SI1610822T2 - Tekoče farmacevtske formulacije fsh in lh, skupaj z neionsko površinsko aktivno snovjo - Google Patents
Tekoče farmacevtske formulacije fsh in lh, skupaj z neionsko površinsko aktivno snovjoInfo
- Publication number
- SI1610822T2 SI1610822T2 SI200431587T SI200431587T SI1610822T2 SI 1610822 T2 SI1610822 T2 SI 1610822T2 SI 200431587 T SI200431587 T SI 200431587T SI 200431587 T SI200431587 T SI 200431587T SI 1610822 T2 SI1610822 T2 SI 1610822T2
- Authority
- SI
- Slovenia
- Prior art keywords
- fsh
- freeze
- liquid
- pharmaceutical formulations
- ionic surfactant
- Prior art date
Links
- CTKXFMQHOOWWEB-UHFFFAOYSA-N Ethylene oxide/propylene oxide copolymer Chemical compound CCCOC(C)COCCO CTKXFMQHOOWWEB-UHFFFAOYSA-N 0.000 title 1
- 239000000022 bacteriostatic agent Substances 0.000 title 1
- 239000007788 liquid Substances 0.000 title 1
- 239000002736 nonionic surfactant Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229920001993 poloxamer 188 Polymers 0.000 title 1
- 229940044519 poloxamer 188 Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03100882 | 2003-04-02 | ||
| EP03101543 | 2003-05-27 | ||
| EP03101828 | 2003-06-20 | ||
| EP04725385.1A EP1610822B2 (en) | 2003-04-02 | 2004-04-02 | Liquid pharmaceutical formulations of fsh and lh together with a non-ionic surfactant |
| PCT/EP2004/050432 WO2004087213A1 (en) | 2003-04-02 | 2004-04-02 | Liquid pharmaceutical formulations of fsh and lh together with a non-ionic surfactant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI1610822T1 SI1610822T1 (sl) | 2011-02-28 |
| SI1610822T2 true SI1610822T2 (sl) | 2018-12-31 |
Family
ID=33135521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200431587T SI1610822T2 (sl) | 2003-04-02 | 2004-04-02 | Tekoče farmacevtske formulacije fsh in lh, skupaj z neionsko površinsko aktivno snovjo |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7741268B2 (sl) |
| EP (1) | EP1610822B2 (sl) |
| JP (1) | JP4699991B2 (sl) |
| KR (1) | KR101105486B1 (sl) |
| AR (1) | AR043972A1 (sl) |
| AT (1) | ATE492292T2 (sl) |
| AU (1) | AU2004226666B9 (sl) |
| BR (1) | BRPI0409532B8 (sl) |
| CA (1) | CA2518903C (sl) |
| CY (1) | CY1111291T1 (sl) |
| DE (1) | DE602004030673D1 (sl) |
| DK (1) | DK1610822T4 (sl) |
| EA (1) | EA012565B1 (sl) |
| HR (1) | HRP20100727T4 (sl) |
| IL (1) | IL171151A (sl) |
| ME (1) | ME00217B (sl) |
| MX (1) | MXPA05010635A (sl) |
| NO (1) | NO330214B1 (sl) |
| NZ (1) | NZ542247A (sl) |
| PL (1) | PL1610822T5 (sl) |
| PT (1) | PT1610822E (sl) |
| RS (2) | RS57872B1 (sl) |
| SI (1) | SI1610822T2 (sl) |
| WO (1) | WO2004087213A1 (sl) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY139088A (en) * | 2005-02-21 | 2009-08-28 | Lg Life Sciences Ltd | Sustained release composition of protein drug |
| TWI369401B (en) * | 2005-07-05 | 2012-08-01 | Ares Trading Sa | Serum-free culture medium for the production of recombinant gonadotropins |
| AU2006290662B2 (en) | 2005-09-14 | 2010-12-23 | Ares Trading S.A. | Method for the quantitative determination of poloxamers |
| KR101105871B1 (ko) * | 2005-09-27 | 2012-01-16 | 주식회사 엘지생명과학 | 인 난포자극호르몬의 안정한 용액 제형 |
| US8664369B2 (en) * | 2007-11-01 | 2014-03-04 | Merck Serono S.A. | LH liquid formulations |
| ME01337B (me) | 2008-02-08 | 2013-12-20 | Biogenerix Ag | Tečni preparat fsh |
| CN101269215B (zh) * | 2008-05-15 | 2011-03-23 | 上海天伟生物制药有限公司 | 一种糖蛋白激素组合物 |
| CN102309747B (zh) * | 2008-09-17 | 2013-04-17 | 上海天伟生物制药有限公司 | 高纯度绝经期促性腺素冻干针剂 |
| MX2011004453A (es) | 2008-11-04 | 2011-08-12 | Aska Pharm Co Ltd | Composicion acuosa que contiene hormona foliculo estimulante. |
| AU2010234028B2 (en) | 2009-04-01 | 2013-11-14 | Theramex HQ UK Limited | Method for purifying recombinant FSH |
| EP2325194A1 (en) | 2009-11-24 | 2011-05-25 | Glycotope GmbH | Process for the purification of glycoproteins |
| WO2011076117A1 (zh) * | 2009-12-22 | 2011-06-30 | 上海天伟生物制药有限公司 | 绝经期促性腺素组合物 |
| WO2012127500A2 (en) * | 2011-03-11 | 2012-09-27 | Sanzyme Limited | Composition for spermatogenesis |
| US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| KR101699677B1 (ko) * | 2013-11-12 | 2017-01-24 | 카딜라 핼쓰캐어 리미티드 | 고나도트로핀을 위한 제제 |
| ES2719748T3 (es) * | 2014-05-23 | 2019-07-12 | Inst Massone S A | Proceso para obtener HMG-UP (gonadotropina menopáusica humana con grado de ultrapureza) y una composición libre de contaminantes |
| US11376220B2 (en) | 2017-06-30 | 2022-07-05 | Therio, LLC | Single-injection methods and formulations to induce and control multiple ovarian follicles in bovine, caprine, ovine, camelid and other female animals |
| TWI865430B (zh) * | 2017-07-24 | 2024-12-11 | 美商再生元醫藥公司 | 穩定化之抗體組合物及其製法 |
Family Cites Families (58)
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| GB839300A (en) | 1957-09-05 | 1960-06-29 | Organon Labor Ltd | Adrenocorticotropic hormone preparations and process for making same |
| FR3819M (fr) | 1963-03-11 | 1966-01-10 | Serono Ist Farm | Nouvelle hormone hypophysaire a activité différenciée. |
| EP0082481B2 (en) * | 1981-12-23 | 1990-09-12 | Schering Corporation | Stabilised alpha-interferon formulations and their preparation |
| JPS5921613A (ja) * | 1982-07-28 | 1984-02-03 | Takeda Chem Ind Ltd | 直腸投与製剤 |
| US4659696A (en) * | 1982-04-30 | 1987-04-21 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition and its nasal or vaginal use |
| US4746508A (en) * | 1983-06-06 | 1988-05-24 | Beth Israel Hospital Assn. | Drug administration |
| US5639639A (en) * | 1983-11-02 | 1997-06-17 | Genzyme Corporation | Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof |
| US4839341A (en) * | 1984-05-29 | 1989-06-13 | Eli Lilly And Company | Stabilized insulin formulations |
| US4589402A (en) * | 1984-07-26 | 1986-05-20 | Serono Laboratories, Inc. | Method of in vitro fertilization |
| US4962091A (en) * | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
| US5162306A (en) * | 1987-01-23 | 1992-11-10 | Donaldson Lloyd E | Composition and method for producing superovulation in mammals |
| US4780451B1 (en) | 1987-01-23 | 1995-04-04 | Asua International Inc | Composition and method for producing superovulation in cattle |
| IT1206302B (it) * | 1987-06-26 | 1989-04-14 | Serono Cesare Ist Ricerca | Ormone follicolo-stimolante urinario |
| ZA888577B (en) * | 1987-11-27 | 1989-08-30 | Akzo Nv | Stabilization of antibodies |
| US5096885A (en) | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
| US5087615A (en) * | 1989-03-17 | 1992-02-11 | Applied Research Systems Ars Holding N.V. | Novel method of ovulation induction in humans |
| US5733572A (en) * | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
| US5270057A (en) * | 1990-03-20 | 1993-12-14 | Akzo N.V. | Stabilized gonadotropin containing preparations |
| IE64738B1 (en) * | 1990-03-20 | 1995-09-06 | Akzo Nv | Stabilized gonadotropin containing preparations |
| US5384132A (en) * | 1990-03-20 | 1995-01-24 | Akzo N.V. | Stabilized gonadotropin containing preparations |
| US5374620A (en) * | 1990-06-07 | 1994-12-20 | Genentech, Inc. | Growth-promoting composition and its use |
| DE4117078A1 (de) | 1991-05-25 | 1992-11-26 | Boehringer Ingelheim Kg | Verfahren zur herstellung therapeutisch anwendbarer aerosole |
| US5508261A (en) * | 1991-06-18 | 1996-04-16 | University Of Medicine & Dentistry Of New Jersey | Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same |
| EP0673383B1 (en) | 1991-06-18 | 2000-05-31 | University Of Medicine & Dentistry Of New Jersey | Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same |
| IT1250075B (it) | 1991-12-18 | 1995-03-30 | Serono Cesare Ist Ricerca | Composizioni farmaceutiche contenenti gonadotropine. |
| US5356876A (en) * | 1992-01-13 | 1994-10-18 | Trinity University | Methods of terminating pregnancy |
| GB9211268D0 (en) * | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
| DE69334134T2 (de) | 1992-07-31 | 2007-12-20 | Genentech, Inc., South San Francisco | Wässrige Formulierung enthaltend Menschliches Wachstumshormon |
| US5661125A (en) * | 1992-08-06 | 1997-08-26 | Amgen, Inc. | Stable and preserved erythropoietin compositions |
| ES2164098T3 (es) * | 1993-02-02 | 2002-02-16 | Xoma Technology Ltd | Composiciones farmaceuticas que contienen una proteina bactericida aumentadora de la permeabilidad y un tensioactivo. |
| US6238890B1 (en) * | 1994-02-18 | 2001-05-29 | Washington University | Single chain forms of the glycoprotein hormone quartet |
| US5594091A (en) | 1994-02-21 | 1997-01-14 | Takeda Chemical Industries, Ltd. | Matrix for sustained-release preparation |
| US5580856A (en) * | 1994-07-15 | 1996-12-03 | Prestrelski; Steven J. | Formulation of a reconstituted protein, and method and kit for the production thereof |
| DE69528080T2 (de) * | 1994-12-22 | 2003-06-05 | Ortho Pharma Corp | Lösliche arzneizusammensetzungen enthaltend 2-chloro-2'-deoxyadenosine |
| US6524557B1 (en) * | 1994-12-22 | 2003-02-25 | Astrazeneca Ab | Aerosol formulations of peptides and proteins |
| AU5004196A (en) * | 1995-03-10 | 1996-10-02 | Boehringer Mannheim Gmbh | Polypeptide-containing pharmaceutical forms of administration in the form of microparticles and method for the preparation thereof |
| TW426523B (en) | 1995-04-06 | 2001-03-21 | Hoffmann La Roche | Interferon solution |
| FR2733914B1 (fr) | 1995-05-11 | 1997-08-01 | Sanofi Sa | Composition de liquide stable contenant de l'urate oxydase et composition lyophilisee pour sa preparation |
| DK1516628T3 (da) | 1995-07-27 | 2013-09-08 | Genentech Inc | Stabil, isotonisk lyofiliseret proteinformulering |
| US6267958B1 (en) * | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| ATE255903T1 (de) | 1995-11-07 | 2003-12-15 | Genentech Inc | Stabilisierende formulierung für ngf |
| KR20000069680A (ko) * | 1996-12-23 | 2000-11-25 | 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 | 액체 약제 저장을 위한 선형 올레핀 중합체로 된 약제 용기 |
| US6136784A (en) * | 1997-01-08 | 2000-10-24 | Amylin Pharmaceuticals, Inc. | Amylin agonist pharmaceutical compositions containing insulin |
| AU740918B2 (en) | 1997-01-10 | 2001-11-15 | Plantibodies Corporation | Novel epithelial tissue targeting agent |
| TW518235B (en) * | 1997-01-15 | 2003-01-21 | Akzo Nobel Nv | A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage |
| US20010007673A1 (en) * | 1999-11-12 | 2001-07-12 | Merrill Seymour Goldenberg | Sustained-release delayed gels |
| US6113947A (en) * | 1997-06-13 | 2000-09-05 | Genentech, Inc. | Controlled release microencapsulated NGF formulation |
| US6287587B2 (en) | 1997-07-15 | 2001-09-11 | Takeda Chemical Industries, Ltd. | Process for producing sustained-release preparation by in-water drying |
| WO1999021534A1 (en) | 1997-10-27 | 1999-05-06 | Merck Patent Gmbh | Solid state solutions and dispersions of poorly water soluble drugs |
| ZA9811127B (en) | 1997-12-09 | 2000-07-11 | Lilly Co Eli | Stabilized teriparatide solutions. |
| US6541606B2 (en) * | 1997-12-31 | 2003-04-01 | Altus Biologics Inc. | Stabilized protein crystals formulations containing them and methods of making them |
| BR9912243A (pt) * | 1998-07-23 | 2001-10-16 | Lilly Co Eli | Formulações de fsh e variantes de fsh, produtos e processos |
| US20020165146A1 (en) * | 1998-07-23 | 2002-11-07 | Hoffman James Arthur | FSH article of manufacture |
| FR2782455B3 (fr) | 1998-08-20 | 2000-09-15 | Sanofi Sa | Composition pharmaceutique injectable a base d'un sel pharmaceutiquement acceptable du clopidogrel ou de ticlopidine |
| AU765584B2 (en) * | 1998-09-17 | 2003-09-25 | Eli Lilly And Company | Protein formulations |
| CA2377791A1 (en) | 1999-06-30 | 2001-01-11 | Takeda Chemical Industries, Ltd. | Novel polypeptide and dna thereof |
| US6573237B2 (en) * | 2001-03-16 | 2003-06-03 | Eli Lilly And Company | Protein formulations |
| NZ535008A (en) | 2002-02-08 | 2005-09-30 | Alkermes Inc | Polymer-based compositions for sustained release |
-
2004
- 2004-04-02 ME MEP-2008-317A patent/ME00217B/me unknown
- 2004-04-02 EA EA200501531A patent/EA012565B1/ru unknown
- 2004-04-02 SI SI200431587T patent/SI1610822T2/sl unknown
- 2004-04-02 HR HRP20100727TT patent/HRP20100727T4/hr unknown
- 2004-04-02 RS RS20050737A patent/RS57872B1/sr unknown
- 2004-04-02 MX MXPA05010635A patent/MXPA05010635A/es active IP Right Grant
- 2004-04-02 JP JP2006505517A patent/JP4699991B2/ja not_active Expired - Lifetime
- 2004-04-02 AR ARP040101138A patent/AR043972A1/es not_active Application Discontinuation
- 2004-04-02 CA CA2518903A patent/CA2518903C/en not_active Expired - Fee Related
- 2004-04-02 EP EP04725385.1A patent/EP1610822B2/en not_active Expired - Lifetime
- 2004-04-02 WO PCT/EP2004/050432 patent/WO2004087213A1/en not_active Ceased
- 2004-04-02 US US10/551,840 patent/US7741268B2/en not_active Expired - Lifetime
- 2004-04-02 AT AT04725385T patent/ATE492292T2/de active
- 2004-04-02 DK DK04725385.1T patent/DK1610822T4/en active
- 2004-04-02 KR KR1020057018794A patent/KR101105486B1/ko not_active Expired - Lifetime
- 2004-04-02 RS YUP-2005/0737A patent/RS20050737A/sr unknown
- 2004-04-02 AU AU2004226666A patent/AU2004226666B9/en not_active Expired
- 2004-04-02 BR BRPI0409532A patent/BRPI0409532B8/pt not_active IP Right Cessation
- 2004-04-02 PT PT04725385T patent/PT1610822E/pt unknown
- 2004-04-02 DE DE602004030673T patent/DE602004030673D1/de not_active Expired - Lifetime
- 2004-04-02 PL PL04725385T patent/PL1610822T5/pl unknown
- 2004-04-02 NZ NZ542247A patent/NZ542247A/en not_active IP Right Cessation
-
2005
- 2005-09-28 IL IL171151A patent/IL171151A/en active IP Right Grant
- 2005-10-26 NO NO20054982A patent/NO330214B1/no unknown
-
2011
- 2011-01-12 CY CY20111100039T patent/CY1111291T1/el unknown
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