SK4052002A3 - Composition for the prevention and/or treatment of circulatory disorders, comprising derivatives of l-carnitine and extracts of ginkgo biloba - Google Patents
Composition for the prevention and/or treatment of circulatory disorders, comprising derivatives of l-carnitine and extracts of ginkgo biloba Download PDFInfo
- Publication number
- SK4052002A3 SK4052002A3 SK405-2002A SK4052002A SK4052002A3 SK 4052002 A3 SK4052002 A3 SK 4052002A3 SK 4052002 A SK4052002 A SK 4052002A SK 4052002 A3 SK4052002 A3 SK 4052002A3
- Authority
- SK
- Slovakia
- Prior art keywords
- carnitine
- ginkgo biloba
- propionyl
- acetyl
- composition
- Prior art date
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- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- ZXJXZNDDNMQXFV-UHFFFAOYSA-M crystal violet Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1[C+](C=1C=CC(=CC=1)N(C)C)C1=CC=C(N(C)C)C=C1 ZXJXZNDDNMQXFV-UHFFFAOYSA-M 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000011038 discontinuous diafiltration by volume reduction Methods 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- LPTRNLNOHUVQMS-UHFFFAOYSA-N epicatechin Natural products Cc1cc(O)cc2OC(C(O)Cc12)c1ccc(O)c(O)c1 LPTRNLNOHUVQMS-UHFFFAOYSA-N 0.000 description 1
- 235000012734 epicatechin Nutrition 0.000 description 1
- 210000003617 erythrocyte membrane Anatomy 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 230000007760 free radical scavenging Effects 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- AIFCFBUSLAEIBR-UHFFFAOYSA-N ginkgetin Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C(C=1)=CC=C(OC)C=1C1=C(O)C=C(O)C(C(C=2)=O)=C1OC=2C1=CC=C(O)C=C1 AIFCFBUSLAEIBR-UHFFFAOYSA-N 0.000 description 1
- FPUXKXIZEIDQKW-MFJLLLFKSA-N ginkgolide A Natural products O=C1[C@H](C)[C@@]2(O)[C@@H](O1)C[C@]13[C@@H]4OC(=O)[C@]21O[C@@H]1OC(=O)[C@H](O)[C@]31[C@@H](C(C)(C)C)C4 FPUXKXIZEIDQKW-MFJLLLFKSA-N 0.000 description 1
- SQOJOAFXDQDRGF-MMQTXUMRSA-N ginkgolide-b Chemical compound O[C@H]([C@]12[C@H](C(C)(C)C)C[C@H]3OC4=O)C(=O)O[C@H]2O[C@]24[C@@]13[C@@H](O)[C@@H]1OC(=O)[C@@H](C)[C@]21O SQOJOAFXDQDRGF-MMQTXUMRSA-N 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 208000035474 group of disease Diseases 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 210000000548 hind-foot Anatomy 0.000 description 1
- BTXNYTINYBABQR-UHFFFAOYSA-N hypericin Chemical compound C12=C(O)C=C(O)C(C(C=3C(O)=CC(C)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 BTXNYTINYBABQR-UHFFFAOYSA-N 0.000 description 1
- 229940005608 hypericin Drugs 0.000 description 1
- PHOKTTKFQUYZPI-UHFFFAOYSA-N hypericin Natural products Cc1cc(O)c2c3C(=O)C(=Cc4c(O)c5c(O)cc(O)c6c7C(=O)C(=Cc8c(C)c1c2c(c78)c(c34)c56)O)O PHOKTTKFQUYZPI-UHFFFAOYSA-N 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000007654 ischemic lesion Effects 0.000 description 1
- HUOOMAOYXQFIDQ-UHFFFAOYSA-N isoginkgetin Chemical compound C1=CC(OC)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C(C=3C(=CC=C(C=3)C=3OC4=CC(O)=CC(O)=C4C(=O)C=3)OC)=C2O1 HUOOMAOYXQFIDQ-UHFFFAOYSA-N 0.000 description 1
- CGPVRBMMGYBFAC-UHFFFAOYSA-N isoginkgetin Natural products COc1ccc(cc1)C2=COc3c(C2=O)c(O)cc(O)c3c4cc(ccc4OC)C5=CC(=O)c6c(O)cc(O)cc6O5 CGPVRBMMGYBFAC-UHFFFAOYSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 description 1
- IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 description 1
- 235000009498 luteolin Nutrition 0.000 description 1
- 230000002132 lysosomal effect Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 229940033206 melatonin 1 mg Drugs 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000001589 microsome Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- PCOBUQBNVYZTBU-UHFFFAOYSA-N myricetin Natural products OC1=C(O)C(O)=CC(C=2OC3=CC(O)=C(O)C(O)=C3C(=O)C=2)=C1 PCOBUQBNVYZTBU-UHFFFAOYSA-N 0.000 description 1
- 229940116852 myricetin Drugs 0.000 description 1
- 235000007743 myricetin Nutrition 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000003617 peroxidasic effect Effects 0.000 description 1
- 208000028591 pheochromocytoma Diseases 0.000 description 1
- 230000000793 phophlogistic effect Effects 0.000 description 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229940072644 pitressin Drugs 0.000 description 1
- NQJGJBLOXXIGHL-UHFFFAOYSA-N podocarpusflavone A Natural products COc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)c(c3O2)c4cc(ccc4O)C5=COc6cc(O)cc(O)c6C5=O NQJGJBLOXXIGHL-UHFFFAOYSA-N 0.000 description 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- SSKVDVBQSWQEGJ-UHFFFAOYSA-N pseudohypericin Natural products C12=C(O)C=C(O)C(C(C=3C(O)=CC(O)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 SSKVDVBQSWQEGJ-UHFFFAOYSA-N 0.000 description 1
- 230000010410 reperfusion Effects 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical compound C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 description 1
- 229960001685 tacrine Drugs 0.000 description 1
- 230000003867 tiredness Effects 0.000 description 1
- 208000016255 tiredness Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- WKOLLVMJNQIZCI-UHFFFAOYSA-N vanillic acid Chemical compound COC1=CC(C(O)=O)=CC=C1O WKOLLVMJNQIZCI-UHFFFAOYSA-N 0.000 description 1
- TUUBOHWZSQXCSW-UHFFFAOYSA-N vanillic acid Natural products COC1=CC(O)=CC(C(O)=O)=C1 TUUBOHWZSQXCSW-UHFFFAOYSA-N 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999RM000618A IT1306722B1 (it) | 1999-10-08 | 1999-10-08 | Composizione per la prevenzione e/o il trattamento di disfunzionicircolatorie, comprendente derivati della l-carnitina ed estratti di |
| PCT/IT2000/000391 WO2001026666A2 (fr) | 1999-10-08 | 2000-10-02 | Composition pour la prevention et/ou le traitement de troubles circulatoires comprenant des derives de l-carnitine et des extraits de ginkgo biloba |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK4052002A3 true SK4052002A3 (en) | 2002-09-10 |
Family
ID=11406992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK405-2002A SK4052002A3 (en) | 1999-10-08 | 2000-10-02 | Composition for the prevention and/or treatment of circulatory disorders, comprising derivatives of l-carnitine and extracts of ginkgo biloba |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6641849B1 (fr) |
| EP (1) | EP1218022B1 (fr) |
| AR (1) | AR025790A1 (fr) |
| AT (1) | ATE237341T1 (fr) |
| AU (1) | AU780643B2 (fr) |
| CA (1) | CA2386770C (fr) |
| CZ (1) | CZ20021062A3 (fr) |
| DE (1) | DE60002226T2 (fr) |
| DK (1) | DK1218022T3 (fr) |
| ES (1) | ES2195939T3 (fr) |
| HU (1) | HU227042B1 (fr) |
| IL (1) | IL148963A0 (fr) |
| IT (1) | IT1306722B1 (fr) |
| MX (1) | MXPA02003501A (fr) |
| NO (1) | NO20021640L (fr) |
| PL (1) | PL199996B1 (fr) |
| PT (1) | PT1218022E (fr) |
| SK (1) | SK4052002A3 (fr) |
| TN (1) | TNSN00186A1 (fr) |
| TR (1) | TR200200948T2 (fr) |
| WO (1) | WO2001026666A2 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1316998B1 (it) * | 2000-03-02 | 2003-05-26 | Sigma Tau Healthscience Spa | Composizione per la prevenzione e/o il trattamento degli effetticitotossici indotti dall'uso di agenti immunosoppressori. |
| IT1317035B1 (it) * | 2000-05-30 | 2003-05-26 | Sigma Tau Healthscience Spa | Integratore ad attivita' antiossidante comprendente unaalcanoilcarnitina ed una associazione di polifenoli estratti dal |
| CN1638650A (zh) * | 2001-03-09 | 2005-07-13 | 雀巢制品公司 | 改善与年龄有关的生理缺陷并延长寿命的组合物 |
| ITRM20010708A1 (it) | 2001-12-04 | 2003-06-04 | Sigma Tau Ind Farmaceuti | Uso di una alcanoil l-carnitina per il trattamento della disfunzione erettile. |
| US20050232911A1 (en) * | 2004-04-19 | 2005-10-20 | Schreiber Brian D | Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid |
| US7935714B2 (en) | 2004-05-18 | 2011-05-03 | Bright Future Pharmaceutical Laboratories | Compositions for sleeping disorders |
| GB0411166D0 (en) * | 2004-05-19 | 2004-06-23 | Bionovate Ltd | Treatment for asthma and arthritis |
| ITRM20040561A1 (it) * | 2004-11-11 | 2005-02-11 | Sigma Tau Ind Farmaceuti | Uso della acetil l-carnitina in combinazione con propionil l-carnitina e sildenafil per il trattamento della disfunzione erettile. |
| AR070816A1 (es) * | 2008-03-14 | 2010-05-05 | Otsuka Pharma Co Ltd | Farmaco de combinacion para tratar trastornos vasculares |
| EA019237B1 (ru) * | 2008-11-11 | 2014-02-28 | Сигма-Тау Индустрие Фармасьютике Риуните С.П.А. | Соединения, пригодные для лечения целлюлита |
| US20110015154A1 (en) * | 2009-07-20 | 2011-01-20 | Kellermann Gottfried H | Supporting acetylcholine function |
| US20110098265A1 (en) * | 2009-10-28 | 2011-04-28 | Neuroscience, Inc. | Methods for reducing cravings and impulses associated with addictive and compulsive behaviors |
| CZ308282B6 (cs) * | 2010-08-05 | 2020-04-15 | Výzkumný ústav živočišné výroby, v. v. i. | Krmný doplněk pro zvýšení libida kanců |
| CN102783568B (zh) * | 2012-08-29 | 2014-05-14 | 山东中医药大学 | 一种饲料添加剂 |
| ES2666836T3 (es) * | 2014-06-04 | 2018-05-08 | Alfasigma S.P.A. | Formulaciones homogéneas que comprenden ácidos grasos poliinsaturados omega-3 (n-3 PUFA) y resveratrol para administración oral |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1254314B (it) * | 1992-03-27 | 1995-09-14 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche conyenenti l-carnitina e acil- carnitine inassociazione con ace-inibitori per il trattamento di patologie cardiovascolari. |
| DE9318632U1 (de) * | 1993-12-06 | 1995-04-06 | Emsa-Werke Wulf GmbH & Co, 48282 Emsdetten | Vorrichtung zum Aufnehmen von Folienrollen |
| US6221356B1 (en) * | 1996-12-13 | 2001-04-24 | Viva America Marketing, Inc. | Method of preparation of biologically active Ginkgo biloba product |
| AU6141498A (en) * | 1997-02-04 | 1998-08-25 | John V. Kosbab | Compositions and methods for prevention and treatment of vascular degenerative diseases |
| IT1294227B1 (it) * | 1997-08-01 | 1999-03-24 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica contenente l-carnitina o una alcanoil l-carnitina e alcoli alifatici a lunga catena utile per la prevenzione |
| IT1306130B1 (it) * | 1999-04-16 | 2001-05-30 | Sigma Tau Healthscience Spa | Composizione comprendente una carnitina e glutatione, atta adaumentare l'assorbimento del glutatione sinergizzandone gli effetti. |
-
1999
- 1999-10-08 IT IT1999RM000618A patent/IT1306722B1/it active
-
2000
- 2000-09-21 TN TNTNSN00186A patent/TNSN00186A1/fr unknown
- 2000-09-27 AR ARP000105061A patent/AR025790A1/es unknown
- 2000-10-02 MX MXPA02003501A patent/MXPA02003501A/es active IP Right Grant
- 2000-10-02 DE DE60002226T patent/DE60002226T2/de not_active Expired - Lifetime
- 2000-10-02 ES ES00969811T patent/ES2195939T3/es not_active Expired - Lifetime
- 2000-10-02 PL PL354413A patent/PL199996B1/pl unknown
- 2000-10-02 TR TR2002/00948T patent/TR200200948T2/xx unknown
- 2000-10-02 SK SK405-2002A patent/SK4052002A3/sk unknown
- 2000-10-02 WO PCT/IT2000/000391 patent/WO2001026666A2/fr not_active Ceased
- 2000-10-02 CA CA002386770A patent/CA2386770C/fr not_active Expired - Fee Related
- 2000-10-02 CZ CZ20021062A patent/CZ20021062A3/cs unknown
- 2000-10-02 AT AT00969811T patent/ATE237341T1/de active
- 2000-10-02 HU HU0203449A patent/HU227042B1/hu not_active IP Right Cessation
- 2000-10-02 AU AU79456/00A patent/AU780643B2/en not_active Ceased
- 2000-10-02 PT PT00969811T patent/PT1218022E/pt unknown
- 2000-10-02 EP EP00969811A patent/EP1218022B1/fr not_active Expired - Lifetime
- 2000-10-02 US US10/110,018 patent/US6641849B1/en not_active Expired - Lifetime
- 2000-10-02 DK DK00969811T patent/DK1218022T3/da active
- 2000-10-02 IL IL14896300A patent/IL148963A0/xx unknown
-
2002
- 2002-04-05 NO NO20021640A patent/NO20021640L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60002226T2 (de) | 2004-03-04 |
| WO2001026666A3 (fr) | 2001-09-13 |
| HU227042B1 (en) | 2010-05-28 |
| AU7945600A (en) | 2001-04-23 |
| EP1218022A2 (fr) | 2002-07-03 |
| MXPA02003501A (es) | 2002-09-02 |
| WO2001026666A2 (fr) | 2001-04-19 |
| AU780643B2 (en) | 2005-04-07 |
| PL354413A1 (en) | 2004-01-12 |
| TNSN00186A1 (fr) | 2005-11-10 |
| NO20021640L (no) | 2002-05-29 |
| ES2195939T3 (es) | 2003-12-16 |
| PL199996B1 (pl) | 2008-11-28 |
| AR025790A1 (es) | 2002-12-11 |
| CA2386770C (fr) | 2009-09-08 |
| PT1218022E (pt) | 2003-09-30 |
| IL148963A0 (en) | 2002-11-10 |
| HUP0203449A2 (hu) | 2003-02-28 |
| ITRM990618A0 (it) | 1999-10-08 |
| IT1306722B1 (it) | 2001-10-02 |
| DE60002226D1 (de) | 2003-05-22 |
| CZ20021062A3 (cs) | 2002-08-14 |
| NO20021640D0 (no) | 2002-04-05 |
| HUP0203449A3 (en) | 2005-04-28 |
| CA2386770A1 (fr) | 2001-04-19 |
| DK1218022T3 (da) | 2003-08-11 |
| ITRM990618A1 (it) | 2001-04-08 |
| US6641849B1 (en) | 2003-11-04 |
| EP1218022B1 (fr) | 2003-04-16 |
| TR200200948T2 (tr) | 2002-10-21 |
| ATE237341T1 (de) | 2003-05-15 |
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