation reaction Methods 0.000 description 1
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- 229960003990 apomorphine hydrochloride Drugs 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 238000009246 art therapy Methods 0.000 description 1
- 239000003693 atypical antipsychotic agent Substances 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
- 229940092714 benzenesulfonic acid Drugs 0.000 description 1
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- 239000011230 binding agent Substances 0.000 description 1
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- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
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- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
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- 230000008034 disappearance Effects 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
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- 239000000839 emulsion Substances 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
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- 229910052731 fluorine Inorganic materials 0.000 description 1
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- 235000019253 formic acid Nutrition 0.000 description 1
- 238000001640 fractional crystallisation Methods 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
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- 230000004886 head movement Effects 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000003137 locomotive effect Effects 0.000 description 1
- 230000006742 locomotor activity Effects 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
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- 230000037023 motor activity Effects 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 210000001009 nucleus accumben Anatomy 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229960005017 olanzapine Drugs 0.000 description 1
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- TVPRCLHSULCNLV-UHFFFAOYSA-N pyridazin-3-one Chemical compound O=C1C=CC=N[N]1 TVPRCLHSULCNLV-UHFFFAOYSA-N 0.000 description 1
- ZTHJULTYCAQOIJ-WXXKFALUSA-N quetiapine fumarate Chemical compound [H+].[H+].[O-]C(=O)\C=C\C([O-])=O.C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12.C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 ZTHJULTYCAQOIJ-WXXKFALUSA-N 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 229940035004 seroquel Drugs 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0103063A HU225955B1 (en) | 2001-07-26 | 2001-07-26 | Novel 2h-pyridazin-3-one derivatives, process for their preparation, their use and pharmaceutical compositions containing them |
| PCT/HU2002/000072 WO2003010166A1 (fr) | 2001-07-26 | 2002-07-24 | Nouveaux derives de 2h-pyridazine-3-one, compositions pharmaceutiques contenant ces derives et procede de preparation de l'ingredient actif |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK552004A3 true SK552004A3 (en) | 2004-08-03 |
Family
ID=89979562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK55-2004A SK552004A3 (en) | 2001-07-26 | 2002-07-24 | Novel 2H-pyridazine-3-one derivatives, pharmaceutical compositions containing same and a process for the preparation of the active ingredient |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7098210B2 (fr) |
| EP (1) | EP1417206B1 (fr) |
| JP (1) | JP4249012B2 (fr) |
| KR (1) | KR100909514B1 (fr) |
| CN (1) | CN1247571C (fr) |
| AR (2) | AR036248A1 (fr) |
| AT (1) | ATE466859T1 (fr) |
| AU (1) | AU2002321669B8 (fr) |
| BR (1) | BR0211440A (fr) |
| CA (1) | CA2453917C (fr) |
| CY (1) | CY1110240T1 (fr) |
| CZ (1) | CZ2004123A3 (fr) |
| DE (1) | DE60236294D1 (fr) |
| DK (1) | DK1417206T3 (fr) |
| EA (1) | EA006246B1 (fr) |
| ES (1) | ES2345541T3 (fr) |
| HU (1) | HU225955B1 (fr) |
| MA (1) | MA27867A1 (fr) |
| MX (1) | MXPA04000814A (fr) |
| NO (1) | NO326155B1 (fr) |
| NZ (1) | NZ531154A (fr) |
| PL (1) | PL206824B1 (fr) |
| PT (1) | PT1417206E (fr) |
| SI (1) | SI1417206T1 (fr) |
| SK (1) | SK552004A3 (fr) |
| WO (1) | WO2003010166A1 (fr) |
| ZA (1) | ZA200400482B (fr) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU227255B1 (en) | 2002-04-26 | 2010-12-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Novel piperidine-alkyl-amino-pyridazine derivatives, pharmaceutical compositions containing the same and process for the preparation of the active ingredient |
| JP5355080B2 (ja) | 2005-06-08 | 2013-11-27 | イグニス・イノベイション・インコーポレーテッド | 発光デバイス・ディスプレイを駆動するための方法およびシステム |
| US9269322B2 (en) | 2006-01-09 | 2016-02-23 | Ignis Innovation Inc. | Method and system for driving an active matrix display circuit |
| US9489891B2 (en) | 2006-01-09 | 2016-11-08 | Ignis Innovation Inc. | Method and system for driving an active matrix display circuit |
| JP5164857B2 (ja) | 2006-01-09 | 2013-03-21 | イグニス・イノベイション・インコーポレーテッド | アクティブマトリクスディスプレイ回路の駆動方法および表示システム |
| HUP0600555A3 (en) * | 2006-07-03 | 2008-10-28 | Egis Gyogyszergyar Nyrt | Use of 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]izoxazol-3-yl)piperidin-1-yl]ethylamino}2-methyl-3(2h)-piridazinon for the production of pharmaceutical compositions for influencing cognitive functions and causing neuroprotective effect |
| US8614652B2 (en) | 2008-04-18 | 2013-12-24 | Ignis Innovation Inc. | System and driving method for light emitting device display |
| CA2637343A1 (fr) | 2008-07-29 | 2010-01-29 | Ignis Innovation Inc. | Amelioration de pilote de source d'affichage |
| US9370075B2 (en) | 2008-12-09 | 2016-06-14 | Ignis Innovation Inc. | System and method for fast compensation programming of pixels in a display |
| US8283967B2 (en) | 2009-11-12 | 2012-10-09 | Ignis Innovation Inc. | Stable current source for system integration to display substrate |
| CA2687631A1 (fr) | 2009-12-06 | 2011-06-06 | Ignis Innovation Inc | Mecanisme de commande a faible puissance pour applications d'affichage |
| CA2696778A1 (fr) | 2010-03-17 | 2011-09-17 | Ignis Innovation Inc. | Procedes d'extraction des parametres d'uniformite de duree de vie |
| US20140368491A1 (en) | 2013-03-08 | 2014-12-18 | Ignis Innovation Inc. | Pixel circuits for amoled displays |
| US9351368B2 (en) | 2013-03-08 | 2016-05-24 | Ignis Innovation Inc. | Pixel circuits for AMOLED displays |
| US9886899B2 (en) | 2011-05-17 | 2018-02-06 | Ignis Innovation Inc. | Pixel Circuits for AMOLED displays |
| CN103597534B (zh) | 2011-05-28 | 2017-02-15 | 伊格尼斯创新公司 | 用于快速补偿显示器中的像素的编程的系统和方法 |
| US9747834B2 (en) | 2012-05-11 | 2017-08-29 | Ignis Innovation Inc. | Pixel circuits including feedback capacitors and reset capacitors, and display systems therefore |
| US9786223B2 (en) | 2012-12-11 | 2017-10-10 | Ignis Innovation Inc. | Pixel circuits for AMOLED displays |
| US9336717B2 (en) | 2012-12-11 | 2016-05-10 | Ignis Innovation Inc. | Pixel circuits for AMOLED displays |
| WO2014124755A1 (fr) | 2013-02-18 | 2014-08-21 | Jürgen Von Der Ohe | Procédé et dispositif de nettoyage au jet froid |
| US9721505B2 (en) | 2013-03-08 | 2017-08-01 | Ignis Innovation Inc. | Pixel circuits for AMOLED displays |
| CA2894717A1 (fr) | 2015-06-19 | 2016-12-19 | Ignis Innovation Inc. | Caracterisation d'un dispositif optoelectronique au moyen d'une ligne de sens partage |
| CA2873476A1 (fr) | 2014-12-08 | 2016-06-08 | Ignis Innovation Inc. | Architecture d'affichage de pixels intelligents |
| CA2886862A1 (fr) | 2015-04-01 | 2016-10-01 | Ignis Innovation Inc. | Ajustement de la luminosite d'affichage en vue d'eviter la surchauffe ou le vieillissement accelere |
| CA2898282A1 (fr) | 2015-07-24 | 2017-01-24 | Ignis Innovation Inc. | Etalonnage hybride de sources de courant destine a des afficheurs a tension polarisee par courant programmes |
| US10373554B2 (en) | 2015-07-24 | 2019-08-06 | Ignis Innovation Inc. | Pixels and reference circuits and timing techniques |
| US10657895B2 (en) | 2015-07-24 | 2020-05-19 | Ignis Innovation Inc. | Pixels and reference circuits and timing techniques |
| CA2908285A1 (fr) | 2015-10-14 | 2017-04-14 | Ignis Innovation Inc. | Pilote comportant une structure de pixel a plusieurs couleurs |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE62890B1 (en) * | 1988-12-06 | 1995-03-08 | Hafslund Nycomed Pharma | New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure |
| IL117646A (en) * | 1995-04-12 | 2000-06-01 | Ferrer Int | 7-¬3-¬4-(6-fluoro-1,2-benzisoxazole-3-YL)piperidin-1-YL¾propoxy¾3-alkyl-chromen-4-ones their preparation their uses and pharmaceutical compositions comprising them |
-
2001
- 2001-07-26 HU HU0103063A patent/HU225955B1/hu not_active IP Right Cessation
-
2002
- 2002-07-24 US US10/484,619 patent/US7098210B2/en not_active Expired - Fee Related
- 2002-07-24 BR BR0211440-2A patent/BR0211440A/pt active Search and Examination
- 2002-07-24 EP EP02755381A patent/EP1417206B1/fr not_active Expired - Lifetime
- 2002-07-24 DE DE60236294T patent/DE60236294D1/de not_active Expired - Lifetime
- 2002-07-24 CZ CZ2004123A patent/CZ2004123A3/cs unknown
- 2002-07-24 DK DK02755381.7T patent/DK1417206T3/da active
- 2002-07-24 CA CA002453917A patent/CA2453917C/fr not_active Expired - Fee Related
- 2002-07-24 ES ES02755381T patent/ES2345541T3/es not_active Expired - Lifetime
- 2002-07-24 MX MXPA04000814A patent/MXPA04000814A/es active IP Right Grant
- 2002-07-24 JP JP2003515525A patent/JP4249012B2/ja not_active Expired - Fee Related
- 2002-07-24 SI SI200230914T patent/SI1417206T1/sl unknown
- 2002-07-24 AU AU2002321669A patent/AU2002321669B8/en not_active Ceased
- 2002-07-24 EA EA200400223A patent/EA006246B1/ru not_active IP Right Cessation
- 2002-07-24 WO PCT/HU2002/000072 patent/WO2003010166A1/fr not_active Ceased
- 2002-07-24 SK SK55-2004A patent/SK552004A3/sk unknown
- 2002-07-24 PT PT02755381T patent/PT1417206E/pt unknown
- 2002-07-24 KR KR1020047001151A patent/KR100909514B1/ko not_active Expired - Fee Related
- 2002-07-24 AT AT02755381T patent/ATE466859T1/de active
- 2002-07-24 PL PL367447A patent/PL206824B1/pl unknown
- 2002-07-24 CN CNB028163737A patent/CN1247571C/zh not_active Expired - Fee Related
- 2002-07-24 NZ NZ531154A patent/NZ531154A/en not_active IP Right Cessation
- 2002-07-26 AR ARP020102834A patent/AR036248A1/es not_active Application Discontinuation
-
2004
- 2004-01-19 MA MA27487A patent/MA27867A1/fr unknown
- 2004-01-20 NO NO20040268A patent/NO326155B1/no not_active IP Right Cessation
- 2004-01-22 ZA ZA2004/00482A patent/ZA200400482B/en unknown
-
2010
- 2010-07-22 CY CY20101100690T patent/CY1110240T1/el unknown
-
2012
- 2012-11-08 AR ARP120104216A patent/AR088808A2/es unknown
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