[go: up one dir, main page]

SG165343A1 - Jnk inhibitors for the treatment of endometriosis - Google Patents

Jnk inhibitors for the treatment of endometriosis

Info

Publication number
SG165343A1
SG165343A1 SG201006416-0A SG2010064160A SG165343A1 SG 165343 A1 SG165343 A1 SG 165343A1 SG 2010064160 A SG2010064160 A SG 2010064160A SG 165343 A1 SG165343 A1 SG 165343A1
Authority
SG
Singapore
Prior art keywords
endometriosis
treatment
jnk inhibitors
jnk inhibitor
jnk
Prior art date
Application number
SG201006416-0A
Other languages
English (en)
Inventor
Stephen S Palmer
Selvaraj Nataraja
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Publication of SG165343A1 publication Critical patent/SG165343A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG201006416-0A 2005-07-15 2006-07-12 Jnk inhibitors for the treatment of endometriosis SG165343A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69965805P 2005-07-15 2005-07-15
EP05109447 2005-10-11

Publications (1)

Publication Number Publication Date
SG165343A1 true SG165343A1 (en) 2010-10-28

Family

ID=35709133

Family Applications (1)

Application Number Title Priority Date Filing Date
SG201006416-0A SG165343A1 (en) 2005-07-15 2006-07-12 Jnk inhibitors for the treatment of endometriosis

Country Status (11)

Country Link
US (1) US8592414B2 (fr)
EP (1) EP1904181A2 (fr)
JP (1) JP2009509916A (fr)
KR (1) KR20130087052A (fr)
AU (1) AU2006270184B2 (fr)
BR (1) BRPI0613042A2 (fr)
CA (1) CA2611598A1 (fr)
EA (1) EA016437B1 (fr)
MX (1) MX2008000663A (fr)
SG (1) SG165343A1 (fr)
WO (1) WO2007011762A2 (fr)

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE169334T1 (de) 1983-11-02 1998-08-15 Applied Research Systems Herstellung heterodimirer menschlicher fruchtbarkeitshormone
US4923805A (en) 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
IT1206302B (it) 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
US4988679A (en) * 1989-01-03 1991-01-29 Leonard Chavkin Liquid sustained release composition
IE82916B1 (en) * 1990-11-02 2003-06-11 Elan Corp Plc Formulations and their use in the treatment of neurological diseases
SG63617A1 (en) 1991-01-18 1999-03-30 Amgen Boulder Inc Methods for treating tumar necrosis factor mediated diseases
US5433951A (en) * 1993-10-13 1995-07-18 Bristol-Myers Squibb Company Sustained release formulation containing captopril and method
DE59509577D1 (de) 1995-02-16 2001-10-11 Merck Patent Gmbh Vinylenverbindungen und flüssigkristallines Medium
FR2762514B1 (fr) 1997-04-29 1999-10-22 Sanofi Sa Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments pour le traitement des maladies entrainant une demyelinisation
SE9801474D0 (sv) 1998-04-27 1998-04-27 Active Biotech Ab Quinoline Derivatives
TW591026B (en) 1998-06-23 2004-06-11 Upjohn Co Inhibitors of alpha4beta1 mediated cell adhesion
WO2000035920A2 (fr) 1998-12-17 2000-06-22 F. Hoffmann-La Roche Ag 4,5-azolo-oxindoles
TR200101747T2 (tr) 1998-12-17 2001-11-21 F.Hoffmann-La Roche Ag 4- ve 5-alkinil oksindoller ve 4- ve 5-alkeniloksindoller.
CA2354591A1 (fr) 1998-12-17 2000-06-22 F. Hoffmann-La Roche Ag 4-aryloxindoles utilises comme inhibiteurs de proteines kinases jnk
AU4483000A (en) 1999-04-23 2000-11-10 Vertex Pharmaceuticals Incorporated Inhibitors of c-jun n-terminal kinases (jnk)
WO2000075118A1 (fr) 1999-06-03 2000-12-14 Vertex Pharmaceuticals Incorporated INHIBITEURS DE KINASES c-JUN N-TERMINALES (JNK)
CA2381882C (fr) 1999-08-13 2011-01-25 Vertex Pharmaceuticals Incorporated Inhibiteurs de c-jun n-terminal kinases (jnk) et d'autres proteines-kinases
NZ517578A (en) 1999-08-19 2004-02-27 Signal Pharm Inc Pyrazoloanthrone and derivatives thereof as JNK inhibitors and their compositions
EP1088821A1 (fr) 1999-09-28 2001-04-04 Applied Research Systems ARS Holding N.V. Derives des sulfamides pharmaceutiquement actifs
EP1088822A1 (fr) 1999-09-28 2001-04-04 Applied Research Systems ARS Holding N.V. Dérivés de sulfonyl hydrazides pharmaceutiquement actifs
EP1088815A1 (fr) 1999-09-28 2001-04-04 Applied Research Systems ARS Holding N.V. Dérivés d'acides amines sulphonyle pharmaceutiquement actifs
US20020115689A1 (en) 1999-12-21 2002-08-22 Joanne Waldstreicher Combination therapy for treating neurodegenerative disease
EP1110957A1 (fr) * 1999-12-24 2001-06-27 Applied Research Systems ARS Holding N.V. Dérivés de benzazole et leur utilisation comme modulateurs de JNK
ES2336817T3 (es) * 2000-02-25 2010-04-16 Siemens Healthcare Diagnostics Inc. Marcadores relacionados con la endometriosis y usos de los mismos.
EP1193267A1 (fr) 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Composés de sulfonamides hydrophiles pharmaceutiquement actifs
EP1193268A1 (fr) 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Dérivés de sulfonamide pharmaceutiquement actifs comportant des groupes lipophiles ainsi que ionisables comme inhibiteurs de protéine junkinases
US6399626B1 (en) 2000-10-02 2002-06-04 Wyeth Hydroxyesters of 7-desmethylrapamycin
US20030134836A1 (en) * 2001-01-12 2003-07-17 Amgen Inc. Substituted arylamine derivatives and methods of use
US7115617B2 (en) 2001-08-22 2006-10-03 Amgen Inc. Amino-substituted pyrimidinyl derivatives and methods of use
EP1450792B1 (fr) 2001-12-07 2006-09-27 Applied Research Systems ARS Holding N.V. Derives de benzazole pour le traitement de sclerodermie
WO2003057725A2 (fr) * 2002-01-09 2003-07-17 University Of Lausanne Inhibiteurs peptidiques, a permeabilite cellulaire, du processus de transduction du signal jnk
GB0204159D0 (en) 2002-02-22 2002-04-10 British Biotech Pharm Metalloproteinase inhibitors
JP2005533748A (ja) * 2002-03-08 2005-11-10 シグナル ファーマシューティカルズ，インコーポレイテッド 増殖性障害および癌を治療、予防、または管理するための併用療法
ATE383356T1 (de) 2002-04-25 2008-01-15 Serono Lab Piperazinbenzothiazole als wirkstoffe in der behandlung von ischämien und krankheiten des zns- systems
TW200410631A (en) 2002-09-25 2004-07-01 Meiji Seika Kaisha Slow-releasable pesticide granules
TWI291467B (en) 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
WO2004082665A1 (fr) * 2003-03-17 2004-09-30 Takeda Pharmaceutical Company Limited Composition à libération contrôlée
CA2534314C (fr) 2003-09-12 2012-11-13 Applied Research Systems Ars Holding N.V. Derives de benzothiazole pour le traitement du diabete
US20070079629A1 (en) 2003-10-30 2007-04-12 Laboratories Serono S.A. Process and apparatus for cooling and atomizing liquid or pasty-like substances
RU2253489C1 (ru) * 2004-04-07 2005-06-10 Научный центр акушерства, гинекологии и перинатологии РАМН Способ лечения бесплодия у женщин с наружным генитальным эндометриозом
EA011614B1 (ru) * 2004-11-17 2009-04-28 Арес Трейдинг С.А. Препараты бензотиазола и их применение
US7838522B2 (en) * 2004-11-17 2010-11-23 Ares Trading S.A. Benzothiazole formulations and use thereof

Also Published As

Publication number Publication date
US8592414B2 (en) 2013-11-26
WO2007011762A8 (fr) 2007-08-02
AU2006270184B2 (en) 2011-09-29
WO2007011762A3 (fr) 2007-04-05
EA016437B1 (ru) 2012-05-30
BRPI0613042A2 (pt) 2010-12-14
WO2007011762A2 (fr) 2007-01-25
US20090176761A1 (en) 2009-07-09
KR20130087052A (ko) 2013-08-05
CA2611598A1 (fr) 2007-01-25
MX2008000663A (es) 2008-03-13
AU2006270184A1 (en) 2007-01-25
EA200800343A1 (ru) 2008-06-30
EP1904181A2 (fr) 2008-04-02
JP2009509916A (ja) 2009-03-12

Similar Documents

Publication Publication Date Title
EA200800755A1 (ru) Ikk ингибиторы, предназначенные для лечения эндометриоза
MY150697A (en) Methods of treating cancer using pyridopyrimdinone inhibitors of p13k alpha
JO2886B1 (en) Useful compounds in the inhibition of CHK1
MX366119B (es) Uso de un agente inhibidor de masp-2 para el tratamiento de condiciones renales mediadas por complemento dependiente de la masp-2.
MY150797A (en) Combination therapies comprising quinaxoline inhibitors of pi3k-alpha for use in the treatment of cancer
MY153669A (en) Ocular allergy treatments field of the invention
TN2010000209A1 (en) Treatment of uterine cancer and ovarian cancer with a parp inhibitor alone or in combination with anti-tumor agents
TW200605886A (en) Indazoles useful in treating cardiovascular diseases
MX2008011633A (es) Aminoquinolonas como inhibidores de gsk-3.
MX2008011872A (es) Analogos de tiazolidinediona para el tratamiento de la hipertension y para disminuir lipidos.
MX2010004967A (es) Uso de inhibidor de cfms para el tratamiento y la prevención del cancer de hueso, así como la perdida osea y el dolor de hueso asociados con el cancer de hueso.
WO2007140317A3 (fr) Méthodes d'utilisation d'inhibiteurs de la phospholipase a2 cytosolique dans le traitement de la thrombose
TW200733976A (en) Method for the treatment of cognitive dysfunction
MXPA05011501A (es) Combinacion terapeutica de un inhibidor de cox-2 y un inhibidor de aromatasa.
WO2007030360A3 (fr) Inhibiteurs pi3k utiles dans le traitement de l'endometriose
WO2007097980A3 (fr) Inhibiteur de l'ubiquitine/protéasome pour le traitement de l'atrophie musculaire spinale
TW200730190A (en) New combination to treat liver fibrosis
WO2009148600A3 (fr) Composés à base de lysine deutérée
UA96736C2 (ru) Ингибиторы pi3k для лечения эндометриоза
SG165343A1 (en) Jnk inhibitors for the treatment of endometriosis
WO2008063853A3 (fr) Procédé de traitement d'un cancer
ZA200710497B (en) Glepp-1 inhibitors in the treatment of autoimmune and/or inflammatory disorders
TW200642688A (en) New use of PDE7 inhibitors
UA89242C2 (ru) Способ лечения эндометриоза с применением ингибитора jnk, которым является производное бензотиазола
NO20080782L (no) JNK-inhibitorer for behandling av endometriose