SI1697005T1 - Kombinacija flupirtina in tramadola - Google Patents
Kombinacija flupirtina in tramadolaInfo
- Publication number
- SI1697005T1 SI1697005T1 SI200431786T SI200431786T SI1697005T1 SI 1697005 T1 SI1697005 T1 SI 1697005T1 SI 200431786 T SI200431786 T SI 200431786T SI 200431786 T SI200431786 T SI 200431786T SI 1697005 T1 SI1697005 T1 SI 1697005T1
- Authority
- SI
- Slovenia
- Prior art keywords
- flupirtine
- tramadol
- combination
- treament
- pain
- Prior art date
Links
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 title abstract 2
- JUUFBMODXQKSTD-UHFFFAOYSA-N N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester Chemical compound N1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CC=C(F)C=C1 JUUFBMODXQKSTD-UHFFFAOYSA-N 0.000 title abstract 2
- 229960003667 flupirtine Drugs 0.000 title abstract 2
- 229960004380 tramadol Drugs 0.000 title abstract 2
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 title abstract 2
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Artificial Filaments (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52976103P | 2003-12-17 | 2003-12-17 | |
| EP04803682A EP1697005B1 (en) | 2003-12-17 | 2004-12-09 | Combination of flupirtine and tramadol |
| PCT/EP2004/014025 WO2005058420A1 (en) | 2003-12-17 | 2004-12-09 | Combination of flupirtine and tramadol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1697005T1 true SI1697005T1 (sl) | 2012-01-31 |
Family
ID=34700037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200431786T SI1697005T1 (sl) | 2003-12-17 | 2004-12-09 | Kombinacija flupirtina in tramadola |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7553858B2 (sl) |
| EP (1) | EP1697005B1 (sl) |
| JP (1) | JP4933265B2 (sl) |
| CN (1) | CN1889996A (sl) |
| AT (1) | ATE525112T1 (sl) |
| AU (1) | AU2004298333B2 (sl) |
| CA (1) | CA2546302C (sl) |
| DK (1) | DK1697005T3 (sl) |
| ES (1) | ES2373957T3 (sl) |
| HR (1) | HRP20110914T1 (sl) |
| MX (1) | MXPA06006999A (sl) |
| NO (1) | NO335734B1 (sl) |
| NZ (1) | NZ547256A (sl) |
| PL (1) | PL1697005T3 (sl) |
| PT (1) | PT1697005E (sl) |
| RU (1) | RU2463042C2 (sl) |
| SI (1) | SI1697005T1 (sl) |
| WO (1) | WO2005058420A1 (sl) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060052370A1 (en) * | 2004-08-24 | 2006-03-09 | Meyerson Laurence R | Methods and compositions for treating nociceptive pain |
| US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| BRPI0607017B8 (pt) | 2005-04-06 | 2021-05-25 | Adamas Pharmaceuticals Inc | composição farmacêutica compreendendo memantina e donezepil, e seu uso para o tratamento de condições relacionadas ao snc |
| WO2008134048A2 (en) * | 2007-04-27 | 2008-11-06 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing and purifying aminoalkyl tetracycline compounds |
| CN102333532A (zh) * | 2009-01-30 | 2012-01-25 | 瑞乐威尔澳大利亚私人有限公司 | 药物抗滥用,方法及组合物 |
| DE102010063612A1 (de) | 2010-12-20 | 2012-06-21 | Awd.Pharma Gmbh & Co. Kg | Neue Multikomponentenkristalle aus ([2-Amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamidsäureethylester und 2-[2-[(2,6-Dichlorphenyl)-amino]-phenyl]-essigsäure |
| DE102010063609A1 (de) | 2010-12-20 | 2012-06-21 | Awd.Pharma Gmbh & Co. Kg | Neue Multikomponentenkristalle aus ([2-Amino-6-(4-fluoro-benzylamino)-pyridin-3yl)-carbamidsäureethylester und einer Arylpropionsäure |
| MX2014010460A (es) * | 2012-03-02 | 2014-10-13 | Meda Pharma Gmbh & Co Kg | Formulaciones farmaceuticas que contienen flupirtina. |
| US9693949B1 (en) | 2015-12-22 | 2017-07-04 | Revogenex Ireland Ltd | Intravenous administration of tramadol |
| US9980900B2 (en) | 2015-12-22 | 2018-05-29 | Revogenex Ireland Ltd | Intravenous administration of tramadol |
| RU2678976C1 (ru) * | 2018-03-21 | 2019-02-05 | федеральное государственное бюджетное образовательное учреждение высшего образования "Тверской государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ профилактики длительного болевого синдрома в отдаленном послеоперационном периоде у пациентов с дисплазией соединительной ткани |
| TWI886158B (zh) | 2019-10-10 | 2025-06-11 | 加拿大商再諾製藥公司 | 選擇性鉀通道調節劑之固態晶型 |
| BR112022010733A2 (pt) * | 2019-12-06 | 2022-08-23 | Xenon Pharmaceuticals Inc | Métodos para tratar dor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0532627A (ja) * | 1991-07-29 | 1993-02-09 | Asta Medica Ag | 筋肉痙攣により帰因するか又は筋肉痙攣の結果である疾病及び症候群を治療するための医薬品及びその製法 |
| DE4236752A1 (de) * | 1992-10-30 | 1994-05-05 | Asta Medica Ag | Kombinationspräparat aus Flupirtin und Morphin zur Behandlung von Schmerzen und zur Vermeidung der Morphin-Abhängigkeit |
| DE19807535A1 (de) * | 1998-02-21 | 1999-08-26 | Asta Medica Ag | Pharmazeutische Kombinationen mit Tramadol |
| HUP0301296A2 (hu) * | 1999-08-03 | 2003-08-28 | Awd.Pharma Gmbh & Co. Kg | Flupirtin alkalmazása degeneratív ízületi fájdalom kezelésére |
-
2004
- 2004-12-03 US US11/002,762 patent/US7553858B2/en not_active Expired - Fee Related
- 2004-12-09 AU AU2004298333A patent/AU2004298333B2/en not_active Ceased
- 2004-12-09 PT PT04803682T patent/PT1697005E/pt unknown
- 2004-12-09 CA CA2546302A patent/CA2546302C/en not_active Expired - Fee Related
- 2004-12-09 SI SI200431786T patent/SI1697005T1/sl unknown
- 2004-12-09 MX MXPA06006999A patent/MXPA06006999A/es active IP Right Grant
- 2004-12-09 ES ES04803682T patent/ES2373957T3/es not_active Expired - Lifetime
- 2004-12-09 JP JP2006544286A patent/JP4933265B2/ja not_active Expired - Fee Related
- 2004-12-09 AT AT04803682T patent/ATE525112T1/de active
- 2004-12-09 DK DK04803682.6T patent/DK1697005T3/da active
- 2004-12-09 HR HR20110914T patent/HRP20110914T1/hr unknown
- 2004-12-09 NZ NZ547256A patent/NZ547256A/en not_active IP Right Cessation
- 2004-12-09 WO PCT/EP2004/014025 patent/WO2005058420A1/en not_active Ceased
- 2004-12-09 RU RU2006125520/15A patent/RU2463042C2/ru not_active IP Right Cessation
- 2004-12-09 EP EP04803682A patent/EP1697005B1/en not_active Expired - Lifetime
- 2004-12-09 CN CNA2004800366436A patent/CN1889996A/zh active Pending
- 2004-12-09 PL PL04803682T patent/PL1697005T3/pl unknown
-
2006
- 2006-07-17 NO NO20063308A patent/NO335734B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1697005B1 (en) | 2011-09-21 |
| AU2004298333B2 (en) | 2009-12-17 |
| CN1889996A (zh) | 2007-01-03 |
| MXPA06006999A (es) | 2006-12-14 |
| DK1697005T3 (da) | 2011-12-12 |
| EP1697005A1 (en) | 2006-09-06 |
| NO335734B1 (no) | 2015-02-02 |
| PL1697005T3 (pl) | 2012-02-29 |
| WO2005058420A1 (en) | 2005-06-30 |
| NO20063308L (no) | 2006-09-12 |
| CA2546302C (en) | 2012-05-22 |
| RU2463042C2 (ru) | 2012-10-10 |
| RU2006125520A (ru) | 2008-01-27 |
| AU2004298333A1 (en) | 2005-06-30 |
| ATE525112T1 (de) | 2011-10-15 |
| JP4933265B2 (ja) | 2012-05-16 |
| JP2007514672A (ja) | 2007-06-07 |
| HRP20110914T1 (hr) | 2011-12-31 |
| US7553858B2 (en) | 2009-06-30 |
| ES2373957T3 (es) | 2012-02-10 |
| US20050137235A1 (en) | 2005-06-23 |
| CA2546302A1 (en) | 2005-06-30 |
| NZ547256A (en) | 2009-04-30 |
| PT1697005E (pt) | 2011-12-29 |
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