SI1420028T1 - Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli - Google Patents

Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli

Info

Publication number: SI1420028T1
Authority: SI; Slovenia
Prior art keywords: perindopril; synthesis; pharmaceutically acceptable; acceptable salts; salts
Prior art date: 2003-11-19

Application number

SI200330702T

Other languages

English (en)

Inventor

Thierry Dubuffet

Pascal Langlois

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-11-19

Filing date

2003-11-19

Publication date

2007-06-30

2003-11-19 Application filed by Servier Lab filed Critical Servier Lab

2007-06-30 Publication of SI1420028T1 publication Critical patent/SI1420028T1/sl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

SI200330702T 2003-11-19 2003-11-19 Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli SI1420028T1 (sl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03292864A EP1420028B1 (fr)	2003-11-19	2003-11-19	Pocédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables

Publications (1)

Publication Number	Publication Date
SI1420028T1 true SI1420028T1 (sl)	2007-06-30

Family

ID=32116380

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200330702T SI1420028T1 (sl)	2003-11-19	2003-11-19	Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli

Country Status (28)

Country	Link
US (1)	US7208607B1 (sl)
EP (1)	EP1420028B1 (sl)
JP (1)	JP4377412B2 (sl)
KR (1)	KR100863394B1 (sl)
CN (1)	CN100447152C (sl)
AR (1)	AR047312A1 (sl)
AT (1)	ATE354586T1 (sl)
AU (1)	AU2004295132B2 (sl)
BR (1)	BRPI0416746B1 (sl)
CA (1)	CA2546506C (sl)
CY (1)	CY1106544T1 (sl)
DE (1)	DE60311942T2 (sl)
DK (1)	DK1420028T3 (sl)
EA (1)	EA010102B1 (sl)
EG (1)	EG26629A (sl)
ES (1)	ES2282586T3 (sl)
GE (1)	GEP20084547B (sl)
MA (1)	MA28144A1 (sl)
MX (1)	MXPA06005607A (sl)
MY (1)	MY138550A (sl)
NO (1)	NO336349B1 (sl)
NZ (1)	NZ546931A (sl)
PL (1)	PL210769B1 (sl)
PT (1)	PT1420028E (sl)
SI (1)	SI1420028T1 (sl)
UA (1)	UA83269C2 (sl)
WO (1)	WO2005054276A1 (sl)
ZA (1)	ZA200603675B (sl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2252633T3 (es) *	2003-08-29	2006-05-16	Les Laboratoires Servier	Nuevo procedimiento de sintesis de perindopril y de sus bases farmaceuticamente aceptables.
CA2551952A1 (en)	2003-12-29	2005-07-21	Sepracor Inc.	Pyrrole and pyrazole daao inhibitors
EP1904066B1 (en)	2005-07-06	2018-05-23	Sunovion Pharmaceuticals Inc.	COMBINATIONS OF ESZOPICLONE AND TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE OR TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPTHALENAMINE, for treating MENOPAUSE, perimenopause AND COGNITIVE DISORDERS
CA2636324C (en)	2006-01-06	2012-03-20	Sepracor Inc.	Cycloalkylamines as monoamine reuptake inhibitors
WO2007081542A2 (en)	2006-01-06	2007-07-19	Sepracor Inc.	Tetralone-based monoamine reuptake inhibitors
DK2013835T3 (en)	2006-03-31	2015-12-14	Sunovion Pharmaceuticals Inc	Preparation of chiral amides and AMINES
US7884124B2 (en)	2006-06-30	2011-02-08	Sepracor Inc.	Fluoro-substituted inhibitors of D-amino acid oxidase
US7902252B2 (en)	2007-01-18	2011-03-08	Sepracor, Inc.	Inhibitors of D-amino acid oxidase
RU2470011C2 (ru)	2007-05-31	2012-12-20	Сепракор Инк.	Циклоалкиламины, содержащие в качестве заместителя фенил, как ингибиторы обратного захвата моноаминов
WO2016178591A2 (en)	2015-05-05	2016-11-10	Gene Predit, Sa	Genetic markers and treatment of male obesity
PH12018502155B1 (en)	2016-04-20	2024-03-27	Servier Lab	Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
CN112047869B (zh) *	2020-08-20	2021-12-21	华南理工大学	一种氮杂5,6-并环化合物的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2620709B1 (fr) *	1987-09-17	1990-09-07	Adir	Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese

2003
- 2003-11-19 PT PT03292864T patent/PT1420028E/pt unknown
- 2003-11-19 SI SI200330702T patent/SI1420028T1/sl unknown
- 2003-11-19 DK DK03292864T patent/DK1420028T3/da active
- 2003-11-19 ES ES03292864T patent/ES2282586T3/es not_active Expired - Lifetime
- 2003-11-19 EP EP03292864A patent/EP1420028B1/fr not_active Expired - Lifetime
- 2003-11-19 DE DE60311942T patent/DE60311942T2/de not_active Expired - Lifetime
- 2003-11-19 AT AT03292864T patent/ATE354586T1/de active
2004
- 2004-11-18 US US10/580,148 patent/US7208607B1/en not_active Expired - Fee Related
- 2004-11-18 UA UAA200606747A patent/UA83269C2/uk unknown
- 2004-11-18 AR ARP040104252A patent/AR047312A1/es not_active Application Discontinuation
- 2004-11-18 CN CNB2004800336869A patent/CN100447152C/zh not_active Expired - Fee Related
- 2004-11-18 JP JP2006540515A patent/JP4377412B2/ja not_active Expired - Fee Related
- 2004-11-18 PL PL380409A patent/PL210769B1/pl unknown
- 2004-11-18 ZA ZA200603675A patent/ZA200603675B/en unknown
- 2004-11-18 NZ NZ546931A patent/NZ546931A/en not_active IP Right Cessation
- 2004-11-18 CA CA2546506A patent/CA2546506C/fr not_active Expired - Fee Related
- 2004-11-18 MY MYPI20044785A patent/MY138550A/en unknown
- 2004-11-18 MX MXPA06005607A patent/MXPA06005607A/es active IP Right Grant
- 2004-11-18 EA EA200600898A patent/EA010102B1/ru not_active IP Right Cessation
- 2004-11-18 BR BRPI0416746-5A patent/BRPI0416746B1/pt not_active IP Right Cessation
- 2004-11-18 AU AU2004295132A patent/AU2004295132B2/en not_active Ceased
- 2004-11-18 GE GEAP20049463A patent/GEP20084547B/en unknown
- 2004-11-18 KR KR1020067011929A patent/KR100863394B1/ko not_active Expired - Fee Related
- 2004-11-18 WO PCT/FR2004/002936 patent/WO2005054276A1/fr not_active Ceased
2006
- 2006-05-02 MA MA28993A patent/MA28144A1/fr unknown
- 2006-05-16 EG EGPCTNA2006000459A patent/EG26629A/en active
- 2006-06-06 NO NO20062599A patent/NO336349B1/no not_active IP Right Cessation
2007
- 2007-04-26 CY CY20071100562T patent/CY1106544T1/el unknown

Also Published As

Publication number	Publication date
NO20062599L (no)	2006-06-06
EP1420028A2 (fr)	2004-05-19
ATE354586T1 (de)	2007-03-15
PL210769B1 (pl)	2012-02-29
EA010102B1 (ru)	2008-06-30
NO336349B1 (no)	2015-08-03
WO2005054276A1 (fr)	2005-06-16
CA2546506C (fr)	2010-04-06
BRPI0416746A (pt)	2007-01-16
EP1420028A3 (fr)	2004-05-26
CN100447152C (zh)	2008-12-31
CA2546506A1 (fr)	2005-06-16
MXPA06005607A (es)	2006-08-17
EA200600898A1 (ru)	2006-10-27
US7208607B1 (en)	2007-04-24
NZ546931A (en)	2010-01-29
KR20060121202A (ko)	2006-11-28
AR047312A1 (es)	2006-01-18
UA83269C2 (uk)	2008-06-25
CN1882607A (zh)	2006-12-20
ES2282586T3 (es)	2007-10-16
DK1420028T3 (da)	2007-06-18
CY1106544T1 (el)	2012-01-25
JP2008502587A (ja)	2008-01-31
AU2004295132B2 (en)	2010-07-15
DE60311942T2 (de)	2007-12-06
MA28144A1 (fr)	2006-09-01
AU2004295132A1 (en)	2005-06-16
GEP20084547B (en)	2008-11-25
US20070083052A1 (en)	2007-04-12
PL380409A1 (pl)	2007-01-22
HK1096689A1 (en)	2007-06-08
KR100863394B1 (ko)	2008-10-14
ZA200603675B (en)	2007-09-26
EG26629A (en)	2014-04-13
BRPI0416746B1 (pt)	2018-02-14
PT1420028E (pt)	2007-05-31
EP1420028B1 (fr)	2007-02-21
DE60311942D1 (de)	2007-04-05
MY138550A (en)	2009-06-30
JP4377412B2 (ja)	2009-12-02

Publication	Publication Date	Title
AU4847001A (en)	2001-08-20	Method for synthesis of perindopril and its pharmaceutically acceptable salts
AU2001248470A1 (en)	2001-11-01	Method for synthesis of perindopril and its pharmaceutically acceptable salts
SI1420028T1 (sl)	2007-06-30	Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
SI1367061T1 (sl)	2006-04-30	Nov postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
SI1362864T1 (sl)	2007-08-31	Nov postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
SI1348684T1 (sl)	2006-06-30	Nov postopek sinteze (2s)-indolin-2-karboksilne kisline in uporaba pri sintezi perindoprila
SI1380590T1 (sl)	2006-12-31	Postopek za sintezo perindoprila in njenih farmacevtsko sprejemljivih soli
SI1371659T1 (sl)	2006-02-28	Nov postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
SI1420029T1 (sl)	2008-08-31	Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
SI1380591T1 (sl)	2006-02-28	Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
IL175657A0 (en)	2006-09-05	Derivatives of dihydronepetalactone and method for preparation
SI1422236T1 (sl)	2007-06-30	Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
SI1367063T1 (sl)	2006-10-31	Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
SI1367062T1 (sl)	2006-12-31	Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
DK1321471T3 (da)	2005-08-29	Ny syntesefremgangsmåde til perindopril og farmaceutisk acceptable salte heraf
SI1403275T1 (sl)	2006-02-28	Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
PL1753720T3 (pl)	2014-09-30	Proces wytwarzania peryndoprylu i jego soli
SI1268424T1 (sl)	2007-12-31	Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
HK1089179A (en)	2006-11-24	Method for the synthesis of exocyclic derivatives of cycloalkyl-hydrazines and exocyclic derivatives of heterocycloalkyl-hydrazines