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CY1110399T1 - Ρυθμιστες της τετραϋδροπυρανυλο κυκλοπεντυλο τετραϋδροπυριδοπυριδινης για την ενεργοτητα των υποδοχεων των χημειοκινων - Google Patents

Ρυθμιστες της τετραϋδροπυρανυλο κυκλοπεντυλο τετραϋδροπυριδοπυριδινης για την ενεργοτητα των υποδοχεων των χημειοκινων

Info

Publication number
CY1110399T1
CY1110399T1 CY20081100915T CY081100915T CY1110399T1 CY 1110399 T1 CY1110399 T1 CY 1110399T1 CY 20081100915 T CY20081100915 T CY 20081100915T CY 081100915 T CY081100915 T CY 081100915T CY 1110399 T1 CY1110399 T1 CY 1110399T1
Authority
CY
Cyprus
Prior art keywords
regulators
activity
tetrahydropyridine
pyridine
chemokine receptors
Prior art date
Application number
CY20081100915T
Other languages
English (en)
Inventor
Richard Jiao
Gregori Morriello
Lihu Yang
Stephen D Goble
Sander G Mills
Alexander Pasternak
Changyou Zhou
Gabor Butora
Shankaran Kothandaraman
Deodialsingh Guiadeen
Cheng Tang
Christopher Moyes
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of CY1110399T1 publication Critical patent/CY1110399T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Η παρούσα εφεύρεση στρέφεται σε ενώσεις του χημικού τύπου (Ι):(όπου τα R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n και η διακεκομμένη γραμμή καθορίζονται στο παρόν) οι οποίες χρησιμεύουν ως ρυθμιστές της ενεργότητας των υποδοχέων των χημειοκινών. Συγκεκριμένα, οι ενώσεις αυτές χρησιμεύουν ως ρυθμιστές του υποδοχέα χημειοκίνης CCR-2
CY20081100915T 2002-04-29 2008-08-26 Ρυθμιστες της τετραϋδροπυρανυλο κυκλοπεντυλο τετραϋδροπυριδοπυριδινης για την ενεργοτητα των υποδοχεων των χημειοκινων CY1110399T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37618002P 2002-04-29 2002-04-29
EP03724241A EP1501507B1 (en) 2002-04-29 2003-04-25 Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity

Publications (1)

Publication Number Publication Date
CY1110399T1 true CY1110399T1 (el) 2014-04-09

Family

ID=29401316

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100915T CY1110399T1 (el) 2002-04-29 2008-08-26 Ρυθμιστες της τετραϋδροπυρανυλο κυκλοπεντυλο τετραϋδροπυριδοπυριδινης για την ενεργοτητα των υποδοχεων των χημειοκινων

Country Status (15)

Country Link
US (1) US6812234B2 (el)
EP (1) EP1501507B1 (el)
JP (1) JP3780291B2 (el)
AT (1) ATE396993T1 (el)
AU (1) AU2003231114B8 (el)
CA (1) CA2483752C (el)
CY (1) CY1110399T1 (el)
DE (1) DE60321333D1 (el)
DK (1) DK1501507T3 (el)
ES (1) ES2306867T3 (el)
NZ (1) NZ536477A (el)
PT (1) PT1501507E (el)
SI (1) SI1501507T1 (el)
WO (1) WO2003092586A2 (el)
ZA (1) ZA200407940B (el)

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EP1755603A4 (en) * 2004-04-28 2009-03-11 Merck & Co Inc 3,3-DISUBSTITUTED TETRAHYDROPYRANYL CYCLOPENTYL AMIDE MODULATORS OF CHEMOKIN RECEPTOR ACTIVITY
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WO2006004684A2 (en) 2004-06-28 2006-01-12 Incyte Corporation 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
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WO2007053499A2 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
PT2370442E (pt) * 2008-11-26 2013-06-27 Pfizer 3-aminociclopentanocarboxamidas como moduladores de receptor de quimiocina
EA020548B1 (ru) 2008-12-19 2014-12-30 Бёрингер Ингельхайм Интернациональ Гмбх Циклические пиримидин-4-карбоксамиды в качестве антагонистов рецептора ccr2, предназначенные для лечения воспаления, астмы и хозл
ME01908B (me) 2009-12-17 2014-12-20 Boehringer Ingelheim Int Novi antagonisti ccr2 receptora i njihova primjena
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WO2011100227A1 (en) * 2010-02-09 2011-08-18 Bristol-Myers Squibb Company Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity
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Also Published As

Publication number Publication date
AU2003231114B8 (en) 2008-08-14
CA2483752A1 (en) 2003-11-13
JP2005523929A (ja) 2005-08-11
US6812234B2 (en) 2004-11-02
DE60321333D1 (de) 2008-07-10
US20040167156A1 (en) 2004-08-26
EP1501507B1 (en) 2008-05-28
AU2003231114A1 (en) 2003-11-17
WO2003092586A2 (en) 2003-11-13
DK1501507T3 (da) 2008-09-29
ES2306867T3 (es) 2008-11-16
JP3780291B2 (ja) 2006-05-31
ZA200407940B (en) 2006-06-28
NZ536477A (en) 2005-05-27
CA2483752C (en) 2011-03-29
EP1501507A2 (en) 2005-02-02
AU2003231114B2 (en) 2008-07-24
WO2003092586A3 (en) 2004-09-16
EP1501507A4 (en) 2006-05-17
PT1501507E (pt) 2008-08-12
SI1501507T1 (sl) 2008-12-31
ATE396993T1 (de) 2008-06-15

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