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SI3986561T1 - Pirido(2,3-d)pirimidinski derivati kot zaviralci podvojevanja virusa humane imunske pomanjkljivosti - Google Patents

Pirido(2,3-d)pirimidinski derivati kot zaviralci podvojevanja virusa humane imunske pomanjkljivosti

Info

Publication number
SI3986561T1
SI3986561T1 SI202030385T SI202030385T SI3986561T1 SI 3986561 T1 SI3986561 T1 SI 3986561T1 SI 202030385 T SI202030385 T SI 202030385T SI 202030385 T SI202030385 T SI 202030385T SI 3986561 T1 SI3986561 T1 SI 3986561T1
Authority
SI
Slovenia
Prior art keywords
pyrido
inhibitors
immunodeficiency virus
human immunodeficiency
virus replication
Prior art date
Application number
SI202030385T
Other languages
English (en)
Inventor
Eric P Gillis
Christiana Iwuagwu
Original Assignee
VIIV Healthcare UK (No.5) Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by VIIV Healthcare UK (No.5) Limited filed Critical VIIV Healthcare UK (No.5) Limited
Publication of SI3986561T1 publication Critical patent/SI3986561T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI202030385T 2019-06-19 2020-06-17 Pirido(2,3-d)pirimidinski derivati kot zaviralci podvojevanja virusa humane imunske pomanjkljivosti SI3986561T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962863406P 2019-06-19 2019-06-19
EP20743783.1A EP3986561B1 (en) 2019-06-19 2020-06-17 Pyrido[2,3-d]pyrimidine derivatives as inhibitors of human immunodeficiency virus replication
PCT/IB2020/055653 WO2020254985A1 (en) 2019-06-19 2020-06-17 Pyrido[2,3-d]pyrimidine derivatives as inhibitors of human immunodeficiency virus replication

Publications (1)

Publication Number Publication Date
SI3986561T1 true SI3986561T1 (sl) 2024-04-30

Family

ID=71738195

Family Applications (1)

Application Number Title Priority Date Filing Date
SI202030385T SI3986561T1 (sl) 2019-06-19 2020-06-17 Pirido(2,3-d)pirimidinski derivati kot zaviralci podvojevanja virusa humane imunske pomanjkljivosti

Country Status (34)

Country Link
US (2) US12129255B2 (sl)
EP (1) EP3986561B1 (sl)
JP (1) JP7628512B2 (sl)
KR (1) KR20220024608A (sl)
CN (2) CN114245795B (sl)
AR (1) AR119174A1 (sl)
AU (1) AU2020295793B2 (sl)
BR (1) BR112021025655A2 (sl)
CA (1) CA3143136A1 (sl)
CL (1) CL2021003388A1 (sl)
CO (1) CO2021017479A2 (sl)
CR (1) CR20210664A (sl)
DK (1) DK3986561T3 (sl)
ES (1) ES2974541T3 (sl)
FI (1) FI3986561T3 (sl)
HR (1) HRP20240501T1 (sl)
HU (1) HUE065762T2 (sl)
IL (1) IL288750B2 (sl)
LT (1) LT3986561T (sl)
MA (1) MA56526B1 (sl)
MD (1) MD3986561T2 (sl)
MX (1) MX2021016149A (sl)
MY (1) MY206712A (sl)
PE (1) PE20220510A1 (sl)
PH (1) PH12021553180A1 (sl)
PL (1) PL3986561T3 (sl)
PT (1) PT3986561T (sl)
RS (1) RS65304B1 (sl)
SI (1) SI3986561T1 (sl)
SM (1) SMT202400153T1 (sl)
TW (1) TWI850403B (sl)
UA (1) UA128967C2 (sl)
UY (1) UY38755A (sl)
WO (1) WO2020254985A1 (sl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7398448B2 (ja) 2018-10-24 2023-12-14 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド ヒト免疫不全ウイルス複製の阻害剤
PE20220510A1 (es) 2019-06-19 2022-04-07 Viiv Healthcare Uk No 5 Ltd Inhibidores de la replicacion del virus de inmunodeficiencia humana
US12415771B2 (en) 2019-06-19 2025-09-16 Nmd Pharma A/S Compounds for the treatment of neuromuscular disorders
US20220347174A1 (en) * 2019-10-01 2022-11-03 Viiv Healthcare Company Method for treating HIV with Cabotegravir and Rilpivirine
AU2020402659A1 (en) * 2019-12-09 2022-06-02 Viiv Healthcare Company Pharmaceutical compositions comprising cabotegravir
KR20220151655A (ko) * 2020-03-06 2022-11-15 비브 헬스케어 유케이 (넘버5) 리미티드 인간 면역결핍 바이러스 복제의 억제제
CN115397424A (zh) * 2020-04-15 2022-11-25 Viiv保健英国第五有限公司 人类免疫缺陷病毒复制的抑制剂
JP2024535596A (ja) * 2021-10-13 2024-09-30 ビーブ、ヘルスケア、ユーケー、（ナンバー５）、リミテッド ヒト免疫不全ウイルス複製の阻害薬
WO2024249592A1 (en) 2023-05-31 2024-12-05 Gilead Sciences, Inc. Quinazolinyl-indazole derivatives as therapeutic compounds for hiv
AR132951A1 (es) 2023-06-15 2025-08-13 Viiv Healthcare Uk No 5 Ltd Métodos e intermedios para preparar compuestos
WO2025169059A1 (en) 2024-02-05 2025-08-14 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030079979A (ko) 2001-02-02 2003-10-10 브리스톨-마이어스스퀴브컴파니 치환된 아자인돌옥소아세틱 피페라진 유도체의 조성물 및항바이러스 활성
US20030207910A1 (en) 2001-02-02 2003-11-06 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
AU2009266421B2 (en) * 2008-07-02 2013-07-11 Avexa Limited Compounds having antiviral properties
CN102464654B (zh) 2010-11-12 2016-01-13 上海泓博智源医药技术有限公司 抗病毒化合物
ES2553449T3 (es) 2011-07-06 2015-12-09 Gilead Sciences, Inc. Compuestos para el tratamiento de VIH
CN102863512B (zh) 2011-07-07 2016-04-20 上海泓博智源医药技术有限公司 抗病毒化合物
EP2943487B1 (en) 2013-01-09 2016-11-16 Gilead Sciences, Inc. 5-membered heteroaryls and their use as antiviral agents
EP2943493B1 (en) 2013-01-09 2017-08-02 Gilead Sciences, Inc. Therapeutic compounds for the treatment of viral infections
TW201443037A (zh) 2013-01-09 2014-11-16 Gilead Sciences Inc 治療用化合物
TWI694071B (zh) 2013-03-01 2020-05-21 美商基利科學股份有限公司 治療反轉錄病毒科(Retroviridae)病毒感染之治療性化合物
WO2015130966A1 (en) 2014-02-28 2015-09-03 Gilead Sciences, Inc. Antiviral agents
US10202353B2 (en) 2014-02-28 2019-02-12 Gilead Sciences, Inc. Therapeutic compounds
EP3186239B1 (en) 2014-08-29 2018-10-10 Gilead Sciences, Inc. Antiretroviral agents
EP3597646B1 (en) 2016-08-19 2023-06-21 Gilead Sciences, Inc. Therapeutic compounds useful for the prophylactic or therapeutic treatment of an hiv virus infection
ES2826748T3 (es) * 2016-09-02 2021-05-19 Gilead Sciences Inc Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll
UY37710A (es) * 2017-05-02 2018-11-30 Viiv Healthcare Uk No 5 Ltd Inhibidores de la replicación del virus de la inmunodeficiencia humana
JP7398448B2 (ja) * 2018-10-24 2023-12-14 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド ヒト免疫不全ウイルス複製の阻害剤
UY38559A (es) 2019-02-01 2020-07-31 Viiv Healthcare Uk No 5 Ltd Inhibidores de la replicación del virus de la inmunodeficiencia humana
PE20220510A1 (es) 2019-06-19 2022-04-07 Viiv Healthcare Uk No 5 Ltd Inhibidores de la replicacion del virus de inmunodeficiencia humana

Also Published As

Publication number Publication date
MA56526B1 (fr) 2024-05-31
US20210323967A1 (en) 2021-10-21
AU2020295793A1 (en) 2022-01-20
US12129255B2 (en) 2024-10-29
MA56526A (fr) 2022-04-27
RS65304B1 (sr) 2024-04-30
LT3986561T (lt) 2024-04-25
EP3986561A1 (en) 2022-04-27
MY206712A (en) 2025-01-03
CN119039288A (zh) 2024-11-29
FI3986561T3 (fi) 2024-05-02
IL288750B1 (en) 2024-12-01
MD3986561T2 (ro) 2024-06-30
PT3986561T (pt) 2024-03-15
MX2021016149A (es) 2022-05-18
JP7628512B2 (ja) 2025-02-10
US20250019383A1 (en) 2025-01-16
UY38755A (es) 2020-11-30
UA128967C2 (uk) 2024-12-11
PE20220510A1 (es) 2022-04-07
DK3986561T3 (da) 2024-03-04
HUE065762T2 (hu) 2024-06-28
CN114245795B (zh) 2024-08-06
JP2022537047A (ja) 2022-08-23
HRP20240501T1 (hr) 2024-07-05
CR20210664A (es) 2022-01-21
KR20220024608A (ko) 2022-03-03
CL2021003388A1 (es) 2022-09-30
IL288750B2 (en) 2025-04-01
ES2974541T3 (es) 2024-06-27
CA3143136A1 (en) 2020-12-24
PL3986561T3 (pl) 2024-06-10
EP3986561B1 (en) 2024-02-14
IL288750A (en) 2022-02-01
PH12021553180A1 (en) 2022-11-07
BR112021025655A2 (pt) 2022-02-01
AR119174A1 (es) 2021-12-01
TWI850403B (zh) 2024-08-01
AU2020295793B2 (en) 2023-07-06
SMT202400153T1 (it) 2024-05-14
CO2021017479A2 (es) 2022-04-19
CN114245795A (zh) 2022-03-25
TW202115055A (zh) 2021-04-16
WO2020254985A1 (en) 2020-12-24

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