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SG10201810361TA - 4'-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus rna replication - Google Patents

4'-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus rna replication

Info

Publication number
SG10201810361TA
SG10201810361TA SG10201810361TA SG10201810361TA SG10201810361TA SG 10201810361T A SG10201810361T A SG 10201810361TA SG 10201810361T A SG10201810361T A SG 10201810361TA SG 10201810361T A SG10201810361T A SG 10201810361TA SG 10201810361T A SG10201810361T A SG 10201810361TA
Authority
SG
Singapore
Prior art keywords
inhibitors
respiratory syncytial
syncytial virus
virus rna
rna replication
Prior art date
Application number
SG10201810361TA
Inventor
Mark Smith
Klaus G Klumpp
Original Assignee
Riboscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riboscience Llc filed Critical Riboscience Llc
Publication of SG10201810361TA publication Critical patent/SG10201810361TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

4'-Vinyl Substituted Nucleoside Derivatives As Inhibitors Of Respiratory Syncytial Virus RNA Replication The application discloses compounds of Formula I wherein the variable substituents are as defined herein. The compounds of Formula I and pharmaceutical compositions comprising compounds of Formula I are useful for the treatment of diseases mediated by RSV. O Base Rz Rx Ry O I Rw Y [No Available Figure]
SG10201810361TA 2014-09-26 2015-09-25 4'-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus rna replication SG10201810361TA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462055704P 2014-09-26 2014-09-26

Publications (1)

Publication Number Publication Date
SG10201810361TA true SG10201810361TA (en) 2018-12-28

Family

ID=55582038

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201702430WA SG11201702430WA (en) 2014-09-26 2015-09-25 4'-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus rna replication
SG10201810361TA SG10201810361TA (en) 2014-09-26 2015-09-25 4'-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus rna replication

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201702430WA SG11201702430WA (en) 2014-09-26 2015-09-25 4'-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus rna replication

Country Status (20)

Country Link
US (1) US10358458B2 (en)
EP (1) EP3197457B1 (en)
JP (1) JP6671355B2 (en)
KR (1) KR102573609B1 (en)
CN (1) CN107073002B (en)
AU (1) AU2015320511B2 (en)
BR (1) BR112017006264A2 (en)
CA (1) CA2962770C (en)
CL (1) CL2017000707A1 (en)
CO (1) CO2017003994A2 (en)
CR (1) CR20170157A (en)
EA (1) EA031726B1 (en)
IL (1) IL251368B (en)
MA (1) MA40149A1 (en)
MX (1) MX381291B (en)
PE (1) PE20170698A1 (en)
PH (1) PH12017500558A1 (en)
SG (2) SG11201702430WA (en)
WO (1) WO2016049415A1 (en)
ZA (1) ZA201702858B (en)

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EP3197457B1 (en) 2014-09-26 2022-11-09 Riboscience LLC 4'-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus rna replication
KR20210145787A (en) * 2019-04-02 2021-12-02 알리고스 테라퓨틱스 인코포레이티드 Compounds targeting PRMT5
US20230123911A1 (en) * 2020-01-31 2023-04-20 Octagon Therapeutics, Inc. Modulation of immune cells
CN112194694B (en) * 2020-09-29 2022-03-25 佛山科学技术学院 Urodylate phenylpropionate phosphoramidate compound, pharmaceutical composition thereof, and preparation method and application thereof
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors
PE20250684A1 (en) 2022-03-15 2025-03-04 Rome Therapeutics Inc COMPOUNDS AND METHODS FOR THE TREATMENT OF DISEASES
WO2024103016A1 (en) * 2022-11-11 2024-05-16 Rome Therapeutics, Inc. 4'-halomethyl-cytidine phosphoramidates and related compounds and their use in treating medical conditions

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Also Published As

Publication number Publication date
EP3197457A4 (en) 2018-08-01
PE20170698A1 (en) 2017-06-05
KR102573609B1 (en) 2023-08-31
CR20170157A (en) 2017-07-03
JP6671355B2 (en) 2020-03-25
ZA201702858B (en) 2018-08-29
PH12017500558A1 (en) 2017-08-30
EA031726B1 (en) 2019-02-28
CN107073002A (en) 2017-08-18
SG11201702430WA (en) 2017-04-27
CN107073002B (en) 2019-10-15
IL251368B (en) 2020-05-31
CL2017000707A1 (en) 2017-12-15
MA40149A1 (en) 2019-04-30
MX2017003788A (en) 2017-08-07
EA201790632A1 (en) 2017-09-29
AU2015320511A1 (en) 2017-05-04
AU2015320511B2 (en) 2020-11-12
JP2017529375A (en) 2017-10-05
US20160264611A1 (en) 2016-09-15
US10358458B2 (en) 2019-07-23
MX381291B (en) 2025-03-12
WO2016049415A1 (en) 2016-03-31
NZ730923A (en) 2020-09-25
CA2962770C (en) 2023-08-22
EP3197457A1 (en) 2017-08-02
CA2962770A1 (en) 2016-03-31
BR112017006264A2 (en) 2017-12-12
EP3197457B1 (en) 2022-11-09
IL251368A0 (en) 2017-05-29
KR20170062499A (en) 2017-06-07
CO2017003994A2 (en) 2017-07-11

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