SI0891978T1 - 5H-Thiazolo (3,2-a) pyrimidine derivatives - Google Patents

5H-Thiazolo (3,2-a) pyrimidine derivatives

Info

Publication number: SI0891978T1
Authority: SI; Slovenia
Prior art keywords: thiazolo; pyrimidine derivatives; pyrimidine; derivatives
Prior art date: 1997-07-18

Application number

SI9830130T

Other languages

English (en)

Slovenian (sl)

Inventor

Geo Adam

Sabine Kolczewski

Vincent Mutel

Jrgen Wichmann

Thomas Johannes Woltering

Original Assignee

F. Hoffmann-La Roche Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-18

Filing date

1998-07-11

Publication date

2002-06-30

1998-07-11 Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag

2002-06-30 Publication of SI0891978T1 publication Critical patent/SI0891978T1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
- C07D239/40—One sulfur atom as doubly bound sulfur atom or as unsubstituted mercapto radical

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Addiction (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Cardiology (AREA)
Otolaryngology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SI9830130T 1997-07-18 1998-07-11 5H-Thiazolo (3,2-a) pyrimidine derivatives SI0891978T1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97112324		1997-07-18
EP98112915A EP0891978B1 (en)	1997-07-18	1998-07-11	5H-Thiazolo (3,2-a) pyrimidine derivatives

Publications (1)

Publication Number	Publication Date
SI0891978T1 true SI0891978T1 (en)	2002-06-30

Family

ID=8227080

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9830130T SI0891978T1 (en)	1997-07-18	1998-07-11	5H-Thiazolo (3,2-a) pyrimidine derivatives

Country Status (32)

Country	Link
US (1)	US5958931A (xx)
EP (1)	EP0891978B1 (xx)
JP (1)	JP3100573B2 (xx)
KR (1)	KR100296837B1 (xx)
CN (1)	CN1102596C (xx)
AR (1)	AR016129A1 (xx)
AT (1)	ATE214704T1 (xx)
AU (1)	AU738207B2 (xx)
BR (1)	BR9802482A (xx)
CA (1)	CA2243234C (xx)
CO (1)	CO5210884A1 (xx)
CZ (1)	CZ288944B6 (xx)
DE (1)	DE69804273T2 (xx)
DK (1)	DK0891978T3 (xx)
ES (1)	ES2172840T3 (xx)
HR (1)	HRP980398B1 (xx)
HU (1)	HUP9801587A3 (xx)
ID (1)	ID21824A (xx)
IL (1)	IL125358A (xx)
MA (1)	MA26520A1 (xx)
NO (1)	NO310512B1 (xx)
NZ (1)	NZ330988A (xx)
PE (1)	PE97499A1 (xx)
PL (1)	PL190218B1 (xx)
PT (1)	PT891978E (xx)
RU (1)	RU2197493C2 (xx)
SI (1)	SI0891978T1 (xx)
TR (1)	TR199801367A2 (xx)
TW (1)	TW523518B (xx)
UY (1)	UY25095A1 (xx)
YU (1)	YU29798A (xx)
ZA (1)	ZA986250B (xx)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1074549B1 (en) *	1999-08-06	2003-11-19	F. Hoffmann-La Roche Ag	Tetrahydro-benzo(d)azepines and their use as antagonists at metabotropic glutamate receptors
EP2140862A3 (en) *	2001-01-31	2010-02-17	H.Lundbeck A/S	Use of GAL 3 receptor antagonists for the treatment of depression and /or anxiety and compounds useful in such methods
EP1408042A4 (en) *	2001-06-14	2005-02-02	Banyu Pharma Co Ltd	NEW ISOXAZOLOPYRIDONE DERIVATIVES AND THEIR USE
US7329662B2 (en)	2003-10-03	2008-02-12	Hoffmann-La Roche Inc.	Pyrazolo-pyridine
KR100847160B1 (ko) *	2004-06-21	2008-07-17	에프. 호프만-라 로슈 아게	피라졸로 피리미딘 유도체
RU2378277C2 (ru)	2004-06-21	2010-01-10	Ф. Хоффманн-Ля Рош Аг	Производные пиразолпиримидина
JP4708438B2 (ja)	2005-02-11	2011-06-22	エフ．ホフマン−ラロシュアーゲー	ｍＧｌｕＲ２アンタゴニストとしてのピラゾロピリミジン誘導体
CN101180299B (zh)	2005-03-23	2010-12-15	弗·哈夫曼-拉罗切有限公司	作为mglur2拮抗剂的乙炔基-吡唑并嘧啶衍生物
UA90707C2 (xx) *	2005-04-06	2010-05-25	Астразенека Аб	5-ЗАМІЩЕНІ ПОХІДНІ 7-АМІНО-$1,3]ТІАЗОЛО$4,5-d]ПІРИМІДИНУ$5-ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 7-АМИНО-$1,3]ТИАЗОЛО$4,5-d]ПИРИМИДИНА
AR053347A1 (es) *	2005-04-06	2007-05-02	Astrazeneca Ab	Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos
BRPI0616571A2 (pt)	2005-09-27	2011-06-21	Hoffmann La Roche	oxadiazolil pirazol-piridiminas como antagonistas de mglur2, processo para sua preparação, composição farmacêutica que os contém e uso dos mesmo
AR059898A1 (es)	2006-03-15	2008-05-07	Janssen Pharmaceutica Nv	Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200845978A (en) *	2007-03-07	2008-12-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en)	2007-03-07	2009-01-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
SI2203439T1 (sl)	2007-09-14	2011-05-31	Ortho Mcneil Janssen Pharm	1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni
US8722894B2 (en) *	2007-09-14	2014-05-13	Janssen Pharmaceuticals, Inc.	1,3-disubstituted-4-phenyl-1H-pyridin-2-ones
NZ584152A (en)	2007-09-14	2011-11-25	Ortho Mcneil Janssen Pharm	1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
RU2492170C9 (ru) *	2007-11-14	2013-12-27	Орто-Макнейл-Янссен Фармасьютикалз, Инк.	Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2
AU2009289784B2 (en)	2008-09-02	2012-03-22	Addex Pharma S.A.	3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
US8697689B2 (en)	2008-10-16	2014-04-15	Janssen Pharmaceuticals, Inc.	Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
WO2010060589A1 (en)	2008-11-28	2010-06-03	Ortho-Mcneil-Janssen Pharmaceuticals, Inc.	Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
CN101503414B (zh) *	2009-03-04	2013-10-30	沈阳药科大学	噻唑并[3,2-b]-1,2,4-三嗪衍生物及其应用
CN102439008B (zh)	2009-05-12	2015-04-29	杨森制药有限公司	1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
MY153913A (en)	2009-05-12	2015-04-15	Janssen Pharmaceuticals Inc	7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
BRPI1010831A2 (pt)	2009-05-12	2016-04-05	Addex Pharmaceuticals Sa	derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2
PT2649069E (pt)	2010-11-08	2015-11-20	Janssen Pharmaceuticals Inc	Derivados de 1,2,4-triazolo[4,3-a]piridina e sua utilização como moduladores alostéricos positivos de recetores mglur2
WO2012062759A1 (en)	2010-11-08	2012-05-18	Janssen Pharmaceuticals, Inc.	1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JP5852665B2 (ja)	2010-11-08	2016-02-03	ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド	１，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
JO3368B1 (ar)	2013-06-04	2019-03-13	Janssen Pharmaceutica Nv	مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar)	2013-09-06	2019-03-13	Janssen Pharmaceutica Nv	مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
RS58047B1 (sr)	2013-10-11	2019-02-28	Hoffmann La Roche	Tiazolopirimidinoni kao modulatori aktivnosti nmda receptora
ES2860298T3 (es)	2014-01-21	2021-10-04	Janssen Pharmaceutica Nv	Combinaciones que comprenden moduladores alostéricos positivos del receptor glutamatérgico metabotrópico de subtipo 2 y su uso
AU2015208233B2 (en)	2014-01-21	2019-08-29	Janssen Pharmaceutica Nv	Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
CN116076518A (zh) *	2017-03-31	2023-05-09	巴斯夫欧洲公司	用于防除动物害虫的嘧啶鎓化合物及其混合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3660418A (en) *	1970-03-16	1972-05-02	Sandoz Ag	Certain 2 3 5 6-tetrahydroimidazo(2 1-b)thiazoles
GB1582744A (en) *	1976-06-04	1981-01-14	Gruenenthal Gmbh	7h-thiazolo (and 1,3,4-thiadiazolo-)(3,2-a) pyrimidin-7-one-5-carboxylic acids derivatives and medicaments therof
SU1169330A1 (ru) *	1983-11-10	1995-11-27	Институт Тонкой Органической Химии Им.А.Л.Мнджояна	Способ получения 4-п-алкоксифенил-2,6-диоксогексагидропиримидинов
HUT42077A (en) *	1985-06-03	1987-06-29	Squibb & Sons Inc	Process for producing diesters of 2-tioxo- or 2-oxo-pyrimidine-1,5-dicarboxylic acid and 1-acyl-pyrimidine-5-carboxylic acids and esters
ZA905407B (en) *	1989-06-13	1991-04-24	Daiichi Seiyaku Co	Pyrrolo(2,1-b)thiozle derivatives
EP0524055A1 (fr) *	1991-07-19	1993-01-20	Synthelabo	Dérivés d'imidazo[2,1-b]benzothiazole-3-acétamide, leur préparation et leur application en thérapeutique
ZA931109B (en) *	1992-03-04	1993-09-22	Akzo Nv	Tetrahydropyrimidine derivatives.
PL182285B1 (pl) *	1994-08-12	2001-12-31	Lilly Co Eli	Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL
GB9609976D0 (en) *	1996-05-13	1996-07-17	Lilly Industries Ltd	Pharmaceutical compounds
WO1998006724A1 (en) *	1996-08-09	1998-02-19	Yamanouchi Pharmaceutical Co., Ltd.	Metabotropic glutamate receptor agonists

1998
- 1998-07-11 AT AT98112915T patent/ATE214704T1/de not_active IP Right Cessation
- 1998-07-11 DE DE69804273T patent/DE69804273T2/de not_active Expired - Fee Related
- 1998-07-11 EP EP98112915A patent/EP0891978B1/en not_active Expired - Lifetime
- 1998-07-11 DK DK98112915T patent/DK0891978T3/da active
- 1998-07-11 PT PT98112915T patent/PT891978E/pt unknown
- 1998-07-11 ES ES98112915T patent/ES2172840T3/es not_active Expired - Lifetime
- 1998-07-11 SI SI9830130T patent/SI0891978T1/xx unknown
- 1998-07-14 ZA ZA986250A patent/ZA986250B/xx unknown
- 1998-07-14 ID IDP981000A patent/ID21824A/id unknown
- 1998-07-14 NO NO19983244A patent/NO310512B1/no not_active IP Right Cessation
- 1998-07-14 TR TR1998/01367A patent/TR199801367A2/xx unknown
- 1998-07-14 US US09/115,191 patent/US5958931A/en not_active Expired - Fee Related
- 1998-07-14 MA MA25167A patent/MA26520A1/fr unknown
- 1998-07-14 NZ NZ330988A patent/NZ330988A/xx unknown
- 1998-07-15 HU HU9801587A patent/HUP9801587A3/hu unknown
- 1998-07-15 CN CN98116063A patent/CN1102596C/zh not_active Expired - Fee Related
- 1998-07-15 IL IL12535898A patent/IL125358A/en not_active IP Right Cessation
- 1998-07-15 CA CA002243234A patent/CA2243234C/en not_active Expired - Fee Related
- 1998-07-15 JP JP10199363A patent/JP3100573B2/ja not_active Expired - Fee Related
- 1998-07-15 PE PE1998000625A patent/PE97499A1/es not_active Application Discontinuation
- 1998-07-15 YU YU29798A patent/YU29798A/sh unknown
- 1998-07-16 AR ARP980103469A patent/AR016129A1/es not_active Application Discontinuation
- 1998-07-16 CO CO98040510A patent/CO5210884A1/es not_active Application Discontinuation
- 1998-07-16 CZ CZ19982239A patent/CZ288944B6/cs not_active IP Right Cessation
- 1998-07-16 KR KR1019980028788A patent/KR100296837B1/ko not_active Expired - Fee Related
- 1998-07-16 HR HR980398A patent/HRP980398B1/xx not_active IP Right Cessation
- 1998-07-16 PL PL98327532A patent/PL190218B1/pl unknown
- 1998-07-16 BR BR9802482-5A patent/BR9802482A/pt not_active Application Discontinuation
- 1998-07-16 UY UY25095A patent/UY25095A1/es unknown
- 1998-07-17 AU AU77302/98A patent/AU738207B2/en not_active Ceased
- 1998-07-17 RU RU98114683/04A patent/RU2197493C2/ru not_active IP Right Cessation
- 1998-07-21 TW TW087111834A patent/TW523518B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL190218B1 (pl)	2005-11-30
HUP9801587A2 (hu)	1999-11-29
DK0891978T3 (da)	2002-07-01
CA2243234C (en)	2007-09-18
PE97499A1 (es)	1999-10-12
YU29798A (sh)	2001-12-26
DE69804273D1 (de)	2002-04-25
AU7730298A (en)	1999-01-28
NZ330988A (en)	1999-03-29
IL125358A (en)	2002-09-12
CZ288944B6 (cs)	2001-10-17
ES2172840T3 (es)	2002-10-01
PT891978E (pt)	2002-07-31
EP0891978A3 (en)	1999-02-03
HRP980398B1 (en)	2002-06-30
JP3100573B2 (ja)	2000-10-16
HUP9801587A3 (en)	2001-09-28
NO983244L (no)	1999-01-19
CA2243234A1 (en)	1999-01-18
CZ223998A3 (cs)	1999-02-17
HRP980398A2 (en)	1999-04-30
ID21824A (id)	1999-07-29
US5958931A (en)	1999-09-28
KR19990013919A (ko)	1999-02-25
KR100296837B1 (ko)	2001-10-26
MA26520A1 (fr)	2004-12-20
DE69804273T2 (de)	2002-10-31
RU2197493C2 (ru)	2003-01-27
PL327532A1 (en)	1999-02-01
CN1102596C (zh)	2003-03-05
CN1206010A (zh)	1999-01-27
HK1018439A1 (en)	1999-12-24
BR9802482A (pt)	2000-03-14
NO310512B1 (no)	2001-07-16
EP0891978B1 (en)	2002-03-20
EP0891978A2 (en)	1999-01-20
JPH1171380A (ja)	1999-03-16
UY25095A1 (es)	2001-01-31
IL125358A0 (en)	1999-03-12
TR199801367A3 (tr)	1999-02-22
HU9801587D0 (en)	1998-09-28
ZA986250B (en)	1999-01-22
AR016129A1 (es)	2001-06-20
AU738207B2 (en)	2001-09-13
TW523518B (en)	2003-03-11
ATE214704T1 (de)	2002-04-15
TR199801367A2 (xx)	1999-02-22
NO983244D0 (no)	1998-07-14
CO5210884A1 (es)	2002-10-30

Publication	Publication Date	Title
SI0891978T1 (en)	2002-06-30	5H-Thiazolo (3,2-a) pyrimidine derivatives
SI1220856T1 (en)	2005-06-30	Pyrazolo(4,3-d)pyrimidine derivatives
EG23758A (en)	2007-08-08	Pyrrolo (2,3-d) pyrimidine compounds
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SG71077A1 (en)	2000-03-21	8-Substituted-1,3, 8-triaza-spiro (4.5)decan-4-on derivatives
IL131521A0 (en)	2001-01-28	Pyrimidine derivatives
SI0921125T1 (en)	2002-04-30	1,3,8-Triazaspiro(4,5)decan-4-on derivatives
ZA985121B (en)	1999-12-13	3-Substituted 3,4-dihyrothieno(2,3-d)pyrimidine derivatives their preparation and use.
IL127399A0 (en)	1999-10-28	1,3,8-Triaza-spiro (4,5) decan-4-on derivatives
ZA983177B (en)	1999-01-22	5,7-Disubstituted-4-aminopyrdo [2,3] pyrimidine compounds
AUPO912997A0 (en)	1997-10-02	Antiviral agents
ZA982436B (en)	1999-09-23	Thiazolimine derivatives.
IL136500A0 (en)	2001-06-14	1,4-diazacycloheptane derivatives
HU9503012D0 (en)	1995-12-28	New pyrimidine derivatives
ZA982912B (en)	1998-10-09	6,7-disubstituted-4-aminopyrido [2,3-d] pyrimidine compounds
AU3467197A (en)	1998-10-22	Tetracyclical derivatives from pyrimidine
AU5678798A (en)	1998-08-25	Antiviral agents
ZA983175B (en)	1998-10-21	5, 6, 7-Trisubstituted-4-aminopyrido (2, 3-d) pyrimidine compounds
ZA985559B (en)	1999-01-20	Tetrahydroimidazo Ä2,1-aÜsoquinoline derivatives
ZA981307B (en)	1999-08-17	4-aminoethoxyindazole derivatives.
AU7073296A (en)	1997-11-19	5,6,7,8-tetrahydropyrido{2,3-d}pyrimidines
EP0954316A4 (en)	2002-02-13	PYRIMIDINE DERIVATIVES
AU3500997A (en)	1998-01-14	5,6,7,8-tetrahydropyrido{2,3-d}pyrimidine derivatives
HK1027096A (en)	2001-01-05	6,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds
HK1027095A (en)	2001-01-05	5,6,7-trisubstituted-4-aminopyridol[2,3-d]pyrimidine compounds