SI1567112T1 - Thiazolidin-4-oni za inhibiranje proteinov hyak3 - Google Patents
Thiazolidin-4-oni za inhibiranje proteinov hyak3Info
- Publication number
- SI1567112T1 SI1567112T1 SI200331463T SI200331463T SI1567112T1 SI 1567112 T1 SI1567112 T1 SI 1567112T1 SI 200331463 T SI200331463 T SI 200331463T SI 200331463 T SI200331463 T SI 200331463T SI 1567112 T1 SI1567112 T1 SI 1567112T1
- Authority
- SI
- Slovenia
- Prior art keywords
- thiazolidin
- ones
- hyak3 proteins
- inhibiting hyak3
- inhibiting
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42838402P | 2002-11-22 | 2002-11-22 | |
| EP03796448A EP1567112B1 (en) | 2002-11-22 | 2003-11-18 | THIAZOLIDIN-4-ONES FOR INHIBITING hYAK3 PROTEINS |
| PCT/US2003/037658 WO2004047760A2 (en) | 2002-11-22 | 2003-11-18 | Novel chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1567112T1 true SI1567112T1 (sl) | 2009-02-28 |
Family
ID=32393394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200331463T SI1567112T1 (sl) | 2002-11-22 | 2003-11-18 | Thiazolidin-4-oni za inhibiranje proteinov hyak3 |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US7767701B2 (sl) |
| EP (1) | EP1567112B1 (sl) |
| JP (1) | JP2006509765A (sl) |
| KR (1) | KR20050085115A (sl) |
| CN (1) | CN100579978C (sl) |
| AP (1) | AP1967A (sl) |
| AR (1) | AR045407A1 (sl) |
| AT (1) | ATE411302T1 (sl) |
| AU (1) | AU2003298693B2 (sl) |
| BR (1) | BR0316502A (sl) |
| CA (1) | CA2507256A1 (sl) |
| CY (1) | CY1108655T1 (sl) |
| DE (1) | DE60324178D1 (sl) |
| DK (1) | DK1567112T3 (sl) |
| EA (1) | EA008865B1 (sl) |
| EC (1) | ECSP055808A (sl) |
| ES (1) | ES2315566T3 (sl) |
| IS (1) | IS2659B (sl) |
| MA (1) | MA27701A1 (sl) |
| MX (1) | MXPA05005406A (sl) |
| MY (1) | MY140132A (sl) |
| NO (1) | NO20052928L (sl) |
| NZ (1) | NZ539873A (sl) |
| OA (1) | OA12963A (sl) |
| PL (1) | PL377564A1 (sl) |
| PT (1) | PT1567112E (sl) |
| SI (1) | SI1567112T1 (sl) |
| TW (1) | TWI309648B (sl) |
| UA (1) | UA80572C2 (sl) |
| WO (1) | WO2004047760A2 (sl) |
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| ATE412650T1 (de) * | 2003-07-11 | 2008-11-15 | Warner Lambert Co | Isethionat salz eines selektiven cdk4 inhibitors |
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| USRE43833E1 (en) | 2003-11-21 | 2012-11-27 | Actelion Pharmaceuticals Ltd. | Thiazolidin-4-one derivatives |
| EP2295418A1 (en) | 2003-11-21 | 2011-03-16 | Actelion Pharmaceuticals Ltd. | 5-(benz-(z)-ylidene)-thiazolidin-4-one derivatives as immunosuppressant agents |
| JP2007523957A (ja) * | 2004-02-25 | 2007-08-23 | スミスクライン・ビーチャム・コーポレイション | 新規化学化合物 |
| PE20060373A1 (es) | 2004-06-24 | 2006-04-29 | Smithkline Beecham Corp | Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 |
| BRPI0512843A (pt) * | 2004-07-01 | 2008-04-08 | Hoffmann La Roche | inibidores de quinolina |
| WO2006002829A1 (en) * | 2004-07-01 | 2006-01-12 | F. Hoffmann-La Roche Ag | Thiazolinone unsubstituted quinolines |
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| US7253285B2 (en) * | 2004-09-17 | 2007-08-07 | Hoffmann-La Roche Inc. | Thiazolinone 4-monosubstituted quinolines |
| EA200700848A1 (ru) * | 2004-10-12 | 2007-10-26 | Апплайд Резеч Системз Арс Холдинг Н. В. | Ингибиторы pi3-гамма-киназы для лечения анемии |
| EP1805175B1 (en) * | 2004-10-14 | 2008-03-05 | F. Hoffmann-Roche AG | Novel azaindole thiazolinones as anti-cancer agents |
| KR100875408B1 (ko) * | 2004-10-14 | 2008-12-23 | 에프. 호프만-라 로슈 아게 | Ｃｄｋ1 항증식성 활성을 갖는 1,5-나프티리딘 아졸리디논 |
| CA2583311A1 (en) * | 2004-10-14 | 2006-04-20 | F. Hoffmann-La Roche Ag | Quinazolinylmethylenethiazolinones as cdk1 inhibitors |
| US7304074B2 (en) * | 2005-04-05 | 2007-12-04 | Hoffmann-La Roche Inc. | Substituted 1,5-naphthyridine azolinones |
| AR053602A1 (es) * | 2005-05-03 | 2007-05-09 | Smithkline Beecham Corp | Compuesto de 2- arilamino -4-oxo-1,3-tiazol-5(4h)- substituido, composicion farmaceutica que lo comprende, proceso para prepararla y uso del compuesto para preparar un medicamento |
| EP1885362A4 (en) * | 2005-05-23 | 2010-09-22 | Glaxosmithkline Llc | NEW CHEMICAL COMPOUNDS |
| PE20070083A1 (es) * | 2005-06-08 | 2007-01-27 | Smithkline Beecham Corp | (5z)-5-(6-quinoxalinilmetilideno)-2-[(2,6-diclorofenil)amino]-1,3-tiazol-4(5h)-ona |
| JP2008543769A (ja) * | 2005-06-08 | 2008-12-04 | スミスクライン・ビーチャム・コーポレイション | （５ｚ）−５−（６−キノキサリニルメチリデン）−２−［（２，４，６−トリクロロフェニル）アミノ］−１，３−チアゾール−４（５ｈ）−オン |
| TW200745066A (en) * | 2005-09-16 | 2007-12-16 | Torrent Pharmaceuticals Ltd | Novel PTP1B inhibitors |
| WO2007056683A2 (en) * | 2005-11-08 | 2007-05-18 | Smithkline Beecham Corporation | Novel chemical compounds |
| EP1993538A4 (en) * | 2006-03-02 | 2010-05-19 | Glaxosmithkline Llc | THIAZOLONES AS INHIBITORS OF P13-KINASES |
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| US8912340B2 (en) | 2006-11-23 | 2014-12-16 | Actelion Pharmaceuticals Ltd. | Process for the preparation of 2-imino-thiazolidin-4-one derivatives |
| DK2094676T3 (da) * | 2006-11-23 | 2013-06-10 | Actelion Pharmaceuticals Ltd | Ny fremgangsmåde til fremstillingen af 2-iminothiazolidin-4-on-derivater |
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| CN101274918A (zh) * | 2007-03-30 | 2008-10-01 | 中国科学院上海药物研究所 | 一类取代五元杂环化合物,其制备方法和医学用途 |
| EP2423204A4 (en) | 2009-04-20 | 2013-01-09 | Sbi Biotech Co Ltd | THIAZOLIDINONDERIVAT |
| JP5910976B2 (ja) | 2012-07-30 | 2016-04-27 | 国立大学法人京都大学 | 精神神経疾患又は悪性腫瘍に関する化合物及び医薬組成物 |
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| HRP20220490T8 (hr) * | 2014-05-28 | 2022-06-10 | Universität Bern | Spojevi tiazolidinona i njihova upotreba u liječenju psihijatrijskih ili neuroloških poremećaja i inflamacije, posebno neuroinflamacije |
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| DE10115227A1 (de) | 2001-03-28 | 2002-12-19 | Bayer Ag | Optischer Datenträger enthaltend in der Informationsschicht eine lichtabsorbierende Verbindung mit mehreren chromophoren Zentren |
| US6452014B1 (en) | 2000-12-22 | 2002-09-17 | Geron Corporation | Telomerase inhibitors and methods of their use |
| AR037714A1 (es) | 2001-12-06 | 2004-12-01 | Maxia Pharmaceuticals Inc | Derivados de tiazolidinona y oxazolidinona 2-sustituidos para la inhibicion de fosfatasas y el tratamiento de cancer |
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2003
- 2003-11-18 ES ES03796448T patent/ES2315566T3/es not_active Expired - Lifetime
- 2003-11-18 JP JP2004555721A patent/JP2006509765A/ja not_active Ceased
- 2003-11-18 UA UAA200504788A patent/UA80572C2/uk unknown
- 2003-11-18 PT PT03796448T patent/PT1567112E/pt unknown
- 2003-11-18 CA CA002507256A patent/CA2507256A1/en not_active Abandoned
- 2003-11-18 KR KR1020057009243A patent/KR20050085115A/ko not_active Ceased
- 2003-11-18 NZ NZ539873A patent/NZ539873A/en not_active IP Right Cessation
- 2003-11-18 EA EA200500856A patent/EA008865B1/ru not_active IP Right Cessation
- 2003-11-18 WO PCT/US2003/037658 patent/WO2004047760A2/en not_active Ceased
- 2003-11-18 CN CN200380109119A patent/CN100579978C/zh not_active Expired - Fee Related
- 2003-11-18 MX MXPA05005406A patent/MXPA05005406A/es active IP Right Grant
- 2003-11-18 DE DE60324178T patent/DE60324178D1/de not_active Expired - Lifetime
- 2003-11-18 US US10/535,690 patent/US7767701B2/en not_active Expired - Fee Related
- 2003-11-18 AP AP2005003304A patent/AP1967A/xx active
- 2003-11-18 EP EP03796448A patent/EP1567112B1/en not_active Expired - Lifetime
- 2003-11-18 AT AT03796448T patent/ATE411302T1/de active
- 2003-11-18 OA OA1200500154A patent/OA12963A/en unknown
- 2003-11-18 BR BR0316502-7A patent/BR0316502A/pt not_active IP Right Cessation
- 2003-11-18 DK DK03796448T patent/DK1567112T3/da active
- 2003-11-18 AU AU2003298693A patent/AU2003298693B2/en not_active Ceased
- 2003-11-18 SI SI200331463T patent/SI1567112T1/sl unknown
- 2003-11-18 PL PL377564A patent/PL377564A1/pl not_active Application Discontinuation
- 2003-11-20 TW TW092132476A patent/TWI309648B/zh not_active IP Right Cessation
- 2003-11-20 MY MYPI20034473A patent/MY140132A/en unknown
- 2003-11-20 AR ARP030104299A patent/AR045407A1/es not_active Application Discontinuation
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2005
- 2005-05-20 EC EC2005005808A patent/ECSP055808A/es unknown
- 2005-05-27 MA MA28303A patent/MA27701A1/fr unknown
- 2005-06-02 IS IS7879A patent/IS2659B/is unknown
- 2005-06-15 NO NO20052928A patent/NO20052928L/no not_active Application Discontinuation
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2008
- 2008-12-29 CY CY20081101499T patent/CY1108655T1/el unknown
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