SI1501507T1 - Tetrahidropiranil ciklopentil tetrahidropiridopiridin modulatorji s kemokinsko receptorsko aktivnostjo - Google Patents
Tetrahidropiranil ciklopentil tetrahidropiridopiridin modulatorji s kemokinsko receptorsko aktivnostjoInfo
- Publication number
- SI1501507T1 SI1501507T1 SI200331285T SI200331285T SI1501507T1 SI 1501507 T1 SI1501507 T1 SI 1501507T1 SI 200331285 T SI200331285 T SI 200331285T SI 200331285 T SI200331285 T SI 200331285T SI 1501507 T1 SI1501507 T1 SI 1501507T1
- Authority
- SI
- Slovenia
- Prior art keywords
- chemokine receptor
- receptor activity
- modulators
- tetrahydropyranyl cyclopentyl
- tetrahydropyranyl
- Prior art date
Links
- 102000009410 Chemokine receptor Human genes 0.000 title abstract 2
- 108050000299 Chemokine receptor Proteins 0.000 title abstract 2
- WBUHGSNIYBJEDA-UHFFFAOYSA-N 1-cyclopentyl-2-(oxan-2-yl)-3,4-dihydro-2h-1,5-naphthyridine Chemical compound C1CCCC1N1C2=CC=CN=C2CCC1C1OCCCC1 WBUHGSNIYBJEDA-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102100031151 C-C chemokine receptor type 2 Human genes 0.000 abstract 1
- 101710149815 C-C chemokine receptor type 2 Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37618002P | 2002-04-29 | 2002-04-29 | |
| EP03724241A EP1501507B1 (en) | 2002-04-29 | 2003-04-25 | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| PCT/US2003/012929 WO2003092586A2 (en) | 2002-04-29 | 2003-04-25 | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1501507T1 true SI1501507T1 (sl) | 2008-12-31 |
Family
ID=29401316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200331285T SI1501507T1 (sl) | 2002-04-29 | 2003-04-25 | Tetrahidropiranil ciklopentil tetrahidropiridopiridin modulatorji s kemokinsko receptorsko aktivnostjo |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6812234B2 (sl) |
| EP (1) | EP1501507B1 (sl) |
| JP (1) | JP3780291B2 (sl) |
| AT (1) | ATE396993T1 (sl) |
| AU (1) | AU2003231114B8 (sl) |
| CA (1) | CA2483752C (sl) |
| CY (1) | CY1110399T1 (sl) |
| DE (1) | DE60321333D1 (sl) |
| DK (1) | DK1501507T3 (sl) |
| ES (1) | ES2306867T3 (sl) |
| NZ (1) | NZ536477A (sl) |
| PT (1) | PT1501507E (sl) |
| SI (1) | SI1501507T1 (sl) |
| WO (1) | WO2003092586A2 (sl) |
| ZA (1) | ZA200407940B (sl) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060030582A1 (en) * | 2002-04-29 | 2006-02-09 | Demartino Julie | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| JO2479B1 (en) | 2002-04-29 | 2009-01-20 | ميرك شارب اند دوم ليمتد | Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine |
| GEP20115290B (en) | 2002-11-27 | 2011-09-26 | Incyte Corp | 3-aminopyrrolidine derivatives as modulators of chemokine receptors |
| WO2004082616A2 (en) * | 2003-03-18 | 2004-09-30 | Merck & Co. Inc. | Tetrahydropyranyl cyclopentyl heterocylic amide modulators of chemokine receptor activity |
| CA2521950C (en) * | 2003-04-15 | 2009-11-17 | Merck & Co., Inc. | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors |
| AU2004232939A1 (en) * | 2003-04-17 | 2004-11-04 | Merck Sharp & Dohme Corp. | Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity |
| US20060205761A1 (en) * | 2003-06-06 | 2006-09-14 | Catherine Abbadie | Ccr-2 antagonists for treatment of neuropathic pain |
| BRPI0415836A (pt) * | 2003-10-27 | 2007-01-02 | Merck & Co Inc | composto, métodos para a modulação da atividade de receptor de quimocina em um mamìfero, e para o tratamento, a melhoria, o controle ou a redução do risco de uma doença ou distúrbio inflamatório e imunorregulatório, e de artrite reumatóide, composição farmacêutica |
| AR045875A1 (es) * | 2003-10-27 | 2005-11-16 | Merck & Co Inc | Procedimiento para la preparacion del antagonista ccr-2 |
| WO2005060665A2 (en) | 2003-12-18 | 2005-07-07 | Incyte Corporation | 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors |
| JP2007519633A (ja) * | 2004-01-02 | 2007-07-19 | メルク エンド カムパニー インコーポレーテッド | アルキルアミノ、アリールアミノおよびスルホンアミドシクロペンチルアミド系のケモカイン受容体活性調節剤 |
| AU2005208887B2 (en) * | 2004-01-28 | 2010-02-25 | Merck Sharp & Dohme Corp. | Aminocyclopentyl pyridopyrazinone modulators of chemokine receptor activity |
| WO2005120505A2 (en) * | 2004-04-26 | 2005-12-22 | Merck & Co., Inc | Tetrahydropyranyl cyclopentyl tetrahy-dropyridopyridine modulators of chemokine receptor activity |
| WO2005110409A2 (en) * | 2004-04-26 | 2005-11-24 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl 1-substituted and 1,1-disubstituted tetrahydroisoquinoline modulators of chemokine receptor activity |
| EP1755603A4 (en) * | 2004-04-28 | 2009-03-11 | Merck & Co Inc | 3,3-DISUBSTITUTED TETRAHYDROPYRANYL CYCLOPENTYL AMIDE MODULATORS OF CHEMOKIN RECEPTOR ACTIVITY |
| CA2565486A1 (en) | 2004-05-11 | 2005-12-08 | Incyte Corporation | 3-(4-heteroarylcyclohexylamino)cyclopentanecarboxamides as modulators of chemokine receptors |
| EP1763351B9 (en) * | 2004-06-28 | 2017-05-31 | Incyte Holdings Corporation | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors |
| GEP20094844B (en) | 2004-06-28 | 2009-11-25 | Incyte Corp | 3-aminocyclopentane carboxamides as modulators of chemokine receptors |
| US20070238723A1 (en) * | 2004-10-15 | 2007-10-11 | Goble Stephen D | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors |
| US20080194548A1 (en) * | 2005-01-06 | 2008-08-14 | Forrest Michael J | Drug Combination Therapy and Pharmaceutical Compositions for Treating Inflammatory Disorders |
| JP2008536484A (ja) * | 2005-03-11 | 2008-09-11 | メルク エンド カムパニー インコーポレーテッド | （ｒ）−４，４−ジメトキシ−ピラン−３−オールなどの（ｒ）−４，４−ジアルコキシ−ピラン−３−オールの調製方法 |
| US8067415B2 (en) | 2005-11-01 | 2011-11-29 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of CCR2 |
| US8067457B2 (en) | 2005-11-01 | 2011-11-29 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of CCR2 |
| US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
| PT2370442E (pt) * | 2008-11-26 | 2013-06-27 | Pfizer | 3-aminociclopentanocarboxamidas como moduladores de receptor de quimiocina |
| CN102256963B (zh) | 2008-12-19 | 2014-06-11 | 贝林格尔.英格海姆国际有限公司 | 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺 |
| PT2513093E (pt) | 2009-12-17 | 2014-10-22 | Boehringer Ingelheim Int | Novos antagonistas do receptor ccr2 e suas utilizações |
| MX2012007253A (es) | 2009-12-22 | 2012-07-17 | Cephalon Inc | Derivados triciclicos y sus usos y composiciones farmaceuticas. |
| EP2534158B1 (en) | 2010-02-09 | 2014-01-08 | Bristol-Myers Squibb Company | Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity |
| JP5636094B2 (ja) * | 2010-05-25 | 2014-12-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ２受容体アンタゴニスト |
| EP2685978A2 (en) * | 2011-03-17 | 2014-01-22 | Merck Sharp & Dohme Corp. | Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists |
| US8822460B2 (en) * | 2012-04-06 | 2014-09-02 | Janssen Pharmaceutica Nv | Fused cyclopentyl antagonists of CCR2 |
| JP2014193854A (ja) | 2013-02-28 | 2014-10-09 | Santen Pharmaceut Co Ltd | テトラヒドロピラニルアミノシクロペンチルカルボニルテトラヒドロピリドピリジン誘導体を有効成分として含有する後眼部疾患の予防または治療剤 |
| RS62809B1 (sr) * | 2015-05-21 | 2022-02-28 | Chemocentryx Inc | Modulatori ccr2 |
| AU2016287584B2 (en) | 2015-07-02 | 2020-03-26 | Centrexion Therapeutics Corporation | (4-((3R,4R)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2R,6S)-6-(p-tolyl)tetrahydro-2H-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate |
| US20190336489A1 (en) | 2017-01-17 | 2019-11-07 | Glaxosmithkline Intellectual Property Development Limited | Non peptide heterobivalent molecules for treating inflammatory diseases |
| US11304952B2 (en) | 2017-09-25 | 2022-04-19 | Chemocentryx, Inc. | Combination therapy using a chemokine receptor 2 (CCR2) antagonist and a PD-1/PD-L1 inhibitor |
| EP3737367B1 (en) | 2018-01-08 | 2024-10-02 | ChemoCentryx, Inc. | Ccr2 antagonists for the treatment of cutaneous t-cell lymphoma |
| US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
| CN119925562B (zh) * | 2023-11-03 | 2025-11-28 | 中国科学院上海药物研究所 | 趋化因子受体2拮抗剂在制备治疗糖尿病并发焦虑症的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2002A (en) * | 1841-03-12 | Tor and planter for plowing | ||
| US3647804A (en) | 1970-02-27 | 1972-03-07 | Upjohn Co | Cycloalkanecarboxamides |
| US3772308A (en) | 1972-06-02 | 1973-11-13 | Lilly Co Eli | Cyclopentanecetamides and cyclopentaneacetonitriles |
| CA2143143A1 (en) * | 1994-03-08 | 1995-09-09 | Toshihiko Tanaka | 3-phenylpyrrolidine derivatives |
| JPH09291034A (ja) * | 1996-02-27 | 1997-11-11 | Yoshitomi Pharmaceut Ind Ltd | 縮合ピリジン化合物およびその医薬としての用途 |
| GB9812037D0 (en) | 1998-06-04 | 1998-07-29 | Pfizer Ltd | Piperidones |
| US6312689B1 (en) | 1998-07-23 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Anti-CCR2 antibodies and methods of use therefor |
| US6500844B1 (en) * | 1999-06-11 | 2002-12-31 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| WO2002013824A1 (en) * | 2000-08-17 | 2002-02-21 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| WO2002070523A1 (en) | 2001-03-07 | 2002-09-12 | Pfizer Products Inc. | Modulators of chemokine receptor activity |
| JO2479B1 (en) * | 2002-04-29 | 2009-01-20 | ميرك شارب اند دوم ليمتد | Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine |
-
2003
- 2003-04-25 ES ES03724241T patent/ES2306867T3/es not_active Expired - Lifetime
- 2003-04-25 SI SI200331285T patent/SI1501507T1/sl unknown
- 2003-04-25 PT PT03724241T patent/PT1501507E/pt unknown
- 2003-04-25 WO PCT/US2003/012929 patent/WO2003092586A2/en not_active Ceased
- 2003-04-25 CA CA2483752A patent/CA2483752C/en not_active Expired - Lifetime
- 2003-04-25 DK DK03724241T patent/DK1501507T3/da active
- 2003-04-25 NZ NZ536477A patent/NZ536477A/en not_active IP Right Cessation
- 2003-04-25 AT AT03724241T patent/ATE396993T1/de active
- 2003-04-25 JP JP2004500771A patent/JP3780291B2/ja not_active Expired - Fee Related
- 2003-04-25 AU AU2003231114A patent/AU2003231114B8/en not_active Ceased
- 2003-04-25 EP EP03724241A patent/EP1501507B1/en not_active Expired - Lifetime
- 2003-04-25 DE DE60321333T patent/DE60321333D1/de not_active Expired - Lifetime
- 2003-04-29 US US10/425,167 patent/US6812234B2/en not_active Expired - Lifetime
-
2004
- 2004-10-01 ZA ZA200407940A patent/ZA200407940B/en unknown
-
2008
- 2008-08-26 CY CY20081100915T patent/CY1110399T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ536477A (en) | 2005-05-27 |
| CY1110399T1 (el) | 2014-04-09 |
| AU2003231114A1 (en) | 2003-11-17 |
| PT1501507E (pt) | 2008-08-12 |
| ZA200407940B (en) | 2006-06-28 |
| DK1501507T3 (da) | 2008-09-29 |
| JP2005523929A (ja) | 2005-08-11 |
| ATE396993T1 (de) | 2008-06-15 |
| US20040167156A1 (en) | 2004-08-26 |
| EP1501507A2 (en) | 2005-02-02 |
| CA2483752C (en) | 2011-03-29 |
| WO2003092586A2 (en) | 2003-11-13 |
| WO2003092586A3 (en) | 2004-09-16 |
| ES2306867T3 (es) | 2008-11-16 |
| AU2003231114B8 (en) | 2008-08-14 |
| EP1501507B1 (en) | 2008-05-28 |
| CA2483752A1 (en) | 2003-11-13 |
| US6812234B2 (en) | 2004-11-02 |
| AU2003231114B2 (en) | 2008-07-24 |
| EP1501507A4 (en) | 2006-05-17 |
| JP3780291B2 (ja) | 2006-05-31 |
| DE60321333D1 (de) | 2008-07-10 |
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