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SI3303339T1 - Zaviralci PDE9 z imidazo triazinonskim ogrodjem in imidazo pirazinonskim ogrodjem za zdravljenje perifernih bolezni - Google Patents

Zaviralci PDE9 z imidazo triazinonskim ogrodjem in imidazo pirazinonskim ogrodjem za zdravljenje perifernih bolezni

Info

Publication number
SI3303339T1
SI3303339T1 SI201631145T SI201631145T SI3303339T1 SI 3303339 T1 SI3303339 T1 SI 3303339T1 SI 201631145 T SI201631145 T SI 201631145T SI 201631145 T SI201631145 T SI 201631145T SI 3303339 T1 SI3303339 T1 SI 3303339T1
Authority
SI
Slovenia
Prior art keywords
backbone
imidazo
treatment
triazinone
pyrazinone
Prior art date
Application number
SI201631145T
Other languages
English (en)
Inventor
Niels Svenstrup
Kate Wen
Yazhou Wang
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of SI3303339T1 publication Critical patent/SI3303339T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI201631145T 2015-07-07 2016-07-06 Zaviralci PDE9 z imidazo triazinonskim ogrodjem in imidazo pirazinonskim ogrodjem za zdravljenje perifernih bolezni SI3303339T1 (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA201500393 2015-07-07
DKPA201500407 2015-07-10
DKPA201600209 2016-04-07
EP16734707.9A EP3303339B1 (en) 2015-07-07 2016-07-06 Pde9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases
PCT/EP2016/065964 WO2017005786A1 (en) 2015-07-07 2016-07-06 Pde9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases

Publications (1)

Publication Number Publication Date
SI3303339T1 true SI3303339T1 (sl) 2021-05-31

Family

ID=56345156

Family Applications (2)

Application Number Title Priority Date Filing Date
SI201631793T SI3865484T1 (sl) 2015-07-07 2016-07-06 Zaviralec pde9 z imidazo pirazinonsko hrbtenico za zdravljenje perifernih bolezni
SI201631145T SI3303339T1 (sl) 2015-07-07 2016-07-06 Zaviralci PDE9 z imidazo triazinonskim ogrodjem in imidazo pirazinonskim ogrodjem za zdravljenje perifernih bolezni

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI201631793T SI3865484T1 (sl) 2015-07-07 2016-07-06 Zaviralec pde9 z imidazo pirazinonsko hrbtenico za zdravljenje perifernih bolezni

Country Status (20)

Country Link
US (5) US10513524B2 (sl)
EP (3) EP4335497A3 (sl)
CN (2) CN112010861B (sl)
AU (2) AU2016289856B2 (sl)
BR (1) BR112018000254A2 (sl)
CA (1) CA2990521C (sl)
DK (2) DK3303339T3 (sl)
ES (2) ES2971969T3 (sl)
FI (1) FI3865484T3 (sl)
HR (2) HRP20240082T1 (sl)
HU (2) HUE053968T2 (sl)
IL (2) IL280619B2 (sl)
LT (1) LT3865484T (sl)
MX (1) MX379456B (sl)
PL (1) PL3865484T3 (sl)
PT (1) PT3865484T (sl)
SI (2) SI3865484T1 (sl)
TN (1) TN2017000507A1 (sl)
WO (1) WO2017005786A1 (sl)
ZA (1) ZA201708341B (sl)

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US10513524B2 (en) 2015-07-07 2019-12-24 H. Lundbeck A/S PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases
CA3025586A1 (en) * 2016-07-06 2018-01-11 Imara, Inc. Pde9 inhibitors for treatment of peripheral diseases
RS65143B1 (sr) * 2017-05-26 2024-02-29 Cardurion Pharmaceuticals Inc Postupci izrade i upotrebe pde9 inhibitora
WO2018224455A1 (en) 2017-06-07 2018-12-13 Basf Se Substituted cyclopropyl derivatives
WO2018234488A1 (en) 2017-06-23 2018-12-27 Basf Se Substituted cyclopropyl derivatives
JP2021526134A (ja) * 2018-05-25 2021-09-30 イマラ インク. 6−[(3S,4S)−4−メチル−l−(ピリミジン−2−イルメチル)ピロリジン−3−イル]−3−テトラヒドロピラン−4−イル−7H−イミダゾ[l,5−A]ピラジン−8−オンの一水和物および結晶形態
KR20250108770A (ko) * 2018-08-31 2025-07-15 카듀리온 파마슈티칼스, 인크. 겸상 세포 질환의 치료를 위한 pde9 억제제
CA3136128A1 (en) * 2019-04-05 2020-10-08 Imara Inc. Pde9 inhibitors for treating sickle cell disease
CN114072151A (zh) * 2019-05-07 2022-02-18 伊马拉公司 用于治疗地中海贫血的pde9抑制剂
BR112022021854A2 (pt) 2020-04-29 2022-12-20 Relay Therapeutics Inc Inibidores de fosfatidilinositol 3-quinase alfa e mé-todos de uso dos mesmos
WO2022036111A1 (en) * 2020-08-13 2022-02-17 Imara Inc. Methods and compositions for treating sickle cell disease
CN112552339A (zh) * 2020-12-10 2021-03-26 安徽昊帆生物有限公司 一种o-二苯基磷酰羟胺的制备方法
CA3225285A1 (en) * 2021-07-13 2023-01-19 Alessandro Boezio Pi3k.alpha. inhibitors and methods of use thereof
CN115448864B (zh) * 2022-08-26 2023-12-22 上海方予健康医药科技有限公司 3-氟-3-(1-羟乙基)吡咯烷-1-羧酸叔丁酯的制备方法
CN120676939A (zh) * 2023-01-13 2025-09-19 传达治疗有限公司 Pi3k抑制剂及其制备和使用方法

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