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SI3148994T1 - Spojine 1, 3, 4-tiadiazola in njihova uporaba v zdravljenju raka - Google Patents

Spojine 1, 3, 4-tiadiazola in njihova uporaba v zdravljenju raka

Info

Publication number
SI3148994T1
SI3148994T1 SI201530403T SI201530403T SI3148994T1 SI 3148994 T1 SI3148994 T1 SI 3148994T1 SI 201530403 T SI201530403 T SI 201530403T SI 201530403 T SI201530403 T SI 201530403T SI 3148994 T1 SI3148994 T1 SI 3148994T1
Authority
SI
Slovenia
Prior art keywords
treating cancer
thiadiazole compounds
thiadiazole
compounds
cancer
Prior art date
Application number
SI201530403T
Other languages
English (en)
Inventor
Maurice Raymond Verschoyle Finlay
Chukuemeka Tennyson Ekwuru
Mark David Charles
Piotr Antoni Raubo
Jonathan James Gordon Winter
Johannes Wilhelmus Maria Nissink
Original Assignee
Astrazeneca Ab
Cancer Research Technology Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Cancer Research Technology Limited filed Critical Astrazeneca Ab
Publication of SI3148994T1 publication Critical patent/SI3148994T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI201530403T 2014-05-30 2015-05-27 Spojine 1, 3, 4-tiadiazola in njihova uporaba v zdravljenju raka SI3148994T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1409624.2A GB201409624D0 (en) 2014-05-30 2014-05-30 1,3,4-thiadiazole compounds and their use in treating cancer
PCT/GB2015/051537 WO2015181539A1 (en) 2014-05-30 2015-05-27 1, 3, 4-thiadiazole compounds and their use in treating cancer
EP15726266.8A EP3148994B1 (en) 2014-05-30 2015-05-27 1, 3, 4-thiadiazole compounds and their use in treating cancer

Publications (1)

Publication Number Publication Date
SI3148994T1 true SI3148994T1 (sl) 2018-12-31

Family

ID=51214473

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201530403T SI3148994T1 (sl) 2014-05-30 2015-05-27 Spojine 1, 3, 4-tiadiazola in njihova uporaba v zdravljenju raka

Country Status (40)

Country Link
US (2) US10040788B2 (sl)
EP (1) EP3148994B1 (sl)
JP (1) JP6538830B2 (sl)
KR (1) KR20170005875A (sl)
CN (1) CN106795150B (sl)
AP (1) AP2016009578A0 (sl)
AR (1) AR100694A1 (sl)
AU (1) AU2015265703B2 (sl)
BR (1) BR112016028002B1 (sl)
CA (1) CA2949598C (sl)
CL (1) CL2016003074A1 (sl)
CR (1) CR20160558A (sl)
CY (1) CY1120836T1 (sl)
DK (1) DK3148994T3 (sl)
DO (1) DOP2016000308A (sl)
EA (1) EA030937B1 (sl)
ES (1) ES2688396T3 (sl)
GB (1) GB201409624D0 (sl)
GT (1) GT201600250A (sl)
HR (1) HRP20181490T1 (sl)
HU (1) HUE039879T2 (sl)
IL (1) IL249020B (sl)
LT (1) LT3148994T (sl)
MX (1) MX2016015738A (sl)
MY (1) MY192861A (sl)
NI (1) NI201600176A (sl)
NZ (1) NZ726790A (sl)
PE (1) PE20170148A1 (sl)
PH (1) PH12016502394A1 (sl)
PL (1) PL3148994T3 (sl)
PT (1) PT3148994T (sl)
RS (1) RS57876B1 (sl)
SG (1) SG11201609880QA (sl)
SI (1) SI3148994T1 (sl)
SM (1) SMT201800516T1 (sl)
SV (1) SV2016005330A (sl)
TN (1) TN2016000511A1 (sl)
TW (1) TWI693220B (sl)
UY (1) UY36145A (sl)
WO (1) WO2015181539A1 (sl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201520959D0 (en) * 2015-11-27 2016-01-13 Astrazeneca Ab And Cancer Res Technology Ltd Bis-pyridazine compounds and their use in treating cancer
US9938265B2 (en) 2015-11-30 2018-04-10 Astrazeneca Ab 1,3,4-thiadiazole compounds and their use in treating cancer
TW201733587A (zh) * 2015-11-30 2017-10-01 阿斯特捷利康公司 1,3,4-噻二唑化合物及其在治療癌症中之用途
TW201731511A (zh) * 2015-11-30 2017-09-16 阿斯特捷利康公司 １，３，４-噻二唑化合物及其在治療癌症中之用途
ES2903182T3 (es) * 2017-06-13 2022-03-31 Medshine Discovery Inc Compuesto como inhibidor GLS1
JP2019064976A (ja) * 2017-10-03 2019-04-25 国立大学法人 熊本大学 抗がん剤
WO2020078350A1 (zh) * 2018-10-16 2020-04-23 南京明德新药研发有限公司 噻二唑衍生物及其作为gls1抑制剂的应用
SG11202109451TA (en) * 2019-03-05 2021-09-29 Astrazeneca Ab Fused tricyclic compounds useful as anticancer agents
WO2024233839A1 (en) * 2023-05-10 2024-11-14 Leal Therapeutics, Inc. Small molecule inhibitors of glutaminase
CN116854582B (zh) * 2023-07-10 2025-08-29 泰州葛林美克医药科技有限公司 一种对映纯α-甲氧基苯乙酸的制备方法
CN117003745B (zh) * 2023-07-20 2024-06-07 南京市第一医院 Gls1/hdac双靶点抑制剂及其合成方法和应用
WO2025196447A1 (en) 2024-03-22 2025-09-25 Sitryx Therapeutics Limited Thiadiazoles as glutaminase 1 inhibitors
WO2025196446A1 (en) 2024-03-22 2025-09-25 Sitryx Therapeutics Limited Thiadiazoles as glutaminase 1 inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ540161A (en) * 2002-10-30 2008-03-28 Vertex Pharma Compositions useful as inhibitors of rock and other protein kinases
US20140186325A1 (en) 2011-06-10 2014-07-03 President And Fellows Of Harvard College Methods of Cancer Treatment and Prevention Through the Modulation of SIRT4 Activity
ES2761866T3 (es) * 2011-11-21 2020-05-21 Calithera Biosciences Inc Inhibidores heterocíclicos de glutaminasa
US9618514B2 (en) * 2012-09-17 2017-04-11 Agios Pharmaceuticals, Inc Methods of evaluating patients using E-cadherin and vimentin
ES2899461T3 (es) 2012-11-16 2022-03-11 Calithera Biosciences Inc Inhibidores heterocíclicos de glutaminasa
SG11201504022RA (en) 2012-11-21 2015-06-29 Agios Pharmaceuticals Inc Glutamase inhibitors and method of use
WO2014079011A1 (en) 2012-11-22 2014-05-30 Agios Pharmaceuticals, Inc. Heterocyclic compounds for inhibiting glutaminase and their methods of use
US9029531B2 (en) * 2012-11-22 2015-05-12 Agios Pharmaceuticals, Inc. Compounds and their methods of use
CN105283182A (zh) 2012-12-03 2016-01-27 卡利泰拉生物科技公司 用谷氨酰胺酶的杂环抑制剂治疗癌症

Also Published As

Publication number Publication date
NI201600176A (es) 2017-08-25
AU2015265703B2 (en) 2017-12-07
US10040788B2 (en) 2018-08-07
DOP2016000308A (es) 2017-03-15
HUE039879T2 (hu) 2019-02-28
BR112016028002B1 (pt) 2022-09-27
PT3148994T (pt) 2018-10-22
CR20160558A (es) 2017-09-01
BR112016028002A2 (sl) 2017-08-22
IL249020A0 (en) 2017-01-31
CN106795150A (zh) 2017-05-31
NZ726790A (en) 2017-11-24
US20180305349A1 (en) 2018-10-25
PH12016502394A1 (en) 2017-02-20
KR20170005875A (ko) 2017-01-16
AU2015265703A1 (en) 2016-12-15
GT201600250A (es) 2019-06-10
CA2949598A1 (en) 2015-12-03
PE20170148A1 (es) 2017-04-05
CN106795150B (zh) 2019-10-15
UY36145A (es) 2016-01-08
US10294221B2 (en) 2019-05-21
IL249020B (en) 2020-11-30
EP3148994A1 (en) 2017-04-05
GB201409624D0 (en) 2014-07-16
ES2688396T3 (es) 2018-11-02
TN2016000511A1 (en) 2018-04-04
SV2016005330A (es) 2017-06-07
CL2016003074A1 (es) 2017-04-28
WO2015181539A1 (en) 2015-12-03
RS57876B1 (sr) 2018-12-31
LT3148994T (lt) 2018-11-26
EP3148994B1 (en) 2018-07-11
TWI693220B (zh) 2020-05-11
CY1120836T1 (el) 2019-12-11
JP2017516859A (ja) 2017-06-22
AR100694A1 (es) 2016-10-26
MX2016015738A (es) 2017-02-27
SG11201609880QA (en) 2016-12-29
CA2949598C (en) 2022-08-09
SMT201800516T1 (it) 2018-11-09
DK3148994T3 (en) 2018-10-08
AP2016009578A0 (en) 2016-11-30
EA030937B1 (ru) 2018-10-31
EA201692260A1 (ru) 2017-06-30
US20170197954A1 (en) 2017-07-13
HRP20181490T1 (hr) 2019-01-11
MY192861A (en) 2022-09-13
TW201609720A (zh) 2016-03-16
JP6538830B2 (ja) 2019-07-03
PL3148994T3 (pl) 2019-04-30

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