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SI0739199T1 - Estradiol penetration intensifier for transdermal administration - Google Patents

Estradiol penetration intensifier for transdermal administration

Info

Publication number
SI0739199T1
SI0739199T1 SI9530601T SI9530601T SI0739199T1 SI 0739199 T1 SI0739199 T1 SI 0739199T1 SI 9530601 T SI9530601 T SI 9530601T SI 9530601 T SI9530601 T SI 9530601T SI 0739199 T1 SI0739199 T1 SI 0739199T1
Authority
SI
Slovenia
Prior art keywords
pct
estradiol
transdermal administration
sec
active substance
Prior art date
Application number
SI9530601T
Other languages
English (en)
Slovenian (sl)
Inventor
Reinhold Meconi
Frank Seibertz
Original Assignee
Lts Lohmann Therapie-Systeme Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lts Lohmann Therapie-Systeme Ag filed Critical Lts Lohmann Therapie-Systeme Ag
Publication of SI0739199T1 publication Critical patent/SI0739199T1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Adhesives Or Adhesive Processes (AREA)
SI9530601T 1994-01-13 1995-01-05 Estradiol penetration intensifier for transdermal administration SI0739199T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4400770A DE4400770C1 (de) 1994-01-13 1994-01-13 Wirkstoffhaltiges Pflaster zur Abgabe von Estradiol mit mindestens einem Penetrationsverstärker, Verfahren zu seiner Herstellung und seine Verwendung
PCT/EP1995/000032 WO1995019162A1 (fr) 1994-01-13 1995-01-05 Amplificateur de penetration d'estradiol pour administration transcutanee

Publications (1)

Publication Number Publication Date
SI0739199T1 true SI0739199T1 (en) 2002-10-31

Family

ID=6507821

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9530601T SI0739199T1 (en) 1994-01-13 1995-01-05 Estradiol penetration intensifier for transdermal administration

Country Status (22)

Country Link
US (1) US6090404A (fr)
EP (1) EP0739199B1 (fr)
JP (1) JP3980633B2 (fr)
KR (1) KR100374087B1 (fr)
AT (1) ATE215363T1 (fr)
AU (1) AU707963B2 (fr)
CZ (1) CZ287330B6 (fr)
DE (2) DE4400770C1 (fr)
DK (1) DK0739199T3 (fr)
ES (1) ES2174922T3 (fr)
FI (1) FI118719B (fr)
HU (1) HU222499B1 (fr)
IL (1) IL112145A (fr)
MY (1) MY113680A (fr)
NO (1) NO962933L (fr)
NZ (1) NZ278593A (fr)
PL (1) PL184875B1 (fr)
PT (1) PT739199E (fr)
SI (1) SI0739199T1 (fr)
SK (1) SK280530B6 (fr)
WO (1) WO1995019162A1 (fr)
ZA (1) ZA95226B (fr)

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US6974588B1 (en) * 1999-12-07 2005-12-13 Elan Pharma International Limited Transdermal patch for delivering volatile liquid drugs
GB0103046D0 (en) * 2001-02-07 2001-03-21 Novartis Ag Organic Compounds
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JP2006515629A (ja) * 2003-01-23 2006-06-01 シャイア ラボラトリーズ，インコーポレイテッド 吸収促進剤
CA2580329C (fr) * 2004-09-13 2015-01-06 Chrono Therapeutics Inc. Administration de medicament transdermique biosynchrone
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
US20070042026A1 (en) * 2005-03-17 2007-02-22 Wille John J Prophylactic and therapeutic treatment of topical and transdermal drug-induced skin reactions
WO2006127905A2 (fr) 2005-05-24 2006-11-30 Chrono Therapeutics, Inc. Dispositif d'apport de medicament portatif comprenant un element de dosage et d'administration detachable et remplaçable
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US20130017259A1 (en) 2011-07-06 2013-01-17 The Parkinson's Institute Compositions and Methods for Treatment of Symptoms in Parkinson's Disease Patients
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
RS62297B1 (sr) 2011-11-23 2021-09-30 Therapeuticsmd Inc Prirodne kombinovane hormonske supstitucione formulacije i terapije
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10105487B2 (en) 2013-01-24 2018-10-23 Chrono Therapeutics Inc. Optimized bio-synchronous bioactive agent delivery system
JP2017516768A (ja) 2014-05-22 2017-06-22 セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． 天然の併用ホルモン補充療法剤及び療法
CA2974324A1 (fr) 2015-01-28 2016-08-04 Zita S. Netzel Procedes et systemes d'administration de medicament
WO2016145373A1 (fr) 2015-03-12 2016-09-15 Chrono Therapeutics Inc. Système d'entrée d'état de manque et de support
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
US9931349B2 (en) 2016-04-01 2018-04-03 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
WO2017215863A1 (fr) * 2016-06-15 2017-12-21 Unilever N.V. Procédé et composition cosmétique pour une meilleure administration transdermique de résorcinol substitué par un alkyle
EP3565617A1 (fr) 2017-01-06 2019-11-13 Chrono Therapeutics Inc. Dispositifs et methodes d'administration transdermique de medicament
US11596779B2 (en) 2018-05-29 2023-03-07 Morningside Venture Investments Limited Drug delivery methods and systems
CA3119992A1 (fr) 2018-11-16 2020-05-22 Morningside Venture Investments Limited Systeme d'administration transdermique de medicaments a regulation thermique
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
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Also Published As

Publication number Publication date
ZA95226B (en) 1996-02-07
FI118719B (fi) 2008-02-29
IL112145A0 (en) 1995-03-15
JP3980633B2 (ja) 2007-09-26
AU707963B2 (en) 1999-07-22
NO962933L (no) 1996-09-12
CZ287330B6 (en) 2000-10-11
CZ205396A3 (en) 1996-10-16
KR100374087B1 (ko) 2003-04-23
MY113680A (en) 2002-04-30
SK280530B6 (sk) 2000-03-13
EP0739199B1 (fr) 2002-04-03
HU9601872D0 (en) 1996-09-30
NO962933D0 (no) 1996-07-12
FI962702A0 (fi) 1996-06-28
US6090404A (en) 2000-07-18
PL184875B1 (pl) 2003-01-31
HU222499B1 (hu) 2003-07-28
ATE215363T1 (de) 2002-04-15
WO1995019162A1 (fr) 1995-07-20
JPH09511229A (ja) 1997-11-11
AU1455295A (en) 1995-08-01
PT739199E (pt) 2002-09-30
IL112145A (en) 2000-10-31
DK0739199T3 (da) 2002-07-29
PL315527A1 (en) 1996-11-12
ES2174922T3 (es) 2002-11-16
FI962702L (fi) 1996-08-27
DE59510142D1 (de) 2002-05-08
HUT74455A (en) 1996-12-30
NZ278593A (en) 1997-12-19
EP0739199A1 (fr) 1996-10-30
DE4400770C1 (de) 1995-02-02
KR970700021A (ko) 1997-01-08
SK91596A3 (en) 1997-03-05

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