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FR2947551B1 - NOVEL 1,2,3,4-TETRAHYDRO-PYRIMIDO {1,2-A) PYRIMIDIN-6-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB) - Google Patents

NOVEL 1,2,3,4-TETRAHYDRO-PYRIMIDO {1,2-A) PYRIMIDIN-6-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)

Info

Publication number
FR2947551B1
FR2947551B1 FR0903237A FR0903237A FR2947551B1 FR 2947551 B1 FR2947551 B1 FR 2947551B1 FR 0903237 A FR0903237 A FR 0903237A FR 0903237 A FR0903237 A FR 0903237A FR 2947551 B1 FR2947551 B1 FR 2947551B1
Authority
FR
France
Prior art keywords
pyrimido
pkb
pyrimidin
tetrahydro
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0903237A
Other languages
French (fr)
Other versions
FR2947551A1 (en
Inventor
Eric Bacque
Maurice Brollo
Ahmad Youssef El
Romme Bruno Filoche
Frank Halley
Andreas Karlsson
Laurent Schio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0903237A priority Critical patent/FR2947551B1/en
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to PCT/FR2010/051374 priority patent/WO2011001113A2/en
Priority to EP10742013.5A priority patent/EP2448940B1/en
Priority to CN201080039109.6A priority patent/CN102482286B/en
Priority to HK12109830.1A priority patent/HK1169388B/en
Priority to ES10742013.5T priority patent/ES2487623T3/en
Priority to MX2012000103A priority patent/MX2012000103A/en
Priority to US13/381,790 priority patent/US8846670B2/en
Priority to HRP20140786AT priority patent/HRP20140786T1/en
Priority to PT107420135T priority patent/PT2448940E/en
Priority to PL10742013T priority patent/PL2448940T3/en
Priority to JP2012518119A priority patent/JP5655070B2/en
Priority to MYPI2011006391A priority patent/MY155661A/en
Priority to SG2011097839A priority patent/SG177464A1/en
Priority to SG10201403149YA priority patent/SG10201403149YA/en
Priority to KR1020127002806A priority patent/KR20120103553A/en
Priority to RU2012103477/04A priority patent/RU2561130C2/en
Priority to SI201030717T priority patent/SI2448940T1/en
Priority to DK10742013.5T priority patent/DK2448940T3/en
Priority to CA2766909A priority patent/CA2766909C/en
Priority to ARP100102347A priority patent/AR077363A1/en
Priority to AU2010267815A priority patent/AU2010267815B2/en
Priority to BRPI1015943A priority patent/BRPI1015943A8/en
Priority to UY0001032754A priority patent/UY32754A/en
Priority to TW099121933A priority patent/TWI455940B/en
Publication of FR2947551A1 publication Critical patent/FR2947551A1/en
Priority to IL217293A priority patent/IL217293A/en
Application granted granted Critical
Publication of FR2947551B1 publication Critical patent/FR2947551B1/en
Priority to CY20141100668T priority patent/CY1115599T1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0903237A 2009-07-02 2009-07-02 NOVEL 1,2,3,4-TETRAHYDRO-PYRIMIDO {1,2-A) PYRIMIDIN-6-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB) Expired - Fee Related FR2947551B1 (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
FR0903237A FR2947551B1 (en) 2009-07-02 2009-07-02 NOVEL 1,2,3,4-TETRAHYDRO-PYRIMIDO {1,2-A) PYRIMIDIN-6-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)
KR1020127002806A KR20120103553A (en) 2009-07-02 2010-07-01 Novel 1,2,3,4-tetrahydro-pyrimido(1,2-a)pyrimidin-6-one derivatives, preparation thereof, and pharmaceutical use thereof
CN201080039109.6A CN102482286B (en) 2009-07-02 2010-07-01 Novel 1,2,3,4-tetrahydropyrimido{1,2-a}pyrimidin-6-one derivatives, their preparation and their medical use
HK12109830.1A HK1169388B (en) 2009-07-02 2010-07-01 6,7,8,9-tetrahydro-pyrimido{1,2-a} pyrimidin-4-one derivatives, their preparation and pharmaceutical use thereof
ES10742013.5T ES2487623T3 (en) 2009-07-02 2010-07-01 Derivatives of 6,7,8,9-tetrahydro-pyrimido {1,2-a} pyrimidin-4-one, its preparation and its pharmaceutical application
MX2012000103A MX2012000103A (en) 2009-07-02 2010-07-01 Novel 1,2,3,4-tetrahydro-pyrimido(1,2-a)pyrimidin-6-one derivatives, preparation thereof, and pharmaceutical use thereof.
US13/381,790 US8846670B2 (en) 2009-07-02 2010-07-01 1,2,3,4-tetrahydro-pyrimido(1,2-a)pyrimidin-6-one derivatives, preparation thereof, and pharmaceutical use thereof
HRP20140786AT HRP20140786T1 (en) 2009-07-02 2010-07-01 6,7,8,9-tetrahydro-pyrimido{1,2-a} pyrimidin-4-one derivatives, their preparation and pharmaceutical use thereof
PT107420135T PT2448940E (en) 2009-07-02 2010-07-01 6,7,8,9-tetrahydro-pyrimido{1,2-a} pyrimidin-4-one derivatives, their preparation and pharmaceutical use thereof
PL10742013T PL2448940T3 (en) 2009-07-02 2010-07-01 6,7,8,9-tetrahydro-pyrimido{1,2-a} pyrimidin-4-one derivatives, their preparation and pharmaceutical use thereof
JP2012518119A JP5655070B2 (en) 2009-07-02 2010-07-01 Novel 6,7,8,9-tetrahydropyrimido {1,2-a} pyrimidin-4-one derivatives, their preparation and their pharmaceutical use
MYPI2011006391A MY155661A (en) 2009-07-02 2010-07-01 Novel 1,2,3,4-tetrahydropyrimido{1,2-a}pyrimidin-6-one derivatives, preparation thereof and pharmaceutical use thereof
SG2011097839A SG177464A1 (en) 2009-07-02 2010-07-01 Novel 1,2,3,4-tetrahydro-pyrimido(1,2-a)pyrimidin-6-one derivatives, preparation thereof, and pharmaceutical use thereof
SG10201403149YA SG10201403149YA (en) 2009-07-02 2010-07-01 Novel 1,2,3,4-tetrahydro-pyrimido(1,2-a)pyrimidin-6-one derivatives, preparation thereof and pharmaceutical use thereof
PCT/FR2010/051374 WO2011001113A2 (en) 2009-07-02 2010-07-01 Novel 1,2,3,4-tetrahydro-pyrimido(1,2-a)pyrimidin-6-one derivatives, preparation thereof, and pharmaceutical use thereof
CA2766909A CA2766909C (en) 2009-07-02 2010-07-01 Novel 1,2,3,4-tetrahydro-pyrimido(1,2-a)pyrimidin-6-one derivatives, preparation thereof, and pharmaceutical use thereof
EP10742013.5A EP2448940B1 (en) 2009-07-02 2010-07-01 6,7,8,9-tetrahydro-pyrimido{1,2-a} pyrimidin-4-one derivatives, their preparation and pharmaceutical use thereof
DK10742013.5T DK2448940T3 (en) 2009-07-02 2010-07-01 Derivatives of 6,7,8,9 tetrahydro-pyrimido {1,2-a} pyrimidin-4-one, preparation and pharmaceutical use thereof
SI201030717T SI2448940T1 (en) 2009-07-02 2010-07-01 6,7,8,9-tetrahydro-pyrimidoš1,2-ać pyrimidin-4-one derivatives, their preparation and pharmaceutical use thereof
ARP100102347A AR077363A1 (en) 2009-07-02 2010-07-01 DERIVATIVES OF 1,2,3,4- TETRAHYDRO-PYRIMID {1,2-A} PIRIMIDIN-6-ONA, ITS PREPARATION, ITS USE IN CHEMOTHERAPY AND ITS PHARMACEUTICAL COMPOSITIONS.
AU2010267815A AU2010267815B2 (en) 2009-07-02 2010-07-01 Novel 1,2,3,4-tetrahydro-pyrimido(1,2-a)pyrimidin-6-one derivatives, preparation thereof, and pharmaceutical use thereof
BRPI1015943A BRPI1015943A8 (en) 2009-07-02 2010-07-01 1,2,3,4-tetrahydro-pyrimido {1,2-a} pyrimidin-6-one derivatives, their preparation and their pharmaceutical use.
RU2012103477/04A RU2561130C2 (en) 2009-07-02 2010-07-01 NOVEL DERIVATIVES OF 1,2,3,4-TETRAHYDROPYRIMIDO{1,2-a}PYRIMIDIN-6-ONE, OBTAINING THEREOF AND PHARMACEUTICAL APPLICATION
UY0001032754A UY32754A (en) 2009-07-02 2010-07-02 NEW DERIVATIVES OF 1,2,3,4-TETRAHIDRO-PIRIMIDO {1,2-a} PIRIMIDIN-6-ONA, ITS PREPARATION AND ITS USE IN PHARMACEUTICAL
TW099121933A TWI455940B (en) 2009-07-02 2010-07-02 Novel 1,2,3,4-tetrahydropyrimido[1,2-a]pyrimidin-4-one derivatives, preparation thereof and pharmaceutical use thereof
IL217293A IL217293A (en) 2009-07-02 2011-12-29 6,7,8,9- tetrahydropyrimido {1,2-a} pyrimidin- 4 -one derivatives, process for their preparation, pharmaceutical compositions comprising them and use thereof for the preparation of medicaments
CY20141100668T CY1115599T1 (en) 2009-07-02 2014-08-20 6,7,8,9-tetrahydro-pyrimidine derivatives {1,2-a} PYRIMIDIN-4-ONE, THEIR PREPARATION AND THE PHARMACEUTICAL USE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0903237A FR2947551B1 (en) 2009-07-02 2009-07-02 NOVEL 1,2,3,4-TETRAHYDRO-PYRIMIDO {1,2-A) PYRIMIDIN-6-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)

Publications (2)

Publication Number Publication Date
FR2947551A1 FR2947551A1 (en) 2011-01-07
FR2947551B1 true FR2947551B1 (en) 2012-05-18

Family

ID=42027861

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0903237A Expired - Fee Related FR2947551B1 (en) 2009-07-02 2009-07-02 NOVEL 1,2,3,4-TETRAHYDRO-PYRIMIDO {1,2-A) PYRIMIDIN-6-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)

Country Status (1)

Country Link
FR (1) FR2947551B1 (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2703712A1 (en) * 1977-01-29 1978-08-03 Bayer Ag SUBSTITUTED PYRIMIDINONE ANGLE CLAMP ON (DI) -THIO ANGLE CLAMP ON -PHOSPHORUS- (PHOSPHONE) -ACIDESTER OR. -ESTERAMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS INSECTICIDES, ACARICIDES AND NEMATICIDES
CN1267432C (en) * 2000-09-01 2006-08-02 赛诺菲-安万特 2-pyridyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyridyl-2,3-dihydroimidazo[1,2-a] Pyrimidin-5(1H)one Derivatives
CN1247585C (en) * 2001-09-21 2006-03-29 赛诺菲安万特 Substituted 2-pyridyl-6,7,8,9-tetrahydropyrimido[1,2-A]pyrimidin-4-ones and 7-pyridyl-2,3-dihydroimidazo[1,2- A] Pyrimidin-5(1H)one Derivatives
DE60302221T2 (en) * 2002-02-28 2006-08-03 Sanofi-Aventis HETEROARYL SUBSTITUTED 2-PYRIDINYL AND 2-PYRIMIDINYL-6,7,8,9-TETRAHYDROPYRIMIDO [1,2-A] PYRIMIDIN-4-ONDERIVATE
AR053358A1 (en) * 2005-04-15 2007-05-02 Cancer Rec Tech Ltd DNA INHIBITORS - PK
WO2008148074A2 (en) * 2007-05-24 2008-12-04 Research Foundation Of State University Of New York Inhibitors of mtor and methods of treatment using same

Also Published As

Publication number Publication date
FR2947551A1 (en) 2011-01-07

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Year of fee payment: 7

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Effective date: 20170331