PL2825528T3 - Podstawione pirolidyno-2-karboksyamidy - Google Patents
Podstawione pirolidyno-2-karboksyamidyInfo
- Publication number
- PL2825528T3 PL2825528T3 PL13708466T PL13708466T PL2825528T3 PL 2825528 T3 PL2825528 T3 PL 2825528T3 PL 13708466 T PL13708466 T PL 13708466T PL 13708466 T PL13708466 T PL 13708466T PL 2825528 T3 PL2825528 T3 PL 2825528T3
- Authority
- PL
- Poland
- Prior art keywords
- carboxamides
- substituted pyrrolidine
- pyrrolidine
- substituted
- Prior art date
Links
- VLJNHYLEOZPXFW-UHFFFAOYSA-N pyrrolidine-2-carboxamide Chemical class NC(=O)C1CCCN1 VLJNHYLEOZPXFW-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Polyethers (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261611200P | 2012-03-15 | 2012-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2825528T3 true PL2825528T3 (pl) | 2017-09-29 |
Family
ID=47844360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13708466T PL2825528T3 (pl) | 2012-03-15 | 2013-03-12 | Podstawione pirolidyno-2-karboksyamidy |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8993614B2 (pl) |
| EP (1) | EP2825528B1 (pl) |
| JP (1) | JP6125546B2 (pl) |
| KR (1) | KR20140138165A (pl) |
| CN (1) | CN104271554B (pl) |
| AR (1) | AR090328A1 (pl) |
| AU (1) | AU2013203662B2 (pl) |
| BR (1) | BR112014018959A8 (pl) |
| CA (1) | CA2860781A1 (pl) |
| CL (1) | CL2014001858A1 (pl) |
| CO (1) | CO6990736A2 (pl) |
| CR (1) | CR20140399A (pl) |
| DK (1) | DK2825528T3 (pl) |
| EA (1) | EA025557B1 (pl) |
| ES (1) | ES2634290T3 (pl) |
| HU (1) | HUE032864T2 (pl) |
| IL (1) | IL234173A (pl) |
| MX (1) | MX2014010942A (pl) |
| NZ (1) | NZ626505A (pl) |
| PE (1) | PE20142185A1 (pl) |
| PH (1) | PH12014501542B1 (pl) |
| PL (1) | PL2825528T3 (pl) |
| SG (1) | SG11201404344XA (pl) |
| SI (1) | SI2825528T1 (pl) |
| TW (1) | TWI586648B (pl) |
| UA (1) | UA113541C2 (pl) |
| WO (1) | WO2013135648A1 (pl) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201406889WA (en) | 2012-05-30 | 2015-02-27 | Hoffmann La Roche | Substituted pyrrolidine-2-carboxamides |
| AR094116A1 (es) | 2012-12-20 | 2015-07-08 | Merck Sharp & Dohme | Imidazopiridinas sustituidas como inhibidores de hdm2 |
| JP6346945B2 (ja) * | 2013-06-24 | 2018-06-20 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 安定な静脈内製剤 |
| HK1215453A1 (zh) | 2013-07-03 | 2016-08-26 | 豪夫迈．罗氏有限公司 | 用於将用mdm2拮抗剂进行患者癌症治疗个人化的基於mrna的基因表达 |
| AR097584A1 (es) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano |
| WO2015082384A1 (en) * | 2013-12-05 | 2015-06-11 | F. Hoffmann-La Roche Ag | Novel combination treatment for acute myeloid leukemia (aml) |
| US9657351B2 (en) | 2013-12-06 | 2017-05-23 | Hoffman-La Roche Inc. | MRNA-based gene expression for personalizing patient cancer therapy with an MDM2 antagonist |
| PL3459933T3 (pl) * | 2014-04-15 | 2023-01-23 | F. Hoffmann-La Roche Ag | Stałe postacie farmaceutycznie czynnego związku |
| JP2017520526A (ja) * | 2014-05-22 | 2017-07-27 | ザ・ユニバーシティ・オブ・シドニー | オメガ−３類似体 |
| WO2016055497A1 (en) * | 2014-10-10 | 2016-04-14 | F. Hoffmann-La Roche Ag | Methods for personalizing patient cancer therapy with an mdm2 antagonist |
| CN104496822B (zh) * | 2014-12-15 | 2016-10-26 | 扬州三友合成化工有限公司 | 一种1-氯乙基环己基丙基碳酸酯的制备方法 |
| TWI716405B (zh) | 2015-05-07 | 2021-01-21 | 美商艾吉納斯公司 | 抗ox40抗體及其使用方法 |
| EP3383430A4 (en) | 2015-12-02 | 2019-12-18 | Agenus Inc. | ANTIBODIES AND METHOD FOR USE THEREOF |
| PL3458101T3 (pl) | 2016-05-20 | 2021-05-31 | F. Hoffmann-La Roche Ag | Koniugaty PROTAC-przeciwciało i sposoby ich stosowania |
| CN107698598B (zh) * | 2016-08-08 | 2019-06-21 | 肖飞 | 螺环吲哚酮聚乙二醇碳酸酯类化合物和其组合物、制备方法及用途 |
| JP6848047B2 (ja) * | 2016-08-08 | 2021-03-24 | フェイ シアオ， | スピロインドロンポリエチレングリコールカーボネート系化合物及びその組成物、調製方法及びその使用 |
| WO2018036852A1 (en) | 2016-08-25 | 2018-03-01 | F. Hoffmann-La Roche Ag | Intermittent dosing of an anti-csf-1r antibody in combination with macrophage activating agent |
| MA46770A (fr) | 2016-11-09 | 2019-09-18 | Agenus Inc | Anticorps anti-ox40, anticorps anti-gitr, et leurs procédés d'utilisation |
| JP7304287B2 (ja) | 2016-12-22 | 2023-07-06 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 抗ｐｄ－ｌ１／ｐｄ１治療の不成功後の、抗ｐｄ－ｌ１抗体との組み合わせでの抗ｃｓｆ－１ｒ抗体を用いた腫瘍の治療 |
| CA3086522A1 (en) * | 2017-12-20 | 2019-06-27 | Angex Pharmaceutical, Inc. | Carbamate and urea compounds as multikinase inhibitors |
| CN114230561B (zh) * | 2020-09-09 | 2024-03-19 | 中国人民解放军海军军医大学 | 一种mdm2抑制剂类小分子化合物及用途 |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0720857B2 (ja) | 1988-08-11 | 1995-03-08 | テルモ株式会社 | リポソームおよびその製法 |
| DE69120141T2 (de) | 1990-03-28 | 1996-11-28 | Shuji Kojima | Polymerkombiniertes Arzneimittel zur Magenbehandlung und Verfahren zu dessen Herstellung |
| US5681811A (en) | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
| GB9317618D0 (en) | 1993-08-24 | 1993-10-06 | Royal Free Hosp School Med | Polymer modifications |
| KR100361933B1 (ko) | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
| WO1995016465A1 (en) | 1993-12-14 | 1995-06-22 | Sandoz Ltd. | Pharmaceutical compositions containing alkyl polyoxyalkylene carboxylates |
| DE4435087A1 (de) | 1994-09-30 | 1996-04-04 | Deutsches Krebsforsch | Konjugat zur Behandlung von Infektions-, Autoimmun- und Hauterkrankungen |
| EP0921817B1 (en) | 1997-01-29 | 2001-03-28 | PolyMASC Pharmaceuticals plc | Pegylation process |
| AU9402198A (en) | 1997-09-26 | 1999-04-23 | Becton Dickinson & Company | Preparing conjugates using polyethylene glycol linkers |
| US6165509A (en) | 1998-09-01 | 2000-12-26 | University Of Washington | Pegylated drug complexed with bioadhesive polymer suitable for drug delivery and methods relating thereto |
| US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| US6713454B1 (en) | 1999-09-13 | 2004-03-30 | Nobex Corporation | Prodrugs of etoposide and etoposide analogs |
| US6951939B2 (en) | 2000-06-08 | 2005-10-04 | La Jolla Pharmaceutical Company | Multivalent platform molecules comprising high molecular weight polyethylene oxide |
| US20040171808A1 (en) | 2001-05-30 | 2004-09-02 | Kazunori Kataoka | Method of bonding substance to be incorporated into polymer terminal |
| US6939874B2 (en) * | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
| US7144978B2 (en) | 2002-01-15 | 2006-12-05 | Pan Asia Bio Co., Ltd. | Multidrop tree branching functional polyethylene glycol, methods of preparing and using same |
| MXPA04006855A (es) | 2002-01-18 | 2005-04-19 | Biogen Idec Inc | Compuestos de polimeros de polialquileno y usos de los mismos. |
| US7482376B2 (en) | 2003-07-03 | 2009-01-27 | 3-Dimensional Pharmaceuticals, Inc. | Conjugated complement cascade inhibitors |
| JP4991037B2 (ja) | 2004-04-01 | 2012-08-01 | カーディオム ファーマ コーポレイション | イオンチャネル調節化合物を含む薬物結合体 |
| TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
| WO2006047419A2 (en) | 2004-10-25 | 2006-05-04 | Intezyne Technologies, Incorporated | Heterobifunctional poly(ethylene glycol) and uses thereof |
| NZ561215A (en) | 2005-02-22 | 2010-12-24 | Univ Michigan | Small molecule inhibitors of MDM2 and uses thereof |
| CA2650035C (en) | 2006-04-27 | 2015-02-03 | Intezyne Technologies, Inc. | Poly (ethylene glycol) containing chemically disparate endgroups |
| WO2008109783A2 (en) | 2007-03-06 | 2008-09-12 | The Regents Of The University Of California | Detecting spin perturbations using magnetic resonance imaging |
| CN101357986B (zh) | 2007-06-13 | 2013-06-05 | 康达医药科技有限公司 | 聚乙二醇功能性衍生物和制造方法 |
| WO2009128789A1 (en) | 2008-04-17 | 2009-10-22 | Agency For Science, Technology And Research | Vesicles for intracellular drug delivery |
| US20110104074A1 (en) | 2008-06-18 | 2011-05-05 | University Of Louisville Research Foundation, Inc. | Methods for targeted cancer treatment and detection |
| MY155612A (en) | 2008-07-14 | 2015-11-13 | Biocon Ltd | A method of synthesizing a substantially monodispersed mixture of oligomers |
| US8653131B2 (en) | 2008-08-22 | 2014-02-18 | Baxter Healthcare S.A. | Polymeric benzyl carbonate-derivatives |
| US8354444B2 (en) | 2008-09-18 | 2013-01-15 | Hoffmann-La Roche Inc. | Substituted pyrrolidine-2-carboxamides |
| KR101380013B1 (ko) | 2008-09-18 | 2014-04-10 | 에프. 호프만-라 로슈 아게 | 치환 피롤리딘-2-카르복사미드 |
| US8709467B2 (en) | 2009-06-26 | 2014-04-29 | Cute Lovable Teddy Bear, Llc. | Para-xylylene based microfilm elution devices |
| US20110118283A1 (en) | 2009-11-17 | 2011-05-19 | Qingjie Ding | Substituted Pyrrolidine-2-Carboxamides |
| US20120065210A1 (en) | 2010-09-15 | 2012-03-15 | Xin-Jie Chu | Substituted hexahydropyrrolo[1,2-c]imidazolones |
| CN101991860B (zh) | 2010-11-08 | 2013-06-19 | 中国药科大学 | 泊洛沙姆-羧酸类药物偶联物及其制备方法与应用 |
| TWI535723B (zh) | 2010-11-12 | 2016-06-01 | 密西根大學董事會 | 螺－吲哚酮ｍｄｍ２拮抗劑 |
| CA2825926A1 (en) | 2011-02-02 | 2012-08-09 | Ontario Institute For Cancer Research | Cellulose-based nanoparticles for drug delivery |
| US9212258B2 (en) | 2011-02-23 | 2015-12-15 | The Board Of Trustees Of The University Of Illinois | Amphiphilic dendron-coils, micelles thereof and uses |
| CN102247602B (zh) | 2011-06-13 | 2013-01-02 | 中山大学 | 一种超分子水凝胶双重药物载体及其制备方法和应用 |
| AU2012301793A1 (en) | 2011-08-30 | 2014-03-20 | Quanta Biodesign, Ltd. | Branched discrette PEG constructs |
| SG11201406889WA (en) * | 2012-05-30 | 2015-02-27 | Hoffmann La Roche | Substituted pyrrolidine-2-carboxamides |
-
2013
- 2013-03-05 US US13/785,267 patent/US8993614B2/en not_active Expired - Fee Related
- 2013-03-12 WO PCT/EP2013/054920 patent/WO2013135648A1/en not_active Ceased
- 2013-03-12 PE PE2014001419A patent/PE20142185A1/es not_active Application Discontinuation
- 2013-03-12 CN CN201380021271.9A patent/CN104271554B/zh not_active Expired - Fee Related
- 2013-03-12 EP EP13708466.1A patent/EP2825528B1/en not_active Not-in-force
- 2013-03-12 KR KR20147025671A patent/KR20140138165A/ko not_active Withdrawn
- 2013-03-12 NZ NZ626505A patent/NZ626505A/en not_active IP Right Cessation
- 2013-03-12 HU HUE13708466A patent/HUE032864T2/en unknown
- 2013-03-12 SI SI201330703T patent/SI2825528T1/sl unknown
- 2013-03-12 EA EA201491623A patent/EA025557B1/ru not_active IP Right Cessation
- 2013-03-12 ES ES13708466.1T patent/ES2634290T3/es active Active
- 2013-03-12 SG SG11201404344XA patent/SG11201404344XA/en unknown
- 2013-03-12 DK DK13708466.1T patent/DK2825528T3/en active
- 2013-03-12 JP JP2014561405A patent/JP6125546B2/ja active Active
- 2013-03-12 PL PL13708466T patent/PL2825528T3/pl unknown
- 2013-03-12 BR BR112014018959A patent/BR112014018959A8/pt not_active IP Right Cessation
- 2013-03-12 MX MX2014010942A patent/MX2014010942A/es unknown
- 2013-03-12 AU AU2013203662A patent/AU2013203662B2/en not_active Ceased
- 2013-03-12 CA CA2860781A patent/CA2860781A1/en not_active Abandoned
- 2013-03-13 AR ARP130100814A patent/AR090328A1/es unknown
- 2013-03-14 TW TW102109122A patent/TWI586648B/zh not_active IP Right Cessation
- 2013-12-03 UA UAA201411036A patent/UA113541C2/uk unknown
-
2014
- 2014-06-25 CO CO14137196A patent/CO6990736A2/es active IP Right Grant
- 2014-07-03 PH PH12014501542A patent/PH12014501542B1/en unknown
- 2014-07-14 CL CL2014001858A patent/CL2014001858A1/es unknown
- 2014-08-18 IL IL234173A patent/IL234173A/en not_active IP Right Cessation
- 2014-08-26 CR CR20140399A patent/CR20140399A/es unknown
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