[go: up one dir, main page]

SI3063275T1 - Terapevtske fuzije nukleaza-albumin in postopki - Google Patents

Terapevtske fuzije nukleaza-albumin in postopki

Info

Publication number
SI3063275T1
SI3063275T1 SI201431413T SI201431413T SI3063275T1 SI 3063275 T1 SI3063275 T1 SI 3063275T1 SI 201431413 T SI201431413 T SI 201431413T SI 201431413 T SI201431413 T SI 201431413T SI 3063275 T1 SI3063275 T1 SI 3063275T1
Authority
SI
Slovenia
Prior art keywords
methods
albumin fusions
therapeutic nuclease
nuclease
therapeutic
Prior art date
Application number
SI201431413T
Other languages
English (en)
Slovenian (sl)
Inventor
James Arthur Posada
Chris Gabel
Original Assignee
Resolve Therapeutics, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Resolve Therapeutics, Llc filed Critical Resolve Therapeutics, Llc
Publication of SI3063275T1 publication Critical patent/SI3063275T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
    • C12Y301/21001—Deoxyribonuclease I (3.1.21.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/27—Endoribonucleases producing 3'-phosphomonoesters (3.1.27)
    • C12Y301/27005—Pancreatic ribonuclease (3.1.27.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
SI201431413T 2013-10-31 2014-10-31 Terapevtske fuzije nukleaza-albumin in postopki SI3063275T1 (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361898384P 2013-10-31 2013-10-31
US201361898370P 2013-10-31 2013-10-31
US201361898393P 2013-10-31 2013-10-31
PCT/US2014/063572 WO2015066550A1 (fr) 2013-10-31 2014-10-31 Fusions nucléase-albumine à visée thérapeutique et procédés associés
EP14802986.1A EP3063275B1 (fr) 2013-10-31 2014-10-31 Fusions nucléase-albumine à visée thérapeutique et procédés associés

Publications (1)

Publication Number Publication Date
SI3063275T1 true SI3063275T1 (sl) 2020-02-28

Family

ID=51982759

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201431413T SI3063275T1 (sl) 2013-10-31 2014-10-31 Terapevtske fuzije nukleaza-albumin in postopki

Country Status (8)

Country Link
US (3) US10988745B2 (fr)
EP (1) EP3063275B1 (fr)
DK (1) DK3063275T3 (fr)
ES (1) ES2759252T3 (fr)
HR (1) HRP20192080T1 (fr)
PL (1) PL3063275T3 (fr)
SI (1) SI3063275T1 (fr)
WO (2) WO2015066550A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX341084B (es) 2009-11-02 2016-08-05 Univ Washington Composiciones de nucleasas terapéuticas y métodos.
PE20141172A1 (es) 2011-04-29 2014-09-22 Univ Washington Composiciones de nucleasa terapeuticas y metodos
AU2014207618A1 (en) 2013-01-16 2015-08-06 Emory University Cas9-nucleic acid complexes and uses related thereto
WO2015066550A1 (fr) 2013-10-31 2015-05-07 Resolve Therapeutics, Llc Fusions nucléase-albumine à visée thérapeutique et procédés associés
US10117911B2 (en) 2015-05-29 2018-11-06 Agenovir Corporation Compositions and methods to treat herpes simplex virus infections
EP3328881B1 (fr) 2015-09-08 2019-08-28 Theripion, Inc. Polypeptides de fusion apoa-1 ainsi que compositions et procédés associés
KR20190014525A (ko) 2016-05-27 2019-02-12 애브비 바이오테라퓨틱스 인크. 면역 조절 단백질과 종양 항원을 결합하는 이중특이적 결합 단백질
CN109790526A (zh) * 2016-07-01 2019-05-21 分解治疗有限责任公司 优化的二核酸酶融合体和方法
EP3351263A1 (fr) 2017-01-20 2018-07-25 Universitätsklinikum Hamburg-Eppendorf Composition pharmaceutique destinée au traitement ou à la prévention de l'adhérence tissulaire
IL317968A (en) 2017-08-18 2025-02-01 Neutrolis Inc Engineered deoxyribonuclease enzymes and their use in medicine
KR102777015B1 (ko) 2017-08-22 2025-03-10 사나바이오, 엘엘씨 가용성 인터페론 수용체 및 그의 용도
US11905522B2 (en) * 2018-01-16 2024-02-20 Cls Therapeutics Limited Treatment of diseases by liver expression of an enzyme which has a deoxyribonuclease (DNase) activity
CN110386984B (zh) * 2018-04-17 2022-04-22 杭州尚健生物技术有限公司 结合cd47蛋白的融合蛋白及其应用
US11058724B2 (en) 2018-10-08 2021-07-13 Neutrolis, Inc. Methods of using DNASE1-like 3 in therapy
US10988746B2 (en) 2018-10-08 2021-04-27 Neutrolis, Inc. Manufacturing and engineering of DNASE enzymes for therapy
CN112996911A (zh) * 2018-10-08 2021-06-18 纽特雷斯股份有限公司 用于制造和疗法的脱氧核糖核酸酶的工程改造
CA3124352A1 (fr) * 2019-01-04 2020-07-09 Resolve Therapeutics, Llc Traitement de la maladie de sjogren a l'aide de proteines de fusion de type nucleases
US11352613B2 (en) 2019-02-04 2022-06-07 Neutrolis, Inc. Engineered human extracellular DNASE enzymes
US20220025343A1 (en) * 2019-02-04 2022-01-27 Neutrolis, Inc. Engineered human extracellular dnase enzymes for drug candidate selection
US20220380780A1 (en) * 2019-10-07 2022-12-01 Texas Tech University System Mutant Dnase1L3 with Improved Serum Half-Life
CA3166299A1 (fr) * 2020-01-11 2021-07-15 Paul STABACH Compositions et methodes pour traiter, ameliorer et/ou prevenir des maladies ou des troubles causes par ou associes a un deficit en dnase1 et/ou dnase1l3
US20230072226A1 (en) * 2020-02-20 2023-03-09 Neutrolis, Inc. Basic domain-deleted dnase1-like 3 and uses thereof
EP4161645A4 (fr) * 2020-06-08 2023-11-01 Yale University Compositions et méthodes de traitement et/ou de prévention de la coagulopathie et/ou de la septicémie chez des patients souffrant d'infections bactériennes et/ou virales
CN112480247B (zh) * 2020-11-10 2023-09-22 华通福源生物技术(北京)股份有限公司 抗人血清白蛋白单克隆抗体

Family Cites Families (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1136039A (en) * 1966-10-12 1968-12-11 Nat Res Dev Improvements relating to immunosuppressive agents
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US3941763A (en) 1975-03-28 1976-03-02 American Home Products Corporation PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates
US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
EP0088046B1 (fr) 1982-02-17 1987-12-09 Ciba-Geigy Ag Lipides en phase aqueuse
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
US4615885A (en) 1983-11-01 1986-10-07 Terumo Kabushiki Kaisha Pharmaceutical composition containing urokinase
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
WO1987005330A1 (fr) 1986-03-07 1987-09-11 Michel Louis Eugene Bergh Procede pour ameliorer la stabilite des glycoproteines
US5453269A (en) 1986-04-14 1995-09-26 The General Hospital Corporation Heterobifunctional antibodies having dual specificity for fibrin and thrombolylic agents and methods of use
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
JP3101690B2 (ja) 1987-03-18 2000-10-23 エス・ビィ・２・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
US5559212A (en) 1988-04-06 1996-09-24 Alfacell Corporation Frog embryo and egg-derived tumor cell anti-proliferation protein
US6780613B1 (en) 1988-10-28 2004-08-24 Genentech, Inc. Growth hormone variants
DE68929551T2 (de) * 1988-12-23 2008-03-06 Genentech, Inc., South San Francisco Menschliche DNase
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5840840A (en) 1990-04-17 1998-11-24 The United States Of America As Represented By The Department Of Health And Human Services Selective RNase cytotoxic reagents
US6825037B1 (en) * 1991-02-08 2004-11-30 University Of Vermont Recombinant transferrins, transferrin half-molecules and mutants thereof
US5525491A (en) 1991-02-27 1996-06-11 Creative Biomolecules, Inc. Serine-rich peptide linkers
US6565841B1 (en) 1991-03-15 2003-05-20 Amgen, Inc. Pulmonary administration of granulocyte colony stimulating factor
CA2085469C (fr) 1991-04-17 2007-07-31 Pierre Eid Polypeptides hydrosolubles ayant une haute affinite pour les interferons .alpha. et .beta.
US5637481A (en) 1993-02-01 1997-06-10 Bristol-Myers Squibb Company Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
MX9204374A (es) 1991-07-25 1993-03-01 Idec Pharma Corp Anticuerpo recombinante y metodo para su produccion.
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US5470582A (en) 1992-02-07 1995-11-28 Syntex (U.S.A.) Inc. Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles
GB9300686D0 (en) 1993-01-15 1993-03-03 Imp Cancer Res Tech Compounds for targeting
US20030108548A1 (en) 1993-06-01 2003-06-12 Bluestone Jeffrey A. Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
GB9422383D0 (en) 1994-11-05 1995-01-04 Wellcome Found Antibodies
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US6348343B2 (en) 1995-02-24 2002-02-19 Genentech, Inc. Human DNase I variants
SK284191B6 (sk) 1995-02-24 2004-10-05 Genentech, Inc. Aktín-rezistentný variant humánnej DNázy I
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
US5739277A (en) 1995-04-14 1998-04-14 Genentech Inc. Altered polypeptides with increased half-life
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US6127977A (en) 1996-11-08 2000-10-03 Cohen; Nathan Microstrip patch antenna with fractal structure
BR9606706A (pt) 1995-10-16 1999-04-06 Unilever Nv Análogo de fragmento de anticorpo biespecífico ou bivalente uso processo para produzir o mesmo
US6482626B2 (en) 1996-02-05 2002-11-19 Genentech, Inc. Human DNase
US6716974B1 (en) 1996-05-31 2004-04-06 Maine Medical Center Research Institute Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids
US6391607B1 (en) 1996-06-14 2002-05-21 Genentech, Inc. Human DNase I hyperactive variants
AU3968897A (en) 1996-08-02 1998-02-25 Bristol-Myers Squibb Company A method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
US7247302B1 (en) 1996-08-02 2007-07-24 Bristol-Myers Squibb Company Method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
EP0932417B1 (fr) 1996-10-17 2003-03-05 Immunomedics, Inc. Conjugue d'une toxine non antigenique et proteine de fusion d'un systeme recepteur de penetration intracellulaire
US6653104B2 (en) 1996-10-17 2003-11-25 Immunomedics, Inc. Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells
WO1998023289A1 (fr) 1996-11-27 1998-06-04 The General Hospital Corporation Modulation de la fixation de l'igg au fcrn
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
US20020132252A1 (en) 1997-06-16 2002-09-19 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20020192659A1 (en) 1997-09-17 2002-12-19 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6280991B1 (en) 1997-10-15 2001-08-28 Wisconsin Alumni Research Foundation Engineered cytotoxic ribonclease
US5840296A (en) 1997-10-15 1998-11-24 Raines; Ronald T. Engineered cytotoxic ribonuclease A
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
US6528624B1 (en) 1998-04-02 2003-03-04 Genentech, Inc. Polypeptide variants
DE69937291T2 (de) 1998-04-02 2008-07-10 Genentech, Inc., South San Francisco Antikörpervarianten und fragmente davon
US6242195B1 (en) 1998-04-02 2001-06-05 Genentech, Inc. Methods for determining binding of an analyte to a receptor
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
EP1105427A2 (fr) 1998-08-17 2001-06-13 Abgenix, Inc. Production de molecules modifiees avec demi-vie serique prolongee
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
EP1006183A1 (fr) 1998-12-03 2000-06-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Récepteurs Fc recombinantes et solubles
US6239257B1 (en) 1998-12-30 2001-05-29 Alfacell Corporation Family of proteins belonging to the pancreatic ribonuclease a superfamily
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
KR20060067983A (ko) 1999-01-15 2006-06-20 제넨테크, 인크. 효과기 기능이 변화된 폴리펩티드 변이체
CA2377731A1 (fr) 1999-07-02 2001-01-11 Genentech, Inc. Peptides de fusion comprenant un domaine ligand peptide et un domaine de multimerisation
US6175003B1 (en) 1999-09-10 2001-01-16 Alfacell Corporation Nucleic acids encoding ribonucleases and methods of making them
AU1084901A (en) 1999-10-14 2001-04-23 Martha S. Hayden-Ledbetter Dna vaccines encoding antigen linked to a domain that binds cd40
ES2529300T3 (es) 2000-04-12 2015-02-18 Novozymes Biopharma Dk A/S Proteínas de fusión de albúmina
EP2119793A1 (fr) 2000-06-28 2009-11-18 Glycofi, Inc. Procédés de production de glycoprotéines modifiées
GB0029407D0 (en) 2000-12-01 2001-01-17 Affitech As Product
EP2357187A1 (fr) 2000-12-12 2011-08-17 MedImmune, LLC Molécules à demi-vies longues, compositions et utilisations de celles-ci
US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
AU2002327164A1 (en) 2001-01-29 2002-12-09 Idec Pharmaceuticals Corporation Engineered tetravalent antibodies and methods of use
KR20030091978A (ko) 2001-01-29 2003-12-03 아이덱 파마슈티칼즈 코포레이션 변형된 항체 및 사용 방법
US7148321B2 (en) 2001-03-07 2006-12-12 Emd Lexigen Research Center Corp. Expression technology for proteins containing a hybrid isotype antibody moiety
JP4586310B2 (ja) 2001-07-04 2010-11-24 株式会社Ihi セラミックス複合部材の製造方法
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US20060040262A1 (en) 2002-12-27 2006-02-23 Morris David W Novel compositions and methods in cancer
US20040002587A1 (en) 2002-02-20 2004-01-01 Watkins Jeffry D. Fc region variants
JP2006502091A (ja) 2002-03-01 2006-01-19 イミューノメディクス、インコーポレイテッド クリアランス速度を高めるための二重特異性抗体点変異
US7662925B2 (en) 2002-03-01 2010-02-16 Xencor, Inc. Optimized Fc variants and methods for their generation
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
JP2005529615A (ja) 2002-06-14 2005-10-06 ウイスコンシン アラムニ リサーチ ファンデーション リボヌクレアーゼチモーゲンの設計
DK1534335T4 (en) 2002-08-14 2015-10-05 Macrogenics Inc FCGAMMARIIB-SPECIFIC ANTIBODIES AND PROCEDURES FOR USE THEREOF
EP3321282A1 (fr) 2002-09-27 2018-05-16 Xencor, Inc. Variantes fc optimisées et leurs procédés de génération
US20060235208A1 (en) 2002-09-27 2006-10-19 Xencor, Inc. Fc variants with optimized properties
CA2502904C (fr) 2002-10-15 2013-05-28 Protein Design Labs, Inc. Modification d'affinites de liaison pour fcrn ou de demi-vies seriques d'anticorps par mutagenese
EP1578367A4 (fr) 2002-11-01 2012-05-02 Genentech Inc Compositions et methodes pour le traitement de maladies liees au systeme immunitaire
GB2395337B (en) 2002-11-14 2005-12-28 Gary Michael Wilson Warning Unit
WO2004063351A2 (fr) 2003-01-09 2004-07-29 Macrogenics, Inc. Identification et elaboration d'anticorps avec des regions du variant fc et procedes d'utilisation associes
US8388955B2 (en) 2003-03-03 2013-03-05 Xencor, Inc. Fc variants
US20090010920A1 (en) 2003-03-03 2009-01-08 Xencor, Inc. Fc Variants Having Decreased Affinity for FcyRIIb
US7067298B2 (en) 2003-03-31 2006-06-27 Ambion, Inc. Compositions and methods of using a synthetic Dnase I
US7666417B2 (en) 2003-04-22 2010-02-23 Fred Hutchinson Cancer Research Center Methods and compositions for treating autoimmune diseases or conditions
US9051373B2 (en) * 2003-05-02 2015-06-09 Xencor, Inc. Optimized Fc variants
US7754209B2 (en) 2003-07-26 2010-07-13 Trubion Pharmaceuticals Binding constructs and methods for use thereof
AU2004266159A1 (en) 2003-08-22 2005-03-03 Biogen Idec Ma Inc. Improved antibodies having altered effector function and methods for making the same
GB0324368D0 (en) 2003-10-17 2003-11-19 Univ Cambridge Tech Polypeptides including modified constant regions
ME01775B (fr) 2003-11-05 2011-02-28 Glycart Biotechnology Ag Molecules fixatrices d'antigenes presentant une affinite de fixation du recepteur de fc et une fonction effectrice accrues
WO2005063815A2 (fr) 2003-11-12 2005-07-14 Biogen Idec Ma Inc. Variants de polypeptides de liaison au recepteur fc$g(g) et procede apparentes
EP1697415A1 (fr) 2003-11-12 2006-09-06 Biogen Idec MA Inc. Variants de polypeptide se liant au recepteur fc neonatal (fcrn), proteines de liaison fc dimeres et techniques associees
WO2005077981A2 (fr) 2003-12-22 2005-08-25 Xencor, Inc. Polypeptides fc a nouveaux sites de liaison de ligands fc
RU2370276C2 (ru) 2003-12-31 2009-10-20 Мерк Патент Гмбх Fc-ЭРИТРОПОЭТИН СЛИТЫЙ БЕЛОК С УЛУЧШЕННОЙ ФАРМАКОКИНЕТИКОЙ
EP1706424B1 (fr) 2004-01-12 2009-07-22 Applied Molecular Evolution, Inc. Variants de la region fc
EP1720996A4 (fr) 2004-02-13 2007-03-21 Immunomedics Inc Proteines de fusion contenant des rnases cytotoxiques recombinantes
WO2005092925A2 (fr) 2004-03-24 2005-10-06 Xencor, Inc. Variantes d'immunoglobuline a l'exterieur de la region fc
WO2005123780A2 (fr) 2004-04-09 2005-12-29 Protein Design Labs, Inc. Modification des affinites de liaison pour le fcrn ou de la demi-vie serique d'anticorps par mutagenese
JP2008505853A (ja) 2004-04-13 2008-02-28 クインテセンス バイオサイエンシーズ インコーポレーティッド 細胞傷害性薬剤としての非天然のリボヌクレアーゼ複合体
WO2006085967A2 (fr) 2004-07-09 2006-08-17 Xencor, Inc. Anticorps monoclonaux optimises anti-cd20 a variants fc
PL2471813T3 (pl) 2004-07-15 2015-09-30 Xencor Inc Zoptymalizowane warianty Fc
US20080181892A1 (en) 2004-08-11 2008-07-31 Trubion Pharmaceuticals Binding Domain Fusion Protein
WO2006047350A2 (fr) 2004-10-21 2006-05-04 Xencor, Inc. Variants d'immunoglobuline igg a fonction effectrice optimisee
DE102005009219A1 (de) 2005-02-25 2006-08-31 Martin-Luther-Universität Halle-Wittenberg Ribonuclease-Tandemenzyme und Verfahren zu ihrer Herstellung
US20110123440A1 (en) 2005-03-29 2011-05-26 Genevieve Hansen Altered Antibody FC Regions and Uses Thereof
RU2007145509A (ru) 2005-05-09 2009-06-20 Гликарт Биотехнологи Аг (Ch) Антигенсвязывающие молекулы, имеющие модифицированные fc-участки и измененное связывание с fc-рецепторами
EP1896579A2 (fr) 2005-06-16 2008-03-12 Wisconsin Alumni Research Foundation Variants cytotoxiques de la ribonuclease
ES2354280T3 (es) 2005-06-16 2011-03-11 Wisconsin Alumni Research Foundation Variantes de ribonucleasa citotóxica.
US20080279850A1 (en) 2005-07-25 2008-11-13 Trubion Pharmaceuticals, Inc. B-Cell Reduction Using CD37-Specific and CD20-Specific Binding Molecules
WO2007014278A2 (fr) 2005-07-25 2007-02-01 Trubion Pharmaceuticals, Inc. Reduction de lymphocytes b au moyen de molecules de liaison specifique de cd37 et specifique de cd20
EP1941043B1 (fr) 2005-10-21 2011-04-13 F. Hoffmann-La Roche AG Procede d'expression par recombinaison d'un polypeptide
WO2007121354A2 (fr) 2006-04-14 2007-10-25 Trubion Pharmaceuticals Inc. Protéines de liaison comportant une charnière d'immunoglobulines et des régions fc ayant des fonctions effectrices altérées
WO2007122511A2 (fr) 2006-04-21 2007-11-01 Mab-Factory Gmbh Conjugué anticorps-rnase
GB0611444D0 (en) 2006-06-09 2006-07-19 Medical Res Council Technology Rnase H2 complex and genes therefor
US8409577B2 (en) 2006-06-12 2013-04-02 Emergent Product Development Seattle, Llc Single chain multivalent binding proteins with effector function
WO2008011633A2 (fr) 2006-07-21 2008-01-24 Neose Technologies, Inc. Glycosylation de peptides par l'intermédiaire de séquences de glycosylation à liaison o
CN101511868B (zh) 2006-07-24 2013-03-06 比奥雷克西斯制药公司 毒蜥外泌肽融合蛋白
US8198063B1 (en) 2006-09-12 2012-06-12 Pro Zyme, Inc Rapid deglycosylation of glycoproteins
EP1905841A1 (fr) 2006-09-25 2008-04-02 Max Delbrück Centrum für Molekulare Medizin (MDC) Berlin-Buch; Trex1 comme marqueur du lupus érythemateux
US20080260738A1 (en) 2007-04-18 2008-10-23 Moore Margaret D Single chain fc, methods of making and methods of treatment
WO2008150485A2 (fr) 2007-05-29 2008-12-11 Wyeth Compositions thérapeutiques et procédés
WO2008156713A2 (fr) 2007-06-12 2008-12-24 Wyeth Compositions thérapeutiques anti-cd20 et procédés correspondants
JP2010532764A (ja) 2007-07-06 2010-10-14 トゥルビオン・ファーマシューティカルズ・インコーポレーテッド Ｃ末端に配置された特異的結合性ドメインを有する結合性ペプチド
WO2009015345A1 (fr) 2007-07-25 2009-01-29 Amgen Inc. Compositions pharmaceutiques comprenant des protéines de fusion fc
CA2720628A1 (fr) 2007-07-26 2009-01-29 Novagen Holding Corporation Proteines de fusion
EP2594583A1 (fr) 2007-08-08 2013-05-22 Novozymes Biopharma DK A/S Variants de transferrine et conjugues
CN102026653B (zh) 2007-10-15 2014-06-18 北卡罗来纳-查佩尔山大学 半衰期延长的人因子ⅸ变体
WO2009064777A2 (fr) 2007-11-13 2009-05-22 Sapphire Energy, Inc. Production de polypeptides hybrides fc dans des algues eucaryotes
EP2082805A1 (fr) 2008-01-28 2009-07-29 Basf Se Procédé pour la préparation d'une suspension colloïdale aqueuse de métaux précieux
MX340204B (es) 2008-04-11 2016-06-30 Emergent Product Dev Seattle Inmunoterapeutico de cd37 y combinacion con quimioterapeutico bifuncional del mismo.
MX2011003273A (es) 2008-09-26 2011-04-28 Genentech Inc Metodo para tratar, diagnosticar y supervisar lupus.
CN102227443B (zh) 2008-10-01 2014-05-14 昆特森斯生物科学公司 治疗性核糖核酸酶
CN102317315A (zh) 2009-02-11 2012-01-11 诺维信生物制药丹麦公司 白蛋白变体和缀合物
WO2011051489A2 (fr) 2009-10-30 2011-05-05 Novozymes Biopharma Dk A/S Variants d'albumine
MX341084B (es) 2009-11-02 2016-08-05 Univ Washington Composiciones de nucleasas terapéuticas y métodos.
AU2010325943A1 (en) 2009-12-02 2012-06-21 Acceleron Pharma Inc. Compositions and methods for increasing serum half-life of Fc fusion proteins.
US20110221962A1 (en) 2010-03-10 2011-09-15 Microsoft Corporation Augmented reality via a secondary channel
US10233228B2 (en) 2010-04-09 2019-03-19 Albumedix Ltd Albumin derivatives and variants
US20120022506A1 (en) 2010-07-20 2012-01-26 Rickard Matthew J A Drug delivery device with active iris
CA2827492A1 (fr) 2011-02-23 2012-08-30 Amgen Inc. Milieux de culture de cellules pour exposition aux uvc et procedes associes
EP3461898A1 (fr) 2011-02-25 2019-04-03 The University Court Of The University of Edinburgh Animaux génétiquement modifiés et procédés pour produire ceux-ci
SG194555A1 (en) 2011-04-21 2013-12-30 Isis Pharmaceuticals Inc Modulation of hepatitis b virus (hbv) expression
PE20141172A1 (es) 2011-04-29 2014-09-22 Univ Washington Composiciones de nucleasa terapeuticas y metodos
US20140178479A1 (en) 2011-08-12 2014-06-26 Perosphere, Inc. Concentrated Felbamate Formulations for Parenteral Administration
JP5782185B2 (ja) 2012-06-01 2015-09-24 日本電信電話株式会社 パケット転送処理方法およびパケット転送処理装置
WO2015066550A1 (fr) * 2013-10-31 2015-05-07 Resolve Therapeutics, Llc Fusions nucléase-albumine à visée thérapeutique et procédés associés
US9300829B2 (en) 2014-04-04 2016-03-29 Canon Kabushiki Kaisha Image reading apparatus and correction method thereof
CN109790526A (zh) 2016-07-01 2019-05-21 分解治疗有限责任公司 优化的二核酸酶融合体和方法

Also Published As

Publication number Publication date
US10988745B2 (en) 2021-04-27
EP3063275B1 (fr) 2019-09-25
PL3063275T3 (pl) 2020-03-31
EP3063275A1 (fr) 2016-09-07
ES2759252T3 (es) 2020-05-08
US20250129349A1 (en) 2025-04-24
US12163165B2 (en) 2024-12-10
HRP20192080T1 (hr) 2020-02-07
DK3063275T3 (da) 2019-11-25
US20160251638A1 (en) 2016-09-01
WO2015066550A1 (fr) 2015-05-07
US20210355462A1 (en) 2021-11-18
WO2015066557A1 (fr) 2015-05-07

Similar Documents

Publication Publication Date Title
SI3063275T1 (sl) Terapevtske fuzije nukleaza-albumin in postopki
IL286759A (en) Therapeutic methods and preparations
ZA201504902B (en) Bcl-2bcl-xl inhibitors and therapeutic methods using the same
GB2535360B (en) Methods of preparing polyhemiaminals and polyhexahydrotriazines
GB201320729D0 (en) Therapeutic compounds and their use
ZA201505705B (en) Phi-4 polypeptides and methods for their use
GB202005995D0 (en) Patient interface and aspects thereof
GB201306633D0 (en) Biaising circuitry and method thereof
GB201311361D0 (en) Compounds and their therapeutic use
IL244214B (en) Thienopiperidine derivative and its use
PL2963036T3 (pl) Pochodna 2-acyloaminotiazolu i jego sól
GB201308440D0 (en) Therapeutic
GB2506463B (en) Improved burial systems and methods
GB201310755D0 (en) Therapy
GB201310158D0 (en) Medico-surgical assemblies and means
GB201307989D0 (en) Novel combinations and use
GB201308736D0 (en) Compounds and their therapeutic use
GB201318668D0 (en) Sonosensitive therapeutic
GB201313356D0 (en) Therapeutic Intervention
GB201309967D0 (en) Therapeutic combinations
GB2519994B (en) Assemblies and methods
GB201317804D0 (en) Therapeutic compounds and their use
GB201316173D0 (en) Compounds and their therapeutic use
GB201307677D0 (en) Compounds and their therapeutic use
IL242818B (en) Il-1beta-il-1ra chimera and methods of using the same