SI2825528T1 - Substituirani pirolidin-2-karboksamidi - Google Patents
Substituirani pirolidin-2-karboksamidiInfo
- Publication number
- SI2825528T1 SI2825528T1 SI201330703T SI201330703T SI2825528T1 SI 2825528 T1 SI2825528 T1 SI 2825528T1 SI 201330703 T SI201330703 T SI 201330703T SI 201330703 T SI201330703 T SI 201330703T SI 2825528 T1 SI2825528 T1 SI 2825528T1
- Authority
- SI
- Slovenia
- Prior art keywords
- carboxamides
- substituted pyrrolidine
- pyrrolidine
- substituted
- Prior art date
Links
- VLJNHYLEOZPXFW-UHFFFAOYSA-N pyrrolidine-2-carboxamide Chemical class NC(=O)C1CCCN1 VLJNHYLEOZPXFW-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polyethers (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261611200P | 2012-03-15 | 2012-03-15 | |
| PCT/EP2013/054920 WO2013135648A1 (en) | 2012-03-15 | 2013-03-12 | Substituted pyrrolidine-2-carboxamides |
| EP13708466.1A EP2825528B1 (en) | 2012-03-15 | 2013-03-12 | Substituted pyrrolidine-2-carboxamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2825528T1 true SI2825528T1 (sl) | 2017-08-31 |
Family
ID=47844360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201330703T SI2825528T1 (sl) | 2012-03-15 | 2013-03-12 | Substituirani pirolidin-2-karboksamidi |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8993614B2 (sl) |
| EP (1) | EP2825528B1 (sl) |
| JP (1) | JP6125546B2 (sl) |
| KR (1) | KR20140138165A (sl) |
| CN (1) | CN104271554B (sl) |
| AR (1) | AR090328A1 (sl) |
| AU (1) | AU2013203662B2 (sl) |
| BR (1) | BR112014018959A8 (sl) |
| CA (1) | CA2860781A1 (sl) |
| CL (1) | CL2014001858A1 (sl) |
| CO (1) | CO6990736A2 (sl) |
| CR (1) | CR20140399A (sl) |
| DK (1) | DK2825528T3 (sl) |
| EA (1) | EA025557B1 (sl) |
| ES (1) | ES2634290T3 (sl) |
| HU (1) | HUE032864T2 (sl) |
| IL (1) | IL234173A (sl) |
| MX (1) | MX2014010942A (sl) |
| NZ (1) | NZ626505A (sl) |
| PE (1) | PE20142185A1 (sl) |
| PH (1) | PH12014501542A1 (sl) |
| PL (1) | PL2825528T3 (sl) |
| SG (1) | SG11201404344XA (sl) |
| SI (1) | SI2825528T1 (sl) |
| TW (1) | TWI586648B (sl) |
| UA (1) | UA113541C2 (sl) |
| WO (1) | WO2013135648A1 (sl) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2014150492A (ru) | 2012-05-30 | 2016-07-20 | Ф. Хоффманн-Ля Рош Аг | Замещенные пирролидин-2-карбоксамиды |
| TW201429969A (zh) | 2012-12-20 | 2014-08-01 | Merck Sharp & Dohme | 作爲ｈｄｍ２抑制劑之經取代咪唑吡啶 |
| US20160136280A1 (en) * | 2013-06-24 | 2016-05-19 | Hoffmann-La Roche Inc. | Stable intravenous formulation |
| JP6461126B2 (ja) * | 2013-07-03 | 2019-01-30 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Ｍｄｍ２アンタゴニストを用いた患者のがん治療法をパーソナライズするためのｍｒｎａベースの遺伝子発現 |
| AR097584A1 (es) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano |
| LT3077004T (lt) * | 2013-12-05 | 2020-05-11 | F. Hoffmann-La Roche Ag | Naujas kombinuotasis ūminės mieloidinės leukemijos (ūml) gydymas |
| US9657351B2 (en) | 2013-12-06 | 2017-05-23 | Hoffman-La Roche Inc. | MRNA-based gene expression for personalizing patient cancer therapy with an MDM2 antagonist |
| PL3459933T3 (pl) * | 2014-04-15 | 2023-01-23 | F. Hoffmann-La Roche Ag | Stałe postacie farmaceutycznie czynnego związku |
| JP2017520526A (ja) * | 2014-05-22 | 2017-07-27 | ザ・ユニバーシティ・オブ・シドニー | オメガ−３類似体 |
| JP6608439B2 (ja) * | 2014-10-10 | 2019-11-20 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Ｍｄｍ２アンタゴニストによる患者のがん治療を個別化するための方法 |
| CN104496822B (zh) * | 2014-12-15 | 2016-10-26 | 扬州三友合成化工有限公司 | 一种1-氯乙基环己基丙基碳酸酯的制备方法 |
| TWI716405B (zh) | 2015-05-07 | 2021-01-21 | 美商艾吉納斯公司 | 抗ox40抗體及其使用方法 |
| EP3383430A4 (en) | 2015-12-02 | 2019-12-18 | Agenus Inc. | ANTIBODIES AND METHOD FOR USE THEREOF |
| ES2858151T3 (es) | 2016-05-20 | 2021-09-29 | Hoffmann La Roche | Conjugados de PROTAC-anticuerpo y procedimientos de uso |
| WO2018027477A1 (zh) * | 2016-08-08 | 2018-02-15 | 肖飞 | 螺环吲哚酮聚乙二醇碳酸酯类化合物和其组合物、制备方法及用途 |
| CN107698598B (zh) * | 2016-08-08 | 2019-06-21 | 肖飞 | 螺环吲哚酮聚乙二醇碳酸酯类化合物和其组合物、制备方法及用途 |
| EP3504239B1 (en) | 2016-08-25 | 2024-05-29 | F. Hoffmann-La Roche AG | Intermittent dosing of an anti-csf-1r antibody in combination with macrophage activating agent |
| WO2018089628A1 (en) | 2016-11-09 | 2018-05-17 | Agenus Inc. | Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof |
| EP3558360A1 (en) | 2016-12-22 | 2019-10-30 | F. Hoffmann-La Roche AG | Treatment of tumors with an anti-csf-1r antibody in combination with an anti-pd-l1 antibody after failure of anti-pd-l1/pd1 treatment |
| SG11202005719UA (en) * | 2017-12-20 | 2020-07-29 | Angex Pharmaceutical Inc | Carbamate and urea compounds as multikinase inhibitors |
| CN114230561B (zh) * | 2020-09-09 | 2024-03-19 | 中国人民解放军海军军医大学 | 一种mdm2抑制剂类小分子化合物及用途 |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
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| JPH0720857B2 (ja) | 1988-08-11 | 1995-03-08 | テルモ株式会社 | リポソームおよびその製法 |
| EP0452179B1 (en) | 1990-03-28 | 1996-06-12 | Nippon Oil And Fats Company, Limited | Polymer-combined drug for gastric treatment and a method for producing the drug |
| US5681811A (en) | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
| GB9317618D0 (en) | 1993-08-24 | 1993-10-06 | Royal Free Hosp School Med | Polymer modifications |
| KR100361933B1 (ko) | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
| AU1313695A (en) | 1993-12-14 | 1995-07-03 | Sandoz Ltd. | Pharmaceutical compositions containing alkyl polyoxyalkylene carboxylates |
| DE4435087A1 (de) | 1994-09-30 | 1996-04-04 | Deutsches Krebsforsch | Konjugat zur Behandlung von Infektions-, Autoimmun- und Hauterkrankungen |
| AU5773798A (en) | 1997-01-29 | 1998-08-18 | Polymasc Pharmaceuticals Plc | Pegylation process |
| WO1999017120A1 (en) | 1997-09-26 | 1999-04-08 | Becton, Dickinson And Company | Preparing conjugates using polyethylene glycol linkers |
| US6165509A (en) | 1998-09-01 | 2000-12-26 | University Of Washington | Pegylated drug complexed with bioadhesive polymer suitable for drug delivery and methods relating thereto |
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| US6713454B1 (en) | 1999-09-13 | 2004-03-30 | Nobex Corporation | Prodrugs of etoposide and etoposide analogs |
| AU2001268228A1 (en) | 2000-06-08 | 2001-12-17 | La Jolla Pharmaceutical Company | Multivalent platform molecules comprising high molecular weight polyethylene oxide |
| EP1405871A4 (en) | 2001-05-30 | 2004-11-17 | Mitsubishi Kagaku Iatron Inc | METHOD FOR BINDING A SUBSTANCE TO BE INCORPORATED AT A POLYMER END |
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| US7144978B2 (en) | 2002-01-15 | 2006-12-05 | Pan Asia Bio Co., Ltd. | Multidrop tree branching functional polyethylene glycol, methods of preparing and using same |
| CA2473526C (en) | 2002-01-18 | 2013-10-22 | Biogen Idec Ma Inc. | Polyalkylene polymer compounds and uses thereof |
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| US7759383B2 (en) | 2005-02-22 | 2010-07-20 | The Regents Of The University Of Michigan | Small molecule inhibitors of MDM2 and the uses thereof |
| CA2650035C (en) | 2006-04-27 | 2015-02-03 | Intezyne Technologies, Inc. | Poly (ethylene glycol) containing chemically disparate endgroups |
| WO2008109783A2 (en) | 2007-03-06 | 2008-09-12 | The Regents Of The University Of California | Detecting spin perturbations using magnetic resonance imaging |
| JP2008308690A (ja) | 2007-06-13 | 2008-12-25 | Bio-Cancer Treatment Internatl Ltd | ポリ（エチレングリコール）機能性誘導体およびその製造方法 |
| WO2009128789A1 (en) | 2008-04-17 | 2009-10-22 | Agency For Science, Technology And Research | Vesicles for intracellular drug delivery |
| WO2009155431A1 (en) | 2008-06-18 | 2009-12-23 | University Of Louisville Research Foundation, Inc. | Methods for targeted cancer treatment and detection |
| MY155612A (en) | 2008-07-14 | 2015-11-13 | Biocon Ltd | A method of synthesizing a substantially monodispersed mixture of oligomers |
| DK2328619T3 (en) | 2008-08-22 | 2017-03-13 | Baxalta GmbH | POLYMER BENZYL CARBONATE DERIVATES |
| US8354444B2 (en) | 2008-09-18 | 2013-01-15 | Hoffmann-La Roche Inc. | Substituted pyrrolidine-2-carboxamides |
| PE20110367A1 (es) | 2008-09-18 | 2011-06-13 | Hoffmann La Roche | DERIVADOS DE 4-CIANO-4-FENIL-PIRROLIDIN-2-CARBOXAMIDAS SUSTITUIDAS COMO INHIBIDORES DE LA INTERACCION p53-MDM2 |
| WO2010151269A1 (en) | 2009-06-26 | 2010-12-29 | Biotic Laboratories, Inc. | Para-xylylene based multilayer drug elution devices |
| US20110118283A1 (en) | 2009-11-17 | 2011-05-19 | Qingjie Ding | Substituted Pyrrolidine-2-Carboxamides |
| US20120065210A1 (en) | 2010-09-15 | 2012-03-15 | Xin-Jie Chu | Substituted hexahydropyrrolo[1,2-c]imidazolones |
| CN101991860B (zh) | 2010-11-08 | 2013-06-19 | 中国药科大学 | 泊洛沙姆-羧酸类药物偶联物及其制备方法与应用 |
| CA2817585A1 (en) | 2010-11-12 | 2012-05-18 | The Regents Of The University Of Michigan | Spiro-oxindole mdm2 antagonists |
| EP2670780B1 (en) | 2011-02-02 | 2015-08-19 | Ontario Institute for Cancer Research | Cellulose-based nanoparticles for drug delivery |
| WO2012116073A2 (en) | 2011-02-23 | 2012-08-30 | The Board Of Trustees Of The University Of Illinois | Amphiphilic dendron-coils, micelles thereof and uses |
| CN102247602B (zh) | 2011-06-13 | 2013-01-02 | 中山大学 | 一种超分子水凝胶双重药物载体及其制备方法和应用 |
| WO2013033476A1 (en) | 2011-08-30 | 2013-03-07 | Quanta Biodesign, Ltd. | Branched discrette peg constructs |
| RU2014150492A (ru) * | 2012-05-30 | 2016-07-20 | Ф. Хоффманн-Ля Рош Аг | Замещенные пирролидин-2-карбоксамиды |
-
2013
- 2013-03-05 US US13/785,267 patent/US8993614B2/en not_active Expired - Fee Related
- 2013-03-12 WO PCT/EP2013/054920 patent/WO2013135648A1/en not_active Ceased
- 2013-03-12 CA CA2860781A patent/CA2860781A1/en not_active Abandoned
- 2013-03-12 ES ES13708466.1T patent/ES2634290T3/es active Active
- 2013-03-12 CN CN201380021271.9A patent/CN104271554B/zh not_active Expired - Fee Related
- 2013-03-12 JP JP2014561405A patent/JP6125546B2/ja active Active
- 2013-03-12 NZ NZ626505A patent/NZ626505A/en not_active IP Right Cessation
- 2013-03-12 DK DK13708466.1T patent/DK2825528T3/en active
- 2013-03-12 PL PL13708466T patent/PL2825528T3/pl unknown
- 2013-03-12 HU HUE13708466A patent/HUE032864T2/en unknown
- 2013-03-12 SI SI201330703T patent/SI2825528T1/sl unknown
- 2013-03-12 KR KR20147025671A patent/KR20140138165A/ko not_active Withdrawn
- 2013-03-12 PE PE2014001419A patent/PE20142185A1/es not_active Application Discontinuation
- 2013-03-12 EA EA201491623A patent/EA025557B1/ru not_active IP Right Cessation
- 2013-03-12 BR BR112014018959A patent/BR112014018959A8/pt not_active IP Right Cessation
- 2013-03-12 SG SG11201404344XA patent/SG11201404344XA/en unknown
- 2013-03-12 AU AU2013203662A patent/AU2013203662B2/en not_active Ceased
- 2013-03-12 MX MX2014010942A patent/MX2014010942A/es unknown
- 2013-03-12 EP EP13708466.1A patent/EP2825528B1/en not_active Not-in-force
- 2013-03-13 AR ARP130100814A patent/AR090328A1/es unknown
- 2013-03-14 TW TW102109122A patent/TWI586648B/zh not_active IP Right Cessation
- 2013-12-03 UA UAA201411036A patent/UA113541C2/uk unknown
-
2014
- 2014-06-25 CO CO14137196A patent/CO6990736A2/es active IP Right Grant
- 2014-07-03 PH PH12014501542A patent/PH12014501542A1/en unknown
- 2014-07-14 CL CL2014001858A patent/CL2014001858A1/es unknown
- 2014-08-18 IL IL234173A patent/IL234173A/en not_active IP Right Cessation
- 2014-08-26 CR CR20140399A patent/CR20140399A/es unknown
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