[go: up one dir, main page]

SI2734538T2 - Postopek za reverzibilno obarvanje tarčne celice - Google Patents

Postopek za reverzibilno obarvanje tarčne celice

Info

Publication number
SI2734538T2
SI2734538T2 SI201231352T SI201231352T SI2734538T2 SI 2734538 T2 SI2734538 T2 SI 2734538T2 SI 201231352 T SI201231352 T SI 201231352T SI 201231352 T SI201231352 T SI 201231352T SI 2734538 T2 SI2734538 T2 SI 2734538T2
Authority
SI
Slovenia
Prior art keywords
target cell
reversibly staining
reversibly
staining
target
Prior art date
Application number
SI201231352T
Other languages
English (en)
Other versions
SI2734538T1 (sl
Inventor
Thomas Schmidt
Christian Stemberger
Dirk H. Busch
Lothar Germeroth
Original Assignee
Iba Lifesciences Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46682800&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2734538(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Iba Lifesciences Gmbh filed Critical Iba Lifesciences Gmbh
Publication of SI2734538T1 publication Critical patent/SI2734538T1/sl
Publication of SI2734538T2 publication Critical patent/SI2734538T2/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/557Immunoassay; Biospecific binding assay; Materials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • G01N33/56972White blood cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/22Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00Labels used in chemical analysis of biological material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
SI201231352T 2011-07-18 2012-07-17 Postopek za reverzibilno obarvanje tarčne celice SI2734538T2 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161508943P 2011-07-18 2011-07-18
EP12747985.5A EP2734538B2 (en) 2011-07-18 2012-07-17 Method of reversibly staining a target cell
PCT/EP2012/063969 WO2013011011A2 (en) 2011-07-18 2012-07-17 Method of reversibly staining a target cell

Publications (2)

Publication Number Publication Date
SI2734538T1 SI2734538T1 (sl) 2018-09-28
SI2734538T2 true SI2734538T2 (sl) 2024-10-30

Family

ID=46682800

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201231352T SI2734538T2 (sl) 2011-07-18 2012-07-17 Postopek za reverzibilno obarvanje tarčne celice

Country Status (10)

Country Link
US (2) US9023604B2 (sl)
EP (2) EP2734538B2 (sl)
JP (2) JP6310388B2 (sl)
CN (2) CN103797028B (sl)
ES (1) ES2682750T5 (sl)
PL (1) PL2734538T5 (sl)
PT (1) PT2734538T (sl)
SI (1) SI2734538T2 (sl)
TR (1) TR201811128T4 (sl)
WO (1) WO2013011011A2 (sl)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9023604B2 (en) * 2011-07-18 2015-05-05 Iba Gmbh Method of reversibly staining a target cell
SG11201404991YA (en) 2012-02-23 2014-09-26 Stage Cell Therapeutics Gmbh Chromatographic isolation of cells and other complex biological materials
FI3524617T3 (fi) 2013-03-15 2023-06-26 Gladiator Biosciences Inc Gla-domeenit terapeuttisina aineina
SG11201608557UA (en) * 2014-04-16 2016-11-29 Juno Therapeutics Gmbh Methods, kits and apparatus for expanding a population of cells
US11400115B2 (en) 2014-04-23 2022-08-02 Juno Therapeutics, Inc. Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy
US10131876B2 (en) * 2014-04-24 2018-11-20 Miltenyi Biotec Gmbh Method for automated generation of genetically modified T cells
WO2015166049A1 (en) 2014-04-30 2015-11-05 Iba Gmbh Method of isolating a target cell
EP3037820A1 (en) * 2014-12-27 2016-06-29 Miltenyi Biotec GmbH Cell detection methods and reagents having a releasable labelling moiety
EP3253788A4 (en) * 2015-02-06 2018-08-08 Cell IDX, Inc. Antigen-coupled immunoreagents
WO2016166568A1 (en) 2015-04-16 2016-10-20 Juno Therapeutics Gmbh Methods, kits and apparatus for expanding a population of cells
KR20180108567A (ko) * 2015-10-22 2018-10-04 주노 테라퓨틱스 게엠베하 형질도입을 위한 방법, 키트, 제제 및 장치
MA45488A (fr) * 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés, kits et appareil de culture de cellules
MA45489A (fr) * 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés de culture de cellules, kits et appareil associés
CA3028265A1 (en) 2016-06-28 2018-01-04 Technische Universitaet Muenchen Combination of reversible and irreversible cell labeling for analyzing receptor-ligand koff rate
US10294454B2 (en) 2016-08-24 2019-05-21 General Electric Company Methods and kits for cell activation
EP3336546B1 (en) 2016-12-13 2020-07-01 Miltenyi Biotec B.V. & Co. KG Reversible cell labelling with conjugates having two releasable binding sites
EP3336545A1 (en) * 2016-12-13 2018-06-20 Miltenyi Biotec GmbH Reversible labeling of antigens in biological specimens
US10479976B2 (en) 2016-12-16 2019-11-19 Diagnologix, Llc Buoyancy enabled separation method and system
US11517627B2 (en) 2017-01-20 2022-12-06 Juno Therapeutics Gmbh Cell surface conjugates and related cell compositions and methods
IL270142B2 (en) 2017-04-27 2025-05-01 Juno Therapeutics Gmbh Oligomeric particle reagents and methods of use thereof
MX2020000900A (es) 2017-07-29 2021-01-08 Juno Therapeutics Inc Reactivos para expandir celulas que expresan receptores recombinantes.
CA3070579A1 (en) 2017-08-09 2019-02-14 Juno Therapeutics, Inc. Methods for producing genetically engineered cell compositions and related compositions
JP2020533404A (ja) 2017-09-05 2020-11-19 グラディエーター バイオサイエンシーズ インコーポレイテッド 細胞内送達法
WO2019089855A1 (en) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Process for generating therapeutic compositions of engineered cells
SG11202005272SA (en) 2017-12-08 2020-07-29 Juno Therapeutics Inc Process for producing a composition of engineered t cells
CN109917120B (zh) * 2017-12-12 2022-10-28 清华大学 检测翻译后修饰蛋白质与其配体间相互作用的成套试剂
EP3833742A2 (en) 2018-08-09 2021-06-16 Juno Therapeutics, Inc. Processes for generating engineered cells and compositions thereof
US20210246189A1 (en) 2018-09-03 2021-08-12 Technische Universitaet Muenchen A double peptide tag combining reversibility and flexible functionalization
MA53612A (fr) 2018-09-11 2021-09-15 Juno Therapeutics Inc Procédés d'analyse par spectrométrie de masse de compositions cellulaires modifiées
CN113227358A (zh) 2018-10-31 2021-08-06 朱诺治疗学有限公司 选择并刺激细胞的方法及用于所述方法的设备
SG11202104183RA (en) 2018-11-06 2021-05-28 Juno Therapeutics Inc Process for producing genetically engineered t cells
EP3959520A1 (en) 2019-04-23 2022-03-02 Miltenyi Biotec B.V. & Co. KG Reversible cell detection with conjugates having a linker for increased fluorescent brightness and an enzymatically releasable fluorescent moiety
KR20220015452A (ko) 2019-05-28 2022-02-08 밀테니 비오텍 비.브이. & 씨오. 케이지 유전자 변형된 t 세포의 생성 방법
AU2020287882A1 (en) 2019-06-07 2022-01-20 Juno Therapeutics, Inc. Automated T cell culture
CN114600172A (zh) 2019-08-30 2022-06-07 朱诺治疗学股份有限公司 用于将细胞分类的机器学习方法
EP4028049A1 (en) 2019-09-11 2022-07-20 Miltenyi Biotec B.V. & Co. KG In vitro method for transduction of t cells in the presence of malignant cells
KR20220101641A (ko) 2019-10-30 2022-07-19 주노 테라퓨틱스 게엠베하 세포 선택 및/또는 자극 장치 및 사용 방법
KR20220146480A (ko) 2020-01-28 2022-11-01 주노 쎄러퓨티크스 인코퍼레이티드 T 세포 형질도입 방법
IL295381A (en) 2020-02-12 2022-10-01 Juno Therapeutics Inc bcma-directed chimeric t-cell antigen receptor compounds and methods and uses thereof
JP2023519098A (ja) 2020-02-12 2023-05-10 ジュノー セラピューティクス インコーポレイテッド Cd19指向性キメラ抗原受容体t細胞組成物ならびにその方法および使用
EP4150057A2 (en) 2020-05-13 2023-03-22 Juno Therapeutics, Inc. Process for producing donor-batched cells expressing a recombinant receptor
US12403428B2 (en) 2020-06-24 2025-09-02 Asahi Kasei Life Science Corporation Evaluation method for protein-containing solution
WO2022043023A1 (en) 2020-08-27 2022-03-03 Miltenyi Biotec B.V. & Co. KG Releasable reagents for cell separation
CN112285083B (zh) * 2020-10-28 2022-01-07 上海睿钰生物科技有限公司 一种细胞杀伤效力的评价方法
CN117916256A (zh) 2021-05-06 2024-04-19 朱诺治疗学有限公司 用于刺激和转导t细胞的方法
WO2023147510A1 (en) 2022-01-28 2023-08-03 Juno Therapeutics, Inc. Chromatography arrays and related methods and kits
EP4227423A1 (en) 2022-02-09 2023-08-16 Technische Universität München Means and methods for identifying high affinity t-cells
WO2023209175A1 (en) 2022-04-28 2023-11-02 Bio-Recell Ltd. Method for separating target cells
US20250297282A1 (en) 2022-05-05 2025-09-25 Juno Therapeutics Gmbh Viral-binding protein and related reagents, articles, and methods of use
WO2023230581A1 (en) 2022-05-25 2023-11-30 Celgene Corporation Methods of manufacturing t cell therapies
WO2024100604A1 (en) 2022-11-09 2024-05-16 Juno Therapeutics Gmbh Methods for manufacturing engineered immune cells
CN121100267A (zh) 2022-12-09 2025-12-09 朱诺治疗学股份有限公司 使用全息成像预测细胞表型的机器学习方法
EP4658675A1 (en) 2023-02-03 2025-12-10 C3S2 GmbH Methods for non-viral manufacturing of engineered immune cells
WO2024182516A1 (en) 2023-02-28 2024-09-06 Juno Therapeutics, Inc. Cell therapy for treating systemic autoimmune diseases
WO2025049253A1 (en) 2023-08-25 2025-03-06 Juno Therapeutics, Inc. Bridged cycle‑based inhibitors of dna‑dependent protein kinase and compositions and application in gene editing
WO2025049250A1 (en) 2023-08-25 2025-03-06 Juno Therapeutics, Inc. 6,6-core silacycle based inhibitors of dna-dependent protein kinase and compositions and application in gene editing
WO2025049254A1 (en) 2023-08-25 2025-03-06 Juno Therapeutics, Inc. Pyrazolopyridine based inhibitors of dna-dependent protein kinase and compositions and application in gene editing
WO2025049247A1 (en) 2023-08-25 2025-03-06 Juno Therapeutics, Inc. 5,6-core silacycle based inhibitors of dna-dependent protein kinase and compositions and application in gene editing
WO2025083196A1 (en) 2023-10-18 2025-04-24 Tq Therapeutics Gmbh A method of manufacturing a cellular therapy product and respective kits and devices
WO2025160395A1 (en) 2024-01-25 2025-07-31 Juno Therapeutics, Inc. Use of bridged cycle-based inhibitors of dna-dependent protein kinase in combination of dna polymerase theta inhibitor and compositions and application in gene editing
WO2025179188A1 (en) 2024-02-22 2025-08-28 Juno Therapeutics, Inc. Pyrazole-based inhibitors of dna-dependent protein kinase and compositions and applications in gene editing

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4851341A (en) 1986-12-19 1989-07-25 Immunex Corporation Immunoaffinity purification system
DE4237113B4 (de) 1992-11-03 2006-10-12 "Iba Gmbh" Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins
DE19641876B4 (de) 1996-10-10 2011-09-29 Iba Gmbh Streptavidinmuteine
US5985658A (en) 1997-11-14 1999-11-16 Health Research Incorporated Calmodulin-based cell separation technique
EP1227321A1 (en) * 2000-12-28 2002-07-31 Institut für Bioanalytik GmbH Reversible MHC multimer staining for functional purification of antigen-specific T cells
DE10113776B4 (de) 2001-03-21 2012-08-09 "Iba Gmbh" Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins
IL160358A0 (en) * 2001-08-23 2004-07-25 Genmab As Human antibodies specific for interleukin 15 (il-15)
FR2841905B1 (fr) 2002-07-05 2004-09-03 Centre Nat Rech Scient Fragments fab mutants de l'anticorps anti-cd4 chimere 13b8.2 et leurs applications
JP4517081B2 (ja) * 2005-12-22 2010-08-04 独立行政法人産業技術総合研究所 免疫センサ用デバイス
US8372950B2 (en) * 2006-11-02 2013-02-12 Kagoshima University IgG binding peptide
CN101587043B (zh) * 2008-05-20 2013-10-02 北京莱尔生物医药科技有限公司 从生物体液样本中富集与检测稀有细胞的整合方法
WO2010017103A2 (en) 2008-08-04 2010-02-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic Fully human anti-human nkg2d monoclonal antibodies
US9023604B2 (en) * 2011-07-18 2015-05-05 Iba Gmbh Method of reversibly staining a target cell

Also Published As

Publication number Publication date
JP2018119982A (ja) 2018-08-02
US9188589B2 (en) 2015-11-17
CN107843730A (zh) 2018-03-27
JP6310388B2 (ja) 2018-04-11
PL2734538T3 (pl) 2018-10-31
US20150301046A1 (en) 2015-10-22
WO2013011011A2 (en) 2013-01-24
EP3418295A1 (en) 2018-12-26
EP2734538B1 (en) 2018-05-02
TR201811128T4 (tr) 2018-08-27
ES2682750T3 (es) 2018-09-21
PL2734538T5 (pl) 2025-11-12
EP3418295B1 (en) 2020-09-02
JP2014529361A (ja) 2014-11-06
US20140295458A1 (en) 2014-10-02
CN103797028A (zh) 2014-05-14
EP2734538A2 (en) 2014-05-28
SI2734538T1 (sl) 2018-09-28
HK1258907A1 (en) 2019-11-22
PT2734538T (pt) 2018-08-02
EP2734538B2 (en) 2024-07-03
US9023604B2 (en) 2015-05-05
CN103797028B (zh) 2017-08-25
ES2682750T5 (en) 2025-02-04
CN107843730B (zh) 2021-08-20
WO2013011011A3 (en) 2013-05-02
JP6770989B2 (ja) 2020-10-21

Similar Documents

Publication Publication Date Title
SI2734538T2 (sl) Postopek za reverzibilno obarvanje tarčne celice
EP2631962A4 (en) THIN BATTERY
GB201103590D0 (en) Fuel cell
EP2729561A4 (en) CELL CULTURE METHOD
PL2776455T3 (pl) Rodopsyny kanałowe do kontroli optycznej komórek
EP2698839A4 (en) BLOCK OF CELLS
EP2709128A4 (en) ELECTROCHEMICAL CELL
EP2787185A4 (en) METHOD FOR CONTROLLING AN INJECTOR
GB201110042D0 (en) Growth of cells
EP2707886A4 (en) ELECTROLYTE
GB201102454D0 (en) Energy access control
ZA201305116B (en) Fuel cells
SG11201402350QA (en) Haploid cells
GB201118641D0 (en) Electrochemical cell
GB2504996A8 (en) Stem cell culture method
EP2690694A4 (en) FUEL CELL
LT2727171T (lt) Ličio akumuliatorius
ZA201405069B (en) Fuel cell
AU337548S (en) Face of a solar cell
PL2673503T3 (pl) Sposób określania utraconej energii
EP2693546A4 (en) FUEL CELL
IL231177A0 (en) Intracellular selection of cells
EP2696414A4 (en) FUEL CELL
EP2693545A4 (en) FUEL CELL
EP2612745A4 (en) laminating