SK284952B6 - Použitie N-piperidino-5-(4-chlórfenyl)-1-(2,4-dichlórfenyl)-4- metylpyrazol-3-karboxamidu na prípravu liečebných prostriedkov, farmaceutická kompozícia a súprava s jeho obsahom - Google Patents

Použitie N-piperidino-5-(4-chlórfenyl)-1-(2,4-dichlórfenyl)-4- metylpyrazol-3-karboxamidu na prípravu liečebných prostriedkov, farmaceutická kompozícia a súprava s jeho obsahom Download PDF

Info

Publication number: SK284952B6
Authority: SK; Slovakia
Prior art keywords: nicotine; methylpyrazole; dichlorophenyl; carboxamide; chlorophenyl
Prior art date: 2000-02-09

Application number

SK1129-2002A

Other languages

English (en)

Slovak (sk)

Other versions

SK11292002A3 (sk

Inventor

Jean Charles Blanchard

Fran�Ois Menard

Original Assignee

Sanofi - Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-09

Filing date

2001-02-07

Publication date

2006-03-02

2001-02-07 Application filed by Sanofi - Aventis filed Critical Sanofi - Aventis

2003-02-04 Publication of SK11292002A3 publication Critical patent/SK11292002A3/sk

2006-03-02 Publication of SK284952B6 publication Critical patent/SK284952B6/sk

Links

JZCPYUJPEARBJL-UHFFFAOYSA-N rimonabant Chemical compound CC=1C(C(=O)NN2CCCCC2)=NN(C=2C(=CC(Cl)=CC=2)Cl)C=1C1=CC=C(Cl)C=C1 JZCPYUJPEARBJL-UHFFFAOYSA-N 0.000 title claims abstract description 10
238000002360 preparation method Methods 0.000 title claims abstract description 8
239000008194 pharmaceutical composition Substances 0.000 title claims description 8
229940126601 medicinal product Drugs 0.000 title abstract 2
241000208125 Nicotiana Species 0.000 claims abstract description 20
235000002637 Nicotiana tabacum Nutrition 0.000 claims abstract description 20
150000003839 salts Chemical class 0.000 claims abstract description 20
239000012453 solvate Substances 0.000 claims abstract description 19
SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 27
229960002715 nicotine Drugs 0.000 claims description 27
SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 27
239000013543 active substance Substances 0.000 claims description 18
239000004480 active ingredient Substances 0.000 claims description 12
206010057852 Nicotine dependence Diseases 0.000 claims description 9
208000025569 Tobacco Use disease Diseases 0.000 claims description 9
229940123685 Monoamine oxidase inhibitor Drugs 0.000 claims description 8
239000002899 monoamine oxidase inhibitor Substances 0.000 claims description 8
239000003814 drug Substances 0.000 claims description 6
208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims description 5
239000000556 agonist Substances 0.000 claims description 5
239000004031 partial agonist Substances 0.000 claims description 5
229940124535 smoking cessation aid Drugs 0.000 claims 1
239000000126 substance Substances 0.000 claims 1
229940126062 Compound A Drugs 0.000 description 26
NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 26
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 11
150000001875 compounds Chemical class 0.000 description 9
239000002775 capsule Substances 0.000 description 8
239000000203 mixture Substances 0.000 description 8
239000003826 tablet Substances 0.000 description 7
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 6
235000019333 sodium laurylsulphate Nutrition 0.000 description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 5
229920002261 Corn starch Polymers 0.000 description 5
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
239000002552 dosage form Substances 0.000 description 5
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LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 description 4
235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 4
229940122820 Cannabinoid receptor antagonist Drugs 0.000 description 3
GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 3
229920000858 Cyclodextrin Polymers 0.000 description 3
235000019759 Maize starch Nutrition 0.000 description 3
PHVGLTMQBUFIQQ-UHFFFAOYSA-N Nortryptiline Chemical compound C1CC2=CC=CC=C2C(=CCCNC)C2=CC=CC=C21 PHVGLTMQBUFIQQ-UHFFFAOYSA-N 0.000 description 3
230000001430 anti-depressive effect Effects 0.000 description 3
239000000935 antidepressant agent Substances 0.000 description 3
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239000002249 anxiolytic agent Substances 0.000 description 3
SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 description 3
229960001058 bupropion Drugs 0.000 description 3
QWCRAEMEVRGPNT-UHFFFAOYSA-N buspirone Chemical compound C1C(=O)N(CCCCN2CCN(CC2)C=2N=CC=CN=2)C(=O)CC21CCCC2 QWCRAEMEVRGPNT-UHFFFAOYSA-N 0.000 description 3
229960002495 buspirone Drugs 0.000 description 3
239000003536 cannabinoid receptor antagonist Substances 0.000 description 3
ODQWQRRAPPTVAG-BOPFTXTBSA-N cis-doxepin Chemical compound C1OC2=CC=CC=C2C(=C/CCN(C)C)\C2=CC=CC=C21 ODQWQRRAPPTVAG-BOPFTXTBSA-N 0.000 description 3
229960002896 clonidine Drugs 0.000 description 3
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235000019441 ethanol Nutrition 0.000 description 3
239000007943 implant Substances 0.000 description 3
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WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
241000700159 Rattus Species 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
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WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
239000004005 microsphere Substances 0.000 description 2
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239000000843 powder Substances 0.000 description 2
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
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PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
YZOUYRAONFXZSI-SBHWVFSVSA-N (1S,3R,5R,6R,8R,10R,11R,13R,15R,16R,18R,20R,21R,23R,25R,26R,28R,30R,31S,33R,35R,36R,37S,38R,39S,40R,41S,42R,43S,44R,45S,46R,47S,48R,49S)-5,10,15,20,25,30,35-heptakis(hydroxymethyl)-37,39,40,41,42,43,44,45,46,47,48,49-dodecamethoxy-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,38-diol Chemical compound O([C@@H]([C@H]([C@@H]1OC)OC)O[C@H]2[C@@H](O)[C@@H]([C@@H](O[C@@H]3[C@@H](CO)O[C@@H]([C@H]([C@@H]3O)OC)O[C@@H]3[C@@H](CO)O[C@@H]([C@H]([C@@H]3OC)OC)O[C@@H]3[C@@H](CO)O[C@@H]([C@H]([C@@H]3OC)OC)O[C@@H]3[C@@H](CO)O[C@@H]([C@H]([C@@H]3OC)OC)O3)O[C@@H]2CO)OC)[C@H](CO)[C@H]1O[C@@H]1[C@@H](OC)[C@H](OC)[C@H]3[C@@H](CO)O1 YZOUYRAONFXZSI-SBHWVFSVSA-N 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
102000009132 CB1 Cannabinoid Receptor Human genes 0.000 description 1
108010073366 CB1 Cannabinoid Receptor Proteins 0.000 description 1
229940123158 Cannabinoid CB1 receptor antagonist Drugs 0.000 description 1
102000018208 Cannabinoid Receptor Human genes 0.000 description 1
108050007331 Cannabinoid receptor Proteins 0.000 description 1
102100033868 Cannabinoid receptor 1 Human genes 0.000 description 1
UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
208000017667 Chronic Disease Diseases 0.000 description 1
239000004097 EU approved flavor enhancer Substances 0.000 description 1
208000030814 Eating disease Diseases 0.000 description 1
208000019454 Feeding and Eating disease Diseases 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
229920003081 Povidone K 30 Polymers 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
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239000002830 appetite depressant Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
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235000014632 disordered eating Nutrition 0.000 description 1
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150000002148 esters Chemical class 0.000 description 1
235000019264 food flavour enhancer Nutrition 0.000 description 1
GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 description 1
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229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
238000002347 injection Methods 0.000 description 1
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238000007918 intramuscular administration Methods 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
229960001375 lactose Drugs 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
238000000034 method Methods 0.000 description 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
229960002216 methylparaben Drugs 0.000 description 1
239000003094 microcapsule Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
235000013615 non-nutritive sweetener Nutrition 0.000 description 1
239000012053 oil suspension Substances 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
229940124531 pharmaceutical excipient Drugs 0.000 description 1
239000006187 pill Substances 0.000 description 1
229940068196 placebo Drugs 0.000 description 1
239000000902 placebo Substances 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229940068968 polysorbate 80 Drugs 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
230000008092 positive effect Effects 0.000 description 1
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
229960003415 propylparaben Drugs 0.000 description 1
239000004089 psychotropic agent Substances 0.000 description 1
150000003217 pyrazoles Chemical class 0.000 description 1
229940044551 receptor antagonist Drugs 0.000 description 1
239000002464 receptor antagonist Substances 0.000 description 1
230000003893 regulation of appetite Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
230000005586 smoking cessation Effects 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000019669 taste disorders Nutrition 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SK1129-2002A 2000-02-09 2001-02-07 Použitie N-piperidino-5-(4-chlórfenyl)-1-(2,4-dichlórfenyl)-4- metylpyrazol-3-karboxamidu na prípravu liečebných prostriedkov, farmaceutická kompozícia a súprava s jeho obsahom SK284952B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0001682A FR2804604B1 (fr)	2000-02-09	2000-02-09	Utilisation d'un antagoniste des recepteurs aux cannabinoides centraux pour la preparation de medicaments utiles pour faciliter l'arret de la consommation de tabac
PCT/FR2001/000356 WO2001058450A2 (fr)	2000-02-09	2001-02-07	Utilisation d'un antagoniste des recepteurs aux cannabinoides centraux pour la preparation de medicaments utiles pour faciliter l'arret de la consommation de tabac

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SK11292002A3 SK11292002A3 (sk)	2003-02-04
SK284952B6 true SK284952B6 (sk)	2006-03-02

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SK1129-2002A SK284952B6 (sk)	2000-02-09	2001-02-07	Použitie N-piperidino-5-(4-chlórfenyl)-1-(2,4-dichlórfenyl)-4- metylpyrazol-3-karboxamidu na prípravu liečebných prostriedkov, farmaceutická kompozícia a súprava s jeho obsahom

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US (2)	US6930122B2 (ru)
EP (1)	EP1257275B1 (ru)
JP (2)	JP2003522145A (ru)
CN (1)	CN1250220C (ru)
AR (1)	AR028505A1 (ru)
AT (1)	ATE292467T1 (ru)
AU (1)	AU781827B2 (ru)
BG (2)	BG110386A (ru)
BR (1)	BR0108126A (ru)
CA (1)	CA2397262C (ru)
CZ (1)	CZ296685B6 (ru)
DE (1)	DE60109903T2 (ru)
DK (1)	DK1257275T3 (ru)
EE (1)	EE04836B1 (ru)
ES (1)	ES2240416T3 (ru)
FR (1)	FR2804604B1 (ru)
HU (1)	HU225328B1 (ru)
IL (1)	IL150710A0 (ru)
IS (1)	IS6450A (ru)
MX (1)	MXPA02007766A (ru)
NO (1)	NO324521B1 (ru)
NZ (1)	NZ519924A (ru)
PL (1)	PL201685B1 (ru)
PT (1)	PT1257275E (ru)
RS (1)	RS50404B (ru)
RU (1)	RU2257207C2 (ru)
SI (1)	SI1257275T1 (ru)
SK (1)	SK284952B6 (ru)
TW (1)	TWI243677B (ru)
UA (1)	UA72783C2 (ru)
WO (1)	WO2001058450A2 (ru)
ZA (1)	ZA200205317B (ru)

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2000
- 2000-02-09 FR FR0001682A patent/FR2804604B1/fr not_active Expired - Fee Related
2001
- 2001-02-07 JP JP2001557560A patent/JP2003522145A/ja not_active Ceased
- 2001-02-07 MX MXPA02007766A patent/MXPA02007766A/es active IP Right Grant
- 2001-02-07 SK SK1129-2002A patent/SK284952B6/sk not_active IP Right Cessation
- 2001-02-07 ES ES01907722T patent/ES2240416T3/es not_active Expired - Lifetime
- 2001-02-07 CN CNB018047130A patent/CN1250220C/zh not_active Expired - Fee Related
- 2001-02-07 HU HU0300237A patent/HU225328B1/hu not_active IP Right Cessation
- 2001-02-07 BR BR0108126-8A patent/BR0108126A/pt not_active Application Discontinuation
- 2001-02-07 NZ NZ519924A patent/NZ519924A/en unknown
- 2001-02-07 DK DK01907722T patent/DK1257275T3/da active
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- 2001-02-07 AT AT01907722T patent/ATE292467T1/de not_active IP Right Cessation
- 2001-02-07 DE DE60109903T patent/DE60109903T2/de not_active Expired - Fee Related
- 2001-02-07 US US10/203,077 patent/US6930122B2/en not_active Expired - Fee Related
- 2001-02-07 SI SI200130365T patent/SI1257275T1/xx unknown
- 2001-02-07 WO PCT/FR2001/000356 patent/WO2001058450A2/fr not_active Ceased
- 2001-02-07 EE EEP200200439A patent/EE04836B1/xx not_active IP Right Cessation
- 2001-02-07 PT PT01907722T patent/PT1257275E/pt unknown
- 2001-02-07 EP EP01907722A patent/EP1257275B1/fr not_active Expired - Lifetime
- 2001-02-07 AU AU35620/01A patent/AU781827B2/en not_active Ceased
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- 2001-02-07 CZ CZ20022698A patent/CZ296685B6/cs not_active IP Right Cessation
- 2001-02-09 AR ARP010100587A patent/AR028505A1/es unknown
- 2001-02-19 TW TW090102783A patent/TWI243677B/zh active
- 2001-07-02 UA UA2002075476A patent/UA72783C2/uk unknown
2002
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- 2002-07-03 ZA ZA200205317A patent/ZA200205317B/en unknown
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2005
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Publication number	Publication date
CA2397262A1 (en)	2001-08-16
ATE292467T1 (de)	2005-04-15
BR0108126A (pt)	2003-01-28
WO2001058450A3 (fr)	2002-04-25
EE04836B1 (et)	2007-06-15
NO20023765D0 (no)	2002-08-08
BG110386A (en)	2009-09-30
FR2804604A1 (fr)	2001-08-10
DK1257275T3 (da)	2005-08-08
CZ296685B6 (cs)	2006-05-17
HU225328B1 (en)	2006-09-28
AU3562001A (en)	2001-08-20
PL201685B1 (pl)	2009-04-30
TWI243677B (en)	2005-11-21
EE200200439A (et)	2003-12-15
CA2397262C (en)	2007-09-11
IS6450A (is)	2002-06-28
EP1257275A2 (fr)	2002-11-20
JP2003522145A (ja)	2003-07-22
US20050187253A1 (en)	2005-08-25
RU2002118309A (ru)	2004-02-20
JP2010018622A (ja)	2010-01-28
EP1257275B1 (fr)	2005-04-06
CN1406128A (zh)	2003-03-26
PT1257275E (pt)	2005-07-29
SI1257275T1 (en)	2005-10-31
UA72783C2 (en)	2005-04-15
BG65856B1 (bg)	2010-03-31
BG106946A (bg)	2003-05-30
IL150710A0 (en)	2003-02-12
PL358221A1 (en)	2004-08-09
US20030087933A1 (en)	2003-05-08
CN1250220C (zh)	2006-04-12
AR028505A1 (es)	2003-05-14
DE60109903T2 (de)	2006-02-09
NO324521B1 (no)	2007-11-12
NO20023765L (no)	2002-10-09
RU2257207C2 (ru)	2005-07-27
ZA200205317B (en)	2003-09-04
FR2804604B1 (fr)	2005-05-27
RS50404B (sr)	2009-12-31
NZ519924A (en)	2005-01-28
HUP0300237A2 (hu)	2003-07-28
WO2001058450A2 (fr)	2001-08-16
AU781827B2 (en)	2005-06-16
HUP0300237A3 (en)	2003-09-29
CZ20022698A3 (cs)	2002-11-13
HK1051140A1 (en)	2003-07-25
US6930122B2 (en)	2005-08-16
YU59002A (sh)	2005-07-19
SK11292002A3 (sk)	2003-02-04
DE60109903D1 (de)	2005-05-12
MXPA02007766A (es)	2002-10-11
ES2240416T3 (es)	2005-10-16

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US6930122B2 (en)	2005-08-16	Use of central cannabinoid receptor antagonist for preparing medicines designed to facilitate smoking cessation
SK99799A3 (en)	2000-06-12	Use of central cannabinoid receptor antagonists for regulating appetence
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US20080227818A1 (en)	2008-09-18	Use of saredutant or its pharmaceutically acceptable salts in the treatment of mixed anxiety-depression disorders
JP2007518755A (ja)	2007-07-12	モノアミン神経伝達物質再取り込み阻害剤及びｎ−メチル−ｄ−アスパラギン酸（ｎｍｄａ）受容体アンタゴニストを含む医薬組成物
EP0884054B9 (en)	2007-02-14	Fixed-dose association of an angiotensin-converting enzyme inhibitor and of a calcium channel antagonist for the treatment of cardiovascular illnesses
HK1051140B (en)	2005-09-23	Use of central cannabinoid receptor antagonist for preparing medicines designed to facilitate smoking cessation
MXPA06008113A (en)	2007-04-10	Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist
HK1102368A (en)	2007-11-16	Use of an antagonist of cb1 receivers associated with a beta3-agonist for preparing medication to be used for treating appetence

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Date	Code	Title	Description
2010-11-08	MM4A	Patent lapsed due to non-payment of maintenance fees	Effective date: 20100207