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SI3184527T1 - Spojine 2,6-diokso,-2,3-dihidro-1H-purina uporabne za zdravljenje stanj povezanih z aktivnostjo TRPA1 kanala - Google Patents

Spojine 2,6-diokso,-2,3-dihidro-1H-purina uporabne za zdravljenje stanj povezanih z aktivnostjo TRPA1 kanala

Info

Publication number
SI3184527T1
SI3184527T1 SI200832113T SI200832113T SI3184527T1 SI 3184527 T1 SI3184527 T1 SI 3184527T1 SI 200832113 T SI200832113 T SI 200832113T SI 200832113 T SI200832113 T SI 200832113T SI 3184527 T1 SI3184527 T1 SI 3184527T1
Authority
SI
Slovenia
Prior art keywords
dioxo
dihydro
activity
compounds useful
disorders related
Prior art date
Application number
SI200832113T
Other languages
English (en)
Inventor
Howard Ng
Manfred Weigele
Magdalene Moran
Jayhong Chong
Christopher Fanger
Glenn R. Larsen
Camino Donato Del
Neil Hayward
Steven P. Adams
Amy Ripka
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of SI3184527T1 publication Critical patent/SI3184527T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/105—Persulfides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SI200832113T 2007-06-22 2008-06-23 Spojine 2,6-diokso,-2,3-dihidro-1H-purina uporabne za zdravljenje stanj povezanih z aktivnostjo TRPA1 kanala SI3184527T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94584007P 2007-06-22 2007-06-22
US94586607P 2007-06-22 2007-06-22
EP16195618.0A EP3184527B1 (en) 2007-06-22 2008-06-23 2,6-dioxo,-2,3-dihydro-1h-purine compounds useful for treating disorders related to the activity of the trpa1 channel

Publications (1)

Publication Number Publication Date
SI3184527T1 true SI3184527T1 (sl) 2020-03-31

Family

ID=40186010

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200832113T SI3184527T1 (sl) 2007-06-22 2008-06-23 Spojine 2,6-diokso,-2,3-dihidro-1H-purina uporabne za zdravljenje stanj povezanih z aktivnostjo TRPA1 kanala

Country Status (11)

Country Link
US (3) US8163761B2 (sl)
EP (3) EP3663295A1 (sl)
JP (5) JP2010530901A (sl)
CN (4) CN101801362B (sl)
AU (1) AU2008268463B2 (sl)
CA (2) CA2691468C (sl)
DK (1) DK2170309T3 (sl)
ES (1) ES2609912T3 (sl)
HR (1) HRP20200357T1 (sl)
SI (1) SI3184527T1 (sl)
WO (1) WO2009002933A1 (sl)

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Also Published As

Publication number Publication date
US20180133170A1 (en) 2018-05-17
CN101801362B (zh) 2014-01-22
CA2691468A1 (en) 2008-12-31
US8163761B2 (en) 2012-04-24
JP5932883B2 (ja) 2016-06-08
CN108042542A (zh) 2018-05-18
AU2008268463A2 (en) 2010-02-25
EP3184527B1 (en) 2020-01-29
HRP20200357T1 (hr) 2020-06-12
AU2008268463A1 (en) 2008-12-31
US20130059869A1 (en) 2013-03-07
JP2017165790A (ja) 2017-09-21
JP6258266B2 (ja) 2018-01-10
JP2019147808A (ja) 2019-09-05
JP2015180700A (ja) 2015-10-15
DK2170309T3 (en) 2017-01-09
EP3663295A1 (en) 2020-06-10
CN104825457A (zh) 2015-08-12
CA2962043A1 (en) 2008-12-31
CN103751194A (zh) 2014-04-30
CN103751194B (zh) 2018-01-05
EP2170309B1 (en) 2016-10-26
EP2170309A4 (en) 2010-11-03
US20090143377A1 (en) 2009-06-04
CN104825457B (zh) 2019-11-19
EP3184527A1 (en) 2017-06-28
WO2009002933A1 (en) 2008-12-31
EP2170309A1 (en) 2010-04-07
ES2609912T3 (es) 2017-04-25
CN101801362A (zh) 2010-08-11
CA2691468C (en) 2017-05-09
JP2010530901A (ja) 2010-09-16
AU2008268463B2 (en) 2015-03-05
JP2014141535A (ja) 2014-08-07

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