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SI3204398T1 - Postopki ločevanja diastereoizomerov gemcitabin-fosfata - Google Patents

Postopki ločevanja diastereoizomerov gemcitabin-fosfata

Info

Publication number
SI3204398T1
SI3204398T1 SI201531226T SI201531226T SI3204398T1 SI 3204398 T1 SI3204398 T1 SI 3204398T1 SI 201531226 T SI201531226 T SI 201531226T SI 201531226 T SI201531226 T SI 201531226T SI 3204398 T1 SI3204398 T1 SI 3204398T1
Authority
SI
Slovenia
Prior art keywords
gemcitabine
separating
methods
phosphate diastereoisomers
diastereoisomers
Prior art date
Application number
SI201531226T
Other languages
English (en)
Inventor
Hugh Griffith
Original Assignee
NuCana plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NuCana plc filed Critical NuCana plc
Publication of SI3204398T1 publication Critical patent/SI3204398T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SI201531226T 2014-10-06 2015-09-29 Postopki ločevanja diastereoizomerov gemcitabin-fosfata SI3204398T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1417644.0A GB201417644D0 (en) 2014-10-06 2014-10-06 Method of separating phosphate diastereoisomers
EP15782005.1A EP3204398B1 (en) 2014-10-06 2015-09-29 Methods of separating gemcitabine-phosphate diastereoisomers
PCT/GB2015/052839 WO2016055769A1 (en) 2014-10-06 2015-09-29 Methods of separating gemcitabine-phosphate diastereoisomers

Publications (1)

Publication Number Publication Date
SI3204398T1 true SI3204398T1 (sl) 2020-09-30

Family

ID=51946917

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201531226T SI3204398T1 (sl) 2014-10-06 2015-09-29 Postopki ločevanja diastereoizomerov gemcitabin-fosfata

Country Status (30)

Country Link
US (1) US10669300B2 (sl)
EP (2) EP3204398B1 (sl)
JP (2) JP6893172B2 (sl)
KR (1) KR102532498B1 (sl)
CN (2) CN107108682B (sl)
AU (2) AU2015329767B2 (sl)
CA (1) CA2959977C (sl)
CL (1) CL2017000819A1 (sl)
CY (1) CY1123061T1 (sl)
DK (1) DK3204398T3 (sl)
EA (1) EA033118B1 (sl)
ES (1) ES2793957T3 (sl)
GB (1) GB201417644D0 (sl)
HR (1) HRP20200849T1 (sl)
HU (1) HUE050882T2 (sl)
IL (1) IL251125B (sl)
LT (1) LT3204398T (sl)
MA (1) MA41039B1 (sl)
ME (1) ME03730B (sl)
MX (2) MX373944B (sl)
MY (1) MY183302A (sl)
PH (1) PH12017500586A1 (sl)
PL (1) PL3204398T3 (sl)
PT (1) PT3204398T (sl)
RS (1) RS60634B1 (sl)
SG (2) SG10201902952SA (sl)
SI (1) SI3204398T1 (sl)
SM (1) SMT202000410T1 (sl)
WO (1) WO2016055769A1 (sl)
ZA (1) ZA201701723B (sl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0317009D0 (en) * 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
CN104903339A (zh) 2012-11-16 2015-09-09 卡迪夫大学学院顾问有限公司 用于制备核苷前体药物的方法
PL3160978T3 (pl) 2014-06-25 2020-11-30 NuCana plc Proleki gemcytabiny
EA033046B1 (ru) 2014-06-25 2019-08-30 НУКАНА ПиЭлСи Состав, содержащий пролекарство гемцитабина
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
CN106543252A (zh) * 2015-09-16 2017-03-29 博瑞生物医药（苏州）股份有限公司 核苷氨基磷酸酯类前药的制备方法及其中间体
CN106543220A (zh) 2015-09-16 2017-03-29 博瑞生物医药（苏州）股份有限公司 氨基磷酸酯化合物及其制备方法和晶体
CN112156102B (zh) 2015-09-16 2023-10-03 济南高合医疗科技有限公司 一种nuc-1031单一异构体的晶型及其制备方法
WO2017060661A1 (en) 2015-10-05 2017-04-13 Nucana Biomed Limited Combination therapy
SG11201804774YA (en) 2015-12-11 2018-07-30 NuCana plc Diastereoselective synthesis of phosphate derivatives and of the gemcitabine prodrug nuc-1031
GB201522771D0 (en) * 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative
WO2018019188A1 (zh) * 2016-07-23 2018-02-01 博瑞生物医药（苏州）股份有限公司 核苷氨基磷酸酯类前药的多晶型及其制备方法
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
CN107400156B (zh) * 2017-09-19 2020-01-31 北京大学 一种分离麦角甾烷型三萜25r-与25s-差向异构体的方法
CN115028594A (zh) * 2020-06-03 2022-09-09 吴卫东 恩替他滨药用前体化合物及其制备方法和医学用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001058835A1 (en) * 2000-02-11 2001-08-16 Degussa Ag Resolution of dl-racemic mixtures
GB0317009D0 (en) * 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
FR2954310B1 (fr) * 2009-12-18 2014-07-25 Univ Rouen Procede de dedoublement d'enantiomeres par evapocristallisation preferentielle
CN104903339A (zh) 2012-11-16 2015-09-09 卡迪夫大学学院顾问有限公司 用于制备核苷前体药物的方法
WO2014204856A1 (en) 2013-06-17 2014-12-24 Catabasis Pharmaceuticals, Inc. Fatty acid anticancer derivatives and their uses
WO2015081133A2 (en) * 2013-11-27 2015-06-04 Idenix Pharmaceuticals, Inc. Nucleotides for the treatment of liver cancer
PL3160978T3 (pl) 2014-06-25 2020-11-30 NuCana plc Proleki gemcytabiny
EA033046B1 (ru) * 2014-06-25 2019-08-30 НУКАНА ПиЭлСи Состав, содержащий пролекарство гемцитабина
JP6646663B2 (ja) 2014-07-22 2020-02-14 ニューカナ バイオメッド リミテッドＮｕｃａｎａ Ｂｉｏｍｅｄ Ｌｉｍｉｔｅｄ ゲムシタビン−［フェニル（ベンゾキシ−ｌ−アラニニル）］ホスフェートの製造方法リン酸誘導体を製造する方法
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
KR20180021697A (ko) 2015-05-14 2018-03-05 뉴카나 피엘씨 암 치료
WO2017060661A1 (en) 2015-10-05 2017-04-13 Nucana Biomed Limited Combination therapy
SG11201804774YA (en) 2015-12-11 2018-07-30 NuCana plc Diastereoselective synthesis of phosphate derivatives and of the gemcitabine prodrug nuc-1031
CA3008749C (en) 2015-12-23 2024-01-02 NuCana plc Treatment of ovarian cancer or biliary tract cancer with a combination of gemcitabine-(phenyl-benzoxy-l-alaninyl)]-phosphate and cisplatin
CA3008769A1 (en) 2015-12-23 2017-06-29 NuCana plc Combination therapy comprising nuc-1031 and cisplatin
GB201522771D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative

Also Published As

Publication number Publication date
JP6893172B2 (ja) 2021-06-23
AU2020203714A1 (en) 2020-06-25
GB201417644D0 (en) 2014-11-19
AU2015329767B2 (en) 2020-03-12
MX2017004446A (es) 2017-06-19
MX387346B (es) 2025-03-18
EP3725794A1 (en) 2020-10-21
JP2017530172A (ja) 2017-10-12
LT3204398T (lt) 2020-09-10
SMT202000410T1 (it) 2020-09-10
BR112017006855A2 (pt) 2017-12-12
KR102532498B1 (ko) 2023-05-12
PL3204398T3 (pl) 2020-11-16
SG11201701885UA (en) 2017-04-27
HUE050882T2 (hu) 2021-01-28
CN107108682A (zh) 2017-08-29
CY1123061T1 (el) 2021-10-29
CL2017000819A1 (es) 2017-11-03
KR20170090413A (ko) 2017-08-07
EA201790794A1 (ru) 2017-07-31
IL251125B (en) 2020-07-30
AU2015329767A1 (en) 2017-04-13
CN107108682B (zh) 2020-12-18
RS60634B1 (sr) 2020-09-30
EP3204398B1 (en) 2020-05-13
ZA201701723B (en) 2023-11-29
US20170226147A1 (en) 2017-08-10
MY183302A (en) 2021-02-18
CN112552362A (zh) 2021-03-26
PT3204398T (pt) 2020-05-28
WO2016055769A1 (en) 2016-04-14
EP3204398A1 (en) 2017-08-16
CA2959977A1 (en) 2016-04-14
MA41039B1 (fr) 2020-08-31
JP2020128392A (ja) 2020-08-27
ME03730B (me) 2021-01-20
JP6967625B2 (ja) 2021-11-17
ES2793957T3 (es) 2020-11-17
DK3204398T3 (da) 2020-06-02
MX2020003758A (es) 2021-10-26
PH12017500586A1 (en) 2017-08-30
SG10201902952SA (en) 2019-05-30
MX373944B (es) 2020-07-13
AU2020203714B2 (en) 2021-07-22
EA033118B1 (ru) 2019-08-30
CA2959977C (en) 2024-01-02
US10669300B2 (en) 2020-06-02
HRP20200849T1 (hr) 2020-10-30
IL251125A0 (en) 2017-04-30

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