SI1480983T1 - Heteroaryl substituted 2-pyridinyl and 2-pyrimidinyl-6,7,8,9-tetrahydropydimido(1,2-a)pyrimidin-4-one derivatives - Google Patents

Heteroaryl substituted 2-pyridinyl and 2-pyrimidinyl-6,7,8,9-tetrahydropydimido(1,2-a)pyrimidin-4-one derivatives

Info

Publication number: SI1480983T1
Authority: SI; Slovenia
Prior art keywords: tetrahydropydimido; pyrimidin; pyridinyl; pyrimidinyl; derivatives
Prior art date: 2002-02-28

Application number

SI200330138T

Other languages

Slovenian (sl)

Inventor

Alistair Lochead

Alain Nedelec

Mourad Saady

Philippe Yaiche

Original Assignee

Sanofi Aventis

Mitsubishi Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-28

Filing date

2003-02-26

Publication date

2006-04-30

2002-02-28 Priority claimed from EP02290485A external-priority patent/EP1340758A1/en

2002-02-28 Priority claimed from EP02290486A external-priority patent/EP1348708A1/en

2003-02-26 Application filed by Sanofi Aventis, Mitsubishi Pharma Corp filed Critical Sanofi Aventis

2006-04-30 Publication of SI1480983T1 publication Critical patent/SI1480983T1/en

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Ophthalmology & Optometry (AREA)
Addiction (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Agronomy & Crop Science (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Psychology (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Vascular Medicine (AREA)
Pest Control & Pesticides (AREA)
Plant Pathology (AREA)
Dentistry (AREA)

SI200330138T 2002-02-28 2003-02-26 Heteroaryl substituted 2-pyridinyl and 2-pyrimidinyl-6,7,8,9-tetrahydropydimido(1,2-a)pyrimidin-4-one derivatives SI1480983T1 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
EP02290485A EP1340758A1 (en)	2002-02-28	2002-02-28	Heteroaryl substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives
EP02290486A EP1348708A1 (en)	2002-02-28	2002-02-28	Heteroaryl substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives
PCT/EP2003/002651 WO2003072579A1 (en)	2002-02-28	2003-02-26	HETEROARYL SUBSTITUTED 2-PYRIDINYL AND 2-PYRIMIDINYL -6,7,8,9- TETRAHYDROPYRIMIDO[1,2-a] PYRIMIDIN-4-ONE DERIVATIVES
EP03717210A EP1480983B1 (en)	2002-02-28	2003-02-26	Heteroaryl substituted 2-pyridinyl and 2-pyrimidinyl-6,7,8,9-tetrahydropydimido[1,2-a]pyrimidin-4-one derivatives

Publications (1)

Publication Number	Publication Date
SI1480983T1 true SI1480983T1 (en)	2006-04-30

Family

ID=27767034

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200330138T SI1480983T1 (en)	2002-02-28	2003-02-26	Heteroaryl substituted 2-pyridinyl and 2-pyrimidinyl-6,7,8,9-tetrahydropydimido(1,2-a)pyrimidin-4-one derivatives

Country Status (22)

Country	Link
US (2)	US7232827B2 (en)
EP (1)	EP1480983B1 (en)
JP (1)	JP4458851B2 (en)
KR (1)	KR101030629B1 (en)
CN (1)	CN1315832C (en)
AR (1)	AR038619A1 (en)
AT (1)	ATE309247T1 (en)
AU (1)	AU2003221500B9 (en)
BR (1)	BR0308109A (en)
CA (1)	CA2474823C (en)
DE (1)	DE60302221T2 (en)
DK (1)	DK1480983T3 (en)
EA (1)	EA007737B1 (en)
ES (1)	ES2250883T3 (en)
IL (1)	IL163287A (en)
MX (1)	MXPA04008364A (en)
NO (1)	NO329805B1 (en)
NZ (1)	NZ534466A (en)
PL (1)	PL372465A1 (en)
SI (1)	SI1480983T1 (en)
TW (1)	TWI303637B (en)
WO (1)	WO2003072579A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1603910B1 (en) *	2003-03-07	2009-08-26	Sanofi-Aventis	Substituted 2-(diaza-bicyclo-alkyl)-pyrimidone derivatives
EP1454910A1 (en)	2003-03-07	2004-09-08	Sanofi-Synthelabo	Substituted pyrimidinyl-2-(diaza-bicyclo-alkyl)-pyrimidone derivatives
EP1557417B1 (en) *	2003-12-19	2007-03-07	Sanofi-Aventis	Substituted 8'-pyri(mi)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a] pyrimidin-6-one derivatives
US20080050314A1 (en) *	2004-02-26	2008-02-28	Bayer Healthcare Ag	Diagnostics and Therapeutics for Diseases Associated With Glycogen Synthase Kinase 3 Beta (Gsk3b)
DE102004010207A1 (en)	2004-03-02	2005-09-15	Aventis Pharma S.A.	New 4-benzimidazolyl-3(2H)-pyridazinone derivatives are kinase inhibitors, especially useful for treatment of cancer
DE102004010194A1 (en) *	2004-03-02	2005-10-13	Aventis Pharma Deutschland Gmbh	4-Benzimidazol-2-yl-pyridazin-3-one derivatives, their preparation and use in medicaments
EP2258357A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis with acetylcholinesterase inhibitor
CA2620333A1 (en)	2005-08-26	2007-03-01	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation
JP2009512711A (en)	2005-10-21	2009-03-26	ブレインセルス，インコーポレイティド	Regulation of neurogenesis by PDE inhibition
US20070112017A1 (en)	2005-10-31	2007-05-17	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
EP2382975A3 (en)	2006-05-09	2012-02-29	Braincells, Inc.	Neurogenesis by modulating angiotensin
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
FR2947551B1 (en) *	2009-07-02	2012-05-18	Sanofi Aventis	NOVEL 1,2,3,4-TETRAHYDRO-PYRIMIDO {1,2-A) PYRIMIDIN-6-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)
BRPI1015943A8 (en) *	2009-07-02	2018-01-09	Sanofi Sa	1,2,3,4-tetrahydro-pyrimido {1,2-a} pyrimidin-6-one derivatives, their preparation and their pharmaceutical use.
FR2947550B1 (en) *	2009-07-02	2012-05-18	Sanofi Aventis	NOVEL 2,3-DIHYDRO-1H-IMIDAZO {1,2-A} PYRIMIDIN-5-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)
LT2448939T (en) *	2009-07-02	2017-06-12	Sanofi	2,3-dihydro-1h-imidazo {1,2-a} pyrimidin-5-one derivatives, the preparation and pharmaceutical use thereof
CN102715186A (en) *	2012-06-15	2012-10-10	王学权	Synergistic weeding composition
FR2992314B1 (en)	2012-06-22	2015-10-16	Sanofi Sa	NOVEL 2,3-DIHYDRO-1H-IMIDAZO {1,2-A} PYRIMIDIN-5-ONE AND 1,2,3,4-TETRAHYDRO-PYRIMIDO {1,2-A} PYRIMIDIN-6-ONE DERIVATIVES COMPRISING A SUBSTITUTED MORPHOLINE, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE
DK3126361T3 (en) *	2014-04-01	2020-01-02	Pfizer	CHROMEN AND 1,1A, 2,7B-TETRAHYDROCYCLOPROPA [C] CHROMEN-PYRIDOPYRAZINE DIONS AS GAMMA SECRETASE MODULATORS
WO2015155738A2 (en)	2014-04-09	2015-10-15	Christopher Rudd	Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity
WO2018214866A1 (en) *	2017-05-24	2018-11-29	上海和誉生物医药科技有限公司	Azaaryl derivative, preparation method therefor, and application thereof for use in pharmacy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2002514195A (en) *	1996-12-05	2002-05-14	アムジエン・インコーポレーテツド	Substituted pyrimidine compounds and uses thereof
AR023052A1 (en)	1998-09-25	2002-09-04	Mitsuharu Yoshimura Milton	DERIVATIVES OF PIRIMIDONA
CN1267432C (en)	2000-09-01	2006-08-02	赛诺菲-安万特	2-pyridyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyridyl-2,3-dihydroimidazo[1,2-a] Pyrimidin-5(1H)one Derivatives

2003
- 2003-02-26 DE DE60302221T patent/DE60302221T2/en not_active Expired - Lifetime
- 2003-02-26 AT AT03717210T patent/ATE309247T1/en active
- 2003-02-26 EP EP03717210A patent/EP1480983B1/en not_active Expired - Lifetime
- 2003-02-26 WO PCT/EP2003/002651 patent/WO2003072579A1/en not_active Ceased
- 2003-02-26 US US10/504,677 patent/US7232827B2/en not_active Expired - Fee Related
- 2003-02-26 AU AU2003221500A patent/AU2003221500B9/en not_active Ceased
- 2003-02-26 ES ES03717210T patent/ES2250883T3/en not_active Expired - Lifetime
- 2003-02-26 JP JP2003571285A patent/JP4458851B2/en not_active Expired - Fee Related
- 2003-02-26 MX MXPA04008364A patent/MXPA04008364A/en active IP Right Grant
- 2003-02-26 DK DK03717210T patent/DK1480983T3/en active
- 2003-02-26 EA EA200400936A patent/EA007737B1/en not_active IP Right Cessation
- 2003-02-26 CN CNB038092549A patent/CN1315832C/en not_active Expired - Fee Related
- 2003-02-26 KR KR1020047013466A patent/KR101030629B1/en not_active Expired - Fee Related
- 2003-02-26 CA CA2474823A patent/CA2474823C/en not_active Expired - Fee Related
- 2003-02-26 SI SI200330138T patent/SI1480983T1/en unknown
- 2003-02-26 PL PL03372465A patent/PL372465A1/en not_active IP Right Cessation
- 2003-02-26 NZ NZ534466A patent/NZ534466A/en not_active IP Right Cessation
- 2003-02-26 BR BR0308109-5A patent/BR0308109A/en active Search and Examination
- 2003-02-27 TW TW092104217A patent/TWI303637B/en not_active IP Right Cessation
- 2003-02-28 AR ARP030100657A patent/AR038619A1/en unknown
2004
- 2004-07-29 IL IL163287A patent/IL163287A/en not_active IP Right Cessation
- 2004-08-26 NO NO20043565A patent/NO329805B1/en not_active IP Right Cessation
2007
- 2007-05-16 US US11/749,349 patent/US7465737B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AR038619A1 (en)	2005-01-19
US20070225300A1 (en)	2007-09-27
EA007737B1 (en)	2006-12-29
ES2250883T3 (en)	2006-04-16
CN1649871A (en)	2005-08-03
AU2003221500B9 (en)	2008-11-20
AU2003221500C1 (en)	2008-10-02
TW200402421A (en)	2004-02-16
KR20040087333A (en)	2004-10-13
IL163287A (en)	2009-12-24
AU2003221500A1 (en)	2003-09-09
US7232827B2 (en)	2007-06-19
ATE309247T1 (en)	2005-11-15
DE60302221D1 (en)	2005-12-15
NZ534466A (en)	2006-04-28
CA2474823A1 (en)	2003-09-04
PL372465A1 (en)	2005-07-25
EA200400936A1 (en)	2005-02-24
JP4458851B2 (en)	2010-04-28
CN1315832C (en)	2007-05-16
EP1480983A1 (en)	2004-12-01
BR0308109A (en)	2005-01-04
WO2003072579A1 (en)	2003-09-04
KR101030629B1 (en)	2011-04-20
JP2005519086A (en)	2005-06-30
US7465737B2 (en)	2008-12-16
MXPA04008364A (en)	2005-07-26
NO20043565L (en)	2004-11-25
DK1480983T3 (en)	2006-03-27
AU2003221500B2 (en)	2008-02-14
CA2474823C (en)	2011-02-22
TWI303637B (en)	2008-12-01
EP1480983B1 (en)	2005-11-09
NO329805B1 (en)	2010-12-20
DE60302221T2 (en)	2006-08-03
US20050222172A1 (en)	2005-10-06

Publication	Publication Date	Title
SI1480983T1 (en)	2006-04-30	Heteroaryl substituted 2-pyridinyl and 2-pyrimidinyl-6,7,8,9-tetrahydropydimido(1,2-a)pyrimidin-4-one derivatives
PL392790A1 (en)	2011-01-03	Pyrazole [3, 4-b] pyridine compounds and the use thereof as phosphodiesterase inhibitors
IL158697A0 (en)	2004-05-12	4-amino-5-phenyl-7-cyclobutyl-pyrrolo (2,3-d) pyrimidine derivatives
IL191960A (en)	2015-11-30	Imidazo[1,5-a]pyridine derivatives and pharmaceutical compositions comprising the same
ZA200306341B (en)	2004-11-15	Imidazo (1,2-a)-pyridine derivatives as mGluR5 antagonists.
PL1608654T3 (en)	2010-07-30	8-SUBSTITUTED-6, 7, 8,9-TETRAHY9DROPYRIMIDO (1,2- a) PYRIMIDIN-4-ONE DERIVATIVES
PL377661A1 (en)	2006-02-06	Pyridino[2,3-d]pyrimidine derivatives as selectiive kdr and fgfr inhibitors
AU2002362895A1 (en)	2003-04-28	5-carbamoyl-1,1-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors
IL159832A0 (en)	2004-06-20	4-amino-6-phenyl-pyrrolo[2,3-d] pyrimidine derivatives
AU2002346929A1 (en)	2003-04-28	5-acylamino-1,1-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors
IL166100A0 (en)	2006-01-15	7,8,9-10-tetrahydro-6h-azepino,6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2h-pyrroloÄ2,1-bÜ quinazolinone derivatives
AU2003292007A1 (en)	2004-06-03	4-AMINO-5-PHENYL-7-CYCLOHEXYL-PYRROLO(2,3-d)PYRIMIDINE DERIVATIVES
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