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NO20005712L - Vannlöselige azoler som bredspektrede antifungale midler - Google Patents

Vannlöselige azoler som bredspektrede antifungale midler

Info

Publication number
NO20005712L
NO20005712L NO20005712A NO20005712A NO20005712L NO 20005712 L NO20005712 L NO 20005712L NO 20005712 A NO20005712 A NO 20005712A NO 20005712 A NO20005712 A NO 20005712A NO 20005712 L NO20005712 L NO 20005712L
Authority
NO
Norway
Prior art keywords
broad
water
antifungal agents
spectrum antifungal
soluble azoles
Prior art date
Application number
NO20005712A
Other languages
English (en)
Other versions
NO319851B1 (no
NO20005712D0 (no
Inventor
Lieven Meerpoel
Leo Jacobus Jozef Backx
Louis Jozef Elisabeth Va Veken
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20005712D0 publication Critical patent/NO20005712D0/no
Publication of NO20005712L publication Critical patent/NO20005712L/no
Publication of NO319851B1 publication Critical patent/NO319851B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/101,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
NO20005712A 1998-05-14 2000-11-13 Vannloselige azoler som bredspektrede antifungale midler NO319851B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98201588A EP0957101A1 (en) 1998-05-14 1998-05-14 Water soluble azoles as broad-spectrum antifungals
PCT/EP1999/003242 WO1999058529A1 (en) 1998-05-14 1999-05-06 Water soluble azoles as broad-spectrum antifungals

Publications (3)

Publication Number Publication Date
NO20005712D0 NO20005712D0 (no) 2000-11-13
NO20005712L true NO20005712L (no) 2000-12-07
NO319851B1 NO319851B1 (no) 2005-09-19

Family

ID=8233724

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20005713A NO319760B1 (no) 1998-05-14 2000-11-13 Vannloselige azoler som bredspektrede antifungale midler, deres fremstilling og anvendelse samt farmasoytiske sammensetninger omfattende dem
NO20005712A NO319851B1 (no) 1998-05-14 2000-11-13 Vannloselige azoler som bredspektrede antifungale midler

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20005713A NO319760B1 (no) 1998-05-14 2000-11-13 Vannloselige azoler som bredspektrede antifungale midler, deres fremstilling og anvendelse samt farmasoytiske sammensetninger omfattende dem

Country Status (31)

Country Link
US (2) US6384030B1 (no)
EP (3) EP0957101A1 (no)
JP (2) JP2002514645A (no)
KR (2) KR100593395B1 (no)
CN (2) CN1135229C (no)
AR (2) AR016480A1 (no)
AT (2) ATE221884T1 (no)
AU (2) AU758876B2 (no)
BG (2) BG64388B1 (no)
BR (2) BR9911057A (no)
CA (2) CA2331187C (no)
CO (1) CO5021227A1 (no)
CZ (2) CZ299481B6 (no)
DE (2) DE69902461T2 (no)
DK (1) DK1077976T3 (no)
EE (2) EE04346B1 (no)
ES (2) ES2182531T3 (no)
HR (2) HRP20000741B1 (no)
HU (2) HUP0103536A3 (no)
IL (2) IL139647A0 (no)
MY (2) MY120248A (no)
NO (2) NO319760B1 (no)
NZ (2) NZ507966A (no)
PL (2) PL194086B1 (no)
PT (1) PT1077976E (no)
SI (1) SI1077976T1 (no)
SK (2) SK285763B6 (no)
TR (2) TR200003322T2 (no)
TW (2) TW572899B (no)
WO (2) WO1999058530A1 (no)
ZA (2) ZA200007173B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals
JP2004501867A (ja) * 2000-03-07 2004-01-22 ランバクシー ラボラトリーズ リミテッド 真菌感染症に対する治療薬としてのアゾール化合物
EP1413301A1 (fr) * 2002-10-24 2004-04-28 Bayer CropScience SA Médicaments antifongiques à base de dérivés d'arylamidine
ITMI20032020A1 (it) 2003-10-17 2005-04-18 Italfarmaco Spa Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
AR052342A1 (es) * 2004-12-21 2007-03-14 Janssen Pharmaceutica Nv Derivados sustituidos de triazolona,tetrazolona e imidazolona con actividad selectiva antagonista de alfa2c-adenoreceptores
RU2585760C2 (ru) * 2010-05-19 2016-06-10 Сандоз Аг Способ получения хиральных триазолонов
WO2013036866A1 (en) * 2011-09-07 2013-03-14 The Johns Hopkins University Itraconazole analogs and use thereof
US11028078B2 (en) * 2011-09-07 2021-06-08 The Johns Hopkins University Itraconazole analogs and use thereof
AU2014274830B2 (en) 2013-06-07 2017-11-09 The California Institute For Biomedical Research Small molecule inhibitors of fibrosis
HUE048905T2 (hu) 2014-12-05 2020-08-28 Pulmocide Ltd Antimikotikus vegyület
EP3250036B1 (en) 2014-12-10 2021-05-12 The Scripps Research Institute Small molecule inhibitors of fibrosis
JP6811727B2 (ja) 2015-05-21 2021-01-20 プルモシデ リミテド 抗真菌性の4−(4−(4−(((3r,5r)−5−((1h−1,2,4−トリアゾール−1−イル)メチル)−5−(2,4−ジフルオロフェニル)テトラヒドロフラン−3−イル)メトキシ)−3−メチルフェニル)ピペラジン−1−イル)−n−(2−ヒドロキシシクロヘキシル)ベンズアミド、又はその医薬として許容し得る塩
CN105237392B (zh) * 2015-11-24 2017-12-12 辽宁渤大化工有限公司 芳烷基水杨酸及其衍生物的制备方法
US11390613B2 (en) 2017-08-20 2022-07-19 University Of Connecticut Azole analogues and methods of use thereof
US12435067B2 (en) 2019-08-09 2025-10-07 University Of Connecticut Truncated itraconazole analogues and methods of use thereof
GB201917867D0 (en) 2019-12-06 2020-01-22 Pulmocide Ltd Polymorphs
CN111138421A (zh) * 2019-12-26 2020-05-12 上海英诺富成生物科技有限公司 抗真菌水溶性化合物及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267179A (en) * 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
DK0631578T3 (da) * 1992-03-18 2001-08-27 Janssen Pharmaceutica Nv Itraconazol- og saperconazol-stereoisomerer
AU681753B2 (en) * 1993-12-21 1997-09-04 Merck Sharp & Dohme Corp. Tetrahydrofuran antifungals
PT741737E (pt) * 1994-01-24 2000-04-28 Janssen Pharmaceutica Nv Antifungicos do tipo azole soluveis em agua
FI98688C (fi) * 1994-07-20 1997-07-25 Nokia Telecommunications Oy Menetelmä lyhytsanomalähetyksen käynnistämiseksi solukkoradiojärjestelmässä, solukkoradiojärjestelmä sekä solukkoradiojärjestelmän tilaajarekisteri
IL118464A (en) * 1995-06-02 2000-08-13 Schering Corp (2R-cis)-4-¬4-¬4-¬4¬¬-5-(2',4 dihalophenyl)-tetrahydro-5-(1-H-1,2,4,triazol-1-yl-methyl)furan-3-yl(methoxy¾phenyl¾-1-piperazinyl¬phenyl2,4,dihydro2¬(5)-1-ethyl-2-(5)hydroxy propyl¾-3H-1,2,4-triazol-3-one and pharmaceutical compositions comprising them
CA2224707A1 (en) * 1995-06-19 1997-01-03 Schering Corporation Tetrahydrofuran antifungals
AU725302C (en) * 1997-02-11 2001-08-23 Janssen Pharmaceutica N.V. Amino acid ester containing azole antifungals
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals

Also Published As

Publication number Publication date
AU758876B2 (en) 2003-04-03
EE04346B1 (et) 2004-08-16
NO20005713L (no) 2001-01-11
AR016482A1 (es) 2001-07-04
KR20010041480A (ko) 2001-05-25
US6384030B1 (en) 2002-05-07
DE69902461T2 (de) 2003-04-10
CN1137118C (zh) 2004-02-04
SK286156B6 (sk) 2008-04-07
JP2002514646A (ja) 2002-05-21
HRP20000741A2 (en) 2001-06-30
NO319851B1 (no) 2005-09-19
HRP20000741B1 (hr) 2009-02-28
IL139647A0 (en) 2002-02-10
WO1999058530A1 (en) 1999-11-18
SK16822000A3 (sk) 2001-07-10
AU751135B2 (en) 2002-08-08
CZ298702B6 (cs) 2007-12-27
EE200000657A (et) 2002-04-15
NO319760B1 (no) 2005-09-12
DE69907171D1 (de) 2003-05-28
NO20005712D0 (no) 2000-11-13
ZA200007459B (en) 2002-09-13
KR20010042852A (ko) 2001-05-25
PL194085B1 (pl) 2007-04-30
MY120248A (en) 2005-09-30
CA2331187C (en) 2008-11-18
ES2198915T3 (es) 2004-02-01
IL139649A (en) 2004-09-27
US6448244B1 (en) 2002-09-10
DK1077976T3 (da) 2002-12-02
AR016480A1 (es) 2001-07-04
MY122147A (en) 2006-03-31
PT1077976E (pt) 2002-12-31
TW572899B (en) 2004-01-21
HUP0102031A3 (en) 2002-10-28
BG104717A (en) 2001-07-31
EP1077976A1 (en) 2001-02-28
HK1032781A1 (en) 2001-08-03
EE200000651A (et) 2002-04-15
CO5021227A1 (es) 2001-03-27
BG104933A (en) 2001-10-31
EP1077976B1 (en) 2002-08-07
CN1135229C (zh) 2004-01-21
AU4361599A (en) 1999-11-29
ATE238296T1 (de) 2003-05-15
ATE221884T1 (de) 2002-08-15
DE69907171T2 (de) 2004-02-05
IL139649A0 (en) 2002-02-10
AU4141799A (en) 1999-11-29
CA2331141A1 (en) 1999-11-18
CA2331141C (en) 2008-10-28
PL344037A1 (en) 2001-09-24
EP0957101A1 (en) 1999-11-17
CZ299481B6 (cs) 2008-08-13
CN1300288A (zh) 2001-06-20
HUP0102031A2 (hu) 2002-05-29
CN1300287A (zh) 2001-06-20
HK1033312A1 (en) 2001-08-24
NZ507966A (en) 2002-10-25
TWI259835B (en) 2006-08-11
BR9911057A (pt) 2001-02-06
PL344047A1 (en) 2001-09-24
SK285763B6 (sk) 2007-07-06
EP1077975A1 (en) 2001-02-28
HRP20000740B1 (en) 2003-12-31
DE69902461D1 (de) 2002-09-12
KR100593395B1 (ko) 2006-06-28
SI1077976T1 (en) 2003-02-28
EE04311B1 (et) 2004-06-15
TR200003323T2 (tr) 2001-02-21
HUP0103536A3 (en) 2002-08-28
KR100575147B1 (ko) 2006-05-03
TR200003322T2 (tr) 2001-02-21
JP2002514645A (ja) 2002-05-21
ES2182531T3 (es) 2003-03-01
HUP0103536A2 (hu) 2002-07-29
BG64388B1 (bg) 2004-12-30
PL194086B1 (pl) 2007-04-30
HRP20000740A2 (en) 2001-10-31
NZ507965A (en) 2002-05-31
CA2331187A1 (en) 1999-11-18
NO20005713D0 (no) 2000-11-13
SK16812000A3 (sk) 2001-08-06
CZ20004109A3 (en) 2001-05-16
ZA200007173B (en) 2002-03-04
EP1077975B1 (en) 2003-04-23
WO1999058529A1 (en) 1999-11-18
BR9910448A (pt) 2001-01-02
CZ20004108A3 (en) 2001-05-16
BG64954B1 (bg) 2006-10-31

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Legal Events

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