SK285865B6 - Farmaceutický prostriedok s maskovanou chuťou a spôsob jeho prípravy - Google Patents

Farmaceutický prostriedok s maskovanou chuťou a spôsob jeho prípravy Download PDF

Info

Publication number: SK285865B6
Authority: SK; Slovakia
Prior art keywords: matrix; polymer; composition according; composition; alkaline
Prior art date: 2001-06-21

Application number

SK1592-2003A

Other languages

English (en)

Slovak (sk)

Other versions

SK15922003A3 (sk

Inventor

Philippe Becourt

Josiane Chauvin

Detlev Schwabe

Original Assignee

Aventis Pharma S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-21

Filing date

2002-06-21

Publication date

2007-10-04

2002-06-21 Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.

2004-05-04 Publication of SK15922003A3 publication Critical patent/SK15922003A3/sk

2007-10-04 Publication of SK285865B6 publication Critical patent/SK285865B6/sk

Links

238000000034 method Methods 0.000 title claims abstract description 15
239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 9
238000004519 manufacturing process Methods 0.000 title abstract 2
239000000203 mixture Substances 0.000 claims abstract description 36
229920000642 polymer Polymers 0.000 claims abstract description 29
239000011159 matrix material Substances 0.000 claims abstract description 23
125000005395 methacrylic acid group Chemical group 0.000 claims abstract description 14
239000003795 chemical substances by application Substances 0.000 claims abstract description 12
230000000873 masking effect Effects 0.000 claims abstract description 11
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
239000003960 organic solvent Substances 0.000 claims abstract description 9
239000003463 adsorbent Substances 0.000 claims abstract description 8
230000007935 neutral effect Effects 0.000 claims abstract description 6
239000000825 pharmaceutical preparation Substances 0.000 claims abstract description 6
229940127557 pharmaceutical product Drugs 0.000 claims abstract description 6
239000000725 suspension Substances 0.000 claims abstract description 5
230000002378 acidificating effect Effects 0.000 claims abstract description 4
239000004480 active ingredient Substances 0.000 claims description 19
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical group ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 15
239000001913 cellulose Substances 0.000 claims description 13
229920002678 cellulose Polymers 0.000 claims description 13
239000013543 active substance Substances 0.000 claims description 12
229960003250 telithromycin Drugs 0.000 claims description 7
LJVAJPDWBABPEJ-PNUFFHFMSA-N telithromycin Chemical group O([C@@H]1[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]([C@]2(OC(=O)N(CCCCN3C=C(N=C3)C=3C=NC=CC=3)[C@@H]2[C@@H](C)C(=O)[C@H](C)C[C@@]1(C)OC)C)CC)[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O LJVAJPDWBABPEJ-PNUFFHFMSA-N 0.000 claims description 7
239000003963 antioxidant agent Substances 0.000 claims description 6
239000003765 sweetening agent Substances 0.000 claims description 6
239000001856 Ethyl cellulose Substances 0.000 claims description 5
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 5
230000003078 antioxidant effect Effects 0.000 claims description 5
229920001249 ethyl cellulose Polymers 0.000 claims description 5
235000019325 ethyl cellulose Nutrition 0.000 claims description 5
239000000796 flavoring agent Substances 0.000 claims description 5
235000003599 food sweetener Nutrition 0.000 claims description 5
239000004014 plasticizer Substances 0.000 claims description 5
238000002360 preparation method Methods 0.000 claims description 5
239000003755 preservative agent Substances 0.000 claims description 5
239000002562 thickening agent Substances 0.000 claims description 5
MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims description 4
SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 claims description 4
230000003115 biocidal effect Effects 0.000 claims description 4
230000002209 hydrophobic effect Effects 0.000 claims description 4
229960003194 meglumine Drugs 0.000 claims description 4
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 4
239000000843 powder Substances 0.000 claims description 4
238000001179 sorption measurement Methods 0.000 claims description 4
229930186147 Cephalosporin Natural products 0.000 claims description 3
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
239000007900 aqueous suspension Substances 0.000 claims description 3
229940124587 cephalosporin Drugs 0.000 claims description 3
150000001780 cephalosporins Chemical class 0.000 claims description 3
235000013355 food flavoring agent Nutrition 0.000 claims description 3
239000003120 macrolide antibiotic agent Substances 0.000 claims description 3
JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 claims description 2
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 2
239000004472 Lysine Substances 0.000 claims description 2
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
229930182555 Penicillin Natural products 0.000 claims description 2
239000004098 Tetracycline Substances 0.000 claims description 2
150000001298 alcohols Chemical class 0.000 claims description 2
239000008365 aqueous carrier Substances 0.000 claims description 2
229920006317 cationic polymer Polymers 0.000 claims description 2
239000003153 chemical reaction reagent Substances 0.000 claims description 2
159000000011 group IA salts Chemical class 0.000 claims description 2
150000002576 ketones Chemical class 0.000 claims description 2
150000002734 metacrylic acid derivatives Chemical class 0.000 claims description 2
229910000027 potassium carbonate Inorganic materials 0.000 claims description 2
150000007660 quinolones Chemical class 0.000 claims description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 2
229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
239000002904 solvent Substances 0.000 claims description 2
239000000454 talc Substances 0.000 claims description 2
229910052623 talc Inorganic materials 0.000 claims description 2
235000019364 tetracycline Nutrition 0.000 claims description 2
150000003522 tetracyclines Chemical class 0.000 claims description 2
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
229910052782 aluminium Inorganic materials 0.000 claims 1
150000008282 halocarbons Chemical class 0.000 claims 1
HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 claims 1
239000000391 magnesium silicate Substances 0.000 claims 1
229910052919 magnesium silicate Inorganic materials 0.000 claims 1
235000019792 magnesium silicate Nutrition 0.000 claims 1
229940050561 matrix product Drugs 0.000 claims 1
150000002960 penicillins Chemical class 0.000 claims 1
239000001508 potassium citrate Substances 0.000 claims 1
229960002635 potassium citrate Drugs 0.000 claims 1
QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims 1
235000011082 potassium citrates Nutrition 0.000 claims 1
229910052708 sodium Inorganic materials 0.000 claims 1
239000001509 sodium citrate Substances 0.000 claims 1
229940040944 tetracyclines Drugs 0.000 claims 1
238000009472 formulation Methods 0.000 abstract description 2
150000001447 alkali salts Chemical class 0.000 abstract 1
239000008135 aqueous vehicle Substances 0.000 abstract 1
229920003174 cellulose-based polymer Polymers 0.000 abstract 1
238000000889 atomisation Methods 0.000 description 7
239000000845 maltitol Substances 0.000 description 5
VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 5
235000010449 maltitol Nutrition 0.000 description 5
229940035436 maltitol Drugs 0.000 description 5
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
238000010521 absorption reaction Methods 0.000 description 4
235000006708 antioxidants Nutrition 0.000 description 4
150000001875 compounds Chemical class 0.000 description 4
238000003756 stirring Methods 0.000 description 4
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
239000011859 microparticle Substances 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 description 2
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
229940087168 alpha tocopherol Drugs 0.000 description 2
235000010354 butylated hydroxytoluene Nutrition 0.000 description 2
239000004148 curcumin Substances 0.000 description 2
238000001035 drying Methods 0.000 description 2
230000000694 effects Effects 0.000 description 2
239000010419 fine particle Substances 0.000 description 2
235000019634 flavors Nutrition 0.000 description 2
235000013305 food Nutrition 0.000 description 2
238000001727 in vivo Methods 0.000 description 2
239000003835 ketolide antibiotic agent Substances 0.000 description 2
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
239000000546 pharmaceutical excipient Substances 0.000 description 2
229960000984 tocofersolan Drugs 0.000 description 2
239000000230 xanthan gum Substances 0.000 description 2
229920001285 xanthan gum Polymers 0.000 description 2
235000010493 xanthan gum Nutrition 0.000 description 2
229940082509 xanthan gum Drugs 0.000 description 2
239000002076 α-tocopherol Substances 0.000 description 2
235000004835 α-tocopherol Nutrition 0.000 description 2
RXZBMPWDPOLZGW-XMRMVWPWSA-N (E)-roxithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-XMRMVWPWSA-N 0.000 description 1
MRBKEAMVRSLQPH-UHFFFAOYSA-N 3-tert-butyl-4-hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1 MRBKEAMVRSLQPH-UHFFFAOYSA-N 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
244000307700 Fragaria vesca Species 0.000 description 1
235000016623 Fragaria vesca Nutrition 0.000 description 1
235000011363 Fragaria x ananassa Nutrition 0.000 description 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
230000002411 adverse Effects 0.000 description 1
239000003513 alkali Substances 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 description 1
229960004099 azithromycin Drugs 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
235000019282 butylated hydroxyanisole Nutrition 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
229960002626 clarithromycin Drugs 0.000 description 1
AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
239000000470 constituent Substances 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
IDAGXRIGDWCIET-SDFKWCIISA-L disodium;(2s,3s,4s,5r)-2,3,4,5-tetrahydroxyhexanedioate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O IDAGXRIGDWCIET-SDFKWCIISA-L 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
229960003276 erythromycin Drugs 0.000 description 1
-1 ethylcellulose Chemical class 0.000 description 1
230000037406 food intake Effects 0.000 description 1
230000003993 interaction Effects 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
230000005923 long-lasting effect Effects 0.000 description 1
229940041033 macrolides Drugs 0.000 description 1
239000000463 material Substances 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
229960002216 methylparaben Drugs 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
239000002245 particle Substances 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
229940124531 pharmaceutical excipient Drugs 0.000 description 1
XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
229960005224 roxithromycin Drugs 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000007858 starting material Substances 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
229960002180 tetracycline Drugs 0.000 description 1
229930101283 tetracycline Natural products 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
230000008719 thickening Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Oncology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SK1592-2003A 2001-06-21 2002-06-21 Farmaceutický prostriedok s maskovanou chuťou a spôsob jeho prípravy SK285865B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0108157A FR2826274B1 (fr)	2001-06-21	2001-06-21	Formulation pharmaceutique au gout masque et son procede de preparation
PCT/FR2002/002158 WO2003000225A2 (fr)	2001-06-21	2002-06-21	Formulation pharmaceutique au gout masque et son procede de preparation

Publications (2)

Publication Number	Publication Date
SK15922003A3 SK15922003A3 (sk)	2004-05-04
SK285865B6 true SK285865B6 (sk)	2007-10-04

Family

ID=8864587

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1592-2003A SK285865B6 (sk)	2001-06-21	2002-06-21	Farmaceutický prostriedok s maskovanou chuťou a spôsob jeho prípravy

Country Status (41)

Country	Link
US (2)	US7138138B2 (es)
EP (1)	EP1401397B1 (es)
JP (1)	JP4880871B2 (es)
CN (1)	CN1239149C (es)
AP (1)	AP1595A (es)
AR (1)	AR036096A1 (es)
AT (1)	ATE290366T1 (es)
AU (1)	AU2002329311B2 (es)
BG (1)	BG66314B1 (es)
BR (1)	BRPI0208998A2 (es)
CA (1)	CA2452239C (es)
CO (1)	CO5540278A2 (es)
CZ (1)	CZ299947B6 (es)
DE (1)	DE60203178T2 (es)
EA (1)	EA006016B1 (es)
EC (1)	ECSP034915A (es)
ES (1)	ES2236574T3 (es)
FR (1)	FR2826274B1 (es)
GT (2)	GT200200115A (es)
HR (1)	HRP20031067B1 (es)
HU (1)	HUP0400799A3 (es)
IL (2)	IL159404A0 (es)
JO (1)	JO2325B1 (es)
MA (1)	MA27042A1 (es)
MX (1)	MXPA03011756A (es)
MY (1)	MY134340A (es)
NO (1)	NO332258B1 (es)
NZ (1)	NZ530042A (es)
OA (1)	OA12635A (es)
PA (1)	PA8548301A1 (es)
PE (1)	PE20030201A1 (es)
PL (1)	PL202090B1 (es)
PT (1)	PT1401397E (es)
SK (1)	SK285865B6 (es)
SV (1)	SV2003001098A (es)
TN (1)	TNSN03141A1 (es)
TW (1)	TWI228049B (es)
UA (1)	UA77960C2 (es)
UY (1)	UY27341A1 (es)
WO (1)	WO2003000225A2 (es)
ZA (1)	ZA200309479B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7384921B2 (en) *	2004-02-20	2008-06-10	Enanta Pharmaceuticals, Inc.	Polymorphic forms of 6-11 bicyclic ketolide derivatives
GB2419094A (en)	2004-10-12	2006-04-19	Sandoz Ag	Pharmaceutical composition of unpleasnt tasing active substances
FR2882522B1 (fr) *	2005-02-25	2007-04-13	Aventis Pharma Sa	Composition pharmaceutique solide comprenant de la telithromycine
US7384922B2 (en) *	2005-05-04	2008-06-10	Enanta Pharmaceuticals, Inc.	6-11 bridged oxime erythromycin derivatives
US20060264386A1 (en) *	2005-05-17	2006-11-23	Rongqi Sun	Pharmaceutical formulations of 6-11 bicyclic ketolide derivatives and related macrolides and methods for preparation thereof
SI1978936T1 (sl) *	2006-02-03	2013-10-30	Evonik Roehm Gmbh	Farmacevtski sestavki, ki vsebujejo meĹˇanice polimerov in v vodi slabo topna aktivna sredstva
WO2007108010A2 (en) *	2006-03-21	2007-09-27	Jubilant Organosys Limited	Taste masked pharmaceutical composition for oral solid dosage form and process for preparing the same using magnesium aluminium silicate
WO2008094877A2 (en) *	2007-01-30	2008-08-07	Drugtech Corporation	Compositions for oral delivery of pharmaceuticals
KR100935893B1 (ko) *	2007-09-11	2010-01-07	국방과학연구소	1,1'-다이메틸-5,5’-바이테트라졸의 합성방법
AU2008316830B2 (en)	2007-10-25	2016-03-17	Cempra Pharmaceuticals, Inc.	Process for the preparation of macrolide antibacterial agents
NZ593559A (en)	2008-12-16	2013-05-31	Carlsberg As	Coating of hydroxylated surfaces by gas phase grafting
IN2014DN08939A (es)	2012-03-27	2015-05-22	Cempra Pharmaceuticals Inc
DE102012014848A1 (de) *	2012-07-27	2012-10-31	Heilerde-Gesellschaft Luvos Just GmbH & Co. KG	Heilerde-Zubereitung
CA2957034A1 (en) *	2014-08-05	2016-02-11	Cempra Pharmaceuticals, Inc.	Powder oral suspension formulations of antibacterial agents
US10982177B2 (en)	2017-09-18	2021-04-20	The Clorox Company	Cleaning wipes with particular lotion retention and efficacy characteristics
CN114209661B (zh) *	2022-02-21	2022-04-29	北京罗诺强施医药技术研发中心有限公司	呈细粒形式的固体药物组合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2930409A1 (de) *	1979-07-26	1981-02-12	Bayer Ag	Spruehtrocknung von mikrokapseldispersionen
JPS63150220A (ja) *	1986-12-15	1988-06-22	Dainippon Pharmaceut Co Ltd	経口用固形製剤の製造方法
US4808411A (en) *	1987-06-05	1989-02-28	Abbott Laboratories	Antibiotic-polymer compositions
US5084278A (en) *	1989-06-02	1992-01-28	Nortec Development Associates, Inc.	Taste-masked pharmaceutical compositions
ZA945944B (en) *	1993-08-13	1996-02-08	Eurand America Inc	Procedure for encapsulating nsaids
AUPN969796A0 (en) *	1996-05-07	1996-05-30	F.H. Faulding & Co. Limited	Taste masked liquid suspensions
EP1027036A2 (en) *	1997-10-03	2000-08-16	ELAN CORPORATION, Plc	Taste masked formulations
IN191239B (es) *	1999-06-11	2003-10-11	Ranbaxy Lab Ltd
US6555569B2 (en) *	2000-03-07	2003-04-29	Pfizer Inc.	Use of heteroaryl substituted N-(indole-2-carbonyl-) amides for treatment of infection
KR100502031B1 (ko) *	2000-08-22	2005-07-25	바실리어 파마슈티카 아게	항균 활성을 갖는 신규한 매크롤라이드

2001
- 2001-06-21 FR FR0108157A patent/FR2826274B1/fr not_active Expired - Fee Related
2002
- 2002-05-08 TW TW091109613A patent/TWI228049B/zh not_active IP Right Cessation
- 2002-05-09 JO JO200241A patent/JO2325B1/en active
- 2002-06-11 GT GT200200115A patent/GT200200115A/es unknown
- 2002-06-11 GT GT200200115AK patent/GT200200115AA/es unknown
- 2002-06-17 MY MYPI20022250A patent/MY134340A/en unknown
- 2002-06-18 UY UY27341A patent/UY27341A1/es not_active Application Discontinuation
- 2002-06-18 PE PE2002000522A patent/PE20030201A1/es not_active Application Discontinuation
- 2002-06-19 SV SV2002001098A patent/SV2003001098A/es not_active Application Discontinuation
- 2002-06-19 AR ARP020102300A patent/AR036096A1/es not_active Application Discontinuation
- 2002-06-19 PA PA20028548301A patent/PA8548301A1/es unknown
- 2002-06-21 AU AU2002329311A patent/AU2002329311B2/en not_active Ceased
- 2002-06-21 MX MXPA03011756A patent/MXPA03011756A/es active IP Right Grant
- 2002-06-21 ES ES02764922T patent/ES2236574T3/es not_active Expired - Lifetime
- 2002-06-21 PL PL366803A patent/PL202090B1/pl unknown
- 2002-06-21 OA OA1200300340A patent/OA12635A/fr unknown
- 2002-06-21 CA CA2452239A patent/CA2452239C/fr not_active Expired - Fee Related
- 2002-06-21 EA EA200400061A patent/EA006016B1/ru not_active IP Right Cessation
- 2002-06-21 BR BRPI0208998A patent/BRPI0208998A2/pt not_active IP Right Cessation
- 2002-06-21 HU HU0400799A patent/HUP0400799A3/hu unknown
- 2002-06-21 NZ NZ530042A patent/NZ530042A/en not_active IP Right Cessation
- 2002-06-21 TN TNPCT/FR2002/002158A patent/TNSN03141A1/fr unknown
- 2002-06-21 AT AT02764922T patent/ATE290366T1/de active
- 2002-06-21 HR HR20031067A patent/HRP20031067B1/xx not_active IP Right Cessation
- 2002-06-21 AP APAP/P/2003/002927A patent/AP1595A/en active
- 2002-06-21 CZ CZ20033441A patent/CZ299947B6/cs not_active IP Right Cessation
- 2002-06-21 JP JP2003506872A patent/JP4880871B2/ja not_active Expired - Fee Related
- 2002-06-21 CN CNB028121465A patent/CN1239149C/zh not_active Expired - Fee Related
- 2002-06-21 WO PCT/FR2002/002158 patent/WO2003000225A2/fr not_active Ceased
- 2002-06-21 DE DE60203178T patent/DE60203178T2/de not_active Expired - Lifetime
- 2002-06-21 EP EP02764922A patent/EP1401397B1/fr not_active Expired - Lifetime
- 2002-06-21 SK SK1592-2003A patent/SK285865B6/sk not_active IP Right Cessation
- 2002-06-21 UA UA2004010425A patent/UA77960C2/uk unknown
- 2002-06-21 IL IL15940402A patent/IL159404A0/xx active IP Right Grant
- 2002-06-21 PT PT02764922T patent/PT1401397E/pt unknown
2003
- 2003-12-05 ZA ZA2003/09479A patent/ZA200309479B/en unknown
- 2003-12-12 US US10/735,538 patent/US7138138B2/en not_active Expired - Lifetime
- 2003-12-15 NO NO20035581A patent/NO332258B1/no not_active IP Right Cessation
- 2003-12-16 IL IL159404A patent/IL159404A/en not_active IP Right Cessation
- 2003-12-16 MA MA27445A patent/MA27042A1/fr unknown
- 2003-12-16 BG BG108458A patent/BG66314B1/bg unknown
- 2003-12-18 EC EC2003004915A patent/ECSP034915A/es unknown
- 2003-12-19 CO CO03111139A patent/CO5540278A2/es active IP Right Grant
2006
- 2006-09-20 US US11/533,573 patent/US20070014857A1/en not_active Abandoned

Also Published As

Publication number	Publication date
FR2826274B1 (fr)	2003-09-26
DE60203178T2 (de)	2006-01-26
HRP20031067B1 (en)	2011-10-31
CA2452239C (fr)	2011-07-19
PE20030201A1 (es)	2003-03-12
PT1401397E (pt)	2005-05-31
IL159404A0 (en)	2004-06-01
JP2004534810A (ja)	2004-11-18
JP4880871B2 (ja)	2012-02-22
PL366803A1 (en)	2005-02-07
HK1067558A1 (en)	2005-04-15
ES2236574T3 (es)	2005-07-16
BG108458A (bg)	2005-02-28
AP1595A (en)	2006-04-12
UY27341A1 (es)	2003-01-31
US7138138B2 (en)	2006-11-21
EP1401397A2 (fr)	2004-03-31
US20070014857A1 (en)	2007-01-18
US20040142029A1 (en)	2004-07-22
DE60203178D1 (de)	2005-04-14
CZ299947B6 (cs)	2009-01-07
FR2826274A1 (fr)	2002-12-27
MA27042A1 (fr)	2004-12-20
GT200200115AA (es)	2005-01-12
WO2003000225A3 (fr)	2003-03-13
WO2003000225A2 (fr)	2003-01-03
CN1529585A (zh)	2004-09-15
HRP20031067A2 (en)	2004-04-30
BRPI0208998A2 (pt)	2017-06-06
PL202090B1 (pl)	2009-06-30
EP1401397B1 (fr)	2005-03-09
GT200200115A (es)	2003-02-27
HUP0400799A2 (hu)	2004-08-30
SV2003001098A (es)	2003-03-18
AU2002329311B2 (en)	2007-02-01
BG66314B1 (bg)	2013-04-30
SK15922003A3 (sk)	2004-05-04
CN1239149C (zh)	2006-02-01
CA2452239A1 (fr)	2003-01-03
ECSP034915A (es)	2004-02-26
AR036096A1 (es)	2004-08-11
EA200400061A1 (ru)	2004-06-24
CZ20033441A3 (en)	2004-03-17
MY134340A (en)	2007-12-31
TWI228049B (en)	2005-02-21
PA8548301A1 (es)	2003-09-05
JO2325B1 (en)	2006-06-28
TNSN03141A1 (fr)	2005-12-23
CO5540278A2 (es)	2005-07-29
MXPA03011756A (es)	2004-07-01
IL159404A (en)	2007-08-19
NZ530042A (en)	2005-09-30
OA12635A (fr)	2006-06-15
EA006016B1 (ru)	2005-08-25
NO20035581D0 (no)	2003-12-15
ATE290366T1 (de)	2005-03-15
NO332258B1 (no)	2012-08-13
UA77960C2 (en)	2007-02-15
ZA200309479B (en)	2005-04-26
HUP0400799A3 (en)	2012-08-28
AP2003002927A0 (en)	2003-12-31

Publication	Publication Date	Title
SK285865B6 (sk)	2007-10-04	Farmaceutický prostriedok s maskovanou chuťou a spôsob jeho prípravy
EP1248616B1 (en)	2007-03-21	Functional coating of linezolid microcapsules for oral administration
EP1194153B1 (en)	2004-05-06	Taste masked pharmaceutical liquid formulations
WO1997002020A1 (en)	1997-01-23	Oral pharmaceutical composition containing antimicrobial actives and sustained release pantoprazole
WO2004087096A1 (en)	2004-10-14	Pharmaceutical compositions having reduced bitter taste
US20040241235A1 (en)	2004-12-02	Granules and granules coated with a masked taste
ZA200207737B (en)	2003-05-08	Granulated particles with masked taste.
RU2376013C2 (ru)	2009-12-20	Пероральный препарат и способ его получения
WO2005023236A1 (en)	2005-03-17	Phenylephrine tannate, pyrilamine tannate, and dextromethorphan tannate salts in pharmaceutical compositions
HU214825B (hu)	1998-06-29	Eljárás spiramicint tartalmazó gyógyszerkészítmények előállítására
WO2001085134A1 (en)	2001-11-15	Pharmaceutical solid compositions and process for the production of mouth dissolving tablets
HK1067558B (en)	2006-07-14	Pharmaceutical formulation having a masked taste and method for the production thereof
HK1068059B (zh)	2010-09-24	被掩味的包衣颗粒和粒状物
KR20040040959A (ko)	2004-05-13	쓴맛이 은폐된 세파계 항생제의 조성물 및 그의 제조방법
KR20030058861A (ko)	2003-07-07	피복실 설박탐의 고미가 은폐된 내용제 조성물 및 그제조방법

Legal Events

Date	Code	Title	Description
2016-03-01	MM4A	Patent lapsed due to non-payment of maintenance fees	Effective date: 20150621