SI1077976T1 - Water soluble azoles as broad-spectrum antifungals - Google Patents

Water soluble azoles as broad-spectrum antifungals

Info

Publication number: SI1077976T1
Authority: SI; Slovenia
Prior art keywords: broad; water soluble; spectrum antifungals; soluble azoles; azoles
Prior art date: 1998-05-14

Application number

SI9930131T

Other languages

English (en)

Slovenian (sl)

Inventor

Lieven Meerpoel

Leo Jacobus Jozef Backx

Der Veken Louis Jozef Elisabeth Van

Frank Christopher Odds

Jan Heeres

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-14

Filing date

1999-05-06

Publication date

2003-02-28

1999-05-06 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

2003-02-28 Publication of SI1077976T1 publication Critical patent/SI1077976T1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

SI9930131T 1998-05-14 1999-05-06 Water soluble azoles as broad-spectrum antifungals SI1077976T1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98201588A EP0957101A1 (en)	1998-05-14	1998-05-14	Water soluble azoles as broad-spectrum antifungals
PCT/EP1999/003243 WO1999058530A1 (en)	1998-05-14	1999-05-06	Water soluble azoles as broad-spectrum antifungals

Publications (1)

Publication Number	Publication Date
SI1077976T1 true SI1077976T1 (en)	2003-02-28

Family

ID=8233724

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9930131T SI1077976T1 (en)	1998-05-14	1999-05-06	Water soluble azoles as broad-spectrum antifungals

Country Status (31)

Country	Link
US (2)	US6384030B1 (pl)
EP (3)	EP0957101A1 (pl)
JP (2)	JP2002514645A (pl)
KR (2)	KR100575147B1 (pl)
CN (2)	CN1137118C (pl)
AR (2)	AR016480A1 (pl)
AT (2)	ATE238296T1 (pl)
AU (2)	AU758876B2 (pl)
BG (2)	BG64388B1 (pl)
BR (2)	BR9910448A (pl)
CA (2)	CA2331141C (pl)
CO (1)	CO5021227A1 (pl)
CZ (2)	CZ298702B6 (pl)
DE (2)	DE69902461T2 (pl)
DK (1)	DK1077976T3 (pl)
EE (2)	EE04346B1 (pl)
ES (2)	ES2182531T3 (pl)
HR (2)	HRP20000740B1 (pl)
HU (2)	HUP0103536A3 (pl)
IL (2)	IL139647A0 (pl)
MY (2)	MY122147A (pl)
NO (2)	NO319851B1 (pl)
NZ (2)	NZ507966A (pl)
PL (2)	PL194086B1 (pl)
PT (1)	PT1077976E (pl)
SI (1)	SI1077976T1 (pl)
SK (2)	SK285763B6 (pl)
TR (2)	TR200003323T2 (pl)
TW (2)	TW572899B (pl)
WO (2)	WO1999058530A1 (pl)
ZA (2)	ZA200007173B (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0957101A1 (en) *	1998-05-14	1999-11-17	Janssen Pharmaceutica N.V.	Water soluble azoles as broad-spectrum antifungals
NZ521241A (en) *	2000-03-07	2004-02-27	Ranbaxy Lab Ltd	Azole compounds as therapeutic agents for fungal infections
EP1413301A1 (fr) *	2002-10-24	2004-04-28	Bayer CropScience SA	Médicaments antifongiques à base de dérivés d'arylamidine
ITMI20032020A1 (it)	2003-10-17	2005-04-18	Italfarmaco Spa	Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
AR052342A1 (es) *	2004-12-21	2007-03-14	Janssen Pharmaceutica Nv	Derivados sustituidos de triazolona,tetrazolona e imidazolona con actividad selectiva antagonista de alfa2c-adenoreceptores
EP2571871B1 (en) *	2010-05-19	2017-06-21	Sandoz AG	Process for the preparation of chiral triazolones
WO2013036866A1 (en) *	2011-09-07	2013-03-14	The Johns Hopkins University	Itraconazole analogs and use thereof
US11028078B2 (en)	2011-09-07	2021-06-08	The Johns Hopkins University	Itraconazole analogs and use thereof
DK3003038T3 (da)	2013-06-07	2019-11-11	Scripps Research Inst	2h-1,2,3-triazolderivater som inhibitorer af fibrose
KR102579848B1 (ko)	2014-12-05	2023-09-18	풀모사이드 리미티드	항진균 화합물
AU2015360583B2 (en) *	2014-12-10	2020-01-23	The Scripps Research Institute	Small molecule inhibitors of fibrosis
AU2016263669B2 (en) *	2015-05-21	2020-04-30	Pulmocide Limited	Antifungal 4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4- difluorophenyl)tetrahydrofuran-3-yl) methoxy)-3-methylphenyl)piperazin-1-yl)-N- (2-hydroxycyclohexyl) benzamide, or a pharmaceutically acceptable salt thereof
CN105237392B (zh) *	2015-11-24	2017-12-12	辽宁渤大化工有限公司	芳烷基水杨酸及其衍生物的制备方法
CA3073228A1 (en) *	2017-08-20	2019-02-28	University Of Connecticut	Azole analogues and methods of use thereof
US12435067B2 (en)	2019-08-09	2025-10-07	University Of Connecticut	Truncated itraconazole analogues and methods of use thereof
GB201917867D0 (en)	2019-12-06	2020-01-22	Pulmocide Ltd	Polymorphs
CN111138421A (zh) *	2019-12-26	2020-05-12	上海英诺富成生物科技有限公司	抗真菌水溶性化合物及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4267179A (en) *	1978-06-23	1981-05-12	Janssen Pharmaceutica, N.V.	Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
ATE201408T1 (de) *	1992-03-18	2001-06-15	Janssen Pharmaceutica Nv	Itraconazol- und saperconazolstereoisomere
SK283035B6 (sk) *	1993-12-21	2003-02-04	Schering Corporation	Tetrahydrofuránová zlúčenina, spôsob jej prípravy, jej farmaceuticky prijateľný ester, soľ a farmaceutický prostriedok
EP0741737B1 (en) *	1994-01-24	1999-11-10	Janssen Pharmaceutica N.V.	Watersoluble azole antifungals
FI98688C (fi) *	1994-07-20	1997-07-25	Nokia Telecommunications Oy	Menetelmä lyhytsanomalähetyksen käynnistämiseksi solukkoradiojärjestelmässä, solukkoradiojärjestelmä sekä solukkoradiojärjestelmän tilaajarekisteri
MX9701229A (es) *	1995-06-02	1997-05-31	Schering Corp	Antifungicos de tetrahidrofurano.
JPH11507668A (ja) *	1995-06-19	1999-07-06	シェーリングコーポレイション	テトラヒドロフラン抗真菌剤
WO1998034934A1 (en) *	1997-02-11	1998-08-13	Janssen Pharmaceutica N.V.	Amino acid ester containing azole antifungals
EP0957101A1 (en) *	1998-05-14	1999-11-17	Janssen Pharmaceutica N.V.	Water soluble azoles as broad-spectrum antifungals

1998
- 1998-05-14 EP EP98201588A patent/EP0957101A1/en not_active Withdrawn
1999
- 1999-05-06 ES ES99926304T patent/ES2182531T3/es not_active Expired - Lifetime
- 1999-05-06 PL PL99344037A patent/PL194086B1/pl unknown
- 1999-05-06 PT PT99926304T patent/PT1077976E/pt unknown
- 1999-05-06 WO PCT/EP1999/003243 patent/WO1999058530A1/en not_active Ceased
- 1999-05-06 WO PCT/EP1999/003242 patent/WO1999058529A1/en not_active Ceased
- 1999-05-06 HR HR20000740A patent/HRP20000740B1/xx not_active IP Right Cessation
- 1999-05-06 JP JP2000548333A patent/JP2002514645A/ja active Pending
- 1999-05-06 US US09/700,251 patent/US6384030B1/en not_active Expired - Lifetime
- 1999-05-06 AT AT99924942T patent/ATE238296T1/de not_active IP Right Cessation
- 1999-05-06 EP EP99924942A patent/EP1077975B1/en not_active Expired - Lifetime
- 1999-05-06 TR TR2000/03323T patent/TR200003323T2/xx unknown
- 1999-05-06 ES ES99924942T patent/ES2198915T3/es not_active Expired - Lifetime
- 1999-05-06 BR BR9910448-2A patent/BR9910448A/pt not_active Application Discontinuation
- 1999-05-06 HU HU0103536A patent/HUP0103536A3/hu unknown
- 1999-05-06 NZ NZ507966A patent/NZ507966A/xx not_active IP Right Cessation
- 1999-05-06 SK SK1682-2000A patent/SK285763B6/sk not_active IP Right Cessation
- 1999-05-06 DK DK99926304T patent/DK1077976T3/da active
- 1999-05-06 CZ CZ20004109A patent/CZ298702B6/cs not_active IP Right Cessation
- 1999-05-06 EE EEP200000651A patent/EE04346B1/xx not_active IP Right Cessation
- 1999-05-06 NZ NZ507965A patent/NZ507965A/en not_active IP Right Cessation
- 1999-05-06 DE DE69902461T patent/DE69902461T2/de not_active Expired - Lifetime
- 1999-05-06 IL IL13964799A patent/IL139647A0/xx not_active IP Right Cessation
- 1999-05-06 KR KR1020007011624A patent/KR100575147B1/ko not_active Expired - Fee Related
- 1999-05-06 BR BR9911057-1A patent/BR9911057A/pt not_active Application Discontinuation
- 1999-05-06 PL PL99344047A patent/PL194085B1/pl unknown
- 1999-05-06 JP JP2000548334A patent/JP2002514646A/ja active Pending
- 1999-05-06 CA CA002331141A patent/CA2331141C/en not_active Expired - Fee Related
- 1999-05-06 SI SI9930131T patent/SI1077976T1/xx unknown
- 1999-05-06 KR KR1020007009640A patent/KR100593395B1/ko not_active Expired - Fee Related
- 1999-05-06 AU AU43615/99A patent/AU758876B2/en not_active Ceased
- 1999-05-06 DE DE69907171T patent/DE69907171T2/de not_active Expired - Lifetime
- 1999-05-06 CA CA002331187A patent/CA2331187C/en not_active Expired - Fee Related
- 1999-05-06 CN CNB998059560A patent/CN1137118C/zh not_active Expired - Fee Related
- 1999-05-06 AU AU41417/99A patent/AU751135B2/en not_active Ceased
- 1999-05-06 HU HU0102031A patent/HUP0102031A3/hu unknown
- 1999-05-06 IL IL13964999A patent/IL139649A/en not_active IP Right Cessation
- 1999-05-06 EP EP99926304A patent/EP1077976B1/en not_active Expired - Lifetime
- 1999-05-06 US US09/700,166 patent/US6448244B1/en not_active Expired - Lifetime
- 1999-05-06 AT AT99926304T patent/ATE221884T1/de active
- 1999-05-06 HR HR20000741A patent/HRP20000741B1/xx not_active IP Right Cessation
- 1999-05-06 CZ CZ20004108A patent/CZ299481B6/cs not_active IP Right Cessation
- 1999-05-06 CN CNB998060690A patent/CN1135229C/zh not_active Expired - Fee Related
- 1999-05-06 EE EEP200000657A patent/EE04311B1/xx not_active IP Right Cessation
- 1999-05-06 SK SK1681-2000A patent/SK286156B6/sk not_active IP Right Cessation
- 1999-05-06 TR TR2000/03322T patent/TR200003322T2/xx unknown
- 1999-05-10 TW TW088107504A patent/TW572899B/zh not_active IP Right Cessation
- 1999-05-10 TW TW088107505A patent/TWI259835B/zh not_active IP Right Cessation
- 1999-05-11 MY MYPI99001862A patent/MY122147A/en unknown
- 1999-05-11 MY MYPI99001861A patent/MY120248A/en unknown
- 1999-05-13 AR ARP990102270A patent/AR016480A1/es active IP Right Grant
- 1999-05-13 CO CO99029778A patent/CO5021227A1/es unknown
- 1999-05-13 AR ARP990102276A patent/AR016482A1/es active IP Right Grant
2000
- 2000-08-28 BG BG104717A patent/BG64388B1/bg unknown
- 2000-11-09 BG BG104933A patent/BG64954B1/bg unknown
- 2000-11-13 NO NO20005712A patent/NO319851B1/no not_active IP Right Cessation
- 2000-11-13 NO NO20005713A patent/NO319760B1/no not_active IP Right Cessation
- 2000-12-04 ZA ZA200007173A patent/ZA200007173B/en unknown
- 2000-12-13 ZA ZA200007459A patent/ZA200007459B/xx unknown

Also Published As

Publication number	Publication date
BR9911057A (pt)	2001-02-06
PL194085B1 (pl)	2007-04-30
WO1999058529A1 (en)	1999-11-18
US6384030B1 (en)	2002-05-07
AU4141799A (en)	1999-11-29
EP1077975B1 (en)	2003-04-23
WO1999058530A1 (en)	1999-11-18
HUP0102031A2 (hu)	2002-05-29
NZ507965A (en)	2002-05-31
ATE238296T1 (de)	2003-05-15
EE04346B1 (et)	2004-08-16
HRP20000741A2 (en)	2001-06-30
HK1033312A1 (en)	2001-08-24
NO319760B1 (no)	2005-09-12
PL344047A1 (en)	2001-09-24
MY122147A (en)	2006-03-31
PT1077976E (pt)	2002-12-31
HK1032781A1 (en)	2001-08-03
HUP0102031A3 (en)	2002-10-28
CZ20004108A3 (en)	2001-05-16
TWI259835B (en)	2006-08-11
CZ299481B6 (cs)	2008-08-13
NZ507966A (en)	2002-10-25
PL194086B1 (pl)	2007-04-30
CN1300287A (zh)	2001-06-20
US6448244B1 (en)	2002-09-10
DE69902461T2 (de)	2003-04-10
JP2002514646A (ja)	2002-05-21
JP2002514645A (ja)	2002-05-21
KR100593395B1 (ko)	2006-06-28
CN1300288A (zh)	2001-06-20
BG64954B1 (bg)	2006-10-31
CA2331141A1 (en)	1999-11-18
EE04311B1 (et)	2004-06-15
CZ298702B6 (cs)	2007-12-27
TR200003323T2 (tr)	2001-02-21
EE200000651A (et)	2002-04-15
NO20005713D0 (no)	2000-11-13
ZA200007173B (en)	2002-03-04
SK286156B6 (sk)	2008-04-07
ES2182531T3 (es)	2003-03-01
IL139649A (en)	2004-09-27
HUP0103536A2 (hu)	2002-07-29
NO20005713L (no)	2001-01-11
DE69902461D1 (de)	2002-09-12
DK1077976T3 (da)	2002-12-02
ES2198915T3 (es)	2004-02-01
EP1077976A1 (en)	2001-02-28
MY120248A (en)	2005-09-30
SK16822000A3 (sk)	2001-07-10
BG104933A (en)	2001-10-31
SK285763B6 (sk)	2007-07-06
DE69907171T2 (de)	2004-02-05
IL139649A0 (en)	2002-02-10
DE69907171D1 (de)	2003-05-28
AR016480A1 (es)	2001-07-04
CO5021227A1 (es)	2001-03-27
CN1137118C (zh)	2004-02-04
BR9910448A (pt)	2001-01-02
EP0957101A1 (en)	1999-11-17
HRP20000740B1 (en)	2003-12-31
TR200003322T2 (tr)	2001-02-21
TW572899B (en)	2004-01-21
CZ20004109A3 (en)	2001-05-16
AU751135B2 (en)	2002-08-08
ZA200007459B (en)	2002-09-13
CA2331187A1 (en)	1999-11-18
AU758876B2 (en)	2003-04-03
NO20005712D0 (no)	2000-11-13
AR016482A1 (es)	2001-07-04
PL344037A1 (en)	2001-09-24
BG104717A (en)	2001-07-31
HRP20000741B1 (hr)	2009-02-28
AU4361599A (en)	1999-11-29
SK16812000A3 (sk)	2001-08-06
EP1077975A1 (en)	2001-02-28
EE200000657A (et)	2002-04-15
EP1077976B1 (en)	2002-08-07
HUP0103536A3 (en)	2002-08-28
NO20005712L (no)	2000-12-07
NO319851B1 (no)	2005-09-19
CA2331187C (en)	2008-11-18
CN1135229C (zh)	2004-01-21
KR100575147B1 (ko)	2006-05-03
ATE221884T1 (de)	2002-08-15
HRP20000740A2 (en)	2001-10-31
CA2331141C (en)	2008-10-28
KR20010042852A (ko)	2001-05-25
KR20010041480A (ko)	2001-05-25
BG64388B1 (bg)	2004-12-30
IL139647A0 (en)	2002-02-10

Publication	Publication Date	Title
IL145836A0 (en)	2002-07-25	Substituted azoles
PL347139A1 (en)	2002-03-25	Imidazolyl derivatives
IL153787A0 (en)	2003-07-31	Imidazole derivatives
HUP0100885A3 (en)	2002-12-28	Fungicidal 7-alkyl-triazolopyrimidines
PL344047A1 (en)	2001-09-24	Water soluble azoles as broad-spectrum antifungals
AU7909801A (en)	2002-02-13	Imidazolyl derivatives
ZA200003680B (en)	2001-01-22	Triazole and imidazole derivatives.
PT1470266E (pt)	2014-06-09	Melhoria em sistemas de procteção catódica
PL347573A1 (en)	2002-04-08	Pyrimidin-4-enamine as fungicide
MXPA01006686A (es)	2003-07-21	Composiciones fungicidas quirales de imidazol y metodos para su utilizacion.
IL150506A0 (en)	2003-02-12	New imidazole derivatives
GB9808755D0 (en)	1998-06-24	Fungicidal use
GB2354414B (en)	2004-12-22	Locating network echos
AU5312100A (en)	2000-12-18	Water soluble multi-biotin-containing compounds
GB0003919D0 (en)	2000-04-05	Kinetomatic system III
ZA200105196B (en)	2003-11-13	Chiral imidazole fungicidal compositions and methods for their use.
SI1224180T1 (en)	2003-12-31	Substituted azoles
GB2346462B (en)	2003-11-26	Memories
ZA200108403B (en)	2002-12-24	Substituted azoles.
PL343921A1 (en)	2001-05-21	Toolhead
AU136717S (en)	1999-03-10	Water bubbler
GB9811367D0 (en)	1998-07-22	Imidazole carbenes
GB9805250D0 (en)	1998-05-06	Water soluble films
GB9823484D0 (en)	1998-12-23	Fungicidal use
GB9902416D0 (en)	1999-03-24	Improved finishing agent