SG47843A1 - Amino alkanoic esters of rapamycin - Google Patents
Amino alkanoic esters of rapamycinInfo
- Publication number
- SG47843A1 SG47843A1 SG1996004668A SG1996004668A SG47843A1 SG 47843 A1 SG47843 A1 SG 47843A1 SG 1996004668 A SG1996004668 A SG 1996004668A SG 1996004668 A SG1996004668 A SG 1996004668A SG 47843 A1 SG47843 A1 SG 47843A1
- Authority
- SG
- Singapore
- Prior art keywords
- hydrogen
- arylalkyl
- rapamycin
- alkyl
- image
- Prior art date
Links
- 150000002148 esters Chemical class 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title 1
- 229960002930 sirolimus Drugs 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- -1 fluorenylmethyl Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/174,120 US5389639A (en) | 1993-12-29 | 1993-12-29 | Amino alkanoic esters of rapamycin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG47843A1 true SG47843A1 (en) | 1998-04-17 |
Family
ID=22634919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG1996004668A SG47843A1 (en) | 1993-12-29 | 1994-12-28 | Amino alkanoic esters of rapamycin |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5389639A (fr) |
| EP (1) | EP0737197B1 (fr) |
| JP (1) | JPH09507236A (fr) |
| KR (1) | KR100338582B1 (fr) |
| AT (1) | ATE217312T1 (fr) |
| AU (1) | AU1519895A (fr) |
| CA (1) | CA2179307A1 (fr) |
| DE (1) | DE69430586T2 (fr) |
| DK (1) | DK0737197T3 (fr) |
| ES (1) | ES2177627T3 (fr) |
| PT (1) | PT737197E (fr) |
| SG (1) | SG47843A1 (fr) |
| WO (1) | WO1995018133A1 (fr) |
Families Citing this family (90)
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| US5780462A (en) * | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
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| US6331547B1 (en) | 1999-08-18 | 2001-12-18 | American Home Products Corporation | Water soluble SDZ RAD esters |
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| US20050002986A1 (en) * | 2000-05-12 | 2005-01-06 | Robert Falotico | Drug/drug delivery systems for the prevention and treatment of vascular disease |
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| US5286730A (en) * | 1991-09-17 | 1994-02-15 | American Home Products Corporation | Method of treating immunoinflammatory disease |
| US5151413A (en) * | 1991-11-06 | 1992-09-29 | American Home Products Corporation | Rapamycin acetals as immunosuppressant and antifungal agents |
| US5177203A (en) * | 1992-03-05 | 1993-01-05 | American Home Products Corporation | Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents |
-
1993
- 1993-12-29 US US08/174,120 patent/US5389639A/en not_active Expired - Lifetime
-
1994
- 1994-12-28 EP EP95906728A patent/EP0737197B1/fr not_active Expired - Lifetime
- 1994-12-28 WO PCT/US1994/014960 patent/WO1995018133A1/fr not_active Ceased
- 1994-12-28 JP JP7518187A patent/JPH09507236A/ja not_active Withdrawn
- 1994-12-28 PT PT95906728T patent/PT737197E/pt unknown
- 1994-12-28 SG SG1996004668A patent/SG47843A1/en unknown
- 1994-12-28 AT AT95906728T patent/ATE217312T1/de not_active IP Right Cessation
- 1994-12-28 AU AU15198/95A patent/AU1519895A/en not_active Abandoned
- 1994-12-28 DE DE69430586T patent/DE69430586T2/de not_active Expired - Fee Related
- 1994-12-28 DK DK95906728T patent/DK0737197T3/da active
- 1994-12-28 ES ES95906728T patent/ES2177627T3/es not_active Expired - Lifetime
- 1994-12-28 CA CA002179307A patent/CA2179307A1/fr not_active Abandoned
- 1994-12-28 KR KR1019960703482A patent/KR100338582B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5389639A (en) | 1995-02-14 |
| EP0737197A1 (fr) | 1996-10-16 |
| JPH09507236A (ja) | 1997-07-22 |
| ES2177627T3 (es) | 2002-12-16 |
| WO1995018133A1 (fr) | 1995-07-06 |
| DK0737197T3 (da) | 2002-08-26 |
| HK1011355A1 (en) | 1999-07-09 |
| DE69430586D1 (de) | 2002-06-13 |
| CA2179307A1 (fr) | 1995-07-06 |
| AU1519895A (en) | 1995-07-17 |
| PT737197E (pt) | 2002-09-30 |
| ATE217312T1 (de) | 2002-05-15 |
| EP0737197B1 (fr) | 2002-05-08 |
| KR100338582B1 (ko) | 2002-10-12 |
| DE69430586T2 (de) | 2002-11-21 |
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